Anticancer effect of arsenic compounds on apoptosis in oral cavity cancer cells (Englisch)
- Neue Suche nach: Huang, B.-M.
- Neue Suche nach: Huang, B.-M.
In:
Toxicology letters
;
295
, s1
;
S229-S230
;
2018
-
ISSN:
- Aufsatz (Zeitschrift) / Print
-
Titel:Anticancer effect of arsenic compounds on apoptosis in oral cavity cancer cells
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Beteiligte:Huang, B.-M. ( Autor:in )
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Erschienen in:Toxicology letters ; 295, s1 ; S229-S230
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Verlag:
- Neue Suche nach: Elsevier Science B.V., Amsterdam.
-
Erscheinungsdatum:01.01.2018
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Format / Umfang:S229-S230
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ISSN:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Print
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Sprache:Englisch
- Neue Suche nach: 363.179
- Weitere Informationen zu Dewey Decimal Classification
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Klassifikation:
DDC: 363.179 -
Datenquelle:
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Author Index| 2018
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EUROTOX Contents| 2018
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Risk assessment of chemical mixtures – Regulatory requirements and current scientific approachesSolecki, R. et al. | 2018
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Aggregate and cumulative exposure of bisphenols from food and personal care products: A hands-on trainingKarrer, C. / Delmaar, C. / Bokkers, B. / Hungerbühler, K. / von Goetz, N. et al. | 2018
- S4
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Presentation of the EFSA WEB app based on PROASTCortinas Abrahantes, J. et al. | 2018
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Developing TK databases and tools to support food safety assessmentDorne, J.-L.C.M. / Amzal, B. / Quignot, N. / Wiecek, W. / Bechaux, C. / Darney, K. / Grech, A. / Brochot, C. / Beaudouin, R. / Bois, F. et al. | 2018
- S7
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Kidney-based in vitro models for toxicity testingJennings, P. et al. | 2018
- S8
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Beyond the Chip: Development and application of a micro-physiological flux analyzerNahmias, Y. et al. | 2018
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Scientific issues that need to be addressed for a successful read-across predictionCronin, M.T.D. et al. | 2018
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The OECD framework for AOP Development and the supporting toolsGourmelon, A. et al. | 2018
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D – Adverse Outcome Pathways are the future for regulatory toxicology| 2018
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- S172
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Ad hoc risk assessments by Front Office Food and Product SafetyJeurissen, S. / de Jonge, R. / Schuur, G. / Keizers, P. / Hoogenboom, R. et al. | 2018
- S173
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Exploring the presence of ESBL-producing bacteria in different aquatic ecosystems in EnglandAnjum, U. / Reid, R. / Hoosen, H. / Lobo-Bedmar, M.C. / Fernández, A. Peña et al. | 2018
- S174
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Effect of the herbicide paraquat in larval phase of the BullfrogEstrada, A.C. Razo / Jiménez-García, B.G. / Pérez, N.-A. Romero / Guzmán-Ibarra, R.D.C. et al. | 2018
- S175
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Environmental risk assessment and spatiotemporal variability of atmospheric volatile organic compounds and nitrogen dioxide using passive sampler in Meknes City (Morocco)Ghazi, I. El / Berni, I. / Menouni, A. / Kestemont, M.-P. / Amane, M. / Jaafari, S. El et al. | 2018
- S176
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Behavioral effects changes in rats exposed to real-life chemical mixture at doses around toxicological reference valuesDocea, A.O. / Calina, D. / Gofita, E. / Arsene, A.L. / Zlatian, O. / Nicolae, A. Crenguţa / Drăgoi, C.M. / Nosyrev, A. / Izotov, B. / Buga, A.M. et al. | 2018
- S177
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Primary risk assessment done after detection of fipronil in eggs in BelgiumFierens, S. / Lernout, T. / Vleminckx, C. et al. | 2018
- S179
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Evaluation of an integrated strategy for skin allergy risk assessment using six ingredients and two cosmetic product typesVandenbossche, E. / Baltazar, M. / Butcher, J. / Cubberley, R. / Gilmour, N. / MacKay, C. / Pendlington, R. / Reynolds, J. / Maxwell, G. et al. | 2018
- S181
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Immunoprotective effects of selenium on hepatorenal toxicity induced by scorpion venomMegdad-Lamraoui, A. / Adi-Bessalem, S. / Laraba-Djebari, F. et al. | 2018
- S184
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Reduced risk of allergy induction for hairdressers? An occupational risk assessment for the new oxidative hair dye 2-methoxymethyl-p-phenylenediamineGoebel, C. / Gargano, E.M. / Gaspari, A.A. / Blömeke, B. et al. | 2018
- S186
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Characterization of cytochrome p450 induction by the type ii pyrethroid lambda-cyhalothrinAnadón, A. / Ares, I. / Rodríguez, J.-L. / Martínez, M. / Lopez-Torres, B. / Roura-Martínez, D. / Martínez-Larrañaga, M.-R. / Martínez, M.-A. et al. | 2018
- S187
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In vivo comparison between two nephrotoxic agents, sodium fluoride and uranyl nitrate: phenotypic aspects and molecular mechanisms involvedBontemps, A. / Conquet, L. / Elie, C. / Magneron, V. / Gloaguen, C. / Kereselidze, D. / Tack, K. / Barbier, O. / Guéguen, Y. et al. | 2018
- S189
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Respiratory hazard of Li-ion battery components: elective toxicity of lithium cobalt oxide (LiCoO2) particles via IL-1β and HIF-1αSironval, V. / Reylandt, L. / Ibouraadaten, S. / Palmai-Pallag, M. / Yakoub, Y. / Tomatis, M. / Ucakar, B. / Vanbever, R. / Marbaix, E. / Lison, D. et al. | 2018
- S190
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Revisiting the paradigm of silica pathogenicity: silanols, not crystallinity, as key determinantPavan, C. / Turci, F. / Tomatis, M. / Leinardi, R. / Pastero, L. / Fabbiani, M. / Martra, G. / Fubini, B. / Lison, D. et al. | 2018
- S191
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Mechanism of chronic ethanol consumption-induced oxidative stress in mice renal cortex: involvement of iNOSSilva, C.B.P. / Gonzaga, N.A. / Ceron, C.S. / Santos, J.D. / Castro, M.M. / Tirapelli, C.R. et al. | 2018
- S192
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The synthetic psychostimulant 4-fluoromethamphetamine induces in vitro hepatotoxic effects, via CYP2E1 metabolismBravo, R.R.D.S. / Moreira, P. / Carvalho, F. / Bastos, M.D.L. / Carmo, H. / Silva, D. Dias da et al. | 2018
- S193
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Unravelling essential key events in mitochondrial adverse outcome pathwaysvan der Stel, W. / Darici, S. / van de Water, B. / Danen, E. et al. | 2018
- S195
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The mechanism for potentiation of the combined effects of 2, 4-D and methylmercury in warm-blooded organismsRakitskii, V. / Sinitskaya, T. et al. | 2018
- S196
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A human relevance investigation of PPARα-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in ratsSingh, P. / Strupp, C. / Bomann, W.H. / Spézia, F. / Gervais, F. / Forster, R. / Richert, L. et al. | 2018
- S197
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Hepatic and thyroid effects of phenobarbital in the minipigBoje Nielsen, J. / Decorde, J. / Erratico, C.-A. / Parmentier, C. / Untrau, M. / Bansard, C. / Ancian, P. / Fonsi, M. / Richert, L. / Forster, R. et al. | 2018
- S198
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Multiple targets/molecular initiating events, for OP neurotoxicity may be related with interactions of cholinesterase and phenylvalerate activities in chicken, the model of delayed neurotoxicityEstévez, J. / Benavent, M. / Selva, V. / Mangas, I. / del Río, E. / Sogorb, M.A. / Vilanova-Gisbert, E. et al. | 2018
- S199
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Sterigmatocystin induces oxidative stress in male Wistar ratsRašić, D. / Želježić, D. / Micek, V. / Kifer, D. / Jakšić, D. / Peraica, M. / Kopjar, N. / Klarić, M. Šegvić et al. | 2018
- S200
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Combined assays on isolated heart mitochondria and Cor.4U hiPS-derived cardiomyocytes to predict drug-induced cardiotoxicityMartel, C. / Pertuiset, C. / Aubry, B. / Porceddu, M. / Buron, N. / Kettenhofen, R. / Fouassier, A. / Borgne-Sanchez, A. et al. | 2018
- S203
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Carbon nanotubes influence surface properties of the phospholipid membraneKondej, D. / Sosnowski, T.R. et al. | 2018
- S204
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Behavioral alterations in the short and long term after chronic exposure of silver nanoparticles to young ratsOrzelska-Gorka, J. / Struzynska, L. / Talarek, S. / Kedzierska, E. / Biala, G. et al. | 2018
- S209
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Iron oxide nanoparticle toxicity on human cell lines, aquatic and soil organisms and interactions with metal pollutantsCabellos, J. / González-Andrés, V. / Diez-Ortiz, M. / Janer, G. et al. | 2018
- S210
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Hazard assessment for a Ti-based nano-additived material: from core-shell production to final partVerstraelen, S. / Van Rompay, A. / Jacobs, A. / Hollanders, K. / Boonen, F. / Geukens, G. / Frijns, E. / Geerts, L. / Weltens, R. et al. | 2018
- S211
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Single-walled and multi-walled carbon nanotubes induce epigenetic alterations in association with the nuclear deposition in 16 HBE cellsGhosh, M. / Öner, D. / Bové, H. / Moisse, M. / Boeckx, B. / Duca, R.C. / Vanoirbeek, J.A.J. / Ameloot, M. / Bekaert, B. / Lambrechts, D. et al. | 2018
- S212
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Insights into the role of the physicochemical properties in the toxicity of SiO2 nanoparticles in rat alveolar epithelial RLE-6TN cellsBrandão, M.F.P. / Bessa, M.J. / Costa, C. / Fraga, S. / Haase, A. / Teixeira, J.P. et al. | 2018
- S215
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Data-driven identification of interspecies pathway perturbations in vivo and in vitro: the case of Nrf2Souza, T.M. / Kleinjans, J.C.S. / Jennen, D.G.J. et al. | 2018
- S217
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Enabling high throughput transcriptomics (HTTr) for mechanistic toxicology by tuning dynamic rangeVan Steenhouse, H. / Yeakley, J. / Shepard, P. / McComb, J. / Seligmann, B. et al. | 2018
- S218
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FDA SEND process streamlining and implementation – CT-compatible simulated studyAnzai, T. / Aerni, R. / Wasko, M. / Mura, F. / Horikawa, S.-I. / Sato, S.-I. / Murase, Y. / Hatakeyama, H. et al. | 2018
- S219
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Application of a new biochip array platform to the simultaneous screening of drugs of abuse in urine and oral fluid in under 20minAnderson, V. / Cardwell, S. / Doone, D. / Dicks, J. / Speers, A. / Darragh, J. / Vance, P. / Dyttus, O. / Rodríguez, M.L. / Benchikh, M.E. et al. | 2018
- S221
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Follow-up on worthiness of LICl use in the rats' dietSadykova, E.O. / Shestakova, S.I. / Timonin, A.N. / Trebukh, M.D. et al. | 2018
- S222
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Reviewing the use of two species in toxicology studies supporting drug developmentPrior, H. / Gellatly, N. / Sewell, F. / Kimber, I. et al. | 2018
- S223
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Use of recovery animals for human safety assessment across the pharmaceutical development packageSewell, F. / Gellatly, N. / Prior, H. et al. | 2018
- S224
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Rotational thromboelastometry for ex vivo assessment of drug effects on platelet functionAuthier, S. / Negro, F. Silva / Saint-Jean, C. / Li, C. / Forster, R. / Foulon, O. et al. | 2018
- S225
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DNA microarray analysis on characteristics of hepatocyte-like cells derived from human iPS cells for the application to the cell based drug safety testsIshida, S. / Horiuchi, S. / kuroda, Y. / Fujii, R. / Kim, S.-R. / Kanda, Y. et al. | 2018
- S226
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Guidance for synthesising epidemiology evidence for the UK Committee on Toxicity (COT) and on Carcinogenicity (COC) of chemicals in foods, consumer products and the environmentGott, D. / Hansell, A. / Potter, C. et al. | 2018
- S227
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Introducing WikiPathways to link molecular pathways to adverse outcome pathways to support regulatory risk assessmentMartens, M. / Willighagen, E. / Nymark, P. / Grafström, R. / Burgoon, L.D. / Aladjov, H.T. / Andón, F. Torres / Evelo, C.T. et al. | 2018
- S228
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Antibody-drug conjugates: strategies, experiences and challenges from the non-clinical development to clinical development in cancer treatment in FranceBurbank, M.G. / Menoret, C. / Lopes, S. / Gazin, V. / Boudali, L. et al. | 2018
- S229
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Anticancer effect of arsenic compounds on apoptosis in oral cavity cancer cellsHuang, B.-M. et al. | 2018
- S231
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New approach for assessment of Wistar Hannover male rats reproductive toxicityKolianchuk, Y. / Prodanchuk, M. / Nedopytanska, N. / Rashkivska, I. / Bubalo, V. / Usenko, T. et al. | 2018
- S232
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Coenzyme Q10 supplementation rescues infertility and reproductive outcomes following exposure to the endocrine disruptor bisphenol A in Caenorhabditis elegansHornos Carneiro, M.F. / Shin, N. / Colaiacovo, M.P. et al. | 2018
- S233
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Prenatal administration of SMe1EC2 changed anxiety- and depression-like behavior with changes in the brain oxytocin expression of adult offspringStefanik, P. / Olexova, L. / Dzirbikova, Z. / Ujhazy, E. / Mach, M. et al. | 2018
- S235
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Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneysCurcic, M. / Đorđević, A. Buha / Milovanović, V. / Janković, S. / Vučinić, S. / Antonijević, E. / Đukić-Ćosić, D. / Bulat, Z. / Matović, V. / Antonijević, B. et al. | 2018
- S236
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Toxicity of DEP and metal oxide nanoparticles mixtures in human lung cellsZerboni, A. / Mantecca, P. et al. | 2018
- S237
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A comparative high-content screening-based assessment of e-cigarette liquids in primary bronchial epithelial cellsMarescotti, D. / Taylor, M. / Gonzalez-Suarez, I. / Acali, S. / Walker, P. / Belcastro, V. / Martin, F. / Frentzel, S. / Thorne, D. / Peitsch, M.C. et al. | 2018
- S238
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Quercetin ameliorates cadmium chloride-induced hepatotoxicity in Wistar ratsEgbung, G.E. / Nna, V.U. / Atangwho, I.J. / Obi-Abang, M. et al. | 2018
- S239
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Attenuation of livery injury with hypothermia in acute hepatotoxicityTan, Y.L. / Ho, H.K. et al. | 2018
- S240
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Effects on cigarette smoke extract on cell proliferation and apoptosis in mouse embryonic stem cells via reactive oxygen species-induced endoplasmic reticulum stress signaling pathwaysKim, C.-W. / Go, R.-E. / Choi, K.-C. et al. | 2018
- S242
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The effects of dioxin action on hr-deficient epidermal keratinocytes are associated with changes in expression of AhR-regulated genes both in vitro and in hairless mouse skin in vivoRudyak, S.G. / Shinin, V.V. / Usakin, L.A. / Belushkina, N.N. / Paltsev, M.A. / Panteleyev, A.A. et al. | 2018
- S243
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The interaction between the guanidine polymers of disinfectants and cytoplasmic organellesYoo, S.H. / Jeong, M.H. / Jang, E.H. / Jung, Y.J. / Chung, K.H. et al. | 2018
- S245
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Subchronic toxicity of Al2O3, TiO2 and SiO2 nanoparticles in different combinations for rats and its attenuation with a complex of innocuous bioprotectorsKlinova, S.V. / Minigalieva, I.A. / Privalova, L.I. / Panov, V.G. / Makeev, O.G. / Valamina, I.E. / Shishkina, E.V. et al. | 2018
- S246
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Incorporation of toxicodynamic feedback in a physiologically-based toxicokinetic model of acetaminophen overdoseReddyhoff, D. / Fisher, C.P. / Gardner, I. et al. | 2018
- S249
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New approaches for parameterization and evaluation of PBK models using human in silico, in vitro, biomonitoring and volunteer dataBessems, J. / Schoeters, G. / Santonen, T. et al. | 2018
- S250
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An inter-species comparison approach for triclopyr, utilizing in silico, in vitro and in vivo toxicokinetic properties, for risk assessment purposeCorvaro, M. / Bartels, M. et al. | 2018
- S251
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High-throughput and non-depletive quantification of chemicals in a 3D liver microtissue in vitro assayTeixeira, A. / Lee, M.-Y. / Nicol, B. et al. | 2018
- S252
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Development of a novel in vitro aerosol exposure system: The Independent Holistic Air-Liquid aerosol exposure system (InHALES)Steiner, S. / Herve, P. / Majeed, S. / Pak, C. / Frentzel, S. / Hoeng, J. et al. | 2018
- S254
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Treatment of impaired wounds – Understanding the therapeutic mechanisms of umbilical cord-derived mesenchymal stem cellsCamões, S.P. / de la Fuente, A. / Carvalho, F. / Abal, M. / Santos, J.M. / Miranda, J.P. et al. | 2018
- S255
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Interplay of four genetic high risk variants for urinary bladder cancerSelinski, S. / Ickstadt, K. / Gerullis, H. / Otto, T. / Roth, E. / Volkert, F. / Ovsiannikov, D. / Moormann, O. / Banfi, G. / Nyirady, P. et al. | 2018
- S256
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A simplified numerical scoring system to quantify skin and eye irritation/corrosionPerea, M. / Charmeau-Genevois, C. / Sahigara, F. / Thomas, P. et al. | 2018
- S257
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Microextraction by Packed Sorbent (MEPS) for the determination of Polybrominated Diphenyl Ether (PBDE) in eggs by Gas Chromatography-Mass Spectrometry (GC-MS)Souza, M.C.O. / Rocha, B.A. / Souza, J.M.O. / Barbosa Júnior, F. et al. | 2018
- S258
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TOX-OER MOOC: The liver as target organRocha-Pereira, C. / Soares, J. / Casanova, A.G. / Carmo, H. / Carvalho, F. / Bastos, M.D.L. / Remião, F. et al. | 2018
- S263
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Determination of proinflammatory cytokines level and NF-κB activation level in the human lung cells line stimulated with essential oils for a vehicle ventilation system applicationJanicka, A. / Molska, J. / Zawiślak, M. / Czarny, A. / Zaczyńska, E. et al. | 2018
- S265
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Alginate microencapsulated capsaicin suppresses ROS production and sustains human dermal fibroblasts cells viabilityDragomir, S. / Hudita, A. / Galateanu, B. / Costache, M. / Ion, R.M. / Ginghina, O. / Stan, M. / Baconi, D.L. / Negrei, C. et al. | 2018
- S269
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Co-exposure to cocaine and ethanol induces oxidative impairment in H9c2 cardiomyocytesMartins, M.J. / Bravo, R.R.D.S. / Carmo, H. / Carvalho, F. / Bastos, M.D.L. / Dinis-Oliveira, R.J. / Dias da Silva, D. et al. | 2018
- S270
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A Single Intraventricular dose Toxicity Study of K-6187, mesenchymal stem cells, in Neonatal Sprague-Dawley RatsJeong, J.-S. / Park, D.-Y. / Koh, E.-M. / Chang, Y.-S. / Ahn, S.Y. / Jeong, E.J. et al. | 2018
- S271
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Biomonitoring of 18 trace elements in the urine of workers from a smelting industry in the state of São Paulo (Brazil)Freire, B.M. / Pedron, T. / Pedreira Filho, W.R. / Batista, B.L. et al. | 2018
- S272
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Classification of toxicological findings observed in repeated–dose toxicity tests by using statistical analysis with toxicity test databaseKitsunai, Y. / Takeshita, J.-I. / Watanabe, M. / Sasaki, T. / Hosaka, T. / Shizu, R. / Yoshinari, K. et al. | 2018
- vii
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EUROTOX Sponsors and Exhibitors| 2018
- XXVI
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Keyword Index| 2018
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Zearalenone (mycotoxin) metabolism in urine of farmed pigs and cattleKoivisto, P.T. / Kolmonen, M. / Peltola, P. et al. | 2018
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Caffeic acid boosted the efficiency of benzyl isothiocyanate to induce the death of human breast adenocarcinomaRahaman, M.H.A. / Wan Omar, W.B. / Abd Kadir, N.H. et al. | 2018
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Free access platforms for integrating environmental chemical exposure and hazard informationTan, C. / Leonard, J. / Wambaugh, J. / Isaacs, K. / Villeneuve, D. / LaLone, C. / Edwards, S. / Williams, A. / Grulke, C. et al. | 2018
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Metabolomic analysis of the toxicity pathways elicited by subtoxic concentrations of methylone in primary mouse hepatocytesAraújo, A.M. / Bastos, M.D.L. / Carvalho, F. / Carvalho, M. / Guedes de Pinho, P. et al. | 2018
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Successful implementation of toxicology in occupational health?Takala, J. et al. | 2018
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Cardiac Safety - a Regulatory view pointPrasad, K. et al. | 2018
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Developmental and Reproductive toxicity testing – the next generationBeekhuijzen, M. et al. | 2018
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The importance of AOPs in the context of EU policyLandesmann, B. et al. | 2018
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Rapid toxicity screening of chemicals combining in vitro high-throughput transcriptomics, toxicokinetics and exposure estimatesJudson, R. et al. | 2018
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Microphysiological human stem cell systems for toxicity testingCoecke, S. / Bowe, G. / Browne, P. et al. | 2018
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The value of nonhuman primates for safety assessment of monoclonal antibodiesWeinbauer, G.F. et al. | 2018
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Next Generation Risk Assessment for consumer safety of cosmetics: A case study approachWestmoreland, C. et al. | 2018
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The accelerated removal of kidney stones by concomitant use of camel thorn distillate and Rowatinex drug: A case reportArabrahmatipour, G. / Ebadollahinatanzi, A. et al. | 2018
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Toxicity assessment of Cistus ladanifer extracts: Determination of citotoxicity and antioxidant activityOliveira, A. Palmeira de / Ramos, L. / Vaz, C. / Gaspar, C. / Rolo, J. / Oliveira, A. / Oliveira, R. Palmeira de / Oliveira, J. Martinez de / Delgado, F. et al. | 2018
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K04 – Drug discovery: if you want to see different results do things differentlyRoberts, R.A. et al. | 2018
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Low size citrate coated silver nanoparticles are potent inducers of human neutrophils' oxidative burstSoares, T. / Freitas, M. / Carvalho, F. / Fernandes, E. et al. | 2018
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Evaluating the usefulness of human-induced pluripotent stem cell-derived intestinal organoids in drug discovery researchNakanishi, A. / Onozato, D. / Okumura, H. / Hashita, T. / Iwao, T. / Matsunaga, T. et al. | 2018
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A new credit system for re-registration of toxicologists adopted in The NetherlandsScheepers, P.T.J. / Kroese, E.D. / van Velthoven, M.A. / Louisse, J. / Arts, J.H. et al. | 2018
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Useful series of positive control compounds for colony formation cytotoxicity testIsama, K. / Katsuyama, N. et al. | 2018
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Incorporation of public exposure models into the PLETHEM pharmacokinetic frameworkPendse, S.N. / Diallo, I. / Nicolas, C.I. / Efremenko, A.Y. / Hack, C.E. / Housand, C. / McMullen, P.D. / Yoon, M. / Clewell, H.J. et al. | 2018
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In vitro to in vivo extrapolation of effective concentrations in alternative assays for developmental toxicity testing: Application of generic PBK modellingFragki, S. / Piersma, A.H. / Rorije, E. / Zeilmaker, M.J. et al. | 2018
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Impact of serum on calcium transient assays performed on human-induced pluripotent stem cell-derived cardiomyocytesPetit, M. / Paquet, M. / Paulhac, L. / Kitchener, P. et al. | 2018
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Sharing in the INTERVALS platform study details and data from the assessment of the impact of aerosol from the carbon-heated tobacco product (CHTP) 1.2, a potential modified risk tobacco product, on human organotypic gingival culturesBoue, S. / Zanetti, F. / Hoeng, J. / Peitsch, M.C. et al. | 2018
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The in vitro biological assessment of the stability of cigarette smoke aqueous extractsTaylor, M. / Bozhilova, S. / Baxter, A. / Terry, A. / Thorne, D. / Oke, O. / Gaca, M. et al. | 2018
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Preclinical safety assessment of aqueous medicinal plant extracts containing thujoneTurek, C. / Molnar-Pfitzner, P. / Mörbt, N. / Müller, M.B. / Vögele, P. / Stintzing, F.C. et al. | 2018
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Probabilistic risk of decreased levels of triiodothyronine following chronic exposure to PFOS and PFHxSÖberg, M. / Da Silva, A. / Ringblom, J. / Scott, K. / Lindh, C. / Jakobsson, K. et al. | 2018
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Updates to OECD guidance document 23: aquatic toxicity testing of difficult substances and mixturesStoddart, G. / Hunter, W. / Halder, M. / Salinas, E. / Faßbender, C. et al. | 2018
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Gene-specific 5′-UTR methylation vs. promoter methylation in leukocytes from workers exposed to different levels of VOCsJiménez-Garza, O. / Dávalos-Pérez, A. / Alegría-Torres, J. / Ruiz-García, L. et al. | 2018
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Is the prediction of nephrotoxicity and its mode of action by metabolome analysis in vitro in NRK-52e cells feasible?Birk, B. / Sperber, S. / Huener, H.-A. / Verlohner, A. / Walk, T. / Haake, V. / Spitzer, M. / Kamp, H. / van Ravenzwaay, B. et al. | 2018
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Effects of silver nanocomposite (AgI) on Allium cepa: Part I DNA damage assessment with COMET assayGunes, M. / Yalcin, B. / Ertugrul, H. / Kaya, N. / Akarsu, E. / Kaya, B. et al. | 2018
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Silica nanoparticles impact the permeability of human intestinal barrierCornu, R. / Chrétien, C. / Béduneau, A. / Martin, H. et al. | 2018
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Altered microRNA expression patterns related to polyhexamethyleneguanidine phosphate-induced lung toxicity in human alveolar adenocarcinoma (A549) cellsJang, E.H. / Shin, D.Y. / Yoo, S.H. / Jung, Y.J. / Chung, K.H. et al. | 2018
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Neurotoxicity assessment of four synthetic cathinones in neuroblastoma cells at in vivo relevant concentrationsParra, J. / Araujo, A.R.T.S. / Carvalho, F. / Carmo, H. / Silva, J.P. et al. | 2018
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Reactive oxygen species: the hidden face of biodegradable Fe-based alloysScarcello, E. / Tomatis, M. / Turci, F. / Thomas, A. / Jacques, P.J. / Lison, D. et al. | 2018
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Aerosol trapping, optimization and characterization for comparative in vitro assessment of combustible and heat-non burn tobacco platformsGoedertier, D.P. / Pak, C. / Kondylis, A. / Vuillaume, G. / Hoeng, J. / Mathis, C. / Frentzel, S. et al. | 2018
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Occupational risk assessment of pesticides with different EU dermal absorption and Ko-POEM in KoreaYou, A.S. / Lee, N. / Park, S. / Jo, Y. / Oh, J.A. / Park, Y.-K. et al. | 2018
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Safety evaluation of the migration in oily cosmetic products in contact with plastic packagingsMurat, P. / Simon, V. / Galonnier, M. / Pierre-Jacques, F. / Cosledan, S. et al. | 2018
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Silicones – do they all behave the same way in the environment regarding biodegradability/degradability?Creusot, T. / Louvet, G. / Bellemain, A. / Combourieu, B. / Catoire, S. / Ficheux, H.E. et al. | 2018
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Genotoxicity assessment of caffeine-alginate methylsilanetriol with the mammalian erythrocyte micronucleus testVergara-Castañeda, A. / Martino-Roaro, L. / Sanchez-Huesca, R. / Vergara, E. / Sánchez-Carrillo, J.C. / Martínez-Briseño, M. et al. | 2018
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Effect-directed monitoring tools as a toxicological fingerprint for ecological and human risk assessment of water bodiesDe Gussem, V. / Schuijt, L. / van den Brink, P. / van Dijk, J. / Jonker, M. / Kramer, N. / van Wezel, A. et al. | 2018
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Safety profile characterization of a cosmetic silanol compound in vivoMartino-Roaro, L. / Vergara-Castañeda, A. / Sanchez-Huesca, R. / Vergara, E. / Sánchez-Carrillo, J.C. / Lopez-Garduño, U. et al. | 2018
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Role of in silico tools and text mining in the risk assessment of selected alkaloidsSousselier, L. / Raitano, G. / Petoumenou, M. / Benfenati, E. / Nguyen, N. / Ananiadou, S. / Do, Q.T. / Olivier, E. / Michel, S. / Rat, P. et al. | 2018
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Food contaminant mycotoxin altertoxin II: cell membrane as targetDel Favero, G. / Marko, D. et al. | 2018
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Animal-free strategies to prioritize substances of concern: case studies with food contact materialsMertens, B. / Van Bossuyt, M. / Vanhaecke, T. / Rogiers, V. / Van Hoeck, E. et al. | 2018
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Biomonitoring of phthalate metabolites and bisphenols in amniotic fluid from pregnant women in GreeceKatsikantami, I. / Karzi, V. / Tzatzarakis, M.N. / Sifakis, S. / Xezonaki, P. / Vakonaki, E.K. / Rizos, A. / Izotov, B. / Burykina, T. / Tsatsakis, A.M. et al. | 2018
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Hexachlorobenzene exposure induces cell migration and invasion through AhR, COX-2, ER and c-Src in human endometrial stromal cellsChiappini, F.A. / Ceballos, L. / Pontillo, C. / Miret, N. / Núñez, M. / Álvarez, L. / Farina, M. / Randi, A.S. et al. | 2018
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In vitro evaluation of hepatotoxicity by amiodarone in HepatoPac (micropatterned co-cultured hepatocytes) using liver-specific markersNereda, Z. / Kegyes, C. / de Wilde, R. / Gáborik, Z. et al. | 2018
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OncoCilAir™: A physiological in vitro platform to assess the efficacy and the toxicity of lung cancer therapeuticsBenainous, H. / Kilin, V. / Huang, S. / Wiszniewski, L. / Wolf, J.-P. / Bonacina, L. / Constant, S. / Mas, C. et al. | 2018
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The In Vitro assessment of Respiratory Sensitisation Potential of Electronic Cigarette LiquidsStevenson, M. / Czekala, L. / Simms, L. / Tschierske, N. / Johansson, H. / Walele, T. et al. | 2018
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Development of a Robust In Silico Profiler to Screen for Nephrotoxicity EndpointsPletz, J. / Ebbrell, D.J. / Enoch, S.J. / Firman, J.W. / Madden, J.C. / Webb, S.D. / Cronin, M.T.D. et al. | 2018
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The cytotoxicity of doxorubicin in human mammary cells is modulated by the conditioned medium of mesenchymal stem cellsAntunes, B.C. / Camões, S.P. / Castro, M. / Oliveira, N.G. / Miranda, J.P. et al. | 2018
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RE-Place: Centralizing information on alternative methods to animal testing to promote knowledge sharingVan Mulders, M. / Mertens, B. / Rogiers, V. et al. | 2018
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Exploring in vitro the potential effects of repeated drug treatment on the distribution of other xenobiotics at the human blood-brain barrier (BBB)Heymans, M. / Lontouo, C. / Sevin, E. / Gosselet, F. / Culot, M. et al. | 2018
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Using TK data and tools to support regulatory decision making – from the perspectives of cosmetic industryKlaric, M. et al. | 2018
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Scientific considerations for assessing read-across between multi-constituent or UVCB substancesStilgenbauer, E. / Andersson, N. / Bell, D. / Cartlidge, G. / Fedtke, N. / Kojo, A. / Kovari, A. / Papadaki, P. / Temussi, F. et al. | 2018
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Incorporating toxicokinetic data and tools to support public health decision makingTan, C. et al. | 2018
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Unravelling mechanisms of toxicity induced by classical PPAR-gamma agonists through transcriptomic analysis of hiPSC-derived kidney organoidsBusch, S. / Sagemark, J. / Jonebring, A. / Sjögren, A.-K. / Hicks, R. / Persson, M. / Hornberg, J.J. et al. | 2018
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A refuted association between soil contamination from past antimony mining and exposure of children to inorganic arsenicPerharič, L. / Martinčič, M. / Zadnik, V. / Uršič, S. / Mazej, D. / Šlejkovec, Z. / Šter, M. / France-Štiglic, A. / Kukec, A. et al. | 2018
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Early identification of potentially translatable compound-induced neurotoxicity and associated biomarkers utilizing 2D & 3D primary and iPSC-derived microBrain modelsMcDuffie, J.E. et al. | 2018
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Immunosuppression mediated by enzymes that degrade tryptophanVan den Eynde, B. et al. | 2018
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Application of systems biology to guide quantitative translation risk assessmentsCollins, T.A. et al. | 2018
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The usefulness of BALB/c strain mice in the LLNA: BrdU-ELISAKrakowian, D. / Drzewiecka, A. / Gądarowska, D. / Paleczny, M. / Faron, J. / Mrzyk, I. / Gruszka, K. / Sornat, R. / Wołany, M. / Daniel-Wójcik, A. et al. | 2018
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Regulatory perspective of CRA with respect to co-administered biotherapeuticsReichmann, G. et al. | 2018
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Ion channel profiling of stem cell-derived cardiomyocytes: Useful reagents for automated patch-clamp?Morton, M. et al. | 2018
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Translational Aspects of the Cytokine Release AssayWeinstock, D. et al. | 2018
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Current approaches to risk assessment of carcinogensSchrenk, D. et al. | 2018
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Regulatory view on immunotoxicity assessment of biomedical and biotechnologicy applicationsVan der Laan, J.W. et al. | 2018
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Do we neglect peripheral neuropathy? Pathophysiology, assessment and translational aspectArezzo, J.C. et al. | 2018
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Air pollution stress and the ageing phenotypeNawrot, T. et al. | 2018
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Reconnecting exposure, toxicokinetics and toxicity in food safety: OpenFoodTox and TKplate for human health, animal health and ecological risk assessmentDorne, J.-L.C.M. / Amzal, B. / Quignot, N. / Wiecek, W. / Grech, A. / Brochot, C. / Beaudouin, R. / Bois, F. / Ragas, A. / Lautz, L. et al. | 2018
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Integration of mechanism-based in vitro methods and quantitative in vitro-in vivo extrapolation (QIVIVE) modelling for prediction of nephrotoxicityMally, A. / Birk, B. / DiFiore, S. / Ellinger, B. / Jarzina, S. / Taverne, F. / Kramer, N. et al. | 2018
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Advanced models and detection systems for evaluating immunotoxicity of nanomaterials in health and diseaseKohl, Y. et al. | 2018
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New developments in human stem cell-based models for toxicity testingHengstler, J. / Godoy, P. et al. | 2018
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Current strategies in the safety assessment of monoclonal antibodiesKronenberg, S. et al. | 2018
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A framework for a fit-for-purpose evaluation of non-animal methodsBoobis, A.R. et al. | 2018
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Organs-on-chips for toxicity testing: lung-thrombosis chip as a practical exampleOtieno, M. / Barrile, R. / van der Meer, A.D. / Park, H. / Fraser, J. / Simic, D. / Teng, F. / Conegliano, D. / Nguyen, J. / Ng, P. et al. | 2018
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K01 – Consumer toxicology: Natural is good, synthetic is badSiegrist, M. et al. | 2018
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JTp and Tpe as biomarkers of proarrhythmic risk in nonclinical models: Historical data evaluation by the HESI consortiumAuthier, S. / Abernathy, M. / Boulay, E. / Chui, R. / Friedrich, G.S. / Gendron-Parra, N. / Greiter-Wilke, A. / Guillon, J.-M. / Leishman, D.J. / Nichols, J. et al. | 2018
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A pilot education program in collaboration with World Health Organization to increase knowledge and awareness amongst medical students of "Environmental Preventive Medicine"Todaka, E. / Shiga, S. / Poore, K. / Fenichel, P. / Mori, C. et al. | 2018
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Hierarchical Bayesian meta-analysis of human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for human risk assessmentDarney, K. / Testai, E. / Kramer, N. / Dorne, J.-L.C.M. / Bechaux, C. et al. | 2018
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Pharmacokinetics of HuperzineA-PLGA-nanoparticlesin in miceZhang, R. / Shi, T. / Wang, C. / Chen, X. / Li, L. et al. | 2018
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The Adverse Outcome Pathway (AOP) concept as a basis for the development of mechanism-based animal sparing approaches: Kidney toxicity due to lysosomal overload and inhibition of mtDNA polymerase-γ as case studiesJarzina, S. / Reiser, P. / Scherer, J. / DiFiore, S. / Ellinger, B. / Mally, A. et al. | 2018
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Toxicogenomics analysis of phthalates and bisphenol A mixture: Obesity and comorbiditiesBaralić, K.V. / Jorgovanović, D. / Matović, V. / Antonijević, B. / Bulat, Z. / Ćurčić, M. / Antonijević, E. / Đukić-Ćosić, D. et al. | 2018
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Implementation of in vitro methods in the safety evaluation of the skin sensitization potential of chemicals under REACH regulationRovida, C. / Locatelli, M. / Corsini, E. et al. | 2018
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Comparison of organ weight (absolute and relative to brain) in Wistar Han rats at different agesMcPherson, S.M. et al. | 2018
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Di (2-ethylhexyl) adipate (DEHA): systemic toxicity in rats following 28-day intravenous exposureXu, H. / Musi, B. / Wang, Z. / Zhou, T. / Huang, Q. / Liu, J. / Li, T. / Koo, E. et al. | 2018
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Evaluation of tight junction disruption induced particles on airway epithelial cells using an automatized imaging methodAlfaro-Moreno, E. / Engel, M. / de Marco, G. / Kos, V. Munic et al. | 2018
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DMSO-induced drastic changes in cellular processes and epigenetic landscape in vitroVerheijen, M.C.T. / Lienhard, M. / Schrooders, Y.J.M. / Clayton, O. / Nudischer, R. / Timmermann, B. / Boerno, S. / Selevsek, N. / Schlapbach, R. / Gmuender, H. et al. | 2018
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PEG-Serine nanoparticles as novel nanostructure for attenuation of organophosphate poisoning: Synthesize, characterization, in vitro and in vivo studiesMohammadi, H. / Ebrahimnejad, P. / Davoodi, A. / Irannejad, H. et al. | 2018
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MUC5AC overexpression by organic extract of SRM 1648 urban particulate matter via ERK, JNK and p38 MAPK activation in Calu-3 human airway epithelial cellsYoo, S.H. / Jeong, M.H. / Jung, Y.J. / Park, J.S. et al. | 2018
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Potassium octatitanate fibers are possibly carcinogenic in male Fischer 344 ratsAbdelgied, M.A.M. / El-Gazzar, A. / Alexander, D. / Alexander, W. / Numano, T. / Iigo, M. / Naiki, A. / Abdelhamid, M. / Takase, H. / Hirose, A. et al. | 2018
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The effect of PI3K/Akt and Notch signaling pathway in polyhexamethylene guanidine-phosphate induced epithelial-mesenchymal transition in human alveolar epithelial A549 cellsJang, E.H. / Park, J.S. / Shin, D.Y. / Jeong, M.H. et al. | 2018
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Singlet molecular oxygen generated by cholesterol, oleic, linoleic hydroperoxides with nitronium ionDi Mascio, P. / Scalfo, A.C. / Miyamoto, S. / Prado, F.M. / Medeiros, M.H.G. et al. | 2018
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Development of cell assays to predict cytokine storm responses of novel biological therapeuticsMunday, J.R. et al. | 2018
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Gene profiles expressed in hippocampus of aluminum-treated rats and the significance for predicting Al-induced neurotoxicityNiu, Q. et al. | 2018
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Evaluation of cytotoxicity and in silico epitope prediction of a PEGylated snake venom serine protease: a step closer to therapeutic applicationsPinheiro-Junior, E.L. / Boldrini-França, J. / Costa, T.R. / Takeda, A.A.S. / Sampaio, S.V. / Fontes, M.R.M. / Arantes, E.C. et al. | 2018
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GMO safety assessment in the Russian Federation: the immunotoxicological studiesTrebukh, M.D. / Tyshko, N.V. et al. | 2018
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Cosmetic Europe's long range science strategy – A non-animal safety assessment case study for phenoxyethanol, a cosmetic ingredientNepelska, M. / Cronin, M.T.D. / Cubberley, R. / Dent, M. / Firman, J.W. / Fisher, J. / Kenna, G. / Mahony, C. / Nicol, B. / Piechota, S. et al. | 2018
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Effects of heavy metals on Nile tilapia (Oreochromis niloticus L.) obtained from Meycauayan River, Philippines: Studies on health risks, bioaccumulation and oxidative stressGuaring, R.I. / Espiritu, E. et al. | 2018
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Fusarium mycotoxins exposure assessment through diet and urine analytical studyRodriguez-Carrasco, Y. / Carballo, D. / Ferrer, E. / Font, G. / Berrada, H. et al. | 2018
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Assessment of reproductive toxicity of male rats through maternal exposure to dienestrolGonzález, N. / Schreiber, E. / Torrente, M. / Kumar, V. / Domingo, J.L. / Gómez, M.M. et al. | 2018
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Refined assessment and perspectives on the cumulative risk resulting from the dietary exposure to pesticide residues in the Danish populationLarsson, M.O. / Laporte, F. / Bjerre, N. / Nielsen, V.S. / Cedergreen, N. et al. | 2018
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Modeling of ligand-induced acute and chronic inflammation in the gastrointestinal tract using In vitro 3D-human small intestinal microtissuesMarkus, J. / Landry, T. / Stevens, Z. / Klausner, M. / Hayden, P. / Ayehunie, S. et al. | 2018
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Use of a 3-D human in vitro airway model (EpiAirway®-FT) to investigate clinically relevant endpoints for pulmonary disorders: Proof of conceptKidd, D. / Woodhams, A. / Daunt, A. / Postoyalko, A. et al. | 2018
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Real-time cell analysis of the cytotoxicity of γ-ray radiation and the radioprotective effect of TLR5 agonistShi, T. / Zhang, R. / Chen, X. / Wang, C. / Jiang, H. / Li, L. et al. | 2018
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Oleanolic acid: a potential chemotherapeutic agent weakened by P-glycoproteinKayouka, M. / Saliba, E. / Landy, D. / Greige, H. et al. | 2018
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A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: Diacylglycerol transferase (DGAT) 1 inhibitorYokoyama, H. / Kobayashi, A. / Kondo, K. / Oshida, S. / Takahashi, T. / Masuyama, T. / Shoda, T. / Sugai, S. et al. | 2018
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DynOVis: A new tool to visualize dynamic perturbations of biological networks after toxic exposureKuijpers, T. / Kleinjans, J.C.S. / Jennen, D.G.J. et al. | 2018
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An extended mechanistically-based in silico profiler for liver toxicityCronin, M.T.D. / Bienfait, B. / Ebbrell, D.J. / Enoch, S.J. / Firman, J.W. / Madden, J.C. / Mostrag-Szlichtyng, A. / Rathman, J.F. / Vitcheva, V. / Yang, C. et al. | 2018
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Analysis of toxicologically relevant biomarkers in pesticide-treated HepaRG cells by MS-based immunoassaysSchmidt, F.F. / Steinhilber, A.E. / Hammer, H.S. / Mentz, A. / Kalinowski, J. / Lichtenstein, D. / Braeuning, A. / Marx-Stoelting, P. / Lampen, A. / Joos, T. et al. | 2018
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Optimization of the Vitrocell 24/48 in vitro inhalation exposure system for nanoparticlesFrijns, E. / Van Laer, J. / Jacobs, A. / Verstraelen, S. et al. | 2018
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Inflammatory conditions affect the acetaminophen-induced liver injury in a novel 3D model of human multicellular microtissuesKok, T.D. / Jiang, J. / Kelm, J. / van Herwijnen, M. / Kleinjans, J.C.S. et al. | 2018
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Limitations of the T25 method for the assessment of carcinogenic potency of inorganic inhalation carcinogensDanzeisen, R. / Verougstraete, V. et al. | 2018
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In vitro "skin patch tests" for the detection of sensitization, allergy and relative potency assessmentAhmed, S. / Tulah, A. / Bibby, L. / Dickinson, A.M. et al. | 2018
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Use of reconstructed human skin and IL-18 to determine the skin sensitization potency of red and black tattoo inksBil, W. / Bent, S.V.D. / Spiekstra, S. / Rustemeyer, T. / Gibbs, S. et al. | 2018
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Investigation of drug-induced cholestasis in HepaRG cells using untargeted LC-MS metabolomicsCuykx, M. / Beirnaert, C. / Rodrigues, R.M. / Laukens, K. / Vanhaecke, T. / Covaci, A. et al. | 2018
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Liver-based in vitro models for toxicity testingVinken, M. et al. | 2018
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The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifosMiladinović, D. Ćupić / Borozan, S. / Peković, S. / Dacić, S. / Đukić-Ćosić, D. / Ćupić, V. / Ivanović, S. et al. | 2018
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Exposure data for baby wipe productsNalin, A. / Herbin, C. et al. | 2018
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Polyethylemine coated silver nanoparticles induce human neutrophils' oxidative burst via NADPH oxidase, through the activation of PKCSoares, T. / Gónzalez-Gómez, M. / Rivas, J. / Freitas, P. / Carvalho, F. / Fernandes, E. / Freitas, M. et al. | 2018
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Reference reagents for a better harmonisation of Cytokine Release AssaysVessillier, S. et al. | 2018
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Evaluation of emerging biomarkers for major organ toxicities and disease statesEllinger-Ziegelbauer, H.C. / Hellmund, M. / Pavkovic, M. / Petzuch, B. / Raschke, M. / Riefke, B. / Slopianka, M. et al. | 2018
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Current challenges and opportunities in cardiac safety: a clinical perspectiveDarpo, B. et al. | 2018
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Industry perspective on the challenges and opportunities of the safety assessment of biologicalsSims, J. et al. | 2018
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European air pollution modelsHoek, G. / de Hoogh, K. et al. | 2018
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Ecological risk assessment of chemical mixturesRagas, A. et al. | 2018
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Physiology, pharmacology and toxicology of the Nrf2 pathwayCopple, I. et al. | 2018
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Antisense oligonucleotides – recent advances in preclinical safety assessmentFestag, M. et al. | 2018
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Data encounters at the in vitro-in vivo interface: building target to event hypothesisMunoz-Muriedas, J. et al. | 2018
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Future direction in immunotoxicology: immunosuppression as key playerHuaux, F. et al. | 2018
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PrefaceLison, Dominique / Wallace, Heather et al. | 2018
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Microorganisms reduce indoor air pollutionVerdonck, J. / Vanoirbeeck, J.A.J. / Poels, K. / Hoet, P.H.M. / Godderis, L. et al. | 2018
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Application of PBPK modelling of enterocyte exposure aids in vitro to in vivo translational risk assessment of μ-opioid-induced clinical constipationKavanagh, S. / Ribeiro, L. Rosenbrier / Noeske, T. / Sharma, P. et al. | 2018
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Natural antioxidants prevent contrast-induced nephropathy by enhancing nitric oxide synthesis in an animal modelFragkiadoulaki, I. / Mamoulakis, C. / Alegakis, A. / Tzatzarakis, M.N. / Karzi, V. / Stratidakis, A. / Renieri, E. / Vardavas, A. / Leon, G. / Tsitsimpikou, C. et al. | 2018
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Acute mixture toxicity of pesticide formulations and perspective of use in silico methods to complement risk assessment of plant protection productsKolesnyk, S. / Riabukha, O. / Prodanchuk, M. / Zhminko, P. / Vasetska, O. et al. | 2018
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Perinatal exposure to secondary organic aerosol influences neurobehavioral development and inflammatory markers in ratsWin-Shwe, T.-T. / Fujitani, Y. / Hirano, S. et al. | 2018
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Six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of two reduced risk products compared with conventional cigarettesSzostak, J.G. / Phillips, B. / Emmanuel, G. / Wong, E.T. / Titz, B. / Martin, F. / Vuillaume, G. / Leroy, P. / Buettner, A. / Vanscheeuwijck, P. et al. | 2018
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Possible role of n-hexane as endocrine disruptor in occupationally exposed women at reproductive ageRuiz-García, L. / Malacara-Hernández, J.M. / Figueroa-Vega, N. / Bartoloucci, G.B. / Carrieri, M. / Salamon, F. / Jiménez-Garza, O. et al. | 2018
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A new screening approach for the evaluation of retinoic acid receptor alpha (RARα) interaction of chemicalsBirk, B. / Demuth, P. / Roth, N. / Sessler, K. / Hüner, H.-A. / Verlohner, A. / Flick, B. / van Ravenzwaay, B. / Landsiedel, R. et al. | 2018
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Stereotactic surgeries and MRI-guided Convection-Enhanced Delivery (CED) into the striatum in cynomolgus macaquesLuft, J. / von Keutz, A. / Runge, F. / Voß, T. / Grote-Wessels, S. / Korte, S. et al. | 2018
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Percellome toxicogenomics project: newly designed repeated dose studyKanno, J. / Kitajima, S. / Ono, R. / Aisaki, K. et al. | 2018
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In vitro toxic effects of L-glutamic acid-g-p(HEMA) polymeric nanoparticleBakan, N.B. / Gülcemal, S. / Akgöl, S. / Hoet, P.H.M. / Yavaşoğlu, N.U. Karabay et al. | 2018
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A system-based comparative proteomics approach to investigate heavy metals mixtures toxicity mechanism relates to the neurodegeneration on hippocampal cell lineKumar, V. / Karri, V. / Edwin, M. / Coort, S.L. / Evelo, C.T. / Oliveira, E. / Schuhmacher, M. et al. | 2018
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1, 2-Diacetylbenzene with inflammatory related pathway associated neurotoxicityKim, M.-S. / Kang, S.-W. et al. | 2018
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Prenatal high fat diet alters DNA methylation and gene expression of metabolic genes in mouse offspringRouschop, S. / Karl, T. / Maas, L. / Risch, A. / Opperhuizen, A. / van Schooten, F.J. / Godschalk, R. et al. | 2018
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Up-regulation of bisphenol A-mediated BAFF expression in Raw264.7 murine macrophagesLee, S.H. / Yoon, S.S. / Moon, E.Y. et al. | 2018
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Evaluation of human health risks associated with toxic metals present in coastal ecosystem: a study on trophic level transfer of metals in Bay of Bengal, IndiaSatapathy, S. et al. | 2018
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Trends on PM2.5 research, 1997–2016: a bibliometric studyLiang, G. / Sui, J. / Wu, W. / Liu, T. / Xu, S. / Yin, L. / Pu, Y. et al. | 2018
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Subchronic inhaling toxicity study of diphenylcyanarsine in SD ratsLi, L. / Zhang, R. / Yin, Y. / Shi, T. / Wang, C. / Chen, X. / Xu, J. et al. | 2018
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UV-A and UV-B damage: the protective effect of Vitis vinifera L. extract on HaCaT cell lineLolli, F. et al. | 2018
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Genotoxic damage among Bolivian farmers exposed to a complex mixture of pesticidesBarron Cuenca, J.X. / Tirado, N. / Barral, J. / Almaraz, P. / Stenius, U. / Berglund, M. / Dreij, K. et al. | 2018
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Prospective hazards of fenvalerate in extensive pollution influence the apoptosis sensitivityCui, Z.-G. / Jin, Y.-J. / Sun, L. / Zakki, S.A. / Feng, Q. / Inadera, H. et al. | 2018
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Acute and sub-acute oral toxicity study of fermented platycodon extract in ratsHeo, J.-D. / Choi, J. / Kim, J. / Lee, S.-J. / Moon, Y.-G. / Kim, W.-S. / Tak, T.-K. / Lee, J.-H. / Hwang, K.-H. et al. | 2018
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Safety assessment of biotechnologically produced 2'-Fucosyllactose, a novel food additiveSalverda, J. / van Berlo, D. / Wallinga, A. / van Acker, F. / Delsing, D. et al. | 2018
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Safety evaluation of plants collected from the wild served as food in Danish restaurantsEgebjerg, M.M. / Olesen, P.T. / Eriksen, F.D. / Ravn-Haren, G. / Bredsdorff, L. / Pilegaard, K. et al. | 2018
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Multi-omics Analysis reveals that co-exposure to phthalates and metals disturbs urea cycle and choline metabolismSarigiannis, D. / Papaioannou, N. / Kapretsos, N. / Gabriel, C. / Distel, E. / de Oliveira, E. / Karakitsios, S. / Aggerbeck, M. / Barouki, R. et al. | 2018
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Antiandrogenic effects of gibberellins in the recombinant yeast androgen bioassayStypuła-Trębas, S. / Radko, L. / Jedziniak, P. / Posyniak, A. et al. | 2018
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Human tissue based sensitization assessment: set-up of an accurate prediction model for distinguishing skin sensitizers using a new assay adapted to hydrophobic substances and mixturesAndres, E. / Barry, M. / Hundt, A. / Dini, C. / Ferret, P.-J. et al. | 2018
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Cell-based screening of drug-induced metabolic dysfunctionSchwalfenberg, M. / McGarrigle, R. / Hayes, I. / Carey, C. / Hynes, J. et al. | 2018
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3D spheroid cultures from human astrocyte- and neuronal- like cells: New in vitro models to assess magnetite nanoparticle-induced adverse effects on CNSDe Simone, U. / Caloni, F. / Roccio, M. / Gribaldo, L. / Spinillo, A. / Coccini, T. et al. | 2018
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Maternal smoking and changes in drug metabolising enzymes in the human fetusZafeiri, A. / Filis, P. / Soffientini, U. / Lucendo-Villarin, B. / Douglas, A. / Shaw, S. / Iredale, J.P. / Swortwood, M.J. / Huestis, M.A. / Bellingham, M. et al. | 2018
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Effect of rocuronium on duration of ventilation after organophosphorus insecticide poisoning – A pilot randomised controlled trialDhanarisi, H.K.J. / Gawarammana, I. / Mohamed, F. / Eddleston, M. et al. | 2018
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An automated workflow for Adverse Outcome Pathway hypothesis generationDoktorova, T. / Exner, T.E. / Hardy, B. / Noffisat, O. et al. | 2018
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Predicting in silico the Direct-Peptide-Reactivity-Assay (DPRA) within the Allergic Contact Dermatitis framework: A module accounting for test variability and abiotic transformationsDetroyer, A. / Ivanova, H. / Eilstein, J. / Piroird, C. / Imbert, S. / Del Bufalo, A. / Popova, I. / Kuseva, C. / Karakolev, I. / Dimitrov, S. et al. | 2018
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Levels of heavy metals and essential minerals in hair samples of children with autism in Algeria: A case–control studyZebbiche, Y. / Bencherif, M.S. / Boughazi, H. / Aries, S. / Amziane, A. / Djidjik, R. / Alamir, B. et al. | 2018
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BioCelerate Toxicology Data Sharing initiative: Development of a centralized, searchable Preclinical Data Repository for the Biopharmaceutical IndustryBjerregaard, T.G. / Graziano, M. / Vock, E. / Kahlbaugh, G. / Houser, W. / Page, T. / Mera, K. / Fukushima, T. / Kuzumoto, M. / Frahm, S. et al. | 2018
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Discovery of urinary biomarkers for early detection of diabetic- induced chronic kidney diseasesKim, K.S. / Kim, J.S. / Kim, H.S. et al. | 2018
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A novel microtissue-based 3D human liver NASH model for drug discoveryRupp, J. / Strassfeld, T. / Steiert, S. / Guye, P. / Messner, S. / Kostadinova, R. et al. | 2018
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In vitro permeability assay using an epithelial model of Caco-2/HT29-MTX/Raji-B cells: enhancer aspects of a papain-cyclodextrin complexLopes, P.S. / Corazza, F.G. / Nambu, F.A.N. / Ernesto, J.V. / Varca, G.H.C. / Leite-Silva, V.R. / Andréo-Filho, N. et al. | 2018
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Molecular and chemical response signatures illustrate species differences of developing neural progenitor cells from human, mouse and ratMasjosthusmann, S. / Barenys, M. / Baumann, J. / Bendt, F. / Becker, D. / Deenen, R. / Förster, N. / Mosig, A. / Hübenthal, U. / Klose, J. et al. | 2018
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Liver-chips and liver spheroids as models to determine hepatic safety and metabolismFoster, A.J. / Chouhan, B. / Regan, S. / Rollison, H. / Amberntsson, S. / Andersson, L. / Srivastava, A. / Jang, K.-J. / Petropolis, D. / Kodella, K. et al. | 2018
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Use of chemical-specific adjustment factors in health risk assessments: A tale of two preservativesGoodman, J.E. / Pizzurro, D.M. / Lemay, J.C. / Lewandowski, T.A. / Zu, K. et al. | 2018
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Persistent organic pollutants, pre-pregnancy use of combined oral contraceptive and time-to-pregnancy in SELMA cohortBjörvang, R.D. / Gennings, C. / Lin, P.-I. / Hussein, G. / Kiviranta, H. / Rantakokko, P. / Ruokojärvi, P. / Damdimopoulou, P. / Bornehag, C.-G. et al. | 2018
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Glial-neuronal signaling mechanisms underlying the neurotoxic effects of manganesePopichak, K.A. / Afzali, M.F. / Kirkley, K.S. / Tjalkens, R.B. et al. | 2018
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Pro-inflammatory responses to PM0.25 from airport and urban traffic emissionsHe, R. et al. | 2018
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An Evaluation of U.S. Forest Service Worksheets and their usefulness in modern risk assessment for exposure to pesticidesPhang, K. / Bonnar, D. et al. | 2018
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A homeopathic ophthalmic ointment containing Echinacea purpurea, Euphrasia officinalis and Calendula officinalis extracts: A PDE case reportTos, E. Gillio / Rodda, M.D. / Iavello, A. / Cattarello, L. Brunasso / Conto, A. et al. | 2018
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Effects of exposure of T cells to fine particulate matter and the influence of age; a prospective pilot studyZallouha, M. Al / Billet, S. / Landkocz, Y. / Borgie, M. / Poddighe, S. / Delepée, R. / Ledoux, F. / Cazier, F. / Vitagliano, J.J. / Visade, F. et al. | 2018
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EUROTOX Committee| 2018
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Dietary intake of PCDD/Fs by the population of Tarragona County, Catalonia, Spain. Temporal trends (1998-2018)González, N. / Marquès, M. / Nadal, M. / Domingo, J.L. et al. | 2018
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Utility of humanized mouse models for assessment of cytokine release induced by biotherapeuticsO'Donnell, L.M. et al. | 2018
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Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Metabolotes in H9c2 Cardiac Differentiated CellsReis-Mendes, A. / Carvalho, F. / Sousa, E. / Remião, F. / Bastos, M.D.L. / Costa, V.M. et al. | 2018
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Integrative Modeling and AOP-based Simulation of Developmental ToxicityKnudsen, T.B. et al. | 2018
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Adverse outcome pathway (AOP) -informed tiered testing to predict developmental or reproductive toxicity (DART) risks during new active substance R&DCurrie, R. / Delany, J. / Kidley, N. / Papachristos, K. / Wolton, K. / Cowie, D. / Richards-Doran, R. / Wang, S. / Modi, S. et al. | 2018
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Non-clinical safety considerations to support paediatric drug development – a regulatory updateBaldrick, P. et al. | 2018
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Immunotoxicity assessment of biotech products and small moleculesPallardy, M. et al. | 2018
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Repurposing of new medicines: opportunities and challengesRoberts, R.A. et al. | 2018
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The Nrf2-antioxidant response element signaling pathway controls fibrosis and autoimmunity in sclerodermaBatteux, F. et al. | 2018
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Neurocognitive effects of air pollutionSunyer, J. et al. | 2018
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Environmental carcinogenesis: when Nrf2 and the anti-oxidant response would drive the clonal evolution in colorectal cancerHuc, L. / Surya, R. / Dalleau, S. / Baradat, M. / Gueraud, F. / Pierre, F. et al. | 2018
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Mitochondrial toxicity and oxidative stress: Defining the tipping point between adaptive and adverse effects for consumer safety risk assessmentWestmoreland, C. / Cooper, S. / Guo, J. / Li, J. / Middleton, A. / Reynolds, J. / Peng, S. / van de Water, B. / White, A. / Yuan, H. et al. | 2018
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"TKPlate": A web-based platform for toxicokinetic modelling in food safetyQuignot, N. / Wiecek, W. / Amzal, B. / Dorne, J.-L.C.M. et al. | 2018
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Combination of energy drink and alcohol and its associated toxicityArbo, M.D. / Costa-Valle, M. / Tonietto, B. / Altknecht, L. / Duarte, C. / Garcia, S.C. / Dallegrave, E. / Leal, M.B. et al. | 2018
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The validation of GARDskinSandberg, P. / Agemark, M. / Johansson, A. / Gradin, R. / Forreryd, A. / Larne, O. / Edwards, A. / Hoepflinger, V. / Burleson, F. / Gehrke, H. et al. | 2018
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Can we do better with paracetamol poisoning in rural Asia? – A model based approach to reduce cost of management of paracetamol poisoning in Sri LankaPathiraja, V.M. / Gawarammana, I.B. / Buckley, N.A. / Mohamed, F. / Jayamanna, S.F. / Dawson, A.H. et al. | 2018
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(Eco)toxicity assessment of commercial engineered nanomaterials for plastic industry in zebrafishPassos, M. / Pinheiro, I. / Vieira, A. / Martins, J.C. / Campos, A. / Espiña, B. et al. | 2018
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Relationship between developmental toxicity of multi-wall carbon nanotubes and lung inflammation in pregnant mice after repeated intratracheal instillationHojo, M. / Kobayashi, N. / Hasegawa, Y. / Sakamoto, Y. / Murakami, S. / Yamamoto, Y. / Tada, Y. / Maeno, A. / Kubo, Y. / Ando, H. et al. | 2018
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Risk assessment and mechanism of toxicity of mycosynthesised silver nanoparticles to prokaryotic and eukaryotic modelGupta, I.R. / Rai, M.K. et al. | 2018
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A comparative in vitro investigation on the cardiotoxicity of two tyrosine kinase inhibitors: Regorafenib and lenvatinibGunaydin, A. / Boran, T. / Jannuzzi, A.T. / Alpertunga, B. et al. | 2018
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NFIL-3 regulates dendritic cells functions following nickel and cobalt exposurePallardy, M. / Bechara, R. / Nabhan, M. / Hullo, M. et al. | 2018
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Evaluation of the dose-response and fate in the lung and pleura of chrysotile containing brake dust compared to chrysotile or crocidolite asbestos in a 28 day inhalation toxicology studyToth, B. / Bernstein, D.M. / Rogers, R.A. / Kunzendorf, P. / Ernst, H. et al. | 2018
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Guidance for the risk assessment of enzyme-containing consumer productsKruszewski, F.H. / Concoby, B. / Simonsen, M. / Bookstaff, R. / Baccam, M. / Paschal, J. et al. | 2018
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Assessing acute inhalation exposure to hydrogen fluoride from thermal runaway of lithium-ion batteriesHercegovac, J. / Frangos, J. et al. | 2018
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Investigation of the effects of infrared rays on DNA strand in hot environment workers by comet assayKanbur, S. / Beceren, A. / Aydemir, S. / Uzun, M.F. et al. | 2018
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Next generation safety assessment strategy based on combined use of in silico toolsGranitzny, A. / Heinz, S. / Kawamoto, T. / Fuchs, A. / Fautz, R. et al. | 2018
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Pouteria ramiflora (Sapotaceae) leaves extract increases the antiproliferative and pro-apoptotic effects of cisplatin in HepG2 cellsCólus, I.M.S. / Tuttis, K. / Serpeloni, J.M. / Varanda, E.A. / Santos, L.C. / Vilegas, W. / Martínez-Lopez, W. et al. | 2018
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Hierarchical Bayesian exposure assessment of dietary polycyclic aromatic hydrocarbons in 3–6 year old FinnsHirvonen, T.M. / Hokkanen, M. / Pasonen, P. / Uusitalo, L. / Erkkola, M. / Korkalo, L. / Tuominen, P. / Mikkelä, A. et al. | 2018
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In vitro study of the cytotoxic effects of microcystin-LR, cylindrospermopsin and their mixture in the neuronal SH-SY5Y cell lineHinojosa, M.G. / Gutierrez-Praena, D. / Prieto, A.I. / Espinar-López, L. / Cameán, A.M. / Jos, A. et al. | 2018
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Characterization of drug metabolizing enzymes, transporters and permeation in a human organotypic corneal tissue modelKaluzhny, Y. / Kinuthia, M. / Truong, T. / Lapointe, A. / Klausner, M. / Letasiova, S. / Hayden, P. et al. | 2018
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Inter- and intra-laboratory reproducibility of the in vitro photo-toxicity test using 3D reconstructed human epidermis modelKandarova, H. / Liskova, A. / Milasova, T. / Letasiova, S. et al. | 2018
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Primary human hepatocyte spheroid generation and performance in different culture systemsBuesch, S. / Bunger, M. / Schroeder, J. / Stosik, M. et al. | 2018
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Evaluation of the cytotoxicity of cocaine and adulterants in precursor cells of the gliaRocha, R.A. / Figueroa, J. / Manzo, R. / Diaz, D. / Vasquez, A. / Soto, D. / Duffau, B. / Triviño, I. et al. | 2018
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Development of a human autologous 3-cell cytokine release assay that models the vascular wall in vitroKawai, R. / Ahmetaj-Shala, B. / Shih, C.C. / Marei, I. / Bhatti, K. / Kirkby, N.S. / Mitchell, J.A. et al. | 2018
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Prediction of drug-induced liver injuryGhafourian, T. / Baricicova, M. et al. | 2018
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Ligand based and structural based modeling for the understanding, classification and prediction ofmitochondrial toxicityGómez-Tamayo, J.C. / Troger, F. / Pastor, M. / Norinder, U. / Zdrazil, B. / Ecker, G. et al. | 2018
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Large-scale in silico screening of compounds contained in printing inks for food packaging materialsSmieško, M. / Don, C. / Meuwly, R. / Kucsera, S. / Brüschweiler, B.J. et al. | 2018
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Use of in silico methods in IATA for skin corrosion and irritationAbe, A. / Sezaki, T. / Kinoshita, K. et al. | 2018
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Polymethoxyflavones prevent benzo[a]pyrene/dextran sodium sulfate-induced colorectal carcinogenesis through modulating xenobiotic metabolism in ICR micePan, M.-H. / Wu, J.-C. / Wang, Y.-J. / Ho, C.-T. et al. | 2018
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Monitoring of triclosan and parabens in amniotic fluidKarzi, V. / Katsikantami, I. / Tzatzarakis, M.N. / Vakonaki, E.K. / Xezonaki, P. / Stratidakis, A. / Iliaki, E. / Sifakis, S. / Rizos, A. / Tsatsakis, A.M. et al. | 2018
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Exposure to environmental levels of polycyclic aromatic hydrocarbons leads to epigenetic modulation in a rat modelDuca, R.C. / Grova, N. / Gosh, M. / Hoet, P.H.M. / Vanoirbeek, J.A.J. / Appenzeller, B.M.R. / Godderis, L. et al. | 2018
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RVis: a freely available modelling platformLoizou, G.D. et al. | 2018
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Case study: Exposure to mixtures of chemicals in a human study and verification of aggregated exposure models with real-life dataDirven, H. / Andreassen, M. / Karrer, C. / von Goetz, N. / Sakhi, A.K. / Husøy, T. et al. | 2018
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In vitro toxicogenomic and proteomic assessment of e-cigarette aerosol compared to cigarette smokeVerrastro, I. / Haswell, L. / Corke, S. / Baxter, A. / Thorne, D. / Breheny, D. / Minet, E. / Gaca, M. et al. | 2018
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Evaluation of prostate cancer volatilome: An in vitro approachLima, A.R. / Araújo, A.M. / Pinto, J. / Jerónimo, C. / Henrique, R. / Bastos, M.D.L. / Carvalho, M. / Guedes de Pinho, P. et al. | 2018
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Determining mechanisms of mitochondrial toxicity using Agilent Seahorse XF TechnologyRomero, N. / Swain, P.M. / Dranka, B.P. et al. | 2018
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This poster abstract has been withdrawn| 2018
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Editorial Board| 2018
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Synthetic cannabinoids enhance neuronal differentiation in neuroblastoma cells at in vivo relevant concentrationsAlexandre, J. / Carmo, H. / Carvalho, F. / Silva, J.P. et al. | 2018
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Mechanisms of adult and developmental immunotoxicityDietert, R.R. et al. | 2018
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Recent advances on novel translational kidney safety biomarkers and their use in the value chainGautier, J.-C. et al. | 2018
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Challenges in the assessment of reproductive toxicology of anti-obesity drugsBolze, F. / Rojas, J.M. / Bhuwania, R. / Egecioglu, N.E. / Dalgaard, M. / Andersen, L.W. et al. | 2018
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The discovery of innovative medicines with the Right Safety to increase R&D productivityHornberg, J.J. et al. | 2018
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K02 – Nrf2 and its futureYamamoto, M. et al. | 2018
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H – Big data for biologists: A maths in medicine case studyNandi, M. et al. | 2018
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Requirement of Nrf2 for termination of liver regeneration caused by acute proliferative responseTakasu, S. / Ishii, Y. / Kijima, A. / Ogawa, K. / Umemura, T. et al. | 2018
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A lipase biosensor using digital camera for the determination of neurotoxic compoundsPohanka, M. / Zakova, J. / Sedlacek, I. et al. | 2018
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Toxicity of synthetic cathinones in human kidney (HK-2) cellsCarvalho, T. / Vaz, I. / Araújo, A.M. / Remião, F. / Bastos, M.D.L. / Carvalho, M. et al. | 2018
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My family and other animals: comparative requirements for human and animal metabolism studiesMcEwen, A. et al. | 2018
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P19-06 Retrospective histopathology evaluation of respiratory tract tissues from two rat 90-day OECD 413 inhalation studies: Tobacco Heating System 2.2 versus Mentholated Tobacco Heating System 2.2 compared with conventional and mentholated reference cigarettesOviedo, A. / Neves, P.F. / Wong, E.T. / Foong, C. / Vuillaume, G. / Sciuscio, D. / Peitsch, M.C. / Vanscheeuwijck, P. et al. | 2018
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MEtabolomics standaRds Initiative in Toxicology (MERIT)Kamp, H. / Beger, R. / Dorne, J.-L.C.M. / Ebbels, T. / Ekman, D. / Guillou, C. / Goetz, A. / Loizou, G. / Leonards, P. / van Ravenzwaay, B. et al. | 2018
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Transcriptional changes underlying cerium dioxide nanoparticle modulation of allergen induced type II airway inflammationMeldrum, K. / Robertson, S.B. / Gant, T.W. / Tetley, T.D. / Smith, R. / Leonard, M.O. et al. | 2018
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Exploring the usefulness of morphological profiling of cells to study toxicity mechanismsGeorgieva, P. / Schaal, W. / Spjuth, O. et al. | 2018
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Whole-genome expression analysis in THP-1 macrophage-like cells exposed to diverse metal-containing nanomaterialsRössner, P. / Brzicova, T. / Libalova, H. / Vrbova, K. / Sikorova, J. / Philimonenko, V. / Klema, J. / Topinka, J. et al. | 2018
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Characterization of the TiO2 E171 food additiveBrassinne, F. / De Vos, S. / Verleysen, E. / De Temmerman, P.-J. / Ledecq, M. / Mast, J. et al. | 2018
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Microsomal metabolism and mutagenicity of cis- and trans-anetholeFuhlbrueck, J.A. / Schwind, E.C. / Lencioni, A. / Carlsson, M.J. / Cartus, A.T. et al. | 2018
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Role of Hif-1a and its target gene PTP4A3 in regulating cell proliferation during benzene exposurePu, Y. / Sun, R. / Sun, F. / Zhang, J. / Yin, L. / Man, Z. et al. | 2018
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Olive-derived hydroxytyrosol shows anti-inflammatory effect without immunotoxicityYonezawa, Y. / Nejishima, H. / Takeda, Y. / Imai, K. / Ogawa, H. et al. | 2018
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Effect of kynurenic acid and metformin on mercury-exposed SH-SY5Y cellsEngin, A.B. / Karakisa, D. / Engin, E.D. et al. | 2018
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Quercetin attenuates ergotamine induced toxicity in rat liver hepatocytesFard, J. Khalili / Sattari, M. / Hamzeiy, H. / Eghbal, M.A. / Jafari, S. et al. | 2018
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Identification of potential tattoo allergens by combining in vitro assays and chemical analysisSchreiver, I. / Kühn, M. / Yildirim, S. / Eschner, L.-M. / Hutton-Carlson, K. / Serup, J. / Luch, A. et al. | 2018
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Ecotoxicological and toxicological assessment of substances in wastewater: making an informed decisionLovsin Barle, E. / Burri, E. / Hermann, F. / Niederer, C. / Trudel, D. / Arnold, C. et al. | 2018
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Integrated genotoxicity testing (Pig-a and MNT) within 28-day mouse study – A case study with Meptyldinocap metabolite, X12335709Aggarwal, M. / Murphy, L. / Terry, C. / Donner, E.M. et al. | 2018
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A proof-of-concept study: evaluating the applicability of high-throughput screening data and read-across tools for food relevant chemicalsNguyen, J.L. / Maier, A. / Ovesen, J. / Kleinstreuer, N. / Judson, R. / Krishan, M. et al. | 2018
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Identification of oxidative stress potential in phenolic compounds and their link to liver injurySchimming, J.P. / Bischoff, L.J.M. / ter Braak, B. / van de Water, B. et al. | 2018
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Characterization of a lung/liver organ-on-a-chip modelBovard, D. / Sandoz, A. / Morelli, M. / Trivedi, K. / Marescotti, D. / Frentzel, S. / Luettich, K. / Hoeng, J. et al. | 2018
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Differentiation of human pluripotent stem cells (hPSC) into neurons: A fast, reproducible and inducible system for neurotoxicity screeningAleksic, J. / Geti, I. / Apic, G. / Stoop, A. / Kotter, M. et al. | 2018
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The THP-1 Toolbox: A new method that integrates the 4 key events of skin sensitizationClouet, E. / Raffalli, C. / Damiens, M.-H. / Pallardy, M. / Ferret, P.-J. / Kerdine-Römer, S. et al. | 2018
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Cell-type specific effects of using two valproic acid isomers in the neural embryonic stem cell testde Leeuw, V.C. / Hessel, E.V. / Piersma, A.H. et al. | 2018
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Imaging and computational modelling to unravel the dynamics of the oxidative stress pathway upon repeated perturbationKuijper, I.A. / Bischoff, L.J.M. / Noort, D. / Langenberg, J.P. / van de Water, B. / Beltman, J. et al. | 2018
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Development of an in silico model to evaluate in vivo chromosome damaging potential of chemicalsVan Bossuyt, M. / Raitano, G. / Van Hoeck, E. / Rogiers, V. / Benfenati, E. / Mertens, B. et al. | 2018
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Evaluation of biomarkers for haemocomopatibility of polymer biomaterialsMiyajima-Tabata, A. / Komoriya, K. / Tanaka, M. / Hiruma, H. / Kato, R. / Haishima, Y. et al. | 2018
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Toxicogenomics of gold nanoparticles in a marine fish: linkage to established biomarkersTeles, M. / Reyes-López, F. / Balasch, J.C. / Guimarães, L. / Tort, L. / Oliveira, M. et al. | 2018
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Using the SENS-IS assay, to assess skin sensitization hazard of commercial cosmetics finished productsCottrez, F. / Boitel, E. / Groux, H. et al. | 2018
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AllerCatPro – Prediction of protein allergenicity potential from the protein sequenceMaurer-Stroh, S. / Krutz, N.L. / Kern, P.S. / Gunalan, V. / Nguyen, M.N. / Limviphuvadh, V. / Gerberick, G.F. et al. | 2018
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Prediction of adverse male reproductive health effects by integrating in vitro data and physiologically-based kinetic modellingTaxvig, C. / Scholze, M. / Kortenkamp, A. / Boberg, J. / Svingen, T. / Ermler, S. / Hermann, S.S. / Lykkeberg, A.K. / Pedersen, M. / Hass, U. et al. | 2018
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EPA and EFSA approaches for benchmark dose modelingDavis, A. et al. | 2018
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Toxicity evaluation of flavored e-CIG condensed aerosols on in vitro models of the lungBengalli, R.D. / Piunno, Y. / Ferri, E. / Mantecca, P. et al. | 2018
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Developmental changes in drug disposition and response: the challengesNicolas, J.-M. et al. | 2018
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Enantioresolution of pentedrone and methylone and in vitro dopaminergic SH-SY5Y cytotoxicity studiesSilva, B. / Fernandes, C. / Pinto, M. / Guedes de Pinho, P. / Remião, F. et al. | 2018
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Skin sensitisation and developmental immunotoxicity – is there any mechanistic association?Malkiewicz, K. / Mohammed, I.A. / Arabi, A. et al. | 2018
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Seizures and dreams in non-clinical drug development: from brain slices to EEGAuthier, S. et al. | 2018
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Taking safety biomarkers 'out of the box': biomarker panels and drug induced injuriesGlineur, S. / Gryshkova, V. / Valentin, J.-P. / Costa, A. Nogueira da et al. | 2018
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Potential reuse of oncology drugs in the treatment of rare diseasesTong, W. et al. | 2018
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Postnatal development of organ systems: a species comparisonVan Cruchten, S.J. et al. | 2018
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In vitro pharmacology and safety testing of monoclonal antibodiesKiessling, A. et al. | 2018
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The Aryl Hydrocarbon Receptor in Immuno(toxicity): the new, the old, the unexpectedEsser, C. et al. | 2018
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Review of methods for detection of toxic compounds involved in animal poisoningValverde, I. / Espín, S. / Navas, I.M. / Martínez-López, E. / Mateo, R. / García-Fernández, A.J. et al. | 2018
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Ni (II) complexes with different ligands express various degree of cytotoxicityDyakova, L.V. / Zhivkova, T. / Georgieva, M. / Miloshev, G. / Kalfin, R. / Tudose, R. / Marinescu, G. / Pantcheva, I. / Mosoarca, E.-M. / Culita, D.-C. et al. | 2018
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Anti-inflammatory activity of Portuguese thermal watersSilva, A.C. / Vaz, C.V. / Oliveira, A.S. / Correia, S. / Ferreira, R. / Breitenfeld, L. / Oliveira, J. Martinez de / Oliveira, R. Palmeira de / Pereira, C. / Palmeira-de-Oliveira, A. et al. | 2018
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Activities of the Iberoamerican Network of Toxicology and Chemical Safetyde la Peña, E. et al. | 2018
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Evaluation of 6 in silico skin penetration models to predict the in vitro cutaneous distribution of 25 chemicalsKlaric, M. / Cubberley, R. / Sorrell, I. / Duplan, H. / Eilstein, J. / Ellison, C. / Gregoire, S. / Hewitt, N. / Jacques-Jamin, C. / Lange, D. et al. | 2018
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In Vitro to in vivo extrapolation of valproic acid hepatotoxicity: A biokinetic and physiologically based toxicokinetic informed approachFisher, C.P. / Hatley, O. / van Vugt, B. / Bois, F. / Escher, S. / Gardner, I. et al. | 2018
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Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model ratSegawa, M. / Sekine, S. / Sato, T. / Abe, K. / Ito, K. et al. | 2018
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Critical evaluation of thresholds for respiratory effects of toluene diisocyanatePrueitt, R.L. / Lynch, H.N. / Mohar, I. / Goodman, J.E. et al. | 2018
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Study rating – is reliability enough? An appeal for revisiting relevance and adequacy, particularly in environmental risk assessment (ERA)Wess, R.A. et al. | 2018
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Safety of hopoxia-cultured human umbilical cord blood-derived mesenchymal stem cells: subchronic toxicity, tumorigenicityKwon, E. / You, J. / Yoon, J. / Kang, B. et al. | 2018
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High throughput adaptive stress response pathway activation to support read across of valproic acid analogue-induced liver steatosisVrijenhoek, N. / Graepel, R. / Wink, S. / Escher, S. / van de Water, B. et al. | 2018
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Cytotoxicity and lipid peroxidation of beauvericin and ochratoxin A individually and combined in HepG2 cellsJuan-García, A. / Carbone, S. / Fernández-Franzón, M. / Ruiz, M.-J. et al. | 2018
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Protective action of caffeine against acetaminophen-induced liver injury in male CD-1 miceMasubuchi, Y. / Ebato, M. et al. | 2018
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ROS generation and oxidative stress induced by hexachlorobenzene in human intestinal caco-2 cellsChalouati, H. / Boussoufa, D. / Payrastre, L. et al. | 2018
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P13-23 Differently functionalized CuO nanoparticles: efficient antimicrobial against Escherichia coli or the poison to human macrophages?Kubo, A.-L. / Vija, H. / Kahru, A. / Bondarenko, O. et al. | 2018
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Exposure reducing remedies in cytotoxic drug preparationKarakoç, M.D. / Taşköylü, B.Y. et al. | 2018
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Investigation of the effects of alternative flame retardants on embryonal and fetal neurodevelopmental processes using 3D human in vitro modelsKlose, J. / Bendt, F. / Dach, K. / Hübenthal, U. / Kühne, B. / Nimtz, L. / Schmuck, M. / Fritsche, E. et al. | 2018
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Principles for the safety evaluation of cosmetic powdersSteiling, W. / Almeida, J.F. / Assaf Vandecasteele, H. / Gilpin, S. / Kawamoto, T. / O'Keeffe, L. / Pappa, G. / Rettinger, K. / Rothe, H. / Bowden, A. et al. | 2018
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Translational regulation of Ercc5 after benzo[a]pyrene exposure in mouse hepatocytesSmit, E. / Haerkens, R. / Kleinjans, J.C.S. / van den Beucken, T. et al. | 2018
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90-day toxicity and genotoxicity studies with high-purity phenylcapsaicinStiller, S. / Paulsen, T.R. / Weber, K. / Donath, C. / Schreib, G. / Jensen, K.H. et al. | 2018
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Development of a cell-laden 3D hydrogel scaffold assessing neuronal function through microelectrode array recordingsLauria, I. / Bendt, F. / Hartmann, J. / Nimtz, L. / Blaeser, A. / Rütten, S. / Fritsche, E. et al. | 2018
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Category assessment of repeated dose hepatotoxicity of phenolic benzotriazoles for OECD IATA case studies project in 2016Yamada, T. / Matsumoto, M. / Kitajima, S. / Aisaki, K. / Kanno, J. / Hirose, A. et al. | 2018
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The possibility use of psyllium as appropriate alternative for allopurinol in treatment of hyperuricemic patient: A case reportEbadollahinatanzi, A. / Arabrahmatipour, G. et al. | 2018
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Optimization of the use of Caenorhabditis elegans (C.elegans) in reproductive toxicology testing: describing the most optimal test conditionsBressers, S. / Tobor-Kaplon, M. / Beekhuijzen, M. et al. | 2018
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A multi-biomarker assessment of chronic effects of an insecticide Acer 35 EC on Nile Tilapia Oreochromis niloticus under laboratory conditionsGuedegba, N.L. / Imorou Toko, I. / Agbohessi, P.T. / Oreins, N. / François, L. / Palluel, O. / Mandiki, S.N.M. / Porcher, J.-M. / Schiffers, B. / Scippo, M.-L. et al. | 2018
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NEOGENE Project – Task I: Characterization of in utero exposure to environmental tobacco smoke: using cotinine as a biomarkerSilva, A.I. / Madureira, J. / Reis, A.T. / Lage, B. / Esteves, F.C. / Barbosa Júnior, F. / Teixeira, J.P. / Costa, C. et al. | 2018
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Analytical and biological evaluation of cardiotoxicity safety biomarkers in the ratErkens, T. / Boonen, J. / Goeminne, N. / Kegels, A. / Van den Sande, L. / Marien, D. / van Heerden, M. / Vinken, P. et al. | 2018
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Establishment of the human cell line activation test (h-CLAT)Kim, H. / Hong, M.H. / Jo, I.S. / Ahn, I. / Kim, T.S. / Kim, J.H. / Yi, J.S. / Ko, K.Y. / Kim, J.Y. / Lee, J.K. et al. | 2018
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Capturing the current use and applicability of drug transporter data for chemical safety assessment within a non-animal kinetic-based approachPaini, A. / Coecke, S. / Worth, A.P. / Clerbaux, L.-A. et al. | 2018
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IATA used the in chemico, in vitro and in silico methods to evaluate the skin sensitization potentials of cosmetic ingredientsChoi, M. / Cho, S.-A. / Park, S.-R. / An, S. et al. | 2018
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Non-animal vaginal irritation method admitted as nonclinical assessment model (NAM) in the Incubator Phase of the United States Food and Drug Administration (US FDA) Medical Devices Development Tool (MDDT)Hill, E. / Brown, J. / Costin, E.-G. et al. | 2018
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Successful proof of concept of a micronucleus genotoxicity assay performed on reconstructed epidermis exhibiting intrinsic metabolic activityBarcham, R. / Orsini, N. / Andres, E. / Hundt, A. / Luzy, A.-P. / Dini, C. et al. | 2018
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Cytotoxicity testing of therapeutic nanosystems for pulmonary infection using an air-lifted interphase in-vitro test systemKnebel, J. / Ritter, D. / Niehof, M. / Hansen, T. / Strandh, M. / Falciani, C. / Flores, M. / te Welscher, Y. / van Nostrum, C. / Gracia, R. et al. | 2018
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A possible risk of genome editing for human gene therapyOno, R. / Tano, K. / Yasuda, S. / Yasuhiko, Y. / Aisaki, K. / Kitajima, S. / Kanno, J. / Sato, Y. / Hirabayashi, Y. et al. | 2018
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Deriving a no expected sensitization induction level for fragrance ingredients without animal testing: Specific case studies assessed with different approachesNatsch, A. / Emter, R. / Haupt, T. / Ellis, G. et al. | 2018
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Stem cell-based in vitro models: state-of-the-art tools to predict drug-induced tissue injury in humansDe Kock, J. et al. | 2018
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Cytotoxicity of silver nanoparticles in an in vitro model of the intestinal barrierPolet, M. / Laloux, L. / Schneider, Y.-J. et al. | 2018
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The effects of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) on P-glycoprotein activity and expression in the rat instestinal mucosa: An ex vivo and in vivo approachPereira, C.R. / Ghanem, C.I. / Silva, R. / Araújo, M.D. / Monteiro, S.G. / Casanova, A.G. / Chhann, S. / Sousa, E. / Bastos, M.D.L. / Remião, F. et al. | 2018
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P-gp induction and activation as a potential therapeutic approach in intoxications and/or neurological diseases–in vitro and in silico studiesMartins, E. / Palmeira, A. / Carmo, H. / Sousa, E. / Lemos, A. / Pinto, M. / Bastos, M.D.L. / Remião, F. / Silva, R. et al. | 2018
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Quantitative assessment of mitochondrial toxicity and downstream cellular perturbations in Adverse Outcome Pathwaysvan de Water, B. et al. | 2018