Demonstrating Ligandability of the LC3A and LC3B Adapter Interface (Englisch)
- Neue Suche nach: Hartmann, Markus
- Neue Suche nach: Huber, Jessica
- Neue Suche nach: Kramer, Jan S.
- Neue Suche nach: Heering, Jan
- Weitere Informationen zu Heering, Jan:
-
https://orcid.org/0000-0002-4922-1993
- Neue Suche nach: Pietsch, Larissa
- Neue Suche nach: Stark, Holger
- Weitere Informationen zu Stark, Holger:
-
https://orcid.org/0000-0003-3336-1710
- Neue Suche nach: Odadzic, Dalibor
- Neue Suche nach: Bischoff, Iris
- Neue Suche nach: Fürst, Robert
- Neue Suche nach: Schröder, Martin
- Neue Suche nach: Akutsu, Masato
- Neue Suche nach: Chaikuad, Apirat
- Weitere Informationen zu Chaikuad, Apirat:
-
https://orcid.org/0000-0003-1120-2209
- Neue Suche nach: Dötsch, Volker
- Neue Suche nach: Knapp, Stefan
- Weitere Informationen zu Knapp, Stefan:
-
https://orcid.org/0000-0001-5995-6494
- Neue Suche nach: Biondi, Ricardo M.
- Neue Suche nach: Rogov, Vladimir V.
- Neue Suche nach: Proschak, Ewgenij
- Weitere Informationen zu Proschak, Ewgenij:
-
https://orcid.org/0000-0003-1961-1859
- Neue Suche nach: Hartmann, Markus
- Neue Suche nach: Huber, Jessica
- Neue Suche nach: Kramer, Jan S.
- Neue Suche nach: Heering, Jan
- Weitere Informationen zu Heering, Jan:
-
https://orcid.org/0000-0002-4922-1993
- Neue Suche nach: Pietsch, Larissa
- Neue Suche nach: Stark, Holger
- Weitere Informationen zu Stark, Holger:
-
https://orcid.org/0000-0003-3336-1710
- Neue Suche nach: Odadzic, Dalibor
- Neue Suche nach: Bischoff, Iris
- Neue Suche nach: Fürst, Robert
- Neue Suche nach: Schröder, Martin
- Neue Suche nach: Akutsu, Masato
- Neue Suche nach: Chaikuad, Apirat
- Weitere Informationen zu Chaikuad, Apirat:
-
https://orcid.org/0000-0003-1120-2209
- Neue Suche nach: Dötsch, Volker
- Neue Suche nach: Knapp, Stefan
- Weitere Informationen zu Knapp, Stefan:
-
https://orcid.org/0000-0001-5995-6494
- Neue Suche nach: Biondi, Ricardo M.
- Neue Suche nach: Rogov, Vladimir V.
- Neue Suche nach: Proschak, Ewgenij
- Weitere Informationen zu Proschak, Ewgenij:
-
https://orcid.org/0000-0003-1961-1859
In:
Journal of Medicinal Chemistry
;
64
, 7
;
3720-3746
;
2021
- Aufsatz (Zeitschrift) / Elektronische Ressource
-
Titel:Demonstrating Ligandability of the LC3A and LC3B Adapter Interface
-
Weitere Titelangaben:J. Med. Chem.
-
Beteiligte:Hartmann, Markus ( Autor:in ) / Huber, Jessica ( Autor:in ) / Kramer, Jan S. ( Autor:in ) / Heering, Jan ( Autor:in ) / Pietsch, Larissa ( Autor:in ) / Stark, Holger ( Autor:in ) / Odadzic, Dalibor ( Autor:in ) / Bischoff, Iris ( Autor:in ) / Fürst, Robert ( Autor:in ) / Schröder, Martin ( Autor:in )
-
Erschienen in:Journal of Medicinal Chemistry ; 64, 7 ; 3720-3746
-
Verlag:
- Neue Suche nach: American Chemical Society
-
Erscheinungsdatum:08.04.2021
-
ISSN:
-
Coden:
-
DOI:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Elektronische Ressource
-
Sprache:Englisch
-
Datenquelle:
Inhaltsverzeichnis – Band 64, Ausgabe 7
Zeige alle Jahrgänge und Ausgaben
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
- 3493
-
Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug DiscoveryPei, Junping / Wang, Guan / Feng, Lu / Zhang, Jifa / Jiang, Tingting / Sun, Qiu / Ouyang, Liang et al. | 2021
- 3508
-
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging OpportunitiesRobello, Marco / Barresi, Elisabetta / Baglini, Emma / Salerno, Silvia / Taliani, Sabrina / Settimo, Federico Da et al. | 2021
- 3546
-
Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead OptimizationSodhi, Jasleen K. / Benet, Leslie Z. et al. | 2021
- 3560
-
Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug ArsenalNagini, Siddavaram / Nivetha, Ramesh / Palrasu, Manikandan / Mishra, Rajakishore et al. | 2021
- 3578
-
Disentangling the Structure–Activity Relationships of Naphthalene Diimides as Anticancer G‑Quadruplex-Targeting DrugsPlatella, Chiara / Napolitano, Ettore / Riccardi, Claudia / Musumeci, Domenica / Montesarchio, Daniela et al. | 2021
- 3604
-
Synthetic Approaches to the New Drugs Approved during 2019Flick, Andrew C. / Leverett, Carolyn A. / Ding, Hong X. / McInturff, Emma / Fink, Sarah J. / Mahapatra, Subham / Carney, Daniel W. / Lindsey, Erick A. / DeForest, Jacob C. / France, Scott P. et al. | 2021
- 3658
-
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus FusionCockerill, G. Stuart / Angell, Richard M. / Bedernjak, Alexandre / Chuckowree, Irina / Fraser, Ian / Gascon-Simorte, Jose / Gilman, Morgan S. A. / Good, James A. D. / Harland, Rachel / Johnson, Sara M. et al. | 2021
- 3677
-
Discovery of Encequidar, First-in-Class Intestine Specific P‑glycoprotein InhibitorSmolinski, Michael P. / Urgaonkar, Sameer / Pitzonka, Laura / Cutler, Murray / Lee, GwanSun / Suh, Kwee Hyun / Lau, Johnson Y. N. et al. | 2021
- 3694
-
Allosteric Modulation: Dynamics is Double-“E”dgedXiong, Bing et al. | 2021
- 3697
-
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6Shen, Yudao / Li, Fengling / Szewczyk, Magdalena M. / Halabelian, Levon / Chau, Irene / Eram, Mohammad S. / Dela Seña, Carlo / Park, Kwang-Su / Meng, Fanye / Chen, He et al. | 2021
- 3707
-
Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory ActivityKitagawa, Hiroki / Kikuchi, Masaki / Sato, Shin / Watanabe, Hisami / Umezawa, Naoki / Kato, Maiko / Hisamatsu, Yosuke / Umehara, Takashi / Higuchi, Tsunehiko et al. | 2021
- 3720
-
Demonstrating Ligandability of the LC3A and LC3B Adapter InterfaceHartmann, Markus / Huber, Jessica / Kramer, Jan S. / Heering, Jan / Pietsch, Larissa / Stark, Holger / Odadzic, Dalibor / Bischoff, Iris / Fürst, Robert / Schröder, Martin et al. | 2021
- 3747
-
Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type‑1 Capsid Inhibitor Using a Multistep Computational WorkflowMeuser, Megan E. / Reddy, Poli Adi Narayana / Dick, Alexej / Maurancy, Jean Marc / Salvino, Joseph M. / Cocklin, Simon et al. | 2021
- 3767
-
Designed β‑Hairpins Inhibit LDH5 Oligomerization and Enzymatic ActivityNadal-Bufi, Ferran / Mason, Jody M. / Chan, Lai Yue / Craik, David J. / Kaas, Quentin / Troeira Henriques, Sónia et al. | 2021
- 3780
-
Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the BrainHattori, Yasushi / Matsuda, Satoru / Baba, Rina / Matsumiya, Kouta / Iwasaki, Shinji / Constantinescu, Cristian C. / Morley, Thomas J. / Carroll, Vincent M. / Papin, Caroline / Gouasmat, Alexandra et al. | 2021
- 3794
-
Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer’s Disease Mouse ModelHe, Feng / Chou, C. James / Scheiner, Matthias / Poeta, Eleonora / Yuan Chen, Natalia / Gunesch, Sandra / Hoffmann, Matthias / Sotriffer, Christoph / Monti, Barbara / Maurice, Tangui et al. | 2021
- 3813
-
Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for InterventionWhitfield, Hayley / Hemmings, Andrew M. / Mills, Stephen J. / Baker, Kendall / White, Gaye / Rushworth, Stuart / Riley, Andrew M. / Potter, Barry V. L. / Brearley, Charles A. et al. | 2021
- 3827
-
Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A2A ReceptorAmelia, Tasia / van Veldhoven, Jacobus P. D. / Falsini, Matteo / Liu, Rongfang / Heitman, Laura H. / van Westen, Gerard J. P. / Segala, Elena / Verdon, Grégory / Cheng, Robert K. Y. / Cooke, Robert M. et al. | 2021
- 3843
-
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron MicroscopyTerrett, Jack A. / Chen, Huifen / Shore, Daniel G. / Villemure, Elisia / Larouche-Gauthier, Robin / Déry, Martin / Beaumier, Francis / Constantineau-Forget, Léa / Grand-Maître, Chantal / Lépissier, Luce et al. | 2021
- 3870
-
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent AgonistsJiang, Shan / Iliopoulos-Tsoutsouvas, Christos / Tong, Fei / Brust, Christina A. / Keenan, Catherine M. / Raghav, Jimit Girish / Hua, Tian / Wu, Simiao / Ho, Jo-Hao / Wu, Yiran et al. | 2021
- 3885
-
Antimalarial Quinacrine and Chloroquine Lose Their Activity by Decreasing Cationic Amphiphilic Structure with a Slight Decrease in pHKitagawa, Tomohisa / Matsumoto, Atsushi / Terashima, Ichiro / Uesono, Yukifumi et al. | 2021
- 3897
-
Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa)Schaffner, Arnaud-Pierre / Sansilvestri-Morel, Patricia / Despaux, Nicole / Ruano, Elisabeth / Persigand, Thierry / Rupin, Alain / Mennecier, Philippe / Vallez, Marie-Odile / Raimbaud, Eric / Desos, Patrice et al. | 2021
- 3911
-
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of CancerQuiroz, Ryan V. / Reutershan, Michael H. / Schneider, Sebastian E. / Sloman, David / Lacey, Brian M. / Swalm, Brooke M. / Yeung, Charles S. / Gibeau, Craig / Spellman, Daniel S. / Rankic, Danica A. et al. | 2021
- 3940
-
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5‑Fluoro-4-(3H)‑quinazolinone Aryl Urea pan-RAF Kinase InhibitorHuestis, Malcolm P. / Dela Cruz, Darlene / DiPasquale, Antonio G. / Durk, Matthew R. / Eigenbrot, Charles / Gibbons, Paul / Gobbi, Alberto / Hunsaker, Thomas L. / La, Hank / Leung, Dennis H. et al. | 2021
- 3956
-
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl InhibitorZhang, Hefeng / Peng, Xia / Dai, Yang / Shao, Jingwei / Ji, Yinchun / Sun, Yiming / Liu, Bo / Cheng, Xu / Ai, Jing / Duan, Wenhu et al. | 2021
- 3976
-
The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both In Vitro and In VivoZhang, Han / Yu, Peilin / Lin, Hongwei / Jin, Zefang / Zhao, Siqi / Zhang, Yi / Xu, Qingxia / Jin, Hongwei / Liu, Zhenming / Yang, Wei et al. | 2021
- 3997
-
Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ InteractionsJirkovská, Anna / Karabanovich, Galina / Kubeš, Jan / Skalická, Veronika / Melnikova, Iuliia / Korábečný, Jan / Kučera, Tomáš / Jirkovský, Eduard / Nováková, Lucie / Bavlovič Piskáčková, Hana et al. | 2021
- 4020
-
Structure-Based Design of a Selective Class I Histone Deacetylase (HDAC) Near-Infrared (NIR) Probe for Epigenetic Regulation Detection in Triple-Negative Breast Cancer (TNBC)Zhang, Kuojun / Liu, Zhiyi / Yao, Yiwu / Qiu, Yatao / Li, Feng / Chen, Dong / Hamilton, Dale J. / Li, Zheng / Jiang, Sheng et al. | 2021
- 4034
-
Distinct Lugdunins from a New Efficient Synthesis and Broad Exploitation of Its MRSA-Antimicrobial StructureSaur, Julian S. / Wirtz, Sebastian N. / Schilling, Nadine A. / Krismer, Bernhard / Peschel, Andreas / Grond, Stephanie et al. | 2021
- 4059
-
Imaging of Fibroblast Activation Protein in Cancer Xenografts Using Novel (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine-Based Small MoleculesSlania, Stephanie L. / Das, Deepankar / Lisok, Ala / Du, Yong / Jiang, Zirui / Mease, Ronnie C. / Rowe, Steven P. / Nimmagadda, Sridhar / Yang, Xing / Pomper, Martin G. et al. | 2021
- 4071
-
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein InteractionChessari, Gianni / Hardcastle, Ian R. / Ahn, Jong Sook / Anil, Burcu / Anscombe, Elizabeth / Bawn, Ruth H. / Bevan, Luke D. / Blackburn, Timothy J. / Buck, Ildiko / Cano, Celine et al. | 2021
- 4089
-
Structure–Activity Relationship Studies on Oxazolo[3,4‑a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo ActivityAlbanese, Valentina / Ruzza, Chiara / Marzola, Erika / Bernardi, Tatiana / Fabbri, Martina / Fantinati, Anna / Trapella, Claudio / Reinscheid, Rainer K. / Ferrari, Federica / Sturaro, Chiara et al. | 2021
- 4109
-
A Crowding Barrier to Protein Inhibition in Colloidal AggregatesLak, Parnian / O’Donnell, Henry / Du, Xuewen / Jacobson, Matthew P. / Shoichet, Brian K. et al. | 2021
- 4117
-
Enhancing the Pharmacokinetics and Antitumor Activity of an α‑Amanitin-Based Small-Molecule Drug Conjugate via Conjugation with an Fc DomainGallo, Francesca / Korsak, Barbara / Müller, Christoph / Hechler, Torsten / Yanakieva, Desislava / Avrutina, Olga / Kolmar, Harald / Pahl, Andreas et al. | 2021
- 4130
-
Structure–Activity Relationship Study and Biological Evaluation of 2‑(Disubstituted phenyl)-indole-5-propanoic Acid Derivatives as GPR40 Full AgonistsZhao, Xiaodi / Yoon, Dong-Oh / Yoo, Jaeho / Park, Hyun-Ju et al. | 2021
- 4150
-
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazinesPriebbenow, Daniel L. / Mathiew, Mitch / Shi, Da-Hua / Harjani, Jitendra R. / Beveridge, Julia G. / Chavchich, Marina / Edstein, Michael D. / Duffy, Sandra / Avery, Vicky M. / Jacobs, Robert T. et al. | 2021
- 4163
-
Novel CK2-Specific Pt(II) Compound Reverses Cisplatin-Induced Resistance by Inhibiting Cancer Cell Stemness and Suppressing DNA Damage Repair in Non-small Cell Lung Cancer TreatmentsWang, Yuanjiang / Wang, Xinyi / Xu, Gang / Gou, Shaohua et al. | 2021
- 4179
-
Synthesis, Preclinical Evaluation, and First-in-Human PET Study of Quinoline-Containing PSMA Tracers with Decreased Renal ExcretionZhang, Xiaojun / Wu, Yitian / Zeng, Qi / Xie, Tianxin / Yao, Shulin / Zhang, Jinming / Cui, Mengchao et al. | 2021
- 4196
-
Selective Discovery of GPCR Ligands within DNA-Encoded Chemical Libraries Derived from Natural Products: A Case Study on Antagonists of Angiotensin II Type I ReceptorLiang, Qi / He, Jianyu / Zhao, Xue / Xue, Yan / Zuo, Haiyue / Xu, Ru / Jin, Yan / Wang, Jing / Li, Qian / Zhao, Xinfeng et al. | 2021
- 4206
-
Revisiting Pyrazolo[3,4‑d]pyrimidine Nucleosides as Anti-Trypanosoma cruzi and Antileishmanial AgentsBouton, Jakob / Ferreira de Almeida Fiuza, Ludmila / Cardoso Santos, Camila / Mazzarella, Maria Angela / Soeiro, Maria de Nazaré Correia / Maes, Louis / Karalic, Izet / Caljon, Guy / Van Calenbergh, Serge et al. | 2021
- 4239
-
2,4,5-Trisubstituted Pyrimidines as Potent HIV‑1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic StudiesKang, Dongwei / Ruiz, Francesc X. / Sun, Yanying / Feng, Da / Jing, Lanlan / Wang, Zhao / Zhang, Tao / Gao, Shenghua / Sun, Lin / De Clercq, Erik et al. | 2021