P03-35 Elucidation of mechanism underlying growth retardation caused by human growth hormone mutant E74K (Englisch)
- Neue Suche nach: Kircheva, Z. I.
- Neue Suche nach: Strasburger, C. J.
- Neue Suche nach: Wu, Z.
- Neue Suche nach: Kircheva, Z. I.
- Neue Suche nach: Strasburger, C. J.
- Neue Suche nach: Wu, Z.
In:
Program and Abstracts of the Sixth International Congress of the GRS and the IGF Society
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S84
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2012
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ISSN:
- Aufsatz (Zeitschrift) / Print
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Titel:P03-35 Elucidation of mechanism underlying growth retardation caused by human growth hormone mutant E74K
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Beteiligte:
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Erschienen in:GROWTH HORMONE & IGF RESEARCH ; 22 ; S84
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Verlag:
- Neue Suche nach: Elsevier Science B.V., Amsterdam
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Erscheinungsdatum:01.01.2012
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Format / Umfang:S84
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ISSN:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Print
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Sprache:Englisch
- Neue Suche nach: 616.4
- Weitere Informationen zu Dewey Decimal Classification
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Klassifikation:
DDC: 616.4 -
Datenquelle:
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- 1
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The association between insulin-like growth factor-I and cardiac repolarizationIttermann, T. / van Noord, C. / Friedrich, N. / Dorr, M. / Felix, S. B. / Nauck, M. / Volzke, H. / Hofman, A. / Witteman, J. C. M. / Stricker, B. H. et al. | 2012
- 6
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Proximal tubule overexpression of a locally acting IGF isoform, Igf-1Ea, increases inflammation after ischemic injuryRae, F. K. / Suhaimi, N. / Li, J. / Nastasi, T. / Slonimsky, E. / Rosenthal, N. / Little, M. H. et al. | 2012
- 17
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Evaluation of coagulation and fibrinolytic parameters in adult onset GH deficiency and the effects of GH replacement therapy: A placebo controlled studyCakir, I. / Tanriverdi, F. / Karaca, Z. / Kaynar, L. / Eser, B. / Unluhizarci, K. / Kelestimur, F. et al. | 2012
- 22
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Short-term growth hormone or IGF-I administration improves the IGF-IGFBP system in arthritic ratsLopez-Menduina, M. / Martin, A. I. / Castillero, E. / Villanua, M. A. / Lopez-Calderon, A. et al. | 2012
- 30
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The effect of polyethylene glycol recombinant human growth hormone on growth and glucose metabolism in hypophysectomized ratsZhang, Z. X. / Liu, Y. K. / Pan, H. / Pan, L. / Zhang, Q. / Su, H. M. / Zhao, Q. L. / Li, H. / He, C. et al. | 2012
- 36
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Effects of bench step exercise on arterial stiffness in post-menopausal women: Contribution of IGF-1 bioactivity and nitric oxide productionOhta, M. / Hirao, N. / Mori, Y. / Takigami, C. / Eguchi, M. / Tanaka, H. / Ikeda, M. / Yamato, H. et al. | 2012
- 42
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Reduced growth hormone secretion after cranial irradiation contributes to neurocognitive dysfunctionQuik, E. H. / Valk, G. D. / Drent, M. L. / Stalpers, L. J. A. / Kenemans, J. L. / Koppeschaar, H. P. F. / van Dam, P. S. et al. | 2012
- 48
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6th ESPE Advanced Seminars in Developmental EndocrinologyMullis, P. E. et al. | 2012
- 49
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Head circumference in untreated and IGF-I treated patients with Laron syndromeLaron, Z. / Iluz, M. / Kauli, R. et al. | 2012
- 53
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The development of decision limits for the implementation of the GH-2000 detection methodology using current commercial insulin-like growth factor-I and amino-terminal pro-peptide of type III collagen assaysErotokritou-Mulligan, I. / Guha, N. / Stow, M. / Bassett, E. E. / Bartlett, C. / Cowan, D. A. / Sonksen, P. H. / Holt, R. I. G. et al. | 2012
- 59
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Visualization of immunoreactive growth hormone in cultured peripheral bovine lymphocytesKlein, S. / Parvizi, N. et al. | 2012
- 64
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Enhanced oxidative stress in GH-transgenic rat and acromegaly in humansNishizawa, H. / Handayaningsih, A. E. / Iguchi, G. / Cho, Y. / Takahashi, M. / Yamamoto, M. / Suda, K. / Kasahara, K. / Hakuno, F. / Yamanouchi, K. et al. | 2012
- 69
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Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophyGehrig, S. M. / van der Poel, C. / Hoeflich, A. / Naim, T. / Lynch, G. S. / Metzger, F. et al. | 2012
- 76
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The effect of prolonged fasting on levels of growth hormone-binding protein and free growth hormoneSalgin, B. / Marcovecchio, M. L. / Hill, N. / Dunger, D. B. / Frystyk, J. et al. | 2012
- 82
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Acromegaly is associated with decreased skin transepidermal water loss and temperature, and increased skin pH and sebum secretion partially reversible after treatmentBorlu, M. / Karaca, Z. / Yildiz, H. / Tanriverdi, F. / Demirel, B. / Elbuken, G. / Cakir, I. / Dokmetas, H. S. / Colak, R. / Unluhizarci, K. et al. | 2012
- 87
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Differences in the GH-IGF-I axis in children of different weight and fitness statusHosick, P. A. / McMurray, R. G. / Hackney, A. C. / Battaglini, C. L. / Combs, T. P. / Harrell, J. S. et al. | 2012
- 92
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Janus kinase (JAK) 2 V617F mutation as the cause of primary thrombocythemia in acromegaly with severe visceromegaly and divergence between growth hormone and insulin-like growth factor-1 concentrations during the follow-up: causal or casual association?Ciresi, A. / Guarnotta, V. / Tomasello, L. / Calo, V. / Russo, A. / Galluzzo, A. / Giordano, C. et al. | 2012
- 97
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A systematic review of growth hormone for hip fracturesYang, S. / Cao, L. / Cai, S. / Yuan, J. / Wang, J. et al. | 2012
- 102
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The association of macro- and micronutrient intake with growth hormone secretionDenny-Brown, S. / Stanley, T. L. / Grinspoon, S. K. / Makimura, H. et al. | 2012
- 108
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Quantifying insulin receptor isoform expression in FFPE breast tumorsHarrington, S. C. / Weroha, S. J. / Reynolds, C. / Suman, V. J. / Lingle, W. L. / Haluska, P. et al. | 2012
- 116
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Comparison of two dose regimens of growth hormone (GH) with different target IGF-1 levels on glucose metabolism, lipid profile, cardiovascular function and anthropometric parameters in gh-deficient adultsCenci, M. C. P. / Soares, D. V. / Spina, L. D. C. / Brasil, R. R. d. L. O. / Lobo, P. M. / Michmacher, E. / Vaisman, M. / Boguszewski, C. L. / Conceicao, F. L. et al. | 2012
- 122
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Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancerIshizaki, F. / Hara, N. / Takizawa, I. / Nishiyama, T. / Isahaya, E. / Kawasaki, T. / Takahashi, K. et al. | 2012
- 129
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Growth cartilage expression of growth hormone/insulin-like growth factor I axis in spontaneous and growth hormone induced catch-up growthBrito, I. / Gil-Pena, H. / Molinos, I. / Loredo, V. / Henriques-Coelho, T. / Caldas-Afonso, A. / Santos, F. et al. | 2012
- 134
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Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patientsBedogni, G. / Giannone, G. / Maghnie, M. / Giacomozzi, C. / Di Iorgi, N. / Pedicelli, S. / Peschiaroli, E. / Melioli, G. / Muraca, M. / Cappa, M. et al. | 2012
- 139
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Positive associations between serum levels of IGF-I and subcutaneous fat depots in young men. The Odense Androgen StudyAndersen, M. / Brixen, K. / Hagen, C. / Frystyk, J. / Nielsen, T. L. et al. | 2012
- 146
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Posterior pituitary functions are not altered after growth hormone replacement therapy in hypopituitarism due to Sheehan's syndromeKaraca, Z. / Tanriverdi, F. / Atmaca, H. / Unluhizarci, K. / Kelestimur, F. et al. | 2012
- 151
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Female recruits sustaining stress fractures during military basic training demonstrate differential concentrations of circulating IGF-I system components: A preliminary studyStrohbach, C. A. / Scofield, D. E. / Nindl, B. C. / Centi, A. J. / Yanovich, R. / Evans, R. K. / Moran, D. S. et al. | 2012
- 158
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The insulin-like growth factor mutation database (IGFmdb)Rajapaksha, H. / Alvino, C. / McCarthy, P. / Forbes, B. E. et al. | 2012
- 167
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Growth hormone responses to acute resistance exercise with vascular restriction in young and old menManini, T. M. / Yarrow, J. F. / Buford, T. W. / Clark, B. C. / Conover, C. F. / Borst, S. E. et al. | 2012
- 173
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Transgenic overexpression of pregnancy-associated plasma protein-A in skeletal muscle of mice increases myofiber size and central nucleation in sedentary muscle and promotes muscle regeneration in the injured muscleDeb, C. / Li, B. / Baylink, D. J. / Xing, W. / Zhang, W. / Chen, M. / Wergedal, J. E. / Mohan, S. / Qin, X. et al. | 2012
- 180
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Total pubertal growth in patients with juvenile idiopathic arthritis treated with growth hormone: Analysis of a single centerBechtold, S. / Beyerlein, A. / Ripperger, P. / Roeb, J. / Dalla Pozza, R. / Hafner, R. / Haas, J. P. / Schmidt, H. et al. | 2012
- 186
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Impact of hypoxia on IGF-I, IGF-II, IGFBP-3, ALS and IGFBP-1 regulation and on IGF1R gene expression in childrenCustodio, R. J. / do Carmo Custodio, V. I. / Scrideli, C. A. / Sader Milani, S. L. / Cervi, M. C. / Cupo, P. / Martinelli, C. E. et al. | 2012
- 193
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The role of the insulin-like growth factor-I receptor in malignancy: An updateSeccareccia, E. / Brodt, P. et al. | 2012
- 200
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The production and regulation of IGF and IGFBPs in human adipose tissue culturesGude, M. F. / Frystyk, J. / Flyvbjerg, A. / Bruun, J. M. / Richelsen, B. / Pedersen, S. B. et al. | 2012
- 206
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Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodelingTang, M. S. / Redfors, B. / Lindbom, M. / Svensson, J. / Ramunddal, T. / Ohlsson, C. / Shao, Y. / Omerovic, E. et al. | 2012
- 212
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The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockadeBonefeld, K. / Hobolth, L. / Juul, A. / Moller, S. et al. | 2012
- 219
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Cord blood triglycerides are associated with IGF-I levels and contribute to the identification of growth-restricted neonatesSifianou, P. / Zisis, D. et al. | 2012
- 224
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Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out miceGiani, J. F. / Miquet, J. G. / Munoz, M. C. / Burghi, V. / Toblli, J. E. / Masternak, M. M. / Kopchick, J. J. / Bartke, A. / Turyn, D. / Dominici, F. P. et al. | 2012
- 234
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Interstitial fluid contains higher in vitro IGF bioactivity than serum: A study utilizing the suction blister techniqueEspelund, U. / Sondergaard, K. / Bjerring, P. / Flyvbjerg, A. / Frystyk, J. et al. | 2012
- 240
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Growth hormone potentiates thyroid hormone effects on post-exercise phosphocreatine recovery in skeletal muscleKaminsky, P. / Walker, P. M. / Deibener, J. / Barbe, F. / Jeannesson, E. / Escanye, J. M. / Dousset, B. / Klein, M. et al. | 2012
- 245
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Investigation of PAX3/7-FKHR fusion genes and IGF2 gene expression in rhabdomyosarcoma tumorsde Souza, R. R. / Oliveira, I. D. / Caran, E. M. M. / Alves, M. T. d. S. / Abib, S. / Toledo, S. R. C. et al. | 2012
- S1
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OR01-1 Early postnatal nutrition programs the somatotropic axis through epigenetic mechanismKappeler, L. / Cottrell, E. C. / Dahan, A. / Hellstrom, I. / Caldji, C. / Zhang, T. / Diorio, J. / Seckl, J. R. / Bouc, Y. L. / Meaney, M. J. et al. | 2012
- S2
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OR01-4 Validation of a novel approach for the detection of acromegaly with automatic face classification using photographs from the internetSchneider, H. J. / Kosilek, R. / Gunther, M. / Reincke, M. / Schopohl, J. / Wuertz, R. et al. | 2012
- S4
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OR02-3 Insulin receptor substrates (IRSs), interacting with Ras-GAP SH3-domain-binding protein 1 (G3BP1), regulate cap-independent translation of bcl-2 mRNAOzoe, A. / Sone, M. / Fukushima, T. / Kataoka, N. / Chida, K. / Hakuno, F. / Takahashi, S. et al. | 2012
- S5
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OR02-6 AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent proliferationYoneyama, Y. / Yoshinaga, S. / Matsuo, M. / Take, K. / Kabuta, T. / Chida, K. / Hakuno, F. / Takahashi, S. I. et al. | 2012
- S6
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OR03-1 Development of a platform technology to generate long-acting protein therapeuticsWilkinson, I. R. / Bielohuby, M. / Parry, H. / Thorpe, A. / Pradhananga, S. / Sayers, J. R. / Artymiuk, P. J. / Bidlingmaier, M. / Ross, R. J. et al. | 2012
- S7
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OR03-3 Use of an orally active ghrelin mimetic, macimorelin (AEZS-130), as a safe, simple test for adult GH deficiency: Effect of BMI on optimal cutoffMerriam, G. R. / Swerdloff, R. / Wang, C. / Kyle, M. / Kipnes, M. / Cook, D. / Yuen, K. / Bonert, V. / Dobs, A. / Molitch, M. et al. | 2012
- S8
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OR03-5 A phase 2, multicenter, multiple-dose, open-label, parallel-group, active controlled, safety, tolerability, pharmacokinetic and pharmacodynamic study of ACP-001 in adult patients with Growth Hormone Deficiency (AGHD)Hoybye, C. / Pfeiffer, A. F. H. / Ferone, D. / Gilfoyle, D. / Beckert, M. / Christiansen, J. S. et al. | 2012
- S9
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OR04-1 Dissection of growth and aging by IGFBP-2 variants: Functional analysis of the Arg-Gly-Asp sequence from IGFBP-2 in transgenic miceZeissler, A. / Langhammer, M. / Renne, U. / Brenmoehl, J. / Metzger, F. / Bielohuby, M. / Wanke, R. / Renner-Muller, I. / Wolf, E. / Hoeflich, A. et al. | 2012
- S10
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OR04-4 Endogenous insulin-like growth factor binding protein 3 (IGFBP-3) contributes to DNA damage-induced apoptosis in breast cancer cellsMarzec, K. A. / Martin, J. L. / Baxter, R. C. et al. | 2012
- S12
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OR05-1 Cardiovascular risk status in childhood cancer survivors with treated vs. untreated growth hormone deficiencyPetryk, A. / Baker, K. S. / Frohnert, B. / Moran, A. / Sinaiko, A. R. / Steffen, L. M. / Perkins, J. L. / Zhang, L. / Hodges, J. S. / Steinberger, J. et al. | 2012
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OR05-3 Examining the impact of growth hormone on the collagen content of adipose tissueHouseholder, L. A. / Troike, K. M. / List, E. O. / Lubbers, E. R. / Kopchick, J. J. / Berryman, D. E. et al. | 2012
- S14
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OR05-6 Association of SNP rs11107116 in the vicinity of the suppressor of cytokine signaling 2 (SOCS2) gene with serum IGF-I levels during GH replacement therapy in GHD adultsGlad, C. A. M. / Barbosa, E. J. L. / Filipsson, H. / Carlsson, L. M. S. / Nilsson, S. / Svensson, P. A. / Johannsson, G. et al. | 2012
- S15
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OR06-2 Overexpression of microRNA 145 reveals a role for maternal IGF1R in mediating embryo-epithelial juxtacrine communication at implantationKang, Y. J. / Forbes, K. / Aplin, J. et al. | 2012
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OR07-3 Measurement of serum IGF-1 by LC-MS-MS: A multi-site validation study for anti-doping testingBowers, L. D. / Butch, A. / Woldemariam, G. / Cowan, D. / Lopes, F. / Cox, H. / Eichner, D. / Hoofnagle, A. N. / Becker, J. O. / Thevis, M. et al. | 2012
- S20
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OR08-2 IGF-I prevents the development of hepatic fibrosis in nonalcoholic steatohepatitis via regulating oxidative stress and inactivating the hepatic stellate cellsNishizawa, H. / Iguchi, G. / Fukuoka, H. / Takahashi, M. / Yamamoto, M. / Suda, K. / Seino, S. / Takahashi, Y. et al. | 2012
- S21
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OR08-4 Cardioprotection by low-dose IGF-1 in myocardial infarctKelly, G. M. / Cox, O. T. / Kumar, A. H. S. / Caplice, N. M. / O'Connor, R. et al. | 2012
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PL09 Two years in IGFRosenfeld, R. G. et al. | 2012
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OR09-2 Impact of pre-analytical conditions on measured concentrations of compounds of the GH/IGF-system in ratsPopp, S. / Bielohuby, M. / Meurer, S. / Horngacher, A. / Wolf, E. / Bidlingmaier, M. et al. | 2012
- S24
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OR09-4 Analysis of growth hormone, prolactin, and insulin/insulin-like growth factor receptors and ligands in the national cancer institute's 60 cell-line panel covering 9 types of human cancerGosney, E. S. / Junnila, R. K. / Herpy, J. / Kopchick, J. J. et al. | 2012
- S25
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OR10-1 Bioactive IGF-I and IGFBP-1 in Danish children and adolescents 3 to 5 years after onset of type 1 diabetes. Effect of residual @b-cell functionFrystyk, J. / Sorensen, J. S. / Bjerre, M. / Birkebaek, N. H. et al. | 2012
- S27
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OR10-6 IGF-I increases glucose utilization during euglycemic clamps in adolescents with type 1 diabetes mellitusEkstrom, K. E. I. / Pulkkinen, M. A. / Brorsson, A. L. B. / Salemyr, J. / Ortqvist, E. / Carlsson-Skwirut, C. / Bang, P. et al. | 2012
- S28
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OR11-1 Biochemical characterisation of insulin-like growth factor II isoforms associated with tumorigenesisGreenall, S. A. / Cosgrove, L. / Baxter, R. C. / Adams, T. E. et al. | 2012
- S29
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OR11-4 Prevalence of posttraumatic growth hormone deficiency is highly dependent on the diagnostic set-up - results from The Danish National study on posttraumatic hypopituitarismKlose, M. / Stockholm, K. / Janukonyte, J. / Frederiksen, L. / Andersen, M. / Laurberg, P. / Christiansen, J. S. / FeldtRasmussen, U. et al. | 2012
- S30
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OR11-6 Long-term mortality in patients with isolated GHD, ISS, and SGA treated with recombinant GH during childhood in Sweden: Application of a mortality model developed from the general populationWikland, K. A. / Savendahl, L. / Martensson, A. / Borgstrom, B. / Niklasson, A. / Pehrson, N. G. / Bang, P. / Dahlgren, J. / Gustafson, J. / Hagenas, L. et al. | 2012
- S33
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P01-3 Discoidin domain receptor 1 is a new mediator of insulin receptor in breast cancer cellsMorcavallo, A. / Palummo, A. / Voci, C. / Sacco, A. / Albanito, L. / Malaguarnera, R. / Belfiore, A. et al. | 2012
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P01-6 Fenofibrate-mediated inhibition of IGF-I receptor signaling responses and its contribution to anticancer treatmentReiss, K. et al. | 2012
- S35
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P01-9 BMS-754807 and metformin synergistically inhibit breast and ovarian cancer cell proliferationBecker, M. A. / Giri, S. / Finckenstein, F. G. / Lynch, M. / Gottardis, M. M. / Carboni, J. M. / Shridhar, V. / Haluska, P. et al. | 2012
- S36
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P01-14 IGF-I: Vitronectin interactions modulate changes in expression of genes which induce breast cancer cell survival and migrationKashyap, A. S. / Hollier, B. G. / Leavesley, D. I. / Upton, Z. et al. | 2012
- S37
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P01-17 Elevated serum IGF-I concentrations and accelerated aging in long-term growth selected mouse linesLanghammer, M. / Renne, U. / Zeissler, A. / Nuurnberg, G. / Bielohuby, M. / Grass, H. / Barthuber, C. / Schmitz, K. / Baur, C. / Ritz-Timme, S. et al. | 2012
- S38
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P01-20 Identification of microRNAs involved in regulating IGF signalling in the first trimester placentaFarrokhnia, F. / Westwood, M. / Aplin, J. D. / Forbes, K. et al. | 2012
- S39
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P01-23 Effects of IGFBP-1 and IGFBP-2 fragments on migration and IGF-induced proliferation of human dermal fibroblastsBrandt, K. / Gruunler, J. / Brismar, K. et al. | 2012
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P01-26 The Interactions of Insulin-like Growth Factor-I with transglutaminases - a novel pathway with wide ranging clinical implicationsSivaramakrishnan, M. / Croll, T. I. / Upton, Z. / Shooter, G. K. et al. | 2012
- S41
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P01-28 IGF-1-cGP axis and its role in maintaining homeostasis IGF-1 bioactivityGuan, J. / Moon, S. / Chan, W. / Perry, J. / Gluckman, P. / Liu, D. et al. | 2012
- S43
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P01-33 Proinsulin may exert biological effects in MCF-7 human cancer cells through both isoform A of the insulin receptor and atypical IGF-I receptorsMalaguarnera, R. / Sacco, A. / Belfiore, A. et al. | 2012
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P01-41 Clinical features of HypophysitisMuraoka, T. / Fukuda, I. / Kurimoto, M. / Yamakado, Y. / Hizuka, N. / Ichihara, A. et al. | 2012
- S47
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P01-43 Radiotherapy and growth hormone replacement therapy in growth hormone deficient adults with craniopharyngioma: Preliminary data from the Dutch National Registry of Growth Hormone Treatment in Adultsvan Varsseveld, N. C. / de Jong, A. S. H. / van Bunderen, C. C. / Franken, A. A. / Koppeschaar, H. P. / van der Lely, A. J. / Drent, M. L. et al. | 2012
- S48
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P01-47 Effects of 10 years of GH replacement therapy in adults with GH deficiency of childhood or adulthood onsetSvensson, J. / Elbornsson, M. / Koranyi, J. / Bengtsson, B. A. / Johannsson, G. / Gotherstrom, G. et al. | 2012
- S49
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P01-50 Smoking, body composition and bone health in adult patients with Growth Hormone (GH)-treated GH deficiency - an observational studyKlefter, O. N. / Krogh Rasmussen, A. / Feldt-Rasmussen, U. et al. | 2012
- S50
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P02-6 Serum IGF-I in breast cancer patients - a comparative study of IGF-I measurements by both automated methodology (IDS iSYS) as well as gel chromatography at low pHEspelund, U. / Cold, S. / Frystyk, J. et al. | 2012
- S51
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P02-9 Better first year HbA1c in type 1 diabetes mellitus adolescents on long acting insulin analogs vs. NPH insulin is not associated with reversal of their IGF-I deficiencySalemyr, J. / Ekstro, K. / Ortqvist, E. / Pulkkinen, M. / Brorsson, A. L. / Carlsson-Skwirut, C. / Bang, P. et al. | 2012
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P02-14 IGF-I as a diagnostic tool in feline medicine: Evaluation of an ELISAStrage, E. et al. | 2012
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P02-33 Intramuscular administration of PEGylated IGF-I accelerates skeletal muscle regeneration after myotoxic injuryMetzger, F. / Martins, K. J. / Gehrig, S. M. / Naim, T. / Saenger, S. / Baum, D. / Lynch, G. S. et al. | 2012
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P02-35 Severe reductions of brain weights and behavioral changes in transgenic mice overexpressing mutated IGFBP-2 lacking a heparin binding domainSchindler, N. / Gimsa, U. / Langhammer, M. / Brenmoehl, J. / Bielohuby, M. / Russo, V. / Wolf, E. / Metzger, F. / Hoeflich, A. et al. | 2012
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P02-38 Antitumor activity of Pasireotide (SOM230) alone and in combination with Everolimus (RAD001) in DU-145 human prostate cancer modelSchmid, H. A. / Lambertini, C. / Nuciforo, P. et al. | 2012
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P02-3 Prolactinomas in two patients with pituitary developmental gene mutationsDoknic, M. / Pekic, S. / Miljic, D. / Stojanovic, M. / Popovic, V. et al. | 2012
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P02-18 Pharmacological characterisation of NNC0195-0092, a long-acting growth hormone derivativeThygesen, P. / Andersen, H. S. / Rischel, C. / Fels, J. J. / Johansen, N. L. et al. | 2012
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P02-26 A network analysis of gene expression through childhood highlights changes related to both age and growthStevens, A. / Whatmore, A. / Destenaves, B. / Chatelain, P. / Clayton, P. et al. | 2012
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P02-29 Quantification of brown adipocyte markers in white adipose tissues of mice with altered Growth Hormone actionVesel, C. B. / Lubbers, E. R. / List, E. O. / Kopchick, J. J. / Berryman, D. E. et al. | 2012
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P02-41 Non alcoholic fatty liver disease is associated with increased GHBP and reduced GH/IGF-1 levelsFusco, A. / Giampietro, A. / Bianchi, A. / Tartaglione, L. / Cimino, V. / Chiloiro, S. / Iacovazzo, D. / Piacentini, S. / Lugli, F. / Miele, L. et al. | 2012
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P02-51 Product wastage from modern human growth hormone administration devices: A laboratory analysisKappelgaard, A. M. / Wisniewski, T. / Seitz, L. / Pollock, R. F. / Qian, Y. et al. | 2012
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P02-53 Growth Hormone: a potential biomarker for disease progression in Amyotrophic Lateral Sclerosis (ALS)Ngo, S. T. / Steyn, F. J. / Lee, K. / Veldhuis, J. D. / Bellingham, M. C. / McCombe, P. A. / Chen, C. et al. | 2012
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P02-56 Development of methods for the sensitive measurement of pulsatile growth hormone in miceLe Tissier, P. / Li, Q. / Kerman, K. / Grattan, D. et al. | 2012
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P03-5 Activity of a pancreatic @b-cell-specific two-chain product of the IGF-II gene: VesiculinLee, K. L. / Li, X. / Aitken, J. F. / Whiting, L. / Cooper, G. J. S. et al. | 2012
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P03-8 Tumorigenicity of Ewing's sarcoma cells is dependent on the level of beta-arrestin 1Oprea, I. I. / Zheng, H. / Worrall, C. / Nedelcu, D. / Girnita, A. / Girnita, L. et al. | 2012
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P03-13 Preclinical effectiveness of metformin in Ewing sarcomaGarofalo, C. / Mancarella, C. / Manara, M. C. / Picci, P. / Lollini, P. L. / Scotlandi, K. et al. | 2012
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P03-21 IGF-I and the resumption of ovarian activity in cowsObese, F. Y. / Martin, G. / Blackberry, M. / Ayim-Akonnor, M. / Owusu-Ntumy, D. / Gomda, Y. et al. | 2012
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P03-27 The Insulin-like Growth Factor 1 Receptor displaces PKCs from RACK1 to facilitate migration of cancer cellsKiely, P. / Buckley, D. / O'Connor, R. et al. | 2012
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P03-32 Height outcome in late diagnosed growth hormone (GH) deficiency type II with GH-1 gene mutation (GH-R178H) affecting secretion and action: Use of higher than standard dose GH and pubertal suppression to optimise final heightBuchanan, C. R. / Dattani, M. T. / Mullis, P. E. et al. | 2012
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P03-34 Dose-dependent response of @D insulin-like growth factor I and @D height to long-term growth hormone therapy in short Japanese children born small for gestational ageHorikawa, R. / Ogawa, Y. / Kiyomi, F. / Kappelgaard, A. M. et al. | 2012
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P03-37 Once-weekly, CTP-modified hGH (MOD-4023) is effective in growth hormone deficient adults: A phase II, dose and frequency finding studyGoth, M. I. / Popovic, V. / Vanuga, P. / Payer, J. / Pfeifer, M. / Bidlingmaier, M. / Fima, E. et al. | 2012
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P03-42 Altered social outcomes in patients growing up with a hypothalamic pituitary condition: Data fromthe KIMS databaseGleeson, H. / Jonsson, P. / Clayton, P. / Korbonits, M. / Koltowska-Haaggstrom, M. / Toogood, A. / Akerblad, A. C. et al. | 2012
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OR01-3 Pathophysiology of renal calcium handling in acromegaly: What lies behind hypercalciuria?Kamenicky, P. / Blanchard, A. / Gauci, C. / Salenave, S. / Letierce, A. / Lombes, M. / Brailly-Tabard, S. / Azizi, M. / Prie, D. / Souberbielle, J. C. et al. | 2012
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OR01-5 Prevalence of AIP gene mutations in young patients with acromegalySchofl, C. / Honegger, J. / Droste, M. / Grussendorf, M. / Finke, R. / Plockinger, U. / Klingmuller, D. / Jaursch-Hancke, C. / Tonjes, A. / Schneidewind, S. et al. | 2012
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OR02-2 Insulin receptor (InsR) and insulin-like growth factor-I receptor (IGF-GR) translocate to nucleus and regulate IGF-GR gene expression in breast cancer cellsSarfstein, R. / Werner, H. et al. | 2012
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OR05-4 Positive association of serum prolactin concentrations with all-cause and cardiovascular mortality: Results from a 10-year follow-up of the Study of Health Pomerania (SHIP)Haring, R. / Friedrich, N. / Volzke, H. / Vasan, R. S. / Felix, S. B. / Dorr, M. / zu Schwabedissen, H. E. M. / Nauck, M. / Wallaschofski, H. et al. | 2012
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OR07-5 An overview of the GH-2004 project: Catching the growth hormone cheatsHolt, R. I. / Erotokritou-Mulligan, I. / Guha, N. / Stow, M. / Bassett, E. / Bartlett, C. / Cowan, D. A. / Sonksen, P. H. et al. | 2012
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OR11-5 IGFBP-2 is a predictor of longitudinal cardiovascular trends in type 2 diabetesNarayanan, R. P. / Fu, B. / Heald, A. H. / Ollier, W. E. / Gibson, J. M. et al. | 2012
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P01-11 IGF-I acts as a potent chemotactic factor for spleen lymphocytesEscobar, S. A. C. / Perez, Y. A. U. / Escobar, P. C. / de Gomez, M. S. et al. | 2012
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P01-25 Ketogenic low-carb/high-fat diets lead to lower IGF-I levels and reduced longitudinal growth in rats regardless of whether the dietary fat source derives from beef tallow or soybean oilTaxeidi, C. / Bielohuby, M. / Horngacher, A. / Meurer, S. / Bidlingmaier, M. et al. | 2012
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P01-38 Post-stroke inflammatory response may influence pituitary function in patients with brain ischemic and hemorrhagic injuryBondanelli, M. / Malaspina, A. / Montis, A. / Lavezzi, S. / Basaglia, N. / Zatelli, M. C. / Ambrosio, M. R. / degli Uberti, E. et al. | 2012
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P02-4 Long term treatment of rh-IGF-1 and high dose insulin of a Japanese patient with insulin receptor defectTajima, T. / Ishizu, K. / Nakamura, A. et al. | 2012
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P03-17 IGF-I on the dark side: Negative consequences of IGF-I on mitochondrial homeostasisSell, C. / Bitto, A. / Lerner, C. / Torres, C. et al. | 2012
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P03-22 High glucose enhanced the inhibitory effect of mast cell chymase on the IGF-I-stimulated proliferation of rat aortic smooth muscle cellsWang, J. / Xia, K. / Li, N. / Brismar, K. et al. | 2012
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P03-29 Association of change in insulin-like growth factor (IGF)-I and IGF-binding protein 3 after 1 month of growth hormone (GH) therapy with genetic markers and long-term growth on GH in children with GH deficiency or Turner's syndromeClayton, P. / Colle, M. / Skorodok, J. / Destenaves, B. / Corte, G. D. / Zieschang, J. / Chatelain, P. et al. | 2012
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OR02-4 Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130 crosslinks actin filaments and regulates cell migrationYamanaka, D. / Akama, T. / Hakuno, F. / Chida, K. / Suzuki, K. / Minami, S. / Takahashi, S. I. et al. | 2012
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OR04-5 Prohibitin-2 is a binding protein for IGFBP-6 on rhabdomyosarcoma cell membranes and modulates IGFBP-6-dependent migrationBach, L. / Fu, P. et al. | 2012
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OR05-5 Growth hormone-induced insulin resistance involves reduced pyruvat dehydrogenase activity in skeletal muscleNellemann, B. / Pilegaard, H. / Vendelbo, M. / Bienso, R. / Jessen, N. / Moller, N. / Jorgensen, J. O. L. et al. | 2012
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OR09-6 Placental growth hormone (GHV) is the predominant growth hormone transcript in MCF7 breast cancer cellsHerpy, J. / Gosney, E. S. / Kopchick, J. J. et al. | 2012
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OR10-4 A novel mutation (p.D1105E) of IGF1R detected in a family of short stature has dominant negative effect to IGF1R, not to IRKawashima, Y. / Hakuno, F. / Hotsubo, T. / Okada, S. I. / Fujimoto, M. / Nishimura, R. / Hanaki, K. / Takahashi, S. I. / Kanzaki, S. et al. | 2012
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P01-16 IGF receptor signaling regulates mammary epithelial cell fate and tumor susceptibilityWood, T. L. / Rota, L. / Shin, M. / Lazzarino, D. et al. | 2012
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P01-49 Familial acromegaly and familial prolactinoma cases in HungaryDeenes, J. / Kovacs, G. L. / Patocs, A. / Mezoosi, E. / Hubina, E. / Kovacs, L. / Gorombey, Z. / Czirjak, S. / Korbonits, M. / Goth, M. et al. | 2012
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P02-13 Serum IGF-I levels in children with idiopathic short stature (ISS) during treatment with Somatropin in a prospective, longitudinal non-randomised, open, phase II studyDorr, H. G. et al. | 2012
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P02-1 The association of serum prolactin concentration with inflammatory biomarkers - cross-sectional findings from the population-based Study of Health in PomeraniaFriedrich, N. / Schneider, H. J. / Spielhagen, C. / Markus, M. R. P. / Haring, R. / Grabe, H. J. / Buchfelder, M. / Wallaschofski, H. / Nauck, M. et al. | 2012
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P02-42 Bioavailability of Pegvisomant 30mg/mL formulation compared to 15mg/mL Formulation: Pharmacokinetics, safety, and tolerability in healthy subjectsJen, J. / Camacho-Hubner, C. / LaBadie, R. / Liang, Y. / Crownover, P. / Gao, X. / Hey-Hadavi, J. et al. | 2012
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P02-48 A novel long acting human growth hormone (VRS-317): sustained and dose dependent biological activity in growth hormone deficient adultsBright, G. M. / Yuen, K. C. J. / Conway, G. S. / Popovic-Brkic, V. / Merriam, G. R. / Bailey, T. / Hamrahian, A. / Biller, B. M. K. / Kipnes, M. / Humphriss, E. et al. | 2012
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P03-30 Growth hormone treatment for two years is safe and effective in adults with Prader-Willi syndromeHoybye, C. / Sode-Carlsen, R. / Farholt, S. / Rabben, K. F. / Bollerslev, J. / Schreiner, T. / Jurik, A. G. / Frystyk, J. / Christiansen, J. S. et al. | 2012
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P03-39 Cross-sectional studies are prone to selection bias; example from the Danish national study on posttraumatic hypopituitarismKlose, M. / Stockholm, K. / Janukonyte, J. / Andersen, M. / Laurberg, P. / Feldt-Rasmussen, U. et al. | 2012
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P03-44 MR imaging features of growth hormone-producing pituitary adenomaFukuda, I. / Hizuka, N. / Kurimoto, M. / Yamakado, Y. / Muraoka, T. / Ichihara, A. et al. | 2012
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P03-46 Successful pregnancy during use of octreotide and pegvisomant in an acromegalic patientvan der Klauw, M. M. / van der Horst-Schrivers, A. N. A. / Hoek, A. / Bidlingmaier, M. / Wolffenbuttel, B. H. R. et al. | 2012
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OR03-4 Five months treatment with a long-acting GHRH analog improves cognition in healthy older men and women and in patients with mild cognitive impairmentMerriam, G. R. / Vitiello, M. V. / Barsness, S. M. / Borson, S. / Friedman, S. D. / Craft, S. / Kletke, M. / Baker, L. D. et al. | 2012
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PL05 Prolactin and tumorigenesisGoffin, V. et al. | 2012
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OR07-2 Simultaneous stimulation of human 20 kDa growth hormone and 22 kDa growth hormone secretion by ghrelinTong, J. / D'Alessio, D. / Ramisch, J. / Davis, H. / Tschop, M. H. / Bidlingmaier, M. et al. | 2012
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PL10 Neuroprotection and plasticity in the brain related to GH & IGF-IAberg, D. et al. | 2012
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OR10-2 Effects of raloxifene and estrogen on bioactive IGF-I in healthy and GH-deficient womenBirzniece, V. / Gibney, J. / Ho, K. / Frystyk, J. et al. | 2012
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OR11-2 Growth Hormone regulates the circulating levels of the mitochondria-derived peptide humaninLee, C. / Bartke, A. / Fang, Y. / Wan, J. / Cohen, P. et al. | 2012
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P01-10 Selective recruitment of G protein coupled receptor kinases (GRKs) controls trafficking of Insulin-like Growth Factor-1 Receptor (IGF-1R)Zheng, H. / Worrall, C. / Issad, T. / Seregard, S. / Girnita, A. / Girnita, L. et al. | 2012
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P01-15 Effect of short-term treatment with insulin on decreased IGF-I expression and increased liver triglycerides during protein deprivationOzaki, Y. / Takeda, T. / Akanishi, N. / Toyoshima, Y. / Hakuno, F. / Takahashi, S. I. / Takenaka, A. et al. | 2012
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P01-13 Mechanisms behind nuclear translocation of the IGF-1RSjostrom, S. / Warsito, D. / Larsson, O. / Sehat, B. et al. | 2012
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P01-29 IGF-I-dependent intestinal fibrosis in Crohn's1 disease and TNBS-induced colitis is regulated by @aV@b3 integrinKuemmerle, J. F. / Li, C. / Grider, J. R. et al. | 2012
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P01-35 Identification of BRCA1 as a biomarker for IGF-GR targeted therapy in breast cancerCohen-Sinai, T. / Golan, T. / Werner, H. / Berger, R. et al. | 2012
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P02-12 Serum insulin-like growth factor binding protein-3 (IGFBP-3) levels are correlated with glycemic control and lipid metabolism in adolescents with type 2 diabetesLee, D. Y. / Kim, M. S. / Hwang, P. H. et al. | 2012
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P02-32 Ascites from women with ovarian carcinoma contains an elevated in vitro IGF-bioactivity as compared with serumThomsen, J. / Ortoft, G. / Espelund, U. / Hogdall, C. / Hogdall, E. / Frystyk, J. et al. | 2012
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P02-40 Anti-IGF1 receptor immunoliposomes: A single formulation combining two anticancer treatments with enhanced therapeutic efficiencyHantel, C. / Lewrick, F. / Schneider, S. / Zwermann, O. / Perren, A. / Reincke, M. / Peschka-Suss, R. / Beuschlein, F. et al. | 2012
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P02-28 Growth hormone analogues with protracted effect through pegylation or non-covalent albumin bindingThygesen, P. / Wiberg, C. / Andersen, H. S. / Fels, J. J. / Johansen, N. L. et al. | 2012
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P03-6 Structural studies of insulin-like growth factor I interacting with the type 1 Insulin-like growth factor receptor in the presence of inhibiting or enhancing monoclonal anti-bodiesThomas, D. / Kong, G. K. W. / Menting, J. G. / Lawrence, M. et al. | 2012
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P03-24 IGFBP-2 is a novel regulator of the estrogen receptor in breast epithelial cellsZeng, L. / Foulstone, E. / Holly, J. / Perks, C. et al. | 2012
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Aims & Scope/Editorial Board| 2012
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OR03-6 Intranasal administration of Human Growth Hormone (CP024) and induction of IGF-1 in healthy volunteersJordan, F. / King, G. / Shalet, S. / Illum, L. / Lewis, A. et al. | 2012
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OR07-6 Biochemical markers of IGF-I misuse: The response of IGF-I and procollagen type III amino-terminal propeptide (P-III-NP) to the administration of recombinant human IGF-I/IGF binding protein-3 in recreational athletesGuha, N. / Erotokritou-Mulligan, I. / Nevitt, S. P. / Francis, M. / Bartlett, C. / Cowan, D. A. / Bassett, E. E. / Sonksen, P. H. / Holt, R. I. G. et al. | 2012
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OR08-5 Diacylglycerol kinase @z, a novel binding partner of insulin receptor substrate, negatively modulated GLUT4 translocation in 3T3-L1 adipocytesHakuno, F. / Ando, Y. / Kakino, M. / Fujimoto, H. / Chida, K. / Takahashi, S. I. et al. | 2012
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OR11-3 IGF-II and neurogenesis: in vitro and in vivo analysesZiegler, A. N. / Constancia, M. / Sandovici, I. / Wood, T. L. / Levison, S. W. et al. | 2012
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P01-1 Investigating the mechanisms and role of IGFBP-2 nuclear translocation in cancer cellsAzar, W. J. / Werther, G. A. / Russo, V. C. et al. | 2012
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P01-18 IGFBP-2 acts as a survival factor for breast cancer cells: Role of ER-@aZeng, L. / Foulstone, E. / Holly, J. / Perks, C. et al. | 2012
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P02-2 Sex-specific associations of serum prolactin concentrations with cardiac remodeling: Longitudinal results from the study of health Pomerania (SHIP)Haring, R. / Volzke, H. / Vasan, R. S. / Felix, S. B. / Nauck, M. / Dorr, M. / Wallaschofski, H. et al. | 2012
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P02-16 The SOCS2 Ubiquitin ligase complex regulates Growth Hormone Receptor levelsVesterlund, M. / Zadjali, F. / Carow, B. / Persson, T. / Nielsen, M. L. / Kessler, B. M. / Rottenberg, M. / Norstedt, G. / Flores-Morales, A. et al. | 2012
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P03-7 Hyperglycaemia, IGFs and insulin affect alternative splicing of the insulin receptor in DU145 prostate cancer cellsWang, J. / Perks, C. / Foulstone, E. / Ladomery, M. L. / Holly, J. et al. | 2012
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P03-10 Epigenetic reprogramming of IGFBP-2 in prostate cancer mediates hyperglycaemia-induced chemoresistance and the effect of metforminBiernacka, K. / Perks, C. / Gillatt, D. / Persad, R. / Uzoh, C. / Holly, J. et al. | 2012
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P03-25 Pharmacological properties of BI 836845, a fully human IGF ligand neutralizing antibodyHofmann, M. H. / Ostermann, E. / Lamche, H. R. / Friedbichler, K. / Kroez, M. / Borges, E. / Adolf, G. R. / Adam, P. J. et al. | 2012
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P03-45 GH retesting and lipid profile in childhood-onset GHD when reaching final adult heightWacharasindhu, S. / Aroonparkmongkol, S. / Sahakitrungrueng, T. / Supornsilchai, V. / Bongsebandhu-Phubhakdi, C. et al. | 2012
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OR01-2 Increased GH signalling independent of IGF-1 is associated with increased bone strength in the SOCS2 knockout mouseDobie, R. / Huesa, C. / Hof, R. J. v. / MacRae, V. E. / Ahmed, S. F. / Farquharson, C. et al. | 2012
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OR06-4 Serum insulin-like growth factor (IGF)-1 is insufficient to restore body size in the absence of growth hormone receptorWu, Y. / Sun, H. / Yakar, S. et al. | 2012
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OR06-1 Physiological low-oxygen tension mediates the Insulin-Like Growth Factor (IGFs) induced signal transduction in Placental Mesenchymal Stem Cell (PMSC) towards enhanced multipotency via polycomb group proteinsYoussef, A. / Iosef, C. / Han, V. K. et al. | 2012
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PL08 Deconstructing muscle differentiation: defining insulin-like growth factor actions in muscle development and repairRotwein, P. / Anguiano, M. / Gardner, S. / Gross, S. et al. | 2012
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OR10-5 Phase I study of figitumumab and pegvisomant in patients with advanced solid tumorsHaluska, P. / Dirksen, U. / Dudek, A. Z. / Bono, P. / Joensuu, H. / Juergens, H. / Sleight, B. / Pollak, M. et al. | 2012
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OR10-3 Low circulating levels of Insulin-Like Growth factor-I (IGF-I) are associated with a reduced beta-cell function and disposition index in healthy adult malesThankamony, A. / Capalbo, D. / Marcovecchio, L. / Sleigh, A. / McGrath, L. / Juul, A. / Bluck, L. / Dunger, D. et al. | 2012
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P01-32 IGF-1 mediates embryo-epithelial juxtacrine communication at implantation through the osteopontin-integrin @av@b3 systemKang, Y. J. / Forbes, K. / Aplin, J. et al. | 2012
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P02-10 Insulin sensitizers modulate IGFBP-1 in EMPOWIR (Enhance the Metabolic Profile of Women with Insulin Resistance) - a randomized clinical trial (NCT00618071) of normoglycemic hyperinsulinemic women with midlife weight gainMogul, H. R. / Freeman, R. / Hantash, F. M. et al. | 2012
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P02-20 Local overexpression of growth hormone and GH/IGF-1-associated effects in the adult hippocampusAberg, M. / Walser, M. / Sama, M. T. / Wickelgren, R. / Bohlooly-Y, M. / Olsson, B. / Tornell, J. / Isgaard, J. / Aberg, D. et al. | 2012
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P02-43 Tailored GH treatment in paediatric settings - it is time for a paradigm-shift based on two randomized trialsDahlgren, J. / Decker, R. et al. | 2012
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P02-45 Ghrelin and growth hormone levels are decreased in Saudi autistic childrenAl-Zaid, F. / Alhader, A. / AL-Ayadhi, L. et al. | 2012
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P03-3 Insulin-like growth factor I-deficiency causes skeletal defects that can be partially compensated by parathyroid hormone-related protein in miceRodiguez-de la Rosa, L. / Lopez-Herradon, A. / Murillo-Cuesta, S. / Portal-Nunez, S. / Lozano, D. / Esbrit, P. / Varela-Nieto, I. et al. | 2012
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P03-4 The impact of capsaicin-induced sensory denervation on osteogenesis and mRNA expressions of IGF-1, IGF-1R and IGFBP-4 in cortical bone. A study of bone distraction in the osteotomic femur of ratLi, J. / Wang, J. / Long, H. / Gu, F. / Ahmed, M. / Brismar, K. et al. | 2012
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P03-16 Correlations of adiponectin with IGFBP-1 in Swedish men with and without type 2 diabetesGu, H. F. / Gu, T. / Hilding, A. / Karvestedt, L. / Flyvbjerg, A. / Frystyk, J. / Ostenson, C. G. / Brismar, K. et al. | 2012
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P03-23 Effects of targeting p53/Mdm2/IGF-1R axis on skin melanoma migration, invasion and metastasisWorrall, C. / Zheng, H. / Candrea, E. / Takahashi, S. I. / Girnita, L. / Girnita, A. et al. | 2012
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P03-35 Elucidation of mechanism underlying growth retardation caused by human growth hormone mutant E74KKircheva, Z. I. / Strasburger, C. J. / Wu, Z. et al. | 2012
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PL02 IGF receptor signalling and regulation in cancerO'Connor, R. et al. | 2012
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OR02-5 Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of the insulin receptor isoform AMorrione, A. / Morcavallo, A. / Genua, M. / Palummo, A. / Kletvikova, E. / Jiracek, J. / Brzozowski, A. M. / Iozzo, R. V. / Belfiore, A. et al. | 2012
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OR07-4 Regulation of fuel metabolism during acute exercise in hypopituitarism with growth hormone-deficiency (GHD)Christ, E. / Egger, A. / Diem, P. / Alleman, S. / Stettler, C. et al. | 2012
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P01-4 Antitumor effect of ridaforolimus (MK-8669) in combination with dalotuzumab (MK-0646) and aromatase inhibitor letrozole in a postmenopausal breast cancer modelHou, X. / Haines, B. / Harrington, S. / Becker, M. / Weroha, J. / Sathyanarayanan, S. / Haluska, P. et al. | 2012
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P01-8 Wound healing rate is not impaired in mice with deficiency of liver-derived insulin-like growth factor-I (IGF-I)Botusan, I. R. / Sunkari, V. G. / Grunler, J. / Svensson, J. / Jansson, J. O. / Ohlsson, C. / Brismar, K. / Catrina, S. B. et al. | 2012
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P01-34 Low-intensity pulsed ultrasounds produces and increase of IGF-I gene expression during fibula bone repair in ratsMarrero, I. / Deniz, A. et al. | 2012
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P01-39 Polymorphisms in genes related to lipid metabolism contribute to individual differences in serum lipid profile of growth hormone deficient (GHD) adultsBarbosa, E. J. / Glad, C. A. / Nilsson, A. G. / Nystrom, H. F. / Gotherstrom, G. / Svensson, P. A. / Vinotti, I. / Bengtsson, B. A. / Nilsson, S. / Boguszewski, C. L. et al. | 2012
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P01-48 Pediatric patients with Prader-Willi syndrome are responders to growth hormone treatment: Analysis of 3-year data from the ANSWER ProgramCohen, P. / Counts, D. / Abuzzahab, M. J. / Gut, R. / Germak, J. et al. | 2012
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P03-36 Sustained effect of Insulin-Like Growth Factor-I (IGF-I)-based dosing of Growth Hormone Treatment (GHT) in children: Comparative analysis of data from a randomized trial and the ANSWER Program(R)Cohen, P. / Lee, P. A. / Ross, J. L. / Bamba, V. / Karwe, V. / Gut, R. Z. / Germak, J. A. et al. | 2012
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P03-43 Evolving growth hormone deficiency in patients previously thought to have idiopathic short statureRegelmann, M. O. / Chacko, E. / Graber, E. / Klein, M. / Rapaport, R. et al. | 2012
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PL04 IGF-I, obesity and diabetesBang, P. et al. | 2012
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OR07-1 Circulating RNAs as markers of growth hormone dopingKelly, B. N. / Haverstick, D. M. / Vance, M. L. / Thorner, M. O. / Bruns, D. E. et al. | 2012
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OR09-3 Growth hormone receptor blockade inhibits growth hormone-induced chemoresistance by restoring cytotoxic-induced apoptosis in breast cancer cells independently of estrogen receptor expressionMinoia, M. / Gentilin, E. / Mole, D. / Rossi, M. / Filieri, C. / Tagliati, F. / Ambrosio, M. R. / Uberti, E. C. D. / Zatelli, M. C. et al. | 2012
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PL11 Growth hormone: From starvation to obesityKlibanski, A. et al. | 2012
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P01-31 A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signalingYoshihara, H. / Fukushima, T. / Hakuno, F. / Saeki, Y. / Tanaka, K. / Ito, A. / Yoshida, M. / Iemura, S. / Natsume, T. / Asano, T. et al. | 2012
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P02-8 Low IGF-1 levels are associated with and predictive for the incidence of anxiety disorders in primary care patients (DETECT-cohort) and the general population (SHIP-cohort)Sievers, C. / Auer, M. / Athanasoulia, A. / Klotsche, J. / Pieper, L. / Schneider, H. J. / Marz, W. / Nauck, M. / Volzke, H. / John, U. et al. | 2012
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P02-34 Role of Igf-1 signaling in statin-induced myotoxicityBonifacio, A. / Brecht, K. / Krahenbuhl, S. et al. | 2012
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P02-39 IGF-II analogue improves placental efficiency, modifies placental growth and reduces fetal weight distribution in normal miceCharnock, J. C. / Aplin, J. / Westwood, M. / Sibley, C. / Crocker, I. et al. | 2012
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P02-19 Auxology, GH-IGF-I status and response to rhGH in 3-M syndromeHanson, D. / Murray, P. G. / Whatmore, A. / Black, G. C. / Clayton, P. E. et al. | 2012
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P02-23 Differential effects of GH versus IGF-1 during obesityList, E. O. / Berryman, D. E. / Blischak, J. D. / Funk, K. / Tysl, B. / Kutz, L. / Leone, R. / Lubbers, E. R. / Visser, W. E. / Visser, T. J. et al. | 2012
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P02-46 Diurnal variation in the pharmacokinetics of growth hormone administered as a continuous subcutaneous infusion in GH-deficient subjectsJanukonyte, J. / Parkner, T. / Lauritzen, T. / Christiansen, J. S. / Laursen, T. et al. | 2012
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P02-49 Long-term outcomes of Pegvisomant (Somavert(R)) monotherapy: Cross-sectional observations from ACROSTUDYvan der Lely, A. J. / Brue, T. / Buchfelder, M. / Ghigo, E. / Gomez, R. / Hey-Hadavi, J. / Lundgren, F. / Rajicic, N. / Webb, S. / Koltowska-Haggstrom, M. et al. | 2012
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P03-1 Ubiquitin ligase Nedd4 interacts with Insulin Receptor Substrate (IRS)-2 in response to humoral/nutritional stimuli, thereby enhancing IRS-2-mediated IGF/insulin signals through a novel mechanismFukushima, T. / Yoshihara, H. / Hakuno, F. / Saeki, Y. / Tanaka, K. / Ito, A. / Yoshida, M. / Chida, K. / Sakoda, H. / Asano, T. et al. | 2012
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P03-11 Quantifying insulin receptor isoform expression in FFPE breast tumorsHarrington, S. / Weroha, S. J. / Reynolds, C. / Suman, V. J. / Lingle, W. L. / Haluska, P. et al. | 2012
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P03-14 Posttranslational modifications of the insulin-like growth factor-binding protein 3 in patients with non-insulin dependent diabetes mellitus and their effect on ligand bindingNedic, O. / Lagundzin, D. / Masnikosa, R. et al. | 2012
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OR04-6 IGFBP-3 enhances autophagy to promote breast cancer cell survival during stressFirth, S. M. / O'Reilly, V. C. / Hong, M. / Baxter, R. C. / Grkovic, S. et al. | 2012
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OR06-6 IRS2-deficient mice show sensorineural hearing loss that is delayed by concomitant PTP1B loss of functionVarela-Nieto, I. / Murillo-Cuesta, S. / la Rosa, L. R. d. / Gonzalez-Rodriguez, A. / Valverde, A. M. et al. | 2012
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OR08-1 Short-term treatment of old-aged recipient rats with recombinant human growth hormone (rhGH) improves liver repopulation by transplanted hepatocytesStock, P. / Bielohuby, M. / Hempel, M. / Bidlingmaier, M. / Christ, B. et al. | 2012
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OR09-5 Signal tranducer and activator of transcription 5 mediates the anti-obesity actions of growth hormoneNelson, C. N. / Barclay, J. L. / Waters, M. J. et al. | 2012
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P01-5 The role of insulin-like growth factor binding protein-6 in the differentiation of placental mesenchymal stem cells into skeletal muscleAboalola, D. / Han, V. et al. | 2012
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P01-37 Dose sparing effect of an IGF-I-based dosing regimen in short children treated with Growth Hormone in a 2-Year randomized controlled trial: Therapeutic and pharmacoeconomic considerationsCohen, P. / Rogol, A. D. / Weng, W. / Kappelgaard, A. M. / Rosenfeld, R. G. / Germak, J. et al. | 2012
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P02-7 Associations of the DHEAs and IGF with cognitive and mental health parameters in the KORA age population: An epidemiologic perspective on neuroendocrine mechanismsEmeny, R. T. / Lacruz, E. M. / Ladwig, K. H. / Bidlingmaier, M. et al. | 2012
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P02-22 Sodium Butyrate treatment increases Growth Hormone (GH) secretion in autosomal dominant GH deficiency caused by the splice site mutationsMiletta, M. C. / Petkovic, V. / Eble, A. / Fluck, C. E. / Mullis, P. E. et al. | 2012
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P02-21 Development of a new growth hormone receptor antagonistGotsch, F. / Wu, Z. / Strasburger, C. J. et al. | 2012
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P02-31 Effect of different treatments on production of recombinant human growth hormone in CHO cellsZarkesh-Esfahani, S. H. / Rezaei, M. et al. | 2012
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P02-44 Oral octreotide absorption in human subjects: Comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppressionTuvia, S. / Teichman, S. L. / Pelled, D. / Bidlingmaier, M. / Strasburger, C. J. / Kleinberg, D. L. / Melmed, S. / Mamluk, R. et al. | 2012
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P02-52 The decline in pulsatile growth hormone secretion throughout early adulthood in mice is exacerbated by dietary induced weight gainHuang, L. / Steyn, F. J. / Tan, H. Y. / Xie, T. Y. / Veldhuis, J. D. / Ngo, S. T. / Chen, C. et al. | 2012
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P03-12 Functional dysregulation of immune responses in a Balb/c model deficient in circulating IGF-I due to protein malnutrition and infected with Leishmania (Leishmania) infantumCuervo-Escobar, S. / Umana-Perez, A. / Saboia-Vahia, L. / De Jesus, J. B. / Porrozzi, R. / Sanchez-Gomez, M. / Cuervo, P. et al. | 2012
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P03-18 Insulin and IGF-I receptors in human cardiac microvascular endothelial cells; metabolic, mitogenic and anti-inflammatory effectsArnqvist, H. J. / Back, K. / Islam, R. / Johansson, G. S. / Chisalita, S. I. et al. | 2012
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P03-28 Structural studies of the type 1 insulin-like growth factor receptor in apo- and ligand-bound forms by cryo-electron microscopyKong, G. K. W. / Thomas, D. R. / Baumeister, W. / Lawrence, M. C. et al. | 2012
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P03-33 Adult mortality and morbidity in childhood-onset growth hormone deficient patients who received pediatric GH treatment - analysis of the Hypopituitary Control and Complications Study (HypoCCS)Mo, D. / Zimmermann, A. G. / Hardin, D. S. / Erfurth, E. M. / Attanasio, A. F. / Melmed, S. et al. | 2012
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P03-40 Comparison of intuitiveness, ease of use and preference in five growth hormone injection devicesKappelgaard, A. M. / Qvist, M. / Winter, F. / Muller, B. et al. | 2012
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OL Posttranscriptional regulation of the insulin and IGF systemGorospe, M. et al. | 2012
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OR01-6 Regulation of pituitary growth hormone synthesis by sirtuin 1Theodoropoulou, M. / Garcia, J. L. M. / Stalla, J. / Stalla, G. et al. | 2012
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OR03-2 Anovel GH1 mutation resulting in deletion of amino acids 188-190 is associated with retarded growthJunnila, R. K. / Wu, Z. / Kelder, B. / Hesse, V. / Biebermann, H. / Blankenstein, O. / Kopchick, J. J. / Strasburger, C. J. et al. | 2012
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PL06 IGF-II and feto-placental growthConstancia, M. / Zvetkova, I. / Sekita, Y. / Hammerle, C. / Cooper, W. / Sandovici, I. et al. | 2012
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OR06-3 IGF regulation of miR-483-3p expression in the developing human placentaForbes, K. et al. | 2012
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PL07 The essential role of GH/IGF-I in the liverTakahashi, Y. et al. | 2012
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OR08-3 Hepatic IGF-I production is regulated by Kupffer cellsIshikawa, M. / Barclay, J. L. / Brooks, A. J. / McPhee, T. R. / Yoshino, G. / Waters, M. J. et al. | 2012
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OR08-6 Long-term treatment with TNF-@a represses GKAP42 binding to IRS-1 causing impairment of insulin signaling through IRS-1 and insulin-dependent glucose uptake in 3T3-L1 adipocytesAndo, Y. / Shinozawa, Y. / Iijima, Y. / Ooi, Y. / Watanaka, Y. / Chida, K. / Hakuno, F. / Takahashi, S. I. et al. | 2012
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PL12 Growth hormone and IGF-1 in mouse models of growth and metabolismLeRoith, D. / Yakar, S. et al. | 2012
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P01-36 The use of growth hormone and other performance enhancing drugs by university studentsHayward, O. / Holt, R. I. et al. | 2012
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P01-42 The effect of growth hormone replacement therapy (GHRT) on exercise capacity, fat mass, ectopic lipids [intramyocellular (IMCL) and intrahepatocellular lipids (IHCL)] and insulin resistance in hypopituitary patients with growth hormone deficiency (GHD)Christ, E. / Egger, A. / Stettler, C. / Alleman, S. / Buehler, T. / Diem, P. / Boesch, C. et al. | 2012
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P02-5 The association of serum insulin-like growth factor-I with metabolic syndrome in older people: A population-based studyvan Bunderen, C. C. / Oosterwerff, M. M. / van Schoor, N. M. / Deeg, D. J. H. / Lips, P. / Drent, M. L. et al. | 2012
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P02-30 Estrogen regulates exercise-induced pituitary type 1 deiodinase increase and growth hormone secretionIgnacio, D. L. / Silvestre, D. / Cavalcanti-de-Albuquerque, J. P. / Louzada, R. / Frankenfeld, T. G. P. / Werneck-de-Castro, J. P. S. / Carvalho, D. P. et al. | 2012
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P02-50 A new cause of GH deficiency: Mutation in the nuclear encoded mitochondrial isoleucyl tRNA-synthetase (IARS2) in 3 patients with severe short stature, cataracts and peripheral neuropathyDeal, C. / Desilets, V. / Patry, L. / Cavanagh-Papillon, S. / Majewski, J. / Michaud, J. / Shoubridge, E. / Samuels, M. E. et al. | 2012
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P03-19 Animal model based on IGF-I: Differences in hepatic gene expression of insulin like growth factor binding proteins and liver deiodinase 1 in late pregnant dairy cows with different total IGF-I plasma concentrationsPiechotta, M. / Hoeflich, A. / Kaske, M. / Kedves, K. / Wrenzycki, C. / Hoedemaker, M. / Bollwein, H. et al. | 2012
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P03-20 A proteomics approach to characterising insulin receptor phosphorylation In response to metabolic and mitogenic ligandsMcCarthy, P. / Rajapaksha, H. / Wallace, J. / Hoffmann, P. / Forbes, B. et al. | 2012
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P03-41 Natural history of congenital isolated growth hormone deficiencyLaron, Z. / Kauli, R. et al. | 2012
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P01-7 Evaluation of the biological actions of insulin analogues in endometrial cancer cell linesAizen, D. B. / Weinstein, D. / Sarfstein, R. / Bruchim, I. / Laron, Z. / Werner, H. et al. | 2012
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P01-21 Analysis of the effects of insulin analogues on proliferation and differentiation in skin keratinocytesSolomon, R. / Weingarten, G. / Laron, Z. / Werner, H. / Wertheimer, E. et al. | 2012
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P01-30 IGF-I deficiency predisposes to presbycusis and noise-induced hearing loss in a mice modelMurillo-Cuesta, S. / Rodriguez-de la Rosa, L. / Contreras, J. / Cediel, R. / Varela-Nieto, I. et al. | 2012
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P02-17 Sirt1 negatively regulates IGF-I production by growth hormone via deacetylation of Stat5 in liverYamamoto, M. / Iguchi, G. / Fukuoka, H. / Takahashi, M. / Nishizawa, H. / Suda, K. / Seino, S. / Takahashi, Y. et al. | 2012
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P02-24 GH deficiency does not account for metabolic changes in adult patients with craniopharyngiomaRoemmler, J. / Geigenberger, V. / Dimopoulou, C. / Stalla, G. / Schopohl, J. et al. | 2012
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P02-47 First interim results from an international phase IV study in short children born small for gestational age (SGA) treated with Omnitrope(R) (rhGH)Schwarz, H. P. / Birkholz, D. / Metreveli, D. / Horneff, G. / Galesanu, C. / Khan-Boluki, J. / Schuck, E. et al. | 2012
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P02-55 Reduced epiphyseal growth plate GHR signaling in a chronic kidney disease rat model of growth retardationTroib, A. / Wizel, D. / Guterman, M. / Rabkin, R. / Landau, D. / Segev, Y. et al. | 2012
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P03-2 In prostate cancer cells metformin inhibits the cross-talk between membrane-initiated androgens and IGF-GRMalaguarnera, R. / Sacco, A. / Voci, C. / Vigneri, R. / Belfiore, A. et al. | 2012
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P03-15 Hyperglycemia confers resistance to antibodies targeting growth factor receptors on breast cancer cellsZeng, L. / Arshad, A. / Holly, J. / Perks, C. et al. | 2012
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P03-38 Suppressor of cytokine signaling 2 missense mutation identified in a patient with gigantism without growth hormone producing pituitary adenomaSuda, K. / Iguchi, G. / Yamamoto, M. / Nisizawa, H. / Fukuoka, H. / Takahashi, M. / Seino, S. / Takahashi, Y. et al. | 2012
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OR02-1 First crystal structure of insulin bound to its primary binding site on the insulin receptorLawrence, M. / Menting, J. / Kong, G. / Margetts, M. / Ward, C. et al. | 2012
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OR05-2 Pregnancies and live births in a large cohort of patients on growth hormone replacement therapyVila, G. / Akerblad, A. C. / Biller, B. M. / Koltowska-Haggstrom, M. / Lundgren, F. / Riedl, M. / Luger, A. et al. | 2012
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PL01 Two years in GHHo, K. et al. | 2012
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OR09-1 The role of zinc binding and the cellular zinc content in regulated growth hormone secretionPetkovic, V. / Mileta, M. C. / Eble, A. / Iliev, D. I. / Binder, G. / Fluck, C. E. / Mullis, P. E. et al. | 2012
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P01-2 IGF-I treatment unveils cell-context dependent regulation of frataxinFranco, C. / Fernandez, S. / Torres-Aleman, I. et al. | 2012
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P01-19 IGF-1 signalling enhances mitochondria activity and biogenesis in cancer cells independently of glycolytic switchFavre, C. / Lyons, A. / Zhadov, A. / Papkovsky, D. / O'Connor, R. et al. | 2012
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P01-22 Genome-wide analysis of cancer protection pathways in Laron Syndrome patientsLapkina, L. / Laron, Z. / Werner, H. et al. | 2012
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P01-40 BMI and sex have major impact on GH peak levels during the GHRH-Arginine test - establishment of normative data applying a newly developed immunoassayPetersenn, S. / Unger, N. / Mann, K. / Strasburger, C. J. / Bidlingmaier, M. et al. | 2012
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P01-45 Twenty-four months efficacy and safety of LB03002, a new sustained release formulation of rhGH, in children with GHD: Extension of a phase III randomized multicentre studySaenger, P. / Khadilkar, V. / Radjuk, K. A. / Bolshova, E. / Khadgawat, R. / El Kholy, M. / Desai, M. / Peterkova, V. / Mericq, V. / Ji, H. J. et al. | 2012
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P02-11 Regulation of insulin-like growth factor binding protein-6: An inhibitor of fibroblast proliferation and myofibroblast differentiation in Dupuytren's DiseaseRaykha, C. / Crawford, J. / Gan, B. S. / O'Gorman, D. et al. | 2012
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P02-15 The relation between diabetic children and insulin like growth factor-1Rasheed, A. O. et al. | 2012
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P02-36 Circulating levels of IGF-binding proteins in GH transgenic and GH receptor -/- miceFunk, K. R. / List, E. O. / Berryman, D. E. / Kopchick, J. J. et al. | 2012
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P02-54 Prediabetes in adult growth hormone deficiency is associated with a substantial reduction in serum and adipose tissue expression levels of zinc-@a2-glycoproteinBalaz, M. / Ukropcova, B. / Kurdiova, T. / Penesova, A. / Skyba, P. / Belan, V. / Klimes, I. / Payer, J. / Imrich, R. / Smith, S. R. et al. | 2012
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P03-9 Investigation of the anti-tumorigenic effects of the M6P/IGF-II receptorScott, C. D. / Lyon, K. / Firth, S. M. et al. | 2012
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PL03 From Galton to GWAS: what we have learned about the genetics of human stature?Visscher, P. M. et al. | 2012
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OR04-2 Site directed mutagenesis of specific phosphorylation sites in human IGFBP-1 markedly decreases binding affinity for IGF-I and increases IGF-I functionGupta, M. / Iosef, C. C. / Wildgruber, R. / Sardana, G. / Shehab, M. A. et al. | 2012
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OR04-3 Impact of anti-inflammatory actions of IGFBP-3 in asthma and metabolic syndromeOh, Y. et al. | 2012
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OR06-5 Rescue of the age-dependent decline in cerebral glucose uptake by PEGylated IGF-I treatment in a non-human primateMetzger, F. / Dorieux, O. / Chaigneau, M. / Perret, M. / Dhenain, M. et al. | 2012
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P01-24 The combination of the IGF-1 receptor inhibitor picropodophylin (PPP) and the BH3 mimetic ABT-737 has synergistic anti-myeloma activityBieghs, L. / Maes, K. / Van Valckenborgh, E. / Menu, E. / Johnsen, H. E. / Nyegaard, M. / Overgaard, M. T. / Larson, O. / Jernberg-Wiklund, H. / Vanderkerken, K. et al. | 2012
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P01-27 Expression of IGF2 and IGF1R in pediatric adrenocortical tumors (ACT): Overexpression of IGF1R is associated with unfavorable event and metastasis in adrenocortical carcinomasLira, R. C. P. / Fedatto, P. F. / Martinelli, C. E. / Antonini, S. R. R. / Castro, M. / Tucci, S. / Neder, L. / Ramalho, L. Z. / Seidinger, A. L. / Cardinalli, I. et al. | 2012
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P01-46 Effect of short term Growth Hormone (GH) replacement on whole body bone mineral measures of children with Growth Hormone Deficiency (GHD)Khadgawat, R. / Gahlot, M. / Ramot, R. / Singh, V. / Ammini, A. et al. | 2012
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P02-37 Structural and functional alterations in skeletal muscle of IGFBP-4 KO miceZhao, X. / Peng, B. / Pintar, J. et al. | 2012
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P02-25 Adipokine levels in mice with altered Growth Hormone (GH) action over lifespan: Identifying the links between adiposity, insulin sensitivity and longevityLubbers, E. R. / Magon, V. / Jara, A. / Ziegler, A. K. / Miles, B. / List, E. O. / Kopchick, J. J. / Berryman, D. E. et al. | 2012
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P02-27 Challenges encountered in the development of an in vivo mouse model system for testing growth hormone antagonist moleculesBielohuby, M. / Pradhananga, S. / Wilkinson, I. R. / Sayers, J. R. / Artymiuk, P. J. / Ross, R. J. M. / Bidlingmaier, M. et al. | 2012
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P03-26 Insulin-like Growth Factor-II increases de novo steroidogenesis in prostate cancer cellsLubik, A. A. / Gunter, J. H. / Ettinger, S. / Fazil, L. / Stylianou, N. / Hendy, S. C. / Adomat, H. H. / Hollier, B. G. / Gleave, M. E. / Pollak, M. et al. | 2012
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P03-31 Factors affecting IGF-I response to Growth Hormone (GH) replacement therapy during transition in patients with childhood-onset GH deficiencyThankamony, A. / Capalbo, D. / Heywood, J. / Williams, R. / Ong, K. K. / Dunger, D. / Simpson, H. L. et al. | 2012