JTp and Tpe as Biomarkers of proarrhythmic risk in nonclinical models: Historical data evaluation by the HESI consortium (Unbekannt)
- Neue Suche nach: Gendron-Parra, Nicolas
- Neue Suche nach: Abernathy, Matthew M.
- Neue Suche nach: Boulay, Emmanuel
- Neue Suche nach: Chui, Ray
- Neue Suche nach: Friedrichs, Gregory S.
- Neue Suche nach: Greiter-Wilke, Andrea
- Neue Suche nach: Guillon, Jean-michel
- Neue Suche nach: Leishman, Derek J.
- Neue Suche nach: Nichols, Jill
- Neue Suche nach: Pierson, Jennifer
- Neue Suche nach: Skinner, Matt
- Neue Suche nach: Pugsley, Michael K.
- Neue Suche nach: Valentin, Jean-Pierre
- Neue Suche nach: Vargas, Hugo M.
- Neue Suche nach: Authier, Simon
- Neue Suche nach: Gendron-Parra, Nicolas
- Neue Suche nach: Abernathy, Matthew M.
- Neue Suche nach: Boulay, Emmanuel
- Neue Suche nach: Chui, Ray
- Neue Suche nach: Friedrichs, Gregory S.
- Neue Suche nach: Greiter-Wilke, Andrea
- Neue Suche nach: Guillon, Jean-michel
- Neue Suche nach: Leishman, Derek J.
- Neue Suche nach: Nichols, Jill
- Neue Suche nach: Pierson, Jennifer
- Neue Suche nach: Skinner, Matt
- Neue Suche nach: Pugsley, Michael K.
- Neue Suche nach: Valentin, Jean-Pierre
- Neue Suche nach: Vargas, Hugo M.
- Neue Suche nach: Authier, Simon
In:
Journal of pharmacological and toxicological methods
;
93
;
121
;
2018
-
ISSN:
- Aufsatz (Zeitschrift) / Print
-
Titel:JTp and Tpe as Biomarkers of proarrhythmic risk in nonclinical models: Historical data evaluation by the HESI consortium
-
Beteiligte:Gendron-Parra, Nicolas ( Autor:in ) / Abernathy, Matthew M. ( Autor:in ) / Boulay, Emmanuel ( Autor:in ) / Chui, Ray ( Autor:in ) / Friedrichs, Gregory S. ( Autor:in ) / Greiter-Wilke, Andrea ( Autor:in ) / Guillon, Jean-michel ( Autor:in ) / Leishman, Derek J. ( Autor:in ) / Nichols, Jill ( Autor:in ) / Pierson, Jennifer ( Autor:in )
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Erschienen in:
-
Verlag:
- Neue Suche nach: Elsevier Science B.V., Amsterdam.
-
Erscheinungsdatum:01.01.2018
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Format / Umfang:121 pages
-
ISSN:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Print
-
Sprache:Unbekannt
- Neue Suche nach: 615.9
- Weitere Informationen zu Dewey Decimal Classification
-
Klassifikation:
DDC: 615.9 -
Datenquelle:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Inhaltsverzeichnis – Band 93
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Safety pharmacology in and for Africa: Establishment of the pre-clinical drug development platformGuth, Brian D. / Grobler, Anne et al. | 2018
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The use of human tissue in safety assessmentJackson, Samuel J. / Prior, Helen / Holmes, Anthony et al. | 2018
- 35
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An overview of the safety pharmacology society strategic planPugsley, M.K. / Authier, S. / Koerner, J.E. / Redfern, W.S. / Markgraf, C.G. / Brabham, T. / Correll, K. / Soloviev, M.V. / Botchway, A. / Engwall, M. et al. | 2018
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- 113
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- 118
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- 119
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- 120
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- 137
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- 138
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- 138
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- 139
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Quercetin co-administration ameliorates metronidazole induced neurotoxicityChaturvedi, Swati / Uddin, Wahaj et al. | 2018
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- 140
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Coupled impedance and field potential data analysis of in vitro cardiomyocyte assaysBatista, Levy / Doerr, Leo / Beckler, Matthias / Fertig, Niels / Bastogne, Thierry et al. | 2018
- 140
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Genomic comparison of drug metabolizing enzymes in African green monkeys versus other speciesBanerjee, Aryamitra / Attwood, Jordan / Lawrence, Matthew et al. | 2018
- 140
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A data-driven modeling method to analyze cardiomyocyte impedance dataBatista, Levy / Bastogne, Thierry / Atienzar, Franck / Delaunois, Annie / Valentin, Jean-Pierre et al. | 2018
- 141
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Statistical design of in silico experiments for the robustness analysis of electrophysiologic response simulatorsDuponnois, Romain / Docquier, Théo / Aiguier, Thomas / Bastogne, Thierry et al. | 2018
- 141
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Development of an in silico action potential model of the rabbit Purkinje cell for assessment of cardiac safety liabilitiesCano, Jordi / Romero, Lucía / Gomis-Tena, Julio / Amberg, Alexander / Anger, Lennart / Ballet, Veronique / Guillon, Jean-Michel / Pastor, Manuel / Sanz, Ferran / Saiz, Javier et al. | 2018
- 142
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- 142
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In silico QT assay for preclinical assessment of drug-induced proarrhythmicityRomero, Lucía / Cano, Jordi / Gomis-Tena, Julio / Trenor, Beatriz / Sanz, Ferran / Pastor, Manuel / Saiz, Javier et al. | 2018
- 142
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Targettri: A toxicity-based triaging system for novel drug targetsVenhorst, Jennifer / van Someren, Eugene P. / van de Brug, Fred J. / Kalkman, Gino J. / Folkertsma, Simon et al. | 2018
- 143
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- 144
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Successful integrative approach of the pro-arrhythmic risk assessment of the multichannel ion channel inhibitor vanoxerine, via combination of in silico human cardiomyocyte models and in vivo guinea-pig electromechanical window assayMorissette, Pierre / Gerenser, Pamela / Travis, Jeffrey / Fanelli, Patrick / Balasubramanian, Bharathi / Passini, Elisa / Bueno-Orovio, Alfonso / Rodriguez, Blanca / Regan, Christopher / Sannajust, Frederick et al. | 2018
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Unblinded: Responses to CiPA 28 compounds in COR.4U cardiomyocytesKettenhofen, Ralf / Luerman, Greg / Bohlen, Heribert et al. | 2018
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In silico electro-mechanical window shortening and repolarisation abnormalities predict clinical risk of torsade de pointes for 40 reference compoundsPassini, Elisa / Bueno-Orovio, Alfonso / Morissette, Pierre / Sannajust, Frederick / Rodriguez, Blanca et al. | 2018
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Pluricyte® cardiomyocytes as a predictive tool for preclinical safety assessment: A comparison with isolated guinea-pig ventricular cardiomyocytesGuilbot, Stephanie / Printemps, Richard / Hautefeuille, Ludovic / de Korte, Tessa / Le Grand, Marie et al. | 2018
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Current comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi: HEART initiative) –The second stage: Ca transient platformTakasuna, Kiyoshi / Honda, Yayoi / Watanabe, Hitoshi / Kato, Natsumi / Hisada, Sunao et al. | 2018
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Measurements of action potentials from iPSC-derived cardiomyocytes using CellOPTIQ® platform predicts both single ion channel effects and in vitro whole heart electrophysiological responsesMcGlynn, Karen P. / Taylor, Amy E. / Burton, Francis L. / Chapman, Hugh / Kuosmanen, Tarja / Smith, Godfrey L. et al. | 2018
- 147
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Comparison and assessment of CaV1.2 kinetics described by different in silico cellular cardiac electrophysiology modelsWang, Ken / Cooper, Jonathan / Mirams, Gary / Gavaghan, David / Davies, Mark / Schuler, Franz / Lave, Thierry / Singer, Thomas / Polonchuk, Liudmila et al. | 2018
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Testing excipients for possible adverse reactionsArmstrong, Duncan / Dumotier, Berengere / Fekete, Alex / Shankey, Vincent / Bieberich, Andrew / Fatig, Raymond / Pottel, Josh / Shoichet, Brian / Berg, Ellen / Urban, Laszlo et al. | 2018
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Use of hERG binding in lead optimization provides greater predictivity for QTc prolongation in vivo compared to manual patch hERG assayAbernathy, Matthew M. / Leishman, Derek J. et al. | 2018
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Automatic ionic profiling on iPSC-CM from MEA signals using mathematical modeling and machine learningTixier, Eliott / Raphel, Fabien / Lombardi, Damiano / Zitoun, Philippe / Gerbeau, Jean-Frédéric et al. | 2018
- 149
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Hypothermia associated with a putative ophthalmic therapeutic in preclinical speciesDerakhchan, Kathy / Savinainen, Anneli / Newman, Jennifer / Josiah, Serene / Carey, Galen et al. | 2018
- 149
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Towards the use of bioassays as predictors for safety pharmacologyClark, Matthew / Shkrob, Maria / Yuryev, Anton et al. | 2018
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Binding and functional analysis—Complementary approaches in safety pharmacologyJolas, Thierry / Migeon, Jacques / Wei, Haiyang David / Ko, Amber et al. | 2018
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Proposed QT-interval correction method for the influence of changes in core body temperature based on circadian variations in conscious non-restrained cynomolgus monkeysEl Amrani, Abdel-Ilah / El Amrani-Callens, Francine / Loriot, Stéphane / Singh, Pramila / Forster, Roy et al. | 2018
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Multiparametric assessment of cardiotoxicity of chemotherapeutic drugs in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytesMulder, Petra / Famili, Farbod / de Korte, Tessa / Hechard, Celine / Braam, Stefan R. / Vlaming, Maria L. et al. | 2018
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Blinded analysis of CiPA compounds with human engineered heart tissueHansen, Arne / Eder, Alexandra / Mannhardt, Ingra / Eschenhagen, Thomas et al. | 2018
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Application of PBPK modelling of enterocyte exposure aids in vitro to in vivo translational risk assessment of μ-opioid-induced clinical constipationRibeiro, Lyn Rosenbrier / Sharma, Pradeep / Kavanagh, Stefan / Noeske, Tobias et al. | 2018
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Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluationRossman, Eric I. / Cools, Frank / Cordes, Jason S. / Dhuyvetter, Deborah / Doyle, Jennifer / Friedrichs, Gregory S. / Guth, Brian / Parish, Stanley T. / Pugsley, Michael K. / Dustan Sarazan, R. et al. | 2018
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Could a systematic threshold analysis approach optimize the NOEL/OEL setting within a safety pharmacology study?van der Linde, Henk / Van Ammel, Karel / Teisman, Ard / Gallacher, David J. et al. | 2018
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Rotational thromboelastometry for ex vivo assessment of drug effects on platelet functionSt-Jean, Camille / Boulay, Emmanuel / Gendron-Parra, Nicolas / Troncy, Eric / Authier, Simon et al. | 2018
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Action potential recordings and analysis in human ventricular trabeculae for assessment of pro-arrhythmic riskQu, Yusheng / Page, Guy / Abi-Gerges, Najah / Miller, Paul / Ghetti, Andre / Vargas, Hugo M. et al. | 2018
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Generation of expanded primary cells for cell-based toxicity and metabolism screeningsJohannssen, Timo / Runge, Nils / Nörenberg, Astrid et al. | 2018
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Diverse approaches to understand functional pharmacology—Examples of the 5-HT1B and 5-HT2A receptorsJolas, Thierry / Ko, Amber / Migeon, Jacques / Liu, Elsa et al. | 2018
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A comprehensive evaluation of four antineoplastic agents in the Langendorff isolated heart assayRoss, John / Waines, Michelle / Peachee, Vanessa / Walling, Brent / Roche, Brian et al. | 2018
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Neurotransmitter screening via dynamic calcium flux and MEA-based seizure liability assessment in human IPS neuronsHess, Dietmar / Kettenhofen, Ralf / Fleming, Chris / Luerman, Greg / Bohlen, Heribert et al. | 2018
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Development of native and stem cell-derived electrophysiological assays for neurotoxicology screening and translational drug discoveryRush, Anthony M. / Webdale, Louise / Rogers, Marc et al. | 2018
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Dawn of a new era with simultaneous multi-system (ECG, BP, LVP, EEG and respiratory) monitoringAscah, Alexis / Maghezzi, Said / Authier, Simon et al. | 2018
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Cardiovascular safety studies on dopamine D3 receptor antagonists and cocaineAppel, Nathan M. / Acri, Jane B. et al. | 2018
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Investigation of individual analysis of QT interval in beagle dogsMatsubara, Fuminori / Okada, Kazuhide / Miyazaki, Souji / Hashiguchi, Noriko / Nakano, Koji / Tsuboi, Masaru / Kanno, Akihiro / Kazusa, Katsuyuki / Tadano, Kiyoshi / Tasaka, Tomoya et al. | 2018
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Improvement of ECG monitoring quality using solid tip lead transmitters in the guinea-pigLe Quément, Catherine / Loiseau, Mathilde / Garreau, Myriam / Bruezière, Servane / Deal, Anthony / Maurin, Anne / La Rochelle, Christophe Drieu et al. | 2018
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Why are non-rodents not socially housed during cardiovascular telemetry recordings on safety pharmacology studies?Prior, Helen / Gellatly, Nikki / Jackson, Sam et al. | 2018
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A comparison of baseline cardiovascular parameters and the sensitivity to detect changes in systemic blood pressure and heart rate in beagle dogs using DSI M11 disposable telemetry devicesSadekova, Nataliya / Abernathy, Matthew M. / Leishman, Derek / Norton, Kevin et al. | 2018
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Identification of NOEL and NOAEL in functional safety (pharmacology) studies: A survey of a contract research organization master scheduleBaird, Ted / Kilgus, Quinn / Hutchins, Charity / Holdsworth, David / Tapp, Rachel / May, Jonelle / Harter, Marci / Gauvin, David / Dalton, Jill et al. | 2018
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Effects of diurnal variation, group variability, model sensitivity, and acclimation on the evaluation of rat respiratory function using plethysmographyBaublits, Joel T. / Speece, Ty / Atterson, Phil / Love, Sandra / Botchway, Alfred et al. | 2018
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A comparison of methods for delineation of wave boundaries in 12 lead ECGGuyot, Pauline / Voiriot, Pascal / Batista, Levy / Bastogne, Thierry / Papelier, Stéphane et al. | 2018
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Studying inotropic compound effects in relatively mature human iPSC-derived cardiomyocytes using 2D and 3D modelsde korte, Tessa / Mannhardt, Ingra / Hansen, Arne / Saleem, Umber / Eschenhagen, Thomas / Denning, Chris / Braam, Stefan R. / Vlaming, Maria L. et al. | 2018
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Evaluation of human iPS cell-derived cardiomyocytes in high-throughput toxicity screening applicationsAméen, Caroline / Dahlenborg, Kerstin / Åkesson, Karolina / Flood, Maria / Aspegren, Anders / Juhasz, Krisztina / Stoelzle-Feix, Sonja et al. | 2018
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A novel, label-free system to interrogate the function and 3D phenotype of iPSC cardiomyocyte co-culture spheroids for discovery applicationsBurnham, Matthew / Harvey, Rachel / Thomas, Ulrich / Fertig, Niels / Haddrick, Malcolm et al. | 2018
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The gene expression profiles and drug responses of human pluripotent stem cell-derived myocardial micro-tissues on aligned fibrous scaffoldsAiba, Kazuhiro / Hori, Kosuke / Tooi, Norie / Yamamoto, Yuka / Yabuuchi, Mie / Uda, Junki / Craig, Margaret A. / Kato, Kensuke / Nakatsuji, Norio et al. | 2018
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Application of human-induced pluripotent stem cell-derived cardiomyocytes in high-throughput screening assays for drug safety and efficacy testingNacken, Peter / D'Angelo, Jean Marc / Stevenhagen, Fleur / de Korte, Tessa / Wilbers, René / Famili, Farbod / Braam, Stefan R. / Vlaming, Maria L. et al. | 2018
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Development of a 3D-spheroid culture system to assess drug induced liver injury using induced pluripotent stem cell-derived hepatocytesHancock, Michael / Feaster, T.K. / Carlson, Coby / Aoyama, Natsuyo / Schlesinger, David / Mann, David / Anson, Blake D. et al. | 2018
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Cytotoxicity monitoring for safety assessments: iPS cardiomyocytes and cancer cellsStoelzle-Feix, Sonja / Bot, Corina T. / Dragicevic, Elena / Juhasz, Krisztina / Doerr, Leo / Beckler, Matthias / George, Michael / Haedo, Rodolfo / Fertig, Niels et al. | 2018
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Assessing functional and structural cardiotoxicity in cultured human iPSC-cardiomyocytes in a single plate formatGuo, Liang / Furniss, Michael / Hamre, John / Batista, Levy / Bastogne, Thierry / Yan, Zhuge / Wu, Joseph C. / Eldridge, Sandy / Davis, Myrtle et al. | 2018
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Leveraging genetic diversity in vitro: Evolution or revolution in cardiac safety assessment?Fine, Eli J. / Sullivan, Denise D. / Nguyen, Anh H. / Chal, Jerome / Hamilton, Jonathon B. / Coyne, Kevin P. / Coyne, Shawn T. / Mobley, Sheldon L. / Poe-Yamagata, Emma M. / Dobric, Maja et al. | 2018
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Impact of serum in the pharmacological response of human iPSC-derived cardiomyocytesGoineau, Sonia / Legrand, Christophe / Hunault, Marion / Froget, Guillaume / Castagné, Vincent et al. | 2018
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Development of human iPS cell-based platform for developmental neurotoxicity testingYamada, Shigeru / Yamazaki, Daiju / Kanda, Yasunari et al. | 2018
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Validation of cardiotoxicity testing using cardiomyocytes differentiated from human embryonic stem cells in multi-electrode-arrayKim, Ki-Suk / Lee, Hyang-Ae et al. | 2018
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Objective interpretation of calcium transient screening data on hiPS-derived cardiomyocytes using a novel hazard prediction systemKopljar, Ivan / Lu, Hua Rong / Van Ammel, Karel / Otava, Martin / Tekle, Fetene / Teisman, Ard / Gallacher, David J. et al. | 2018
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Multiwell optogenetics for enhanced cell-based assaysMillard, Daniel C. / Clements, Mike / Clements, Isaac C. / Hayes, Heather B. / Nicolini, Anthony M. / Ross, James D. et al. | 2018
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Opening the molecular toolbox: Co-transfection of KCNJ2 and channelrhodopsin 2 mRNAs for precise control of IPS cardiomyocyte pacing and functionalityKettenhofen, Ralf / Wolters, Benjamin / Luerman, Greg / Bohlen, Heribert et al. | 2018
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Trial for data analysis of drug responses in primary rodent neurons and human-induced pluripotent stem cell-derived neurons using MEA and deep learningMiyamoto, Norimasa / Ojima, Atsuko / Kitamura, Tetsuo / Osada, Tomoharu / Kadowaki, Tadashi / Yoshinaga, Takashi et al. | 2018
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Sex-related differences in drug-induced QT prolongation and Torsades de pointes: A new model system with human iPSC-CMsPang, Li / Juo, Jianhua / Lyn-Cook, Beverly / Stockbridge, Norman et al. | 2018
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Development and application of cardiac microtissues to cardiovascular safetyArcher, Caroline / Basak, Jayati / Sargeant, Rebecca / Pilling, James / Wang, Yinhai / Barnes, Jen / Pointon, Amy et al. | 2018
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Comprehensive profiling of axiogenesis ventricular vCor.4U iPSC-derived cardiomyocytes—From electrophysiology to phenotypic assaysEl Haou, Said / Williams, Sarah / Webdale, Louise / Rogers, Marc / Sutton, Kathy et al. | 2018
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Cardiac spheroid co-cultures as a novel in vitro model to study human heart microenvironmentPolonchuk, Liudmila / Chabria, Mamta / Badi, Laura / Hoflack, Jean-Christophe / Davies, Michael J. / Figtree, Gemma / Gentile, Carmine et al. | 2018
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Electrophysiological characterisation of cellular dynamics international ventricular iCell2 iPSC-derived cardiomyocytesWilliams, Sarah / El Haou, Said / Webdale, Louise / Rogers, Marc / Sutton, Kathy et al. | 2018
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Proarrhythmic risk evaluation of vanoxerine in normal and hypertrophic cardiomyopathy human stem cell-derived cardiomyocytesShi, Hong / Huang, Minxue / Levesque, Paul et al. | 2018
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Differentiation and validation of human iPSC-derived atrial cardiomyocytesSutton, Kathy / El Haou, Said / Williams, Sarah / Devalla, Harsha / Stoelzle-Feix, Sonja / Juhasz, Krisztina / Doerr, Leo / Beckler, Matthias / Haarmann, Claudia / George, Michael et al. | 2018
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The influence of fibroblast co-culture and 3D structures on cardiac action potentials of human stem cell-derived cardiomyocytesHortigon-Vinagre, Maria P. / Zamora, Victor / Gintant, Gary / Green, Jonathon / Burton, Francis L. / Smith, Godfrey L. et al. | 2018
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Electrophysiological responses of cultured human iPSC-derived neuronal networks to convulsants or anti-convulsant drugsOdawara, Aoi / Matsuda, Naoki / Ishibashi, Yuto / Yokoi, Remi / Suzuki, Ikuro et al. | 2018
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Modeling heart failure for therapeutic screens in engineered human myocardiumTiburcy, Malte / Meyer, Tim / Long, Chengzu / Olson, Eric N. / Zimmermann, Wolfram H. et al. | 2018
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Drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytesYamazaki, Daiju / Kitaguchi, Takashi / Ishimura, Masakazu / Taniguchi, Tomohiko / Yamanishi, Atsuhiro / Saji, Daisuke / Takahashi, Etsushi / Oguchi, Masao / Moriyama, Yuta / Maeda, Sanae et al. | 2018
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Studying sensitisation and cross-sensitisation potential of ß-lactam antibiotics using a modified biphasic local lymph node assay in miceAhuja, Varun / Stahlmann, Ralf et al. | 2018
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Evolution in diversity of a drugs primary target class poses a challenge to standard secondary pharmacology profiling: A look to future requirements and opportunitiesRibeiro, Lyn Rosenbrier / Larner, Carrie / Persson, Mikael / Scott, Clay et al. | 2018
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Modifying standard assay for assessing allosteric activityMigeon, Jacques / Ko, Amber / Lin, Heng-Hsu / Liu, Elsa / Feng, Jin-Jye et al. | 2018
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Effects of sympathetic tone in the QT interval and heart rate variability indices of beagle dogsYoungblood, Brad / Ferris, Erin / Geist, Beth / Ueyama, Yukie / Muir, William W. / del Rio, Carlos / Hamlin, Robert L. et al. | 2018
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Molecular modeling a tool for postulating the mechanism of drug interaction: Glimepiride alters the pharmacokinetics of sildenafil citrate in diabetic nephropathy animalsTripathi, Alok S. et al. | 2018
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NOAELs or not in safety pharmacology—An industry surveyAndersen, Ninette / Authier, Simon / Bass, Alan / Baird, Ted / Bhatt, Siddhartha / Curtis, Michael / Dragsted, Nils / Engwall, Michael / Jones, David / Lassen, Anders et al. | 2018
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Editorial Board| 2018