Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction (Englisch)
- Neue Suche nach: Wang, Tianyu
- Neue Suche nach: Cai, Shi
- Neue Suche nach: Wang, Mingming
- Neue Suche nach: Zhang, Wanheng
- Neue Suche nach: Zhang, Kuojun
- Neue Suche nach: Chen, Dong
- Neue Suche nach: Li, Zheng
- Weitere Informationen zu Li, Zheng:
- https://orcid.org/0000-0001-6118-9175
- Neue Suche nach: Jiang, Sheng
- Weitere Informationen zu Jiang, Sheng:
- https://orcid.org/0000-0002-4550-5024
- Neue Suche nach: Wang, Tianyu
- Neue Suche nach: Cai, Shi
- Neue Suche nach: Wang, Mingming
- Neue Suche nach: Zhang, Wanheng
- Neue Suche nach: Zhang, Kuojun
- Neue Suche nach: Chen, Dong
- Neue Suche nach: Li, Zheng
- Weitere Informationen zu Li, Zheng:
- https://orcid.org/0000-0001-6118-9175
- Neue Suche nach: Jiang, Sheng
- Weitere Informationen zu Jiang, Sheng:
- https://orcid.org/0000-0002-4550-5024
In:
Journal of Medicinal Chemistry
;
64
, 11
;
7390-7403
;
2021
- Aufsatz (Zeitschrift) / Elektronische Ressource
-
Titel:Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction
-
Weitere Titelangaben:J. Med. Chem.
-
Beteiligte:Wang, Tianyu ( Autor:in ) / Cai, Shi ( Autor:in ) / Wang, Mingming ( Autor:in ) / Zhang, Wanheng ( Autor:in ) / Zhang, Kuojun ( Autor:in ) / Chen, Dong ( Autor:in ) / Li, Zheng ( Autor:in ) / Jiang, Sheng ( Autor:in )
-
Erschienen in:Journal of Medicinal Chemistry ; 64, 11 ; 7390-7403
-
Verlag:
- Neue Suche nach: American Chemical Society
-
Erscheinungsdatum:10.06.2021
-
ISSN:
-
Coden:
-
DOI:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Elektronische Ressource
-
Sprache:Englisch
-
Datenquelle:
Inhaltsverzeichnis – Band 64, Ausgabe 11
Zeige alle Jahrgänge und Ausgaben
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
- 7045
-
Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule DrugsZhang, Donglu / Wei, Cong / Hop, Cornelis E. C. A. / Wright, Matthew R. / Hu, Ming / Lai, Yurong / Khojasteh, S. Cyrus / Humphreys, W. Griff et al. | 2021
- 7060
-
Function, Therapeutic Potential, and Inhibition of Hsp70 ChaperonesAmbrose, Andrew J. / Chapman, Eli et al. | 2021
- 7083
-
Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug DiscoverySun, Jiyun / Xiao, Zhiwei / Haider, Ahmed / Gebhard, Catherine / Xu, Hao / Luo, Hai-Bin / Zhang, Han-Ting / Josephson, Lee / Wang, Lu / Liang, Steven H. et al. | 2021
- 7110
-
Synthetic RNA Modulators in Drug DiscoveryZamani, Farzad / Suzuki, Takayoshi et al. | 2021
- 7156
-
The Medicinal Chemistry of CaffeineFaudone, Giuseppe / Arifi, Silvia / Merk, Daniel et al. | 2021
- 7179
-
The Expanding Role of Chemistry in Optimizing Proteins for Human Health ApplicationsRoman, Bart I. et al. | 2021
- 7189
-
Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating StrategyWu, Yue / Li, Zhihong / McDonough, Michael A. / Schofield, Christopher J. / Zhang, Xiaojin et al. | 2021
- 7210
-
Target-Based Evaluation of “Drug-Like” Properties and Ligand EfficienciesLeeson, Paul D. / Bento, A. Patricia / Gaulton, Anna / Hersey, Anne / Manners, Emma J. / Radoux, Chris J. / Leach, Andrew R. et al. | 2021
- 7231
-
Focused Libraries for Epigenetic Drug Discovery: The Importance of IsosteresGreen, Adam I. / Burslem, George M. et al. | 2021
- 7241
-
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary DiseaseGrand, Darren Le / Gosling, Martin / Baettig, Urs / Bahra, Parmjit / Bala, Kamlesh / Brocklehurst, Cara / Budd, Emma / Butler, Rebecca / Cheung, Atwood K. / Choudhury, Hedaythul et al. | 2021
- 7261
-
Discovery of RRx-001, a Myc and CD47 Downregulating Small Molecule with Tumor Targeted Cytotoxicity and Healthy Tissue Cytoprotective Properties in Clinical DevelopmentOronsky, Bryan / Guo, XiaoNing / Wang, XiaoHui / Cabrales, Pedro / Sher, David / Cannizzo, Lou / Wardle, Bob / Abrouk, Nacer / Lybeck, Michelle / Caroen, Scott et al. | 2021
- 7272
-
Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial BiofilmsNaclerio, George A. / Sintim, Herman O. et al. | 2021
- 7275
-
A Modular Synthetic Route Involving N‑Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3‑Substituted Halogenated Phenazine Antibacterial AgentsYang, Hongfen / Kundra, Shivani / Chojnacki, Michaelle / Liu, Ke / Fuse, Marisa A. / Abouelhassan, Yasmeen / Kallifidas, Dimitris / Zhang, Peilan / Huang, Guangtao / Jin, Shouguang et al. | 2021
- 7296
-
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon ModulatorsNishiguchi, Gisele / Keramatnia, Fatemeh / Min, Jaeki / Chang, Yunchao / Jonchere, Barbara / Das, Sourav / Actis, Marisa / Price, Jeanine / Chepyala, Divyabharathi / Young, Brandon et al. | 2021
- 7312
-
Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC OncoproteinsChi, Ya-Hui / Yeh, Teng-Kuang / Ke, Yi-Yu / Lin, Wen-Hsing / Tsai, Chia-Hua / Wang, Wan-Ping / Chen, Yen-Ting / Su, Yu-Chieh / Wang, Pei-Chen / Chen, Yan-Fu et al. | 2021
- 7331
-
Design, Synthesis, and Biological Evaluation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer TreatmentZhang, Kehui / Ji, Ming / Lin, Songwen / Peng, Shouguo / Zhang, Zhihui / Zhang, Mingyi / Zhang, Jingbo / Zhang, Yan / Wu, Deyu / Tian, Hua et al. | 2021
- 7341
-
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic LeukemiaZhang, Peng / Min, Zhihui / Gao, Yang / Bian, Jiang / Lin, Xin / He, Jie / Ye, Deyong / Li, Yilin / Peng, Chao / Cheng, Yunfeng et al. | 2021
- 7359
-
Selective and Efficient Photoinactivation of Intracellular Staphylococcus aureus and MRSA with Little Accumulation of Drug Resistance: Application of a Ru(II) Complex with Photolabile LigandsSun, Weize / Jian, Yao / Zhou, Mengxue / Yao, Yishan / Tian, Na / Li, Chao / Chen, Jun / Wang, Xuesong / Zhou, Qianxiong et al. | 2021
- 7371
-
Design, Synthesis, and Structure–Activity Relationship of N‑Aryl‑N′‑(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer ImmunotherapyChen, Zhipeng / Zhang, Lina / Yang, Junjie / Zheng, Lu / Hu, Fanjie / Duan, Siqin / Nandakumar, Kutty Selva / Liu, Shuwen / Yin, Hang / Cheng, Kui et al. | 2021
- 7390
-
Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 InteractionWang, Tianyu / Cai, Shi / Wang, Mingming / Zhang, Wanheng / Zhang, Kuojun / Chen, Dong / Li, Zheng / Jiang, Sheng et al. | 2021
- 7404
-
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular CarcinomaZhou, Zongyuan / Li, Yiming / Ma, Xiaofang / Cao, Biyun / Peng, Ting / Sheng, Yuwen / Peng, Huipan / Li, Runze / Cao, Yu / Xi, Ruiying et al. | 2021
- 7422
-
Disulfide-Rich Cyclic Peptides from Clitoria ternatea Protect against β‑Amyloid Toxicity and Oxidative Stress in Transgenic Caenorhabditis elegansKalmankar, Neha V. / Hari, Hrudya / Sowdhamini, Ramanathan / Venkatesan, Radhika et al. | 2021
- 7434
-
Discovery of a Candidate Containing an (S)‑3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro‑1H‑inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid LeukemiaZhang, Dongfeng / Li, Peng / Gao, Yongxin / Song, Yaoyao / Zhu, Yaqin / Su, Hong / Yang, Beibei / Li, Li / Li, Gang / Gong, Ningbo et al. | 2021
- 7453
-
Discovery of G Protein-Biased Ligands against 5‑HT7RLee, Jieon / Kwag, Rina / Lee, Soyeon / Kim, Doyoung / Woo, Jiwan / Cho, Yakdol / Kim, Hak Joong / Kim, Jeongjin / Jeon, Byungsun / Choo, Hyunah et al. | 2021
- 7468
-
Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid CancerRen, Yuhao / Li, Shanshan / Zhu, Ren / Wan, Chengying / Song, Dongmei / Zhu, Jiawen / Cai, Guiping / Long, Sihui / Kong, Lingyi / Yu, Wenying et al. | 2021
- 7483
-
Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK‑3 Inhibitors for the Treatment of Alzheimer’s DiseaseYao, Hong / Uras, Giuseppe / Zhang, Pengfei / Xu, Shengtao / Yin, Ying / Liu, Jie / Qin, Shuai / Li, Xinuo / Allen, Stephanie / Bai, Renren et al. | 2021
- 7507
-
Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer ImmunotherapyWang, Zhisong / Gao, Yan / He, Lei / Sun, Shuhao / Xia, Tingting / Hu, Lu / Yao, Licheng / Wang, Liangliang / Li, Dan / Shi, Hui et al. | 2021
- 7533
-
The Good, the Bad, and the Twisted Revisited: An Analysis of Ligand Geometry in Highly Resolved Protein–Ligand X‑ray StructuresLiebeschuetz, John W. et al. | 2021
- 7544
-
Computational Bioactivity Fingerprint Similarities To Navigate the Discovery of Novel ScaffoldsXiong, Guo-Li / Zhao, Yue / Liu, Lu / Ma, Zhong-Ye / Lu, Ai-Ping / Cheng, Yan / Hou, Ting-Jun / Cao, Dong-Sheng et al. | 2021
- 7555
-
Identification of an N‑acylated‑DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced HyperalgesiaQuillet, Raphaëlle / Schneider, Séverine / Utard, Valérie / Drieu la Rochelle, Armand / Elhabazi, Khadija / Henningsen, Jo Beldring / Gizzi, Patrick / Schmitt, Martine / Kugler, Valérie / Simonneaux, Valérie et al. | 2021
- 7565
-
RGD-Peptide Functionalization Affects the In Vivo Diffusion of a Responsive Trimeric MRI Contrast Agent through Interactions with IntegrinsGambino, Giuseppe / Gambino, Tanja / Connah, Liam / La Cava, Francesca / Evrard, Henry / Angelovski, Goran et al. | 2021
- 7575
-
Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast CancerZhang, Xiaomeng / Wang, Yazhou / Li, Xue / Wu, Jie / Zhao, Liwen / Li, Wei / Liu, Jian et al. | 2021
- 7596
-
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)Pimková Polidarová, Markéta / Břehová, Petra / Kaiser, Martin Maxmilian / Smola, Miroslav / Dračínský, Martin / Smith, Joshua / Marek, Aleš / Dejmek, Milan / Šála, Michal / Gutten, Ondrej et al. | 2021
- 7617
-
Synthesis of Methoxy‑, Methylenedioxy‑, Hydroxy‑, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant CancerHu, De-Xuan / Tang, Wen-Lin / Zhang, Yu / Yang, Hao / Wang, Wenjie / Agama, Keli / Pommier, Yves / An, Lin-Kun et al. | 2021
- 7630
-
Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial ConquerorsWang, Jie / Ansari, Mohammad Fawad / Zhou, Cheng-He et al. | 2021
- 7646
-
Design, Synthesis, and Evaluation of o‑(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In VivoOuYang, Yiqiang / Gao, Jian / Zhao, Lei / Lu, Junfeng / Zhong, Haiqing / Tang, Hua / Jin, Shuanglong / Yue, Lu / Li, Yuezhen / Guo, Wenjie et al. | 2021
- 7667
-
Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP–AMP SynthaseTan, Jing / Wu, Bing / Chen, Tingting / Fan, Chen / Zhao, Jiannan / Xiong, Chaodong / Feng, Chunlan / Xiao, Ruoxuan / Ding, Chunyong / Tang, Wei et al. | 2021
- 7691
-
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/NatriureticJiang, Jinlong / Ding, Fa-Xiang / Zhou, Xiaoyan / Bateman, Thomas J. / Dong, Shuzhi / Gu, Xin / Keh deJesus, Reynalda / Pio, Barbara / Tang, Haifeng / Chobanian, Harry R. et al. | 2021
- 7702
-
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV‑1 InfectivityHuang, Boshi / Wang, Huiqun / Zheng, Yi / Li, Mengchu / Kang, Guifeng / Barreto-de-Souza, Victor / Nassehi, Nima / Knapp, Pamela E. / Selley, Dana E. / Hauser, Kurt F. et al. | 2021
- 7724
-
Photocytotoxicity of Thiophene- and Bithiophene-Dipicolinato Luminescent Lanthanide ComplexesRodrigues, Carime V. / Johnson, Katherine R. / Lombardi, Vincent C. / Rodrigues, Marcelo O. / Sobrinho, Josiane A. / de Bettencourt-Dias, Ana et al. | 2021
- 7735
-
Visualizing Tumors in Real Time: A Highly Sensitive PSMA Probe for NIR-II Imaging and Intraoperative Tumor ResectionZhang, Longfei / Shi, Xiaojing / Li, Yuying / Duan, Xiaojiang / Zhang, Zeyu / Fu, Hualong / Yang, Xing / Tian, Jie / Hu, Zhenhua / Cui, Mengchao et al. | 2021
- 7746
-
Discovery of Hyperstable Noncanonical Plant-Derived Epidermal Growth Factor Receptor Agonist and AnalogsLoo, Shining / Kam, Antony / Li, Bin Bin / Feng, Nan / Wang, Xiaoliang / Tam, James P. et al. | 2021
- 7760
-
Optimization of N‑Phenylpropenoyl‑l‑amino Acids as Potent and Selective Inducible Nitric Oxide Synthase Inhibitors for Parkinson’s DiseaseHu, Xiao-Long / Lv, Xian-Yu / Wang, Rong / Long, Huan / Feng, Jia-Hao / Wang, Bao-Lin / Shen, Wei / Liu, Hao / Xiong, Fei / Zhang, Xiao-Qi et al. | 2021
- 7778
-
Novel Dual-Target μ‑Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain ManagementBonifazi, Alessandro / Battiti, Francisco O. / Sanchez, Julie / Zaidi, Saheem A. / Bow, Eric / Makarova, Mariia / Cao, Jianjing / Shaik, Anver Basha / Sulima, Agnieszka / Rice, Kenner C. et al. | 2021
- 7809
-
Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant ActivityGuzelj, Samo / Nabergoj, Sanja / Gobec, Martina / Pajk, Stane / Klančič, Veronika / Slütter, Bram / Frkanec, Ruža / Štimac, Adela / Šket, Primož / Plavec, Janez et al. | 2021
- 7839
-
Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARPZheng, Mengzhu / Huo, Junfeng / Gu, Xiaoxia / Wang, Yali / Wu, Canrong / Zhang, Qingzhe / Wang, Wang / Liu, Yang / Liu, Yu / Zhou, Xuechen et al. | 2021
- 7853
-
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code ReprogrammingFord, Daniel J. / Duggan, Nisharnthi M. / Fry, Sarah E. / Ripoll-Rozada, Jorge / Agten, Stijn M. / Liu, Wenyu / Corcilius, Leo / Hackeng, Tilman M. / van Oerle, Rene / Spronk, Henri M. H. et al. | 2021