Assessing concordance of nonclinical and clinical QT data: The ILSI-HESI cardiovascular safety subcommittee initiative re-visited (Englisch)
- Neue Suche nach: Skinner, M.
- Neue Suche nach: Valentin, J. P.
- Neue Suche nach: Gintant, G.
- Neue Suche nach: Koerner, J.
- Neue Suche nach: Pettit, S.
- Neue Suche nach: Wisialowski, T.
- Neue Suche nach: Skinner, M.
- Neue Suche nach: Valentin, J. P.
- Neue Suche nach: Gintant, G.
- Neue Suche nach: Koerner, J.
- Neue Suche nach: Pettit, S.
- Neue Suche nach: Wisialowski, T.
In:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
;
66
, 2
;
170-171
;
2012
-
ISSN:
- Aufsatz (Zeitschrift) / Print
-
Titel:Assessing concordance of nonclinical and clinical QT data: The ILSI-HESI cardiovascular safety subcommittee initiative re-visited
-
Beteiligte:Skinner, M. ( Autor:in ) / Valentin, J. P. ( Autor:in ) / Gintant, G. ( Autor:in ) / Koerner, J. ( Autor:in ) / Pettit, S. ( Autor:in ) / Wisialowski, T. ( Autor:in )
-
Erschienen in:JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS ; 66, 2 ; 170-171
-
Verlag:
- Neue Suche nach: Elsevier Science B.V., Amsterdam.
-
Erscheinungsdatum:01.01.2012
-
Format / Umfang:2 pages
-
ISSN:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Print
-
Sprache:Englisch
- Neue Suche nach: 615.9
- Weitere Informationen zu Dewey Decimal Classification
-
Klassifikation:
DDC: 615.9 -
Datenquelle:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Inhaltsverzeichnis – Band 66, Ausgabe 2
Zeige alle Jahrgänge und Ausgaben
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
- 59
-
Methodological innovations expand the safety pharmacology horizonPugsley, M. K. / Curtis, M. J. et al. | 2012
- 63
-
dP/dtmax - A measure of 'baroinometry'Hamlin, R. L. / del Rio, C. et al. | 2012
- 66
-
How do the top 12 pharmaceutical companies operate safety pharmacology?Ewart, L. / Gallacher, D. J. / Gintant, G. / Guillon, J. M. / Leishman, D. / Levesque, P. / McMahon, N. / Mylecraine, L. / Sanders, M. / Suter, W. et al. | 2012
- 71
-
Left ventricular pressure, contractility and dP/dtmax in nonclinical drug safety assessment studiesSarazan, R. D. / Kroehle, J. P. / Main, B. W. et al. | 2012
- 79
-
Safety immunopharmacology: Evaluation of the adverse potential of pharmaceuticals on the immune systemDescotes, J. et al. | 2012
- 84
-
Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6month periodChui, R. W. / Derakhchan, K. / Vargas, H. M. et al. | 2012
- 92
-
Quickly finding a needle in a haystack: A new automated cardiac arrhythmia detection software for preclinical studiesKoeppel, F. / Labarre, D. / Zitoun, P. et al. | 2012
- 98
-
Evaluation of a method to correct the contractility index LVdP/dtmax for changes in heart rateMarkert, M. / Trautmann, T. / Grosz, M. / Ege, A. / Mayer, K. / Guth, B. et al. | 2012
- 106
-
Comparison of non-invasive and implanted telemetric measurement of blood pressure and electrocardiogram in conscious beagle dogsWard, G. / Milliken, P. / Patel, B. / McMahon, N. et al. | 2012
- 114
-
Cardiorespiratory safety evaluation in non-human primatesIngram-Ross, J. L. / Curran, A. K. / Miyamoto, M. / Sheehan, J. / Thomas, G. / Verbeeck, J. / de Waal, E. J. / Verstynen, B. / Pugsley, M. K. et al. | 2012
- 125
-
Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pigGuns, P. J. / Johnson, D. M. / Weltens, E. / Lissens, J. et al. | 2012
- 135
-
Direct effects of arsenic trioxide on action potentials in isolated cardiac tissues: Importance of the choice of species, type of cardiac tissue and perfusion timeLu, H. R. / Vlaminckx, E. / Cools, F. / Gallacher, D. J. et al. | 2012
- 145
-
Cardiac tissue slices with prolonged survival for in vitro drug safety screeningBussek, A. / Schmidt, M. / Bauriedl, J. / Ravens, U. / Wettwer, E. / Lohmann, H. et al. | 2012
- 152
-
Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: Invasive LVP measurements versus the QA intervalJohnson, D. M. / Geys, R. / Lissens, J. / Guns, P. J. et al. | 2012
- 160
-
Detection of ECG intervals in anesthetized guinea-pigs: Man versus machineGuns, P. J. / Van Op den bosch, J. / Weltens, E. / Lissens, J. et al. | 2012
- 160
-
Effects of hNaV1.5 blockers on the rat QRS intervalEricson, A. C. / Kagstrom, J. / Laumola, E. L. / Martinsson, F. / Eriksson, A. B. et al. | 2012
- 160
-
The electro-mechanical window in anaesthetized guinea-pigs: A new marker for TdP risk screeningGuns, P. J. / Van Op den bosch, J. / Weltens, E. / Lissens, J. et al. | 2012
- 161
-
Assessment of respiratory function and duration of action in an anaesthetized dog model with recoveryMontero, J. L. / Doe, C. / Miralpeix, M. / Gavalda, A. et al. | 2012
- 161
-
Simultaneous assessment of in vivo ECG liabilities and load-independent myocardial function in guinea pigsUeyama, Y. / del Rio, C. L. / Hamlin, R. L. et al. | 2012
- 161
-
Potential for increased pulmonary vascular pressure due to verapamilVargas-Pinto, P. A. / Pedraza-Toscano, A. M. / Hamlin, R. L. / Del Rio, C. et al. | 2012
- 161
-
Use of QA interval to assess cardiac contractility in anesthetized ratSaengklub, N. / Limprasutr, V. / Meedech, P. / Kijtawornrat, A. / del Rio, C. / Hamlin, R. L. et al. | 2012
- 162
-
Modified Irwin Screen parameters in rat inhalation toxicology studiesJonasson, H. / Johansson, L. M. et al. | 2012
- 162
-
Functional observation battery in nonhuman primates with continuous intracerebral infusionAuthier, S. / Bienvenu, J. G. / Tavcar, R. / Fournier, S. / Schneider, A. / Wong, K. et al. | 2012
- 162
-
Neurobehavioral assessments of motor activity, startle response, and learning/memory in juvenile ratsToot, J. D. / Herberth, M. T. / Beck, M. J. / Stump, D. G. / Atterson, P. R. / Nemec, M. D. et al. | 2012
- 163
-
The RotaRod test for motor coordination: Methodological considerations and potential added value vs. the Irwin testHimmel, H. M. / Sedlak, N. / Stump, V. et al. | 2012
- 163
-
A harmonized rodent CNS assessment: Reproducibility without boundariesKaiser, R. A. / Barnett, J. / Giuseppina, I. / Wilson, S. / Shearer, J. M. / Diehl, L. M. / Clubb, S. K. / Holzgrefe, H. H. / Meyer, D. J. et al. | 2012
- 163
-
Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafishBuck, L. / Winter, M. / Redfern, W. / Whitfield, T. et al. | 2012
- 163
-
Differential effects of cholinesterase inhibitors in the intravenous PTZ infusion seizure test in the Wistar ratParachou, D. / Cayre, E. / Deal, A. / Bertaina-Anglade, V. / la Rochelle, C. D. et al. | 2012
- 164
-
Cognitive assays for CNS safety evaluation in the ratQuinn, L. / Hernier, A. M. / Davoust, K. / Coquelin, C. / Castagne, V. / Virley, D. et al. | 2012
- 164
-
The development of an Irwin-like test in the nonhuman primate for CNS safety assessmentFroget, G. / Cruz, C. / Hubert, I. / Virley, D. / Lemaire, M. / Duxon, M. S. / Porsolt, R. D. et al. | 2012
- 164
-
High-content analysis of signaling networks enables predictive compound profilingde Bruin, L. / Koblizek, T. I. / Dias, J. / Huang, Z. / Bilter, G. / Chan, H. / Siehoff, A. / Pitt, A. / Lamerdin, J. / Westwick, J. et al. | 2012
- 164
-
Arousal and spectral analysis: EEG in conscious cynomolgus monkeysAuthier, S. / Schaeffer, E. / Weed, M. / Digavalli, S. / Maghezzi, S. / Gervais, J. / Troncy, E. / Fournier, S. et al. | 2012
- 165
-
Mechanistic understanding of drug-induced mitochondrial toxicity using isolated mitochondrial complex assaysLow, E. L. / Burnham, M. / Garside, H. / Valentin, J. P. / Bowes, J. et al. | 2012
- 165
-
Can hERG trafficking be detected in vivo? Effects of sub-acute dosing of arsenic trioxide in telemetered guinea-pigsCools, F. J. / Janssens, S. / Vanlommel, A. / Verrelst, J. / de Hoogt, R. / Rohrbacher, J. / Lu, H. R. / Teisman, A. / Gallacher, D. J. et al. | 2012
- 165
-
Development of a hERG trafficking inhibitor screenBurnham, M. P. / Pollard, C. / Valentin, J. P. / Bowes, J. et al. | 2012
- 166
-
Development of a comprehensive in vitro system for uncovering cardiac liability using ES derived cardiomyocytesSchwengberg, S. / Kettenhofen, R. / Tressat, K. / Bohlen, H. J. et al. | 2012
- 166
-
In vitro detection of cardiotoxicity using human embryonic stem cell derived cardiomyocytePointon, A. V. / Gerges, N. A. / Sidaway, J. E. et al. | 2012
- 166
-
A novel method of selecting human embryonic stem cell derived cardiomyocyte clusters for reliable QT risk assessmentHihara, T. / Yamazaki, K. / Taniguchi, T. / Kohmura, N. / Yoshinaga, T. / Ito, M. / Sawada, K. et al. | 2012
- 166
-
Comparison of electrophysiologic properties of human iPSC and rat embryonic cardiomyocytes using Multi-electrode arraysShi, H. / Kwagh, J. / Lewen, G. / Huang, M. / Flint, O. / Levesque, P. et al. | 2012
- 167
-
Evaluation of abuse liability using self-administration, extinction and reinstatement in the monkey using cocaine and fentanylHygate, D. A. / Manguiat, R. / Wong, W. J. / Medakkar, S. / Hutcheson, D. M. et al. | 2012
- 167
-
Abuse liability testing of dihydrocodeinone in Sprague-Dawley ratsBaird, T. J. / Gauvin, D. V. / Dalton, J. A. / McComb, M. M. / Code, R. A. et al. | 2012
- 167
-
mGluR5 antagonist MTEP and benzodiazepine chlordiazepoxide psychoactive interaction: A rat drug discrimination analysisSwedberg, M. D. / Velasquez, C. / Stahlberg, M. / Hammar, P. et al. | 2012
- 168
-
Testing IKr blockers in five screening models of pro-arrhythmia shows insufficient specificity of isolated cardiomyocytesPeschar, M. / Nalos, L. / Varkevisser, R. / van Veen, T. A. / Houtman, M. J. / Beekman, J. D. / van der Nagel, R. / Thomsen, M. B. / Duker, G. / Sartipy, P. et al. | 2012
- 168
-
Short and long-term delayed reassessment of drug discrimination testing in adult female SD ratsToot, J. D. / Pershing, M. L. / Hackman, M. L. / Beck, M. J. / Stump, D. G. / Atterson, P. R. / Nemec, M. D. et al. | 2012
- 168
-
A large animal model of dependence and withdrawal using male cynomolgus monkeys orally administered ketamine HClSgro, M. / Firman, K. / Poling, J. / Walgren, J. / Carfagna, M. / Kallman, M. J. et al. | 2012
- 168
-
Protein binding and disconnects between hERG potency and QT interval prolongationShi, H. / Huang, M. / Sun, L. / Sun, H. / Xing, D. / Levesque, P. et al. | 2012
- 169
-
Acute or long term exposure to the drug substance: A potentially different outcome in the hERG channel assayGoineau, S. / Legrand, C. / Maujeul, M. / Hautefeuille, L. / Froget, G. et al. | 2012
- 169
-
Mechanisms of hERG channel blockade by methadoneLi, L. / Cui, Y. / Heath, B. / McMahon, N. et al. | 2012
- 169
-
Optimization of hERG screening using IonFlux HT automated systemMartinolle, J. P. / Guillemare, E. / Bertrand, J. P. / Verges, P. / Brun, P. et al. | 2012
- 170
-
Citalopram metabolites inhibit IKs and IKr differentially: Is this a possible explanation for the sudden deaths in dogs?Rohrbacher, J. / Bex, P. / Gallacher, D. J. et al. | 2012
- 170
-
Image-based automatic calcium transient analysis for early cardiotoxicity testing in hiPSC-derived cardiomyocytesMercola, M. / Cerignoli, F. / Whittaker, R. / McDonough, P. / Ingermanson, R. / Towart, R. / Gallacher, D. J. / Price, J. et al. | 2012
- 170
-
Assessing concordance of nonclinical and clinical QT data: The ILSI-HESI cardiovascular safety subcommittee initiative re-visitedSkinner, M. / Valentin, J. P. / Gintant, G. / Koerner, J. / Pettit, S. / Wisialowski, T. et al. | 2012
- 170
-
Can more be done with hERG data? The correlation of hERG block and QT prolongationCrumb, W. J. / Milosavljev, S. / Ekins, S. et al. | 2012
- 171
-
PKPD relationship of hERG blockade and in vivo outcomePehrson, R. / Al-Saffar, A. / Kagstrom, J. / Yan, H. et al. | 2012
- 171
-
Dynamics of drug binding to the hERG channel: An in silico cardiac action potential model for early safety assessmentDi Veroli, G. Y. / Davies, M. / Pollard, C. E. / Valentin, J. P. / Zhang, H. / Boyett, M. / Gerges, N. A. et al. | 2012
- 171
-
Screening with the CytoPatch(TM) Instrument: Taking the advantage of automated patch clamp without taking the loss in data qualityRascher-Eggstein, G. / Scheel, O. / van Bergen, A. / Knott, T. et al. | 2012
- 172
-
Decreased QT variability with DSI ECG pattern recognition: Comparison to algorithm-based analysis in 60 human subjectsMeyer, O. / Holzgrefe, H. H. et al. | 2012
- 172
-
Efficacy of ECG pattern recognition analysis in human subjects with variable T-Wave morphology: Impact on study powerMeyer, O. / Holzgrefe, H. H. et al. | 2012
- 172
-
Integration into preclinical toxicity studies of functional endpoints captured with telemetry: To implant or not?Guillon, J. m. / Slaoui, M. / Battut, C. / Hamon, B. / Doubovetzky, M. / Palazzi, X. et al. | 2012
- 172
-
A new automated arrhythmia detector in preclinical safety studiesMichon, P. / Labarre, D. / Zitoun, P. / Koeppel, F. et al. | 2012
- 173
-
Validation of a novel system for preclinical assessment of ventricular arrhythmiasHamlin, R. L. / Brockway, M. / Brockway, B. / Olson, J. / Martin, R. / Risdal, J. et al. | 2012
- 173
-
A literature-based analysis of cardiovascular adverse events impacting on drug developmentValentin, J. P. / Kenna, J. G. / Lainee, P. / Pollard, C. E. / Redfern, W. S. / Roberts, S. / Hammond, T. G. et al. | 2012
- 173
-
Retrospective data-mining as a tool for preclinical to clinical translational scienceLoenders, B. / Van Ammel, K. / Teisman, A. / Gallacher, D. J. et al. | 2012
- 174
-
Analysis of the QRS complex of the ECGHamlin, R. L. / del Rio, C. / Brown, T. et al. | 2012
- 174
-
Cardiac contractility assessment: A case study with clear impact and relevance of preclinical dataLainee, P. / Philp, K. / Harmer, A. / Bridgland-Taylor, M. / Moors, J. / Knight, R. / Valentin, J. P. et al. | 2012
- 174
-
Translation of preclinical in vivo canine studies to human Phase 1 studies: An evaluation of some ECG and basic hemodynamic parametersVan Ammel, K. J. / Gallacher, D. / Teisman, A. et al. | 2012
- 174
-
Impact of LVP catheterization on the statistical power of ECG parameters in Cynomolgus monkeysMiyamoto, M. / Spatzier, B. N. / Kelly, C. M. / Bate, S. / Thomas, G. et al. | 2012
- 175
-
Assessment of left ventricular dP/dtmax in telemetry studies: Essential or excessive?Skinner, M. / Lainee, P. / Valentin, J. P. / Moors, J. et al. | 2012
- 175
-
Heart rate dependent potentiation of QRS prolongations can be detected in standard dog telemetry studiesCros, C. / Moors, J. / Skinner, M. / Valentin, J. P. / Lainee, P. et al. | 2012
- 175
-
Comparisons of Safety Pharmacology and general toxicology ECG's, and cardiovascular functional/pathology dataMilliken, P. H. / Davies, R. C. / Clements, P. J. / Patel, B. A. / McMahon, N. C. et al. | 2012
- 175
-
3-Model characterization of the relation between cardiac repolarization and temperature in guinea pigLaursen, M. / Lassen, A. B. / Akerlund, O. / Strange Hansen, R. B. / Christensen, T. / Christiansen, J. / Mow, T. et al. | 2012
- 176
-
Pressure-dependent left-ventricular unloading in a chronic model of ischemic heart failure: Evaluation of a novel intra-atrial shuntdel Rio, C. L. / McConnell, P. I. / Nitzan, Y. / Vargas-Pinto, P. / Pedraza-Toscano, A. / Brown, T. / Ueyama, Y. / Abraham, W. T. / Verheye, S. / Hamlin, R. L. et al. | 2012
- 176
-
Assessment of DeltaT50, a clinical biomarker of QT variability in preclinical dog telemetry studiesLainee, P. / Philp, K. / Moors, J. / Skinner, M. / Abrahamsson, C. / Ducker, G. / Valentin, J. P. et al. | 2012
- 176
-
External telemetry significantly improves ECG assessment in Nonhuman Primates (NHP) over standard methodsSchofield, J. / Grant, C. / Prior, H. / Skinner, M. / Valentin, J. P. / Lainee, P. et al. | 2012
- 177
-
Improvements in cardiac injury assessment via combined measurement modalitiesRoche, B. M. / Vinci, T. / Elsass, K. / McCullough, S. / Reed, S. / Behringer, S. et al. | 2012
- 177
-
A pharmacovigilance study in chest diseases outpatient clinicUsta, C. / Cilli, A. / Celenk, B. / Uzun, R. et al. | 2012
- 177
-
Influence of pharmaceutic promotion and advertisement on prescription habits and medicine intakeRodriguez, L. M. / Martinez, L. M. / de los Angeles Rodriguez, M. / Martinez, G. I. / Cardona, J. / Estrada, M. / Martinez, E. / Grajales, D. C. et al. | 2012
- 177
-
Evaluation of drug-induced cardiac conduction disturbance using conscious ferrets-An alternative small animal telemetry modelVargas, H. M. / Derakhchan, K. et al. | 2012
- 178
-
Simultaneous evaluation of cardiovascular, respiratory and CNS functions in the conscious Cynomolgus monkeyGuillon, J. m. / Dupont, T. / Truphemus, P. / Battut, C. / Hamon, B. / Boixel, C. / Doubovetzky, M. et al. | 2012
- 178
-
Electrophysiological properties of iCell cardiomyocytes obtained by automated patch clamp on QPatchSchroder, R. / Christensen, M. / Anson, B. / Sunesen, M. et al. | 2012
- 178
-
Evaluation of a combined model for assessing respiratory and cardiovascular function in the conscious non-restrained monkeyRenninger, J. P. / Murphy, D. J. / Kohrs, L. C. et al. | 2012
- 179
-
The development of an in vitro safety assay utilising human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with Multi/micro-electrode array (MEA) technologyNicks, A. M. / Cui, Y. / McMahon, N. / Sridhar, A. et al. | 2012
- 179
-
Assessment of the concordance between nonclinical repolarization assays and clinical measure of QT interval prolongationKoerner, J. / Darpo, B. / Skinner, M. / Vargas, H. M. / Willard, J. / Pettit, S. / Valentin, J. P. et al. | 2012
- 179
-
A retrospective analysis of gastrointestinal adverse events impacting on drug developmentValentin, J. P. / Al-Saffar, A. / Ewart, L. / Glab, J. / Marks, L. / Redfern, W. S. / Roberts, S. / Hammond, T. G. et al. | 2012
- 179
-
Two novel approaches: Shifting the drug development paradigmCoffee, M. S. / Evans, J. R. / Merriman, D. T. / Roche, B. M. et al. | 2012
- 180
-
Direct effects of arsenic trioxide on action potentials in isolated cardiac tissues: Importance of the choice of species, type of cardiac tissues and perfusion timeLu, H. R. / Vlaminckx, E. / Rohrbacher, J. / Cools, F. / Gallacher, G. J. et al. | 2012
- 180
-
Does terfenadine-induced VT/VF directly relate to its QT prolongation and Torsades de Pointes?Hermans, A. N. / Lu, H. R. / Gallacher, D. J. et al. | 2012
- 180
-
Which possible applications for bioluminescence and fluorescence in preclinical safety studies?Maurin, A. / Martel, E. / Bracq, E. / Brulle, L. / Champeroux, P. / Richard, S. et al. | 2012
- 180
-
How to address metabolite toxicity and species or organ specific toxicity or in vitro?Otto-Bruc, A. E. / Piwnica, D. / Rein, C. / Sabatier, F. et al. | 2012
- 181
-
Itroconazole decreases left ventricular contractility in the isolated rabbit heart: Mechanism of actionVargas, H. M. / Fang, M. / Lawrence, J. / Gao, B. / Acton, P. / Qu, Y. et al. | 2012
- 181
-
Low K^+ alters differentially drugs arrhythmogenic profile in rabbit isolated heartGuillon, J. m. / Ballet, V. / Blanchard, R. h. / Carriot, T. / Barre, C. / Doubovetzky, M. et al. | 2012
- 181
-
Detecting QT/APD shortening with rabbit Purkinje fibre action potentials and guinea pig isolated perfused heartDucroq, J. / Didier, H. / Salvetat, C. / Le Grand, M. et al. | 2012
- 181
-
Utility of the isolated Langendorff-perfused heart model as part of an early screening strategy in safety pharmacologyRamirez, D. S. / Jenkinson, S. / McHarg, A. D. et al. | 2012
- 182
-
Effects of hERG openers and the influence of IKS inhibition in an isolated rabbit heart modelGuerard, N. / Traebert, M. / Suter, W. / Dumotier, B. et al. | 2012
- 182
-
Pharmacological studies in acute rabbit cardiac slicesSchmidt, M. / Bussek, A. / Himmel, H. / Ravens, U. / Wettwer, E. / Lohmann, H. et al. | 2012
- 182
-
Determining the ideal species for ex vivo heart model in predicting cardiac toxicity in drug developmentHenderson, K. A. / Borders, B. R. / Roche, B. M. et al. | 2012
- 183
-
Respiration rate derived from ECG in dogsPehrson, R. / Bulhak, A. et al. | 2012
- 183
-
Comparison of cardiac electrophysiological and mechanical effects of torsadogens in the isolated normal and failing rabbit heartsKijtawornrat, A. / Sawangkoon, S. / Del Rio, C. / Hamlin, R. L. et al. | 2012
- 183
-
Evaluation of Respiratory Inductive Plethysmography using the EMKABelt (Jacket) system in the conscious beagle dogPurbrick, S. / Jordan, S. / Moore, S. / Butler, D. / French, A. / Jones, D. / Peake, E. / Milner, V. / Davies, P. / Meecham, K. et al. | 2012
- 183
-
Effects of autonomic interventions on heart rate variability in ambulatory, telemetrized dogsArthur, S. R. / Lehman, B. L. / Cao, J. / Hennan, J. K. et al. | 2012
- 184
-
Comparison of surgical techniques for implanted telemetry monitoring of cardiorespiratory parameters in three speciesModdrelle, D. S. / O'Donahue, K. / Denton, T. / Herrmann, E. / Dalton, J. / Gauvin, D. / Baird, T. J. et al. | 2012
- 184
-
A modified left thoracotomy approach for enhancing ECG P-wave detection in the cynomolgus monkeyModdrelle, D. S. / Ward, J. / O'Donohue, K. / Baird, T. et al. | 2012
- 184
-
Assessment of the relationship between core body temperature and QT/QTc in the minipig using DihydrocapsaicinTang, H. M. / Sanders, M. / Baird, T. / Greiter-Wilke, A. et al. | 2012
- 185
-
Meaningful telemetry data can be obtained in the same animal with full TK profiling in toxicological studiesJu, H. / Splain, M. / Carey, C. / Irwin, S. / Suter, W. et al. | 2012
- 185
-
Evaluation of a LVdP/dt rate-correction methodTrautmann, T. / Grosz, M. / Ege, A. / Mayer, K. / Markert, M. / Guth, B. et al. | 2012
- 185
-
Evaluation of a CNS compound in two species: Differential pharmacological responses in dogs and minipigsGreiter-Wilke, A. / Baird, T. J. / Mohr, S. / Stewart, L. / Sarmiento, R. M. / Sanders, M. et al. | 2012
- 185
-
Comparison of the cardiovascular profile of sotalol in two conscious dog models, the sling and telemetry modelKimpe, A. / Moesen, E. / Geys, H. / Peeters, T. et al. | 2012
- 186
-
Surgical approach and experimental set-up for high quality cardiovascular signals and accurate analysis of dog telemetry studiesDelpy, E. / Infanti, F. / Garreau, M. / La Rochelle, C. D. et al. | 2012
- 186
-
A comprehensive assessment of cardiovascular risk in telemetered cynomolgus monkeysPrior, H. / Purbrick, S. / Lainee, P. / Bowes, J. / Coulson, M. / Meecham, K. / Valentin, J. P. et al. | 2012
- 186
-
Differentiation between background and drug-induced arrhythmias in dogs using a pattern based approachRossman, E. I. / Wu, X. / Payseur, J. D. / McAllister, P. R. / Wang, K. F. / Murphy, D. J. et al. | 2012
- 187
-
Hemodynamic, ECG and function telemetry in conscious ferrets administered verapamilHunter, R. L. / Clawson, C. A. / Doyle, J. / Adams, S. T. / Main, B. W. et al. | 2012
- 187
-
Cardiovascular and video-electroencephalogram (EEG) telemetry collection in freely moving beagle dogs-A qualification studyMetea, M. R. / Gleason, T. R. / Atterson, P. R. et al. | 2012
- 187
-
Surgical implantation of the D70-PCTR transmitter: Subcutaneous approach/common carotid artery approachMoesen, E. / Peeters, T. / Kimpe, A. et al. | 2012
- 187
-
Simultaneous assessment of blood pressure and respiratory function in dogs: Validation of a non-invasive telemetry methodBailey, E. L. / Grant, C. / Wang, J. L. / Napoleoni, J. G. / Ewart, L. / Lainee, P. / Valentin, J. P. et al. | 2012
- 188
-
Assessment of potential preclinical markers for early detection of myocardial ischemia in the conscious rat and dogMilliken, P. H. / Ward, G. L. / Tennant, A. H. / York, M. J. / McMahon, N. C. / Louttit, J. B. / Patel, B. A. et al. | 2012
- 188
-
A novel IV-diaphragmatic ECG lead implantation approach is well-tolerated in beagle dogs for at least three monthsWalisser, J. A. / Mitchell, A. Z. / Sharma, A. K. / Osinski, M. A. et al. | 2012
- 188
-
Functional evaluation of impedance-based telemetric respiratory monitoring in canine, macaque, and miniature swineBaird, T. J. / Gauvin, D. V. / O'Donohue, K. P. / Abernathy, M. M. / Dalton, J. A. et al. | 2012
- 188
-
Collection of cardiovascular data from cynomolgus monkeys using jacketed external telemetry: Effects of thioridazineTichenor, S. D. / Regalia, D. E. / Kaiser, R. A. / Wilson, S. E. / Erwin, R. F. / Holzgrefe, H. H. / Meyer, D. J. et al. | 2012
- 189
-
Comparison of epicardial and jacketed external ECG waveforms for the detection of QT and QTc interval changesWilson, S. E. / Tichenor, S. D. / Norton, K. et al. | 2012
- 189
-
A step-wise approach to quantitative arrhythmia assessment: A multi-species and multi-drug validationO'Donohue, K. P. / Holdsworth, D. L. / Tapp, R. L. / Harter, M. L. / May, J. R. / Abernathy, M. M. / Gauvin, D. V. / Dalton, J. A. / Baird, T. J. et al. | 2012
- 189
-
Night/day differences in common electrocardiographic indices of arrhythmic liability in telemetered dogsPedraza-Toscano, A. M. / Vargas-Pinto, P. / del Rio, C. / Hamlin, R. L. et al. | 2012
- 189
-
Comparative historical cardiorespiratory data collected by telemetry with impedance in swine, canine, and macaquesAbernathy, M. M. / Holdsworth, D. L. / O'Donohue, K. P. / Dalton, J. A. / Gauvin, D. V. / Baird, T. J. et al. | 2012
- 190
-
A novel biomaterial catheter for improved cardiac contractility measurement in freely moving animalsKroehle, J. / Volovsek, B. / Singer, D. / Sarazan, R. D. et al. | 2012
- 190
-
Assessment of scopolamine on learning and memory on PND 22-28 juvenile rats using an automated video tracking systemToot, J. D. / Pershing, M. L. / Beck, M. J. / Simons, M. L. / Stump, D. G. / Atterson, P. R. et al. | 2012
- 190
-
Surgical technique for intravenous ECG lead placement in the dogMitchell, A. Z. / Taschwer, M. / Argue, C. M. / Osinski, M. A. et al. | 2012
- 191
-
An optimised methodology for the drug discrimination assessment in ratsMaurin, A. / Maleysson, V. / Bracq, E. / Martel, E. / Champeroux, P. / Richard, S. et al. | 2012
- 191
-
Electroencephalogram in freely-moving rats to assess proconvulsant risk at preclinical stageGuillon, J. M. / Mathieu-kia, A. M. / Benhamou, J. / Chenede, X. / Hamon, B. / Martinolle, J. P. / Doubovetzky, M. et al. | 2012
- 191
-
Behavioural effects of Compound X and picrotoxin dose-response following ICV administration in the ratFasdelli, N. / Bison, S. / Guidi, A. / Poffe, A. / Giarola, A. et al. | 2012
- 191
-
Pica behavior is a useful predictor for evaluation of nausea and vomiting with paroxetine in ratsNozaki, Y. / Yabuuchi, M. / Mino, T. et al. | 2012
- 192
-
Inclusion of microchip transponder body temperature measurements in safety pharmacology and toxicology studiesPrior, H. / Motyer, V. / Cobey, D. / Marks, L. / Ewart, L. / Valentin, J. P. / Redfern, W. et al. | 2012
- 192
-
Development of an in vitro screen of neurite outgrowth to predict drug-induced neurotoxicityMcManus, C. L. / Garside, H. / Redfern, W. S. / Valentin, J. P. / Bowes, J. et al. | 2012
- 192
-
Non-invasive methods of body temperature measurements in ratsPrior, H. / Motyer, V. / Marks, L. / Cobey, D. / Ewart, L. / Valentin, J. P. et al. | 2012
- 192
-
Safe method of propofol infusion for children: Population pharmacokinetic and pharmacodynamic analysis of lipid emulsion propofol in childrenByon, H. J. / Kim, H. S. / Kim, J. T. / Kim, C. S. et al. | 2012
- 193
-
Assessing seizure liability in hippocampal slices and neurons using multi-electrode arrays (MEA)Sun, L. / Fan, J. / Kwagh, J. / Chen, S. J. / Burnett, E. / Lewen, G. / Shi, H. / Flint, O. / Levesque, P. et al. | 2012
- 193
-
A review of convulsion and seizure incidence: Small versus large molecule experienceAmouzadeh, H. R. / Williamson, T. / Vargas, H. M. et al. | 2012
- 193
-
A proof of concept study for evaluating antihypertensive compounds in awake, chronically-instrumented, pharmacologically hypertensive monkeysHawk, M. A. / Vinci, T. M. / Hamlin, R. L. / Roche, B. M. / Coffee, M. S. / Gonzalez, E. et al. | 2012
- 194
-
Efficacy of novel phosphodiesterase inhibitors in rats with monocrotaline-induced pulmonary hypertensionBruse, K. D. / Pahl, A. et al. | 2012
- 194
-
Utilization of telemetry to characterize physiological changes following F. tularensis SCHU S4 aerosol infection in unvaccinated and vaccinated Cynomolgus macaquesBruse, K. D. / Zinter, E. / Brooks, K. / Valderas, M. / Wilder, J. / Hutt, J. / Brasel, T. / Sherwood, R. / Wu, T. / Lyons, R. et al. | 2012
- 194
-
Which pathological condition is the most critical for drug-induced torsades de pointes?Chiba, K. / Takasuna, K. / Sanbuissho, A. / Sugiyama, A. et al. | 2012
- 194
-
Development of a conscious rat model of cardiac output and blood pressure measurement for cardiovascular safety studiesLouttit, J. B. / Gibson, B. K. / Lincoln, R. J. / Patel, B. A. / McMahon, N. C. et al. | 2012
- 195
-
Effects of flecainide and dronedarone on atrial and ventricular effective refractory period in the dog with pacing induced atrial remodelingGralinski, M. R. / Senese, P. B. / Huang, J. B. / Wang, H. O. / Buening, J. R. / Janssen, D. L. et al. | 2012
- 195
-
Evaluation of effects on cardiac contractility in conscious common marmosets using telemetryKitayama, T. / Saito, T. / Kajihara, M. / Harada, K. et al. | 2012
- 195
-
A comparison of test article-induced changes in telemetry-based QA interval and left ventricular dP/dt to echocardiography endpoints in the conscious dogKing, L. A. / Turner, S. L. / Zhao, S. Q. / Coatney, R. W. / Murphy, D. J. et al. | 2012
- 196
-
Correlation between respiratory minute volumes and blood gas values in artificially-ventilated beagle dogsMetea, M. R. / Gleason, T. R. / Atterson, P. R. et al. | 2012
- 196
-
Use of non-human primate models to enable early investigational cardiovascular de-riskingRegan, C. P. / Regan, H. K. / Lynch, J. J. et al. | 2012
- 196
-
A model of heart failure via mitral regurgitation and tachypacing: Decreased exercise capacity and functional/neuro humoral remodelingdel Rio, C. L. / Pedraza-Toscano, A. / Vargas-Pinto, P. / Ueyama, Y. / Wallery, J. / Williams, V. / Thibaud, D. / Hamlin, R. L. et al. | 2012
- 197
-
Super-intervals: Application to respiratory safety pharmacology data in ratsAuthier, S. / Some, M. / Fournier, S. / Troncy, E. et al. | 2012
- 197
-
Respiratory assessment in safety pharmacology inhalation studies in telemetered dogsSome, M. et al. | 2012
- 197
-
Effects of inhalation exposure of methacholine on intra-pleural pressure, airway resistance and compliance in conscious telemetered ratsArmstrong, R. / Donington, S. / Moore, S. / Davies, P. / Jordan, S. / Meecham, K. et al. | 2012
- 198
-
Comparison of thoracic impedance pneumography and inductive plethysmography in the assessment of respiratory functionWilson, S. E. / Tichenor, S. D. / Norton, K. et al. | 2012
- 198
-
Current scenario leading to renal failureAlaparthi, V. / Vedagiri, S. / Bhojraj, S. / Medabalimi, S. S. et al. | 2012
- 199
-
An analysis of safety pharmacology operations across the top 12 pharmaceutical companiesEwart, L. / Gallacher, D. / Gintant, G. / Guillon, J. M. / Leishman, D. / McMahon, N. / Levesque, P. / Mylecraine, L. / Suter, W. / Sanders, M. et al. | 2012
- 199
-
Dual recordings of left ventricular and arterial pressure in conscious rats via telemetryMalpas, S. / Stehlin, E. / Guild, S. J. / Budgett, D. / McCormick, D. / Rigel, D. et al. | 2012
- 199
-
A safety pharmacology strategy for inhaled compoundsLindgren, S. / Some, M. / Bulhak, A. / Ericson, A. C. et al. | 2012
- 199
-
Chronic monitoring of brain tissue oxygen in freely moving rats from a fully implanted telemetry systemMalpas, S. / Russell, D. / Gary, E. / Budgett, D. / Taberner, A. et al. | 2012
- 200
-
Simultaneous assessment of proconvulsant and hemodynamic risks in the telemetered ratProvost, D. / Esneault, E. / Peyon, G. / Rompion, S. / Guillaume, P. / Froget, G. et al. | 2012
- 200
-
Evaluation of postural orthostatic hypotension in normotensive and spontaneously hypertensive telemetered ratsGuillaume, P. / Rompion, S. / Froget, G. et al. | 2012
- 200
-
Blood pressure and renal function in mPGES deficient miceStrom, A. C. / Simonsson, E. / Ekstrand, S. / Tallo, K. / Bohlooly, M. / Xu, X. / Ericson, A. C. et al. | 2012
- 200
-
Cardiovascular liabilities of receptor X agonists using selective and non-selective compounds in telemetrized rats and knockout miceLi, J. P. / Thalody, G. / Lehman-McKeeman, L. / Levesque, P. C. / Johnson, V. K. / Hennan, J. K. et al. | 2012
- 201
-
Use of jacketed external telemetry in the conscious guinea-pig in early assessment of cardio-respiratory functionEl Amrani, A. I. / Betat, A. M. / Loriot, S. / Forster, R. / Legrand, J. J. et al. | 2012
- 201
-
Assessing methods for the detection of pharmacologically induced myocardial ischemia in the conscious ratMilliken, P. H. / Le Ruez, T. / Tennant, A. H. / Ward, G. L. / York, M. J. / McMahon, N. C. / Louttit, J. B. / Patel, B. A. et al. | 2012
- 201
-
QT shift method in guinea pigChamperoux, P. / Jude, S. / Martel, E. / Maurin, A. / Bouard, D. / Contamine, A. / Richard, S. et al. | 2012
- 202
-
Functional evaluation of a novel mouse implant for cardiovascular assessmentHarter, M. L. / VanMiddlesworth, J. / O'Donohue, K. / Gauvin, D. / Dalton, J. / Baird, T. et al. | 2012
- 202
-
Feasibility of continuous blood pressure and heart rate assessments in juvenile ratsMatheson, R. / Caron, S. / Trudel, Y. / Norton, K. et al. | 2012
- 202
-
Advantages and utility of native human cardiac myocytes in compound screeningCrumb, W. J. / Milosavljev, S. / Ekins, S. et al. | 2012
- 202
-
Simultaneous measurement of contractility and intracellular Ca^2^+ in canine cardiac myocytes: An assay for early assessment of modulators of contractilityPullen, G. F. / Morton, M. J. / Gerges, N. A. / Pollard, C. E. / Valentin, J. P. et al. | 2012
- 203
-
Evaluation of QTc prolongation in animal and human studies: A qualitative assessment of nonclinical and clinical concordance based on the literatureVargas, H. M. / Bass, A. S. / Koerner, J. / Matis-Mitchell, S. / Pugsley, M. K. / Skinner, M. / Burnham, M. / Pettit, S. / Valentin, J. P. et al. | 2012
- 203
-
Peripherally-restricted dopamine agonist but not norepinephrine uptake inhibitor alters prolactin releaseKinter, L. B. / Venzie, J. / Campbell, P. / Bentley, P. / Andersson, H. / Stewart, J. / Huby, R. / Brott, D. A. et al. | 2012
- 203
-
Continuous and simultaneous monitoring of glucose and electrocardiogram in monkeys treated with quinolonesIshizaka, T. / Yoshimatsu, Y. / Ozawa, M. / Sakurai, K. / Kimotsuki, T. / Sanbuissho, A. / Yasuda, M. et al. | 2012
- 204
-
Gastric secretion in the rat: Influence of analgesicsJaehnige, A. / Hoell, S. / Erni, I. / Schlager-Schaelkle, S. / Guth, B. / Pestel, S. et al. | 2012
- 204
-
Evaluation of gastric emptying in the cynomolgus monkeyEl Amrani, A. I. / Michaud, R. / Loriot, S. / Betat, A. M. / Aubert, N. / Forster, R. / Legrand, J. J. et al. | 2012
- 204
-
Bilateral cannulation of guinea pigs for ototoxicity studies allows multiple assessments and reduction of animalsTapp, R. L. / Abernathy, M. M. / Sweet, J. A. / Yoder, J. D. / Koch, A. A. / Gauvin, D. V. / Baird, T. J. et al. | 2012
- 204
-
An evaluation of the non-invasive faecal pellet assessment method as an early development screen for gastrointestinal liabilityMarks, L. / Cobey, D. / Motyer, V. / Ewart, L. / Fantham, E. / Moore, N. / Prior, H. / Valentin, J. P. et al. | 2012
- 205
-
Association networks as a tool to predict drug-induced nausea in manGlab, J. / Muthas, D. / Boyer, S. / Clark, M. / Valentin, J. P. / Ewart, L. et al. | 2012
- 205
-
Development of a histopathologic evaluation procedure for preliminary ototoxicity screening in guinea pigsAbernathy, M. M. / Tapp, R. L. / Cole, P. I. / Yoder, J. D. / Hedke, C. A. / Olsen-Urbanek, A. L. / Salinas, J. N. / Koch, A. A. / Gauvin, D. V. / Baird, T. J. et al. | 2012
- 205
-
Concordance of drug-induced changes in renal excretory function between safety pharmacology and toxicology studies in ratsChen, Y. / Brott, D. / Altekar, M. / Caccese, R. / Jonasson, H. / Ericson, A. C. / Pehrson, R. / Pinches, M. / Valentin, J. P. / Kinter, L. et al. | 2012
-
Editorial Board| 2012