Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease (Unbekannt)
- Neue Suche nach: Melchiorre, Carlo
- Neue Suche nach: Andrisano, Vincenza
- Neue Suche nach: Bolognesi, Maria L.
- Neue Suche nach: Budriesi, Roberta
- Neue Suche nach: Cavalli, Andrea
- Neue Suche nach: Cavrini, Vanni
- Neue Suche nach: Rosini, Michela
- Neue Suche nach: Tumiatti, Vincenzo
- Neue Suche nach: Recanatini, Maurizio
- Neue Suche nach: Melchiorre, Carlo
- Neue Suche nach: Andrisano, Vincenza
- Neue Suche nach: Bolognesi, Maria L.
- Neue Suche nach: Budriesi, Roberta
- Neue Suche nach: Cavalli, Andrea
- Neue Suche nach: Cavrini, Vanni
- Neue Suche nach: Rosini, Michela
- Neue Suche nach: Tumiatti, Vincenzo
- Neue Suche nach: Recanatini, Maurizio
In:
Journal of Medicinal Chemistry
;
41
, 22
;
4186-4189
;
1998
- Aufsatz (Zeitschrift) / Elektronische Ressource
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Titel:Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease
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Weitere Titelangaben:J. Med. Chem.
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Beteiligte:Melchiorre, Carlo ( Autor:in ) / Andrisano, Vincenza ( Autor:in ) / Bolognesi, Maria L. ( Autor:in ) / Budriesi, Roberta ( Autor:in ) / Cavalli, Andrea ( Autor:in ) / Cavrini, Vanni ( Autor:in ) / Rosini, Michela ( Autor:in ) / Tumiatti, Vincenzo ( Autor:in ) / Recanatini, Maurizio ( Autor:in )
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Erschienen in:Journal of Medicinal Chemistry ; 41, 22 ; 4186-4189
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Verlag:
- Neue Suche nach: American Chemical Society
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Erscheinungsdatum:22.10.1998
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ISSN:
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Coden:
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DOI:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Elektronische Ressource
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Sprache:Unbekannt
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Datenquelle:
Inhaltsverzeichnis – Band 41, Ausgabe 22
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COMMUNICATIONS TO THE EDITOR - Synthesis and Modeling Studies of a Potent Conformationally Rigid Muscarinic Agonist: 1-Azabicyclo(2.2.1)heptanespirofuranoneWu, Edwin S.C. et al. | 1998
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Synthesis and Modeling Studies of a Potent Conformationally Rigid Muscarinic Agonist: 1-Azabicyclo[2.2.1]heptanespirofuranoneWu, Edwin S. C. / Kover, Alexander / Semus, Simon F. et al. | 1998
- 4186
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Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's DiseaseMelchiorre, Carlo / Andrisano, Vincenza / Bolognesi, Maria L. / Budriesi, Roberta / Cavalli, Andrea / Cavrini, Vanni / Rosini, Michela / Tumiatti, Vincenzo / Recanatini, Maurizio et al. | 1998
- 4186
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COMMUNICATIONS TO THE EDITOR - Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's DiseaseMelchiorre, Carlo et al. | 1998
- 4190
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COMMUNICATIONS TO THE EDITOR - Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) ReceptorCho, Nobuo et al. | 1998
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Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) ReceptorCho, Nobuo / Harada, Masataka / Imaeda, Toshihiro / Imada, Takashi / Matsumoto, Hirokazu / Hayase, Yoji / Sasaki, Satoshi / Furuya, Shuichi / Suzuki, Nobuhiro / Okubo, Shoichi et al. | 1998
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COMMUNICATIONS TO THE EDITOR - 6-Amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo(2,3-b) pyridine (RWJ 68354): A Potent and Selective p38 Kinase InhibitorHenry, James R. et al. | 1998
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6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase InhibitorHenry, James R. / Rupert, Kenneth C. / Dodd, John H. / Turchi, Ignatius J. / Wadsworth, Scott A. / Cavender, Druie E. / Fahmy, Bohumila / Olini, Gilbert C. / Davis, Janet E. / Pellegrino-Gensey, J. Lee et al. | 1998
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EXPEDITED ARTICLES - Synthesis and Evaluation of N-(11C)Methylated Analogues of Epibatidine as Tracers for Positron Emission Tomographic Studies of Nicotinic Acetylcholine ReceptorsHorti, Andrew G. et al. | 1998
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Synthesis and Evaluation of N-[11C]Methylated Analogues of Epibatidine as Tracers for Positron Emission Tomographic Studies of Nicotinic Acetylcholine ReceptorsHorti, Andrew G. / Scheffel, Ursula / Kimes, Alane S. / Musachio, John L. / Ravert, Hayden T. / Mathews, William B. / Zhan, Yougen / Finley, Paige A. / London, Edythe D. / Dannals, Robert F. et al. | 1998
- 4207
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Derivation of a Pharmacophore Model for Anandamide Using Constrained Conformational Searching and Comparative Molecular Field AnalysisTong, Weida / Collantes, Elizabeth R. / Welsh, William J. / Berglund, Barbara A. / Howlett, Allyn C. et al. | 1998
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ARTICLES - Derivation of a Pharmacophore Model for Anandamide Using Constrained Conformational Searching and Comparative Molecular Field AnalysisTong, Weida et al. | 1998
- 4216
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ARTICLES - Novel Cyclic Compounds as Potent Phosphodiesterase 4 InhibitorsHe, Wei et al. | 1998
- 4216
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Novel Cyclic Compounds as Potent Phosphodiesterase 4 InhibitorsHe, Wei / Huang, Fu-Chih / Hanney, Barbara / Souness, John / Miller, Bruce / Liang, Guyan / Mason, Jon / Djuric, Stevan et al. | 1998
- 4224
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ARTICLES - In Vitro and in Vivo Activities of Oligodeoxynucleotide-Based Thrombin Inhibitors Containing Neutral Formacetal LinkagesHe, Gong-Xin et al. | 1998
- 4224
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In Vitro and in Vivo Activities of Oligodeoxynucleotide-Based Thrombin Inhibitors Containing Neutral Formacetal LinkagesHe, Gong-Xin / Williams, John P. / Postich, Michael J. / Swaminathan, S. / Shea, Regan G. / Terhorst, Terry / Law, Veronica S. / Mao, Cheri T. / Sueoka, Cathy / Coutré, Steven et al. | 1998
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ARTICLES - Axially Chiral N-Benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK1 Receptor Antagonists: Determination of the Absolute Stereochemical RequirementsIkeura, Yoshinori et al. | 1998
- 4232
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Axially Chiral N-Benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK1 Receptor Antagonists: Determination of the Absolute Stereochemical RequirementsIkeura, Yoshinori / Ishichi, Yuji / Tanaka, Toshimasa / Fujishima, Akira / Murabayashi, Mika / Kawada, Mitsuru / Ishimaru, Takenori / Kamo, Izumi / Doi, Takayuki / Natsugari, Hideaki et al. | 1998
- 4240
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Design of Benzamidine-Type Inhibitors of Factor XaGabriel, Bernhard / Stubbs, Milton T. / Bergner, Andreas / Hauptmann, Jörg / Bode, Wolfram / Stürzebecher, Jörg / Moroder, Luis et al. | 1998
- 4240
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ARTICLES - Design of Benzamidine-Type Inhibitors of Factor XaGabriel, Bernhard et al. | 1998
- 4251
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ARTICLES - Metabolites of the Angiotensin II Antagonist Tasosartan: The Importance of a Second Acidic GroupEllingboe, John W. et al. | 1998
- 4251
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Metabolites of the Angiotensin II Antagonist Tasosartan: The Importance of a Second Acidic GroupEllingboe, John W. / Collini, Michael D. / Quagliato, Dominick / Chen, James / Antane, Madelene / Schmid, Jean / Hartupee, Dale / White, Valerie / Park, C. Hyung / Tanikella, Tarak et al. | 1998
- 4261
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Quantitative Structure−Activity Relationships of 2,4-Diamino-5-(2-X-benzyl)pyrimidines versus Bacterial and Avian Dihydrofolate Reductase †Selassie, Cynthia Dias / Gan, Wei-Xi / Kallander, Lara S. / Klein, Teri E. et al. | 1998
- 4261
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ARTICLES - Quantitative Structure-Activity Relationships of 2,4-Diamino-5-(2-X-benzyl)pyrimidines versus Bacterial and Avian Dihydrofolate ReductaseSelassie, Cynthia Dias et al. | 1998
- 4273
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Design of New Topoisomerase II Inhibitors Based upon a Quinobenzoxazine Self-Assembly ModelZeng, Qingping / Kwok, Yan / Kerwin, Sean M. / Mangold, Gina / Hurley, Laurence H. et al. | 1998
- 4273
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ARTICLES - Design of New Topoisomerase II Inhibitors Based upon a Quinobenzoxazine Self-Assembly ModelZeng, Qingping et al. | 1998
- 4279
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Studies on Selectin Blockers. 7. Structure−Activity Relationships of Sialyl Lewis X Mimetics Based on Modified Ser-Glu DipeptidesTsukida, Takahiro / Moriyama, Hideki / Kurokawa, Kiriko / Achiha, Toshio / Inoue, Yoshimasa / Kondo, Hirosato et al. | 1998
- 4279
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ARTICLES - Studies on Selectin Blockers. 7. Structure -- Activity Relationships of Sialyl Lewis X Mimetics Based on Modified Ser-Glu DipeptidesTsukida, Takahiro et al. | 1998
- 4288
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ARTICLES - Potent and Selective Non-Cysteine-Containing Inhibitors of Protein FarnesyltransferaseAugeri, David J. et al. | 1998
- 4288
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Potent and Selective Non-Cysteine-Containing Inhibitors of Protein FarnesyltransferaseAugeri, David J. / O'Connor, Stephen J. / Janowick, Dave / Szczepankiewicz, Bruce / Sullivan, Gerry / Larsen, John / Kalvin, Douglas / Cohen, Jerry / Devine, Edward / Zhang, Haichao et al. | 1998
- 4301
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Synthesis of Peptide Aldehyde Derivatives as Selective Inhibitors of Human Cathepsin L and Their Inhibitory Effect on Bone ResorptionYasuma, Tsuneo / Oi, Satoru / Choh, Nobuo / Nomura, Toshiyuki / Furuyama, Naoki / Nishimura, Atsushi / Fujisawa, Yukio / Sohda, Takashi et al. | 1998
- 4301
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ARTICLES - Synthesis of Peptide Aldehyde Derivatives as Selective Inhibitors of Human Cathepsin L and Their Inhibitory Effect on Bone ResorptionYasuma, Tsuneo et al. | 1998
- 4309
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ARTICLES - Novel Calcium Antagonists with Both Calcium Overload Inhibition and Antioxidant Activity. 1. 2-(3,5-Di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinonesKato, Tatsuya et al. | 1998
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Novel Calcium Antagonists with Both Calcium Overload Inhibition and Antioxidant Activity. 1. 2-(3,5-Di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinonesKato, Tatsuya / Ozaki, Tomokazu / Tamura, Kazuhiko / Suzuki, Yoshiyuki / Akima, Michitaka / Ohi, Nobuhiro et al. | 1998
- 4317
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Bis-Cationic Heteroaromatics as Macrofilaricides: Synthesis of Bis-Amidine and Bis-Guanylhydrazone Derivatives of Substituted Imidazo[1,2-a]pyridinesSundberg, Richard J. / Biswas, Sujay / Kumar Murthi, Krishna / Rowe, Donna / McCall, John W. / Dzimianski, Michael T. et al. | 1998
- 4317
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ARTICLES - Bis-Cationic Heteroaromatics as Macrofilaricides: Synthesis of Bis-Amidine and Bis-Guanylhydrazone Derivatives of Substituted Imidazo(1,2-a)pyridinesSundberg, Richard J. et al. | 1998
- 4329
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Design of Peptidomimetics That Inhibit the Association of Phosphatidylinositol 3-Kinase with Platelet-Derived Growth Factor-β Receptor and Possess Cellular ActivityEaton, Scott R. / Cody, Wayne L. / Doherty, Annette M. / Holland, Debra R. / Panek, Robert L. / Lu, Gina H. / Dahring, Tawny K. / Rose, David R. et al. | 1998
- 4329
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ARTICLES - Design of Peptidomimetics That Inhibit the Association of Phosphatidylinositol 3-Kinase with Platelet-Derived Growth Factor-b Receptor and Possess Cellular ActivityEaton, Scott R. et al. | 1998
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ARTICLES - 5-Substituted Pyrimidines with a 1,5-Anhydro-2,3-dideoxy-D-arabino-hexitol Moiety at N-1: Synthesis, Antiviral Activity, Conformational Analysis, and Interaction with Viral Thymidine KinaseOstrowski, Tomasz et al. | 1998
- 4343
-
5-Substituted Pyrimidines with a 1,5-Anhydro-2,3-dideoxy-d-arabino-hexitol Moiety at N-1: Synthesis, Antiviral Activity, Conformational Analysis, and Interaction with Viral Thymidine KinaseOstrowski, Tomasz / Wroblowski, Berthold / Busson, Roger / Rozenski, Jozef / De Clercq, Erik / Bennett, Matthew S. / Champness, John N. / Summers, William C. / Sanderson, Mark R. / Herdewijn, Piet et al. | 1998
- 4354
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ARTICLES - 5-Benzylidene 1,2-Dihydrochromeno(3,4-f)quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor AgonistsTegley, Christopher M. et al. | 1998
- 4354
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5-Benzylidene 1,2-Dihydrochromeno[3,4-f]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor AgonistsTegley, Christopher M. / Zhi, Lin / Marschke, Keith B. / Gottardis, Marco M. / Yang, Qinchuan / Jones, Todd K. et al. | 1998
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Bisquinolines. 2. Antimalarial N,N-Bis(7-chloroquinolin-4-yl)heteroalkanediaminesVennerstrom, Jonathan L. / Ager,, Arba L. / Dorn, Arnulf / Andersen, Steven L. / Gerena, Lucia / Ridley, Robert G. / Milhous, Wilbur K. et al. | 1998
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ARTICLES - Bisquinolines. 2. Antimalarial N,N-Bis(7-chloroquinolin-4-yl)heteroalkanediaminesVennerstrom, Jonathan L. et al. | 1998
- 4365
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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase InhibitorsBoschelli, Diane H. / Wu, Zhipei / Klutchko, Sylvester R. / Showalter, H. D. Hollis / Hamby, James M. / Lu, Gina H. / Major, Terry C. / Dahring, Tawny K. / Batley, Brian / Panek, Robert L. et al. | 1998
- 4365
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ARTICLES - Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido(2,3-d)pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase InhibitorsBoschelli, Diane H. et al. | 1998
- 4378
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Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist ActivitySauerberg, Per / Jeppesen, Lone / Olesen, Preben H. / Rasmussen, Thøger / Swedberg, Michael D. B. / Sheardown, Malcolm J. / Fink-Jensen, Anders / Thomsen, Christian / Thøgersen, Henning / Rimvall, Karin et al. | 1998
- 4378
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ARTICLES - Muscarinic Agonists with Antipsychotic-like Activity: Structure-Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist ActivitySauerberg, Per et al. | 1998
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ARTICLES - CoMFA-Based Prediction of Agonist Affinities at Recombinant D1 vs D2 Dopamine ReceptorsWilcox, Richard E. et al. | 1998
- 4385
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CoMFA-Based Prediction of Agonist Affinities at Recombinant D1 vs D2 Dopamine Receptors †Wilcox, Richard E. / Tseng, Tom / Brusniak, Mi-Youn Kim / Ginsburg, Brett / Pearlman, Robert S. / Teeter, Martha / DuRand, Curtiss / Starr, Stephanie / Neve, Kim A. et al. | 1998
- 4400
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Potent Cyano and Carboxamido Side-Chain Analogues of 1‘,1‘-Dimethyl-Δ8-TetrahydrocannabinolSinger, Michael / Ryan, William J. / Saha, Bijali / Martin, Billy R. / Razdan, Raj K. et al. | 1998
- 4400
-
Potent Cyano and Carboxamido Side-Chain Analogues of 1',1'-Dimethyl-cap delta^8-TetrahydrocannabinolSinger, M. / Ryan, W. J. / Saha, B. / Martin, B. R. / Razdan, R. K. et al. | 1998
- 4400
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ARTICLES - Potent Cyano and Carboxamido Side-Chain Analogues of 1',1'-Dimethyl-D8-TetrahydrocannabinolSinger, Michael et al. | 1998
- 4408
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ARTICLES - Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 3. Discovery of a Novel Series of N-Alkyl-N-((fluorophenoxy)benzyl)-N'-arylureas with Weak Toxicological Effects on Adrenal GlandsTanaka, Akira et al. | 1998
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Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 3. Discovery of a Novel Series of N-Alkyl-N-[(fluorophenoxy)benzyl]-N‘-arylureas with Weak Toxicological Effects on Adrenal GlandsTanaka, Akira / Terasawa, Takeshi / Hagihara, Hiroyuki / Ishibe, Noriko / Sawada, Masae / Sakuma, Yuri / Hashimoto, Masaharu / Takasugi, Hisashi / Tanaka, Hirokazu et al. | 1998
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NOTES - Bisphenols That Stimulate Cells To Release Alkali Metal Cations: A Structure-Activity StudyHopp, Laszlo et al. | 1998
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Bisphenols That Stimulate Cells To Release Alkali Metal Cations: A Structure−Activity StudyHopp, Laszlo / Megee, Susan O. / Lloyd, John B. et al. | 1998
- 4424
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A Practical Guide to Combinatorial ChemistryKyle, D. J. et al. | 1998
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Second Supplements to the Second Edition of Rodd's Chemistry of Carbon Compounds. Volume IV: Heterocyclic Compounds. Part C: Five-Membered Heterocyclic Compounds with Two Hetero-Atoms in the Ring from Groups V and VI of the Periodic Table; Part D: Five-Membered Heterocyclic Compounds with More Than Two Hetero-Atoms in the Ring Edited by M. Sainsbury. Elsevier, Amsterdam. 1998. xvi + 281 pp. 15.5 × 23 cm. ISBN-0-444-828702. $187.00.Martin, Arnold et al. | 1998
- 4424
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A Practical Guide to Combinatorial Chemistry Edited by A. W. Czarnik and S. H. DeWitt. American Chemical Society, Washington, D.C. 1997. xiv + 450 pp. 15.5 × 23.5 cm. ISBN 0-8412-3485. $89.95.Kyle, Donald J. et al. | 1998
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BOOK REVIEWS - Second Supplements to the Second Edition of Rodd's Chemistry of Carbon Compounds. Volume IV: Heterocyclic Compounds. Part C: Five-Membered Heterocyclic Compounds with Two Hetero-Atoms in the Ring from Groups V and VI of the Periodic Table; Part D: Five-Membered Heterocyclic Compounds with More Than Two Hetero-Atoms in the RingMartin, Arnold et al. | 1998
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-
BOOK REVIEWS - A Practical Guide to Combinatorial ChemistryKyle, Donald J. et al. | 1998
- 4424
-
Second Supplements to the Second Edition of Rodd's Chemistry of Carbon Compounds. Volume IV: Heterocyclic Compounds. Part C: Five-Membered Heterocyclic Compounds with Two Hetero-Atoms in the Ring from Groups V and VI of the Periodic Table; Part D: Five-Membered Heterocyclic Compounds with More Than Two Hetero-Atoms in the RingMartin, A. et al. | 1998
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High-Performance Capillary ElectrophoresisLinhardt, R. J. et al. | 1998
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BOOK REVIEWS - Analytical ChemistryBorn, Jerry L. et al. | 1998
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Analytical Chemistry Edited by R. Kellner, J.-M. Mermet, M. Otto, and H. M. Widmer. Wiley-VCH, New York. 1998. xxv + 916 pp. 21.5 × 30 cm. ISBN 3-527-286101. $84.95.Born, Jerry L. et al. | 1998
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Analytical ChemistryBorn, J. L. et al. | 1998
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The Combinatorial Index. By Barry A. BuninMitscher, L. A. et al. | 1998
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BOOK REVIEWS - Practical Application of Computer-Aided Drug DesignAbraham, Donald J. et al. | 1998
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The Combinatorial Index By Barry A. Bunin. Academic Press, New York, NY. 1998. xvii + 322 pp. 18 × 26 cm. ISBN 0-12-141340-3. $79.95.Mitscher, Lester A. et al. | 1998
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Practical Application of Computer-Aided Drug Design Edited by Paul S. Charifson. Marcel Dekker, Inc., New York, NY. 1997. x + 52 pp. 16 × 23.5 cm. ISBN 0-8247-9885-6. $150.00.Abraham, Donald J. et al. | 1998
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Practical Application of Computer-Aided Drug DesignAbraham, D. J. et al. | 1998
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BOOK REVIEWS - The Laboratory Companion: A Practical Guide to Materials, Equipment, and TechniqueBoge, Thomas C. et al. | 1998
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The Laboratory Companion: A Practical Guide to Materials, Equipment, and TechniqueBoge, T. C. et al. | 1998
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The Laboratory Companion: A Practical Guide to Materials, Equipment, and Technique By Gary S. Coyne. John Wiley & Sons, New York. 1997. xviii + 527 pp. 18 × 26 cm. ISBN 0-4711-8422-5. $59.95.Boge, Thomas C. et al. | 1998
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Emerging Drugs. The Prospect for Improved Medicines. Annual Executive Briefing. Volume 3. Edited by W. C. Bowman, J. D. Fitzgerald, and J. B. Taylor. Ashley Publications Ltd., London. 1998. vi + 397 pp. 21 x 29.54 cm. ISSN 1361-9195. $690.00.Weinstock, Joseph et al. | 1998
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