Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells (Unbekannt)
- Neue Suche nach: Koehler, Michael F. T.
- Neue Suche nach: Bergeron, Philippe
- Neue Suche nach: Blackwood, Elizabeth M.
- Neue Suche nach: Bowman, Krista
- Neue Suche nach: Clark, Kevin R.
- Neue Suche nach: Firestein, Ron
- Neue Suche nach: Kiefer, James R.
- Neue Suche nach: Maskos, Klaus
- Neue Suche nach: McCleland, Mark L.
- Neue Suche nach: Orren, Linda
- Neue Suche nach: Salphati, Laurent
- Neue Suche nach: Schmidt, Steve
- Neue Suche nach: Schneider, Elisabeth V.
- Neue Suche nach: Wu, Jiansheng
- Neue Suche nach: Beresini, Maureen H.
- Neue Suche nach: Koehler, Michael F. T.
- Neue Suche nach: Bergeron, Philippe
- Neue Suche nach: Blackwood, Elizabeth M.
- Neue Suche nach: Bowman, Krista
- Neue Suche nach: Clark, Kevin R.
- Neue Suche nach: Firestein, Ron
- Neue Suche nach: Kiefer, James R.
- Neue Suche nach: Maskos, Klaus
- Neue Suche nach: McCleland, Mark L.
- Neue Suche nach: Orren, Linda
- Neue Suche nach: Salphati, Laurent
- Neue Suche nach: Schmidt, Steve
- Neue Suche nach: Schneider, Elisabeth V.
- Neue Suche nach: Wu, Jiansheng
- Neue Suche nach: Beresini, Maureen H.
In:
ACS Medicinal
Chemistry Letters
;
7
, 3
;
223-228
;
2016
-
ISSN:
- Aufsatz (Zeitschrift) / Elektronische Ressource
-
Titel:Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells
-
Weitere Titelangaben:ACS Med. Chem. Lett.
-
Beteiligte:Koehler, Michael F. T. ( Autor:in ) / Bergeron, Philippe ( Autor:in ) / Blackwood, Elizabeth M. ( Autor:in ) / Bowman, Krista ( Autor:in ) / Clark, Kevin R. ( Autor:in ) / Firestein, Ron ( Autor:in ) / Kiefer, James R. ( Autor:in ) / Maskos, Klaus ( Autor:in ) / McCleland, Mark L. ( Autor:in ) / Orren, Linda ( Autor:in )
-
Erschienen in:ACS Medicinal Chemistry Letters ; 7, 3 ; 223-228
-
Verlag:
- Neue Suche nach: American Chemical Society
-
Erscheinungsdatum:10.03.2016
-
ISSN:
-
Coden:
-
DOI:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Elektronische Ressource
-
Sprache:Unbekannt
-
Schlagwörter:
-
Datenquelle:
Inhaltsverzeichnis – Band 7, Ausgabe 3
Zeige alle Jahrgänge und Ausgaben
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
- 204
-
In This Issue, Volume 7, Issue 3Kindrachuk, Kristen N. et al. | 2016
- 205
-
MALT1 Inhibitors May Potentially Treat Lymphomas and Autoimmune DisordersAbdel-Magid, Ahmed F. et al. | 2016
- 207
-
Glutaminase GLS1 Inhibitors as Potential Cancer TreatmentAbdel-Magid, Ahmed F. et al. | 2016
- 209
-
Potential Use of Inhibitors of Tankyrases and PARP‑1 as Treatment for Cancer and Other DiseasesAbdel-Magid, Ahmed F. et al. | 2016
- 211
-
Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click ChemistrySchmitz, Janina / Li, Tianwei / Bartz, Ulrike / Gütschow, Michael et al. | 2016
- 217
-
Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 InhibitorsLin, Hong / Zeng, Jin / Xie, Ren / Schulz, Mark J. / Tedesco, Rosanna / Qu, Junya / Erhard, Karl F. / Mack, James F. / Raha, Kaushik / Rendina, Alan R. et al. | 2016
- 223
-
Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout CellsKoehler, Michael F. T. / Bergeron, Philippe / Blackwood, Elizabeth M. / Bowman, Krista / Clark, Kevin R. / Firestein, Ron / Kiefer, James R. / Maskos, Klaus / McCleland, Mark L. / Orren, Linda et al. | 2016
- 229
-
Structure–Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 InhibitorsCongdon, Molly D. / Kharel, Yugesh / Brown, Anne M. / Lewis, Stephanie N. / Bevan, David R. / Lynch, Kevin R. / Santos, Webster L. et al. | 2016
- 235
-
2‑(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis StrainsPissinate, Kenia / Villela, Anne Drumond / Rodrigues-Junior, Valnês / Giacobbo, Bruno Couto / Grams, Estêvão Silveira / Abbadi, Bruno Lopes / Trindade, Rogério Valim / Roesler Nery, Laura / Bonan, Carla Denise / Back, Davi Fernando et al. | 2016
- 240
-
Aloperine and Its Derivatives as a New Class of HIV‑1 Entry InhibitorsDang, Zhao / Zhu, Lei / Lai, Weihong / Bogerd, Hal / Lee, Kuo-Hsiung / Huang, Li / Chen, Chin-Ho et al. | 2016
- 245
-
Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel ImagingWang, Beilei / Liu, Zhenzhen / Ma, Zhao / Li, Minyong / Du, Lupei et al. | 2016
- 250
-
Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S ProteasomeWilson, David L. / Meininger, Isabel / Strater, Zack / Steiner, Stephanie / Tomlin, Frederick / Wu, Julia / Jamali, Haya / Krappmann, Daniel / Götz, Marion G. et al. | 2016
- 256
-
Kinetic ESI-MS Studies of Potent Anti-HIV Aptamers Based on the G‑Quadruplex Forming Sequence d(TGGGAG)Romanucci, Valeria / Marchand, Adrien / Mendoza, Oscar / D’Alonzo, Daniele / Zarrelli, Armando / Gabelica, Valérie / Di Fabio, Giovanni et al. | 2016
- 261
-
Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided ApproachWilson, Jonathan E. / Kurukulasuriya, Ravi / Reibarkh, Mikhail / Reiter, Maud / Zwicker, Aaron / Zhao, Kake / Zhang, Fengqi / Anand, Rajan / Colandrea, Vincent J. / Cumiskey, Anne-Marie et al. | 2016
- 266
-
Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043Tiwari, Rohit / Miller, Patricia A. / Chiarelli, Laurent R. / Mori, Giorgia / Šarkan, Michal / Centárová, Ivana / Cho, Sanghyun / Mikušová, Katarína / Franzblau, Scott G. / Oliver, Allen G. et al. | 2016
- 271
-
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in RodentsWu, Yong-Jin / Guernon, Jason / Yang, Fukang / Snyder, Lawrence / Shi, Jianliang / Mcclure, Andrea / Rajamani, Ramkumar / Park, Hyunsoo / Ng, Alicia / Lewis, Hal et al. | 2016
- 277
-
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain ModelsFocken, Thilo / Liu, Shifeng / Chahal, Navjot / Dauphinais, Maxim / Grimwood, Michael E. / Chowdhury, Sultan / Hemeon, Ivan / Bichler, Paul / Bogucki, David / Waldbrook, Matthew et al. | 2016
- 283
-
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical TrialsDhar, T. G. Murali / Xiao, Hai-Yun / Xie, Jenny / Lehman-McKeeman, Lois D. / Wu, Dauh-Rurng / Dabros, Marta / Yang, Xiaoxia / Taylor, Tracy L. / Zhou, Xia D. / Heimrich, Elizabeth M. et al. | 2016
- 289
-
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5Yang, Fukang / Snyder, Lawrence B. / Balakrishnan, Anand / Brown, Jeffrey M. / Sivarao, Digavalli V. / Easton, Amy / Fernandes, Alda / Gulianello, Michael / Hanumegowda, Umesh M. / Huang, Hong et al. | 2016
- 294
-
Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial DysfunctionValasani, Koteswara Rao / Sun, Qinru / Fang, Du / Zhang, Zhihua / Yu, Qing / Guo, Yaopeng / Li, Jianping / Roy, Anuradha / ShiDu Yan, Shirley et al. | 2016
- 300
-
Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in VivoDowling, James E. / Alimzhanov, Marat / Bao, Larry / Chuaqui, Claudio / Denz, Christopher R. / Jenkins, Emma / Larsen, Nicholas A. / Lyne, Paul D. / Pontz, Timothy / Ye, Qing et al. | 2016
- 306
-
Discovery of G Protein-Biased EP2 Receptor AgonistsOgawa, Seiji / Watanabe, Toshihide / Sugimoto, Isamu / Moriyuki, Kazumi / Goto, Yoshikazu / Yamane, Shinsaku / Watanabe, Akio / Tsuboi, Kazuma / Kinoshita, Atsushi / Kigoshi, Hideo et al. | 2016
- 312
-
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDIPero, Joseph E. / Rossi, Michael A. / Kelly, Michael J. / Lehman, Hannah D. G. F. / Layton, Mark E. / Garbaccio, Robert M. / O’Brien, Julie A. / Magliaro, Brian C. / Uslaner, Jason M. / Huszar, Sarah L. et al. | 2016
- 318
-
Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of BirinapantDeng, Yijun / Haimowitz, Thomas / LaPorte, Matthew G. / Rippin, Susan R. / Alexander, Matthew D. / Kumar, Pavan Tirunahari / Hendi, Mukta S. / Lee, Yu-Hua / Condon, Stephen M. et al. | 2016
- 324
-
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 InhibitorsBogen, Stéphane L. / Pan, Weidong / Gibeau, Craig R. / Lahue, Brian R. / Ma, Yao / Nair, Latha G. / Seigel, Elise / Shipps, Gerald W. / Tian, Yuan / Wang, Yaolin et al. | 2016
- 330
-
Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV‑1 Entry InhibitionMelillo, Bruno / Liang, Shuaiyi / Park, Jongwoo / Schön, Arne / Courter, Joel R. / LaLonde, Judith M. / Wendler, Daniel J. / Princiotto, Amy M. / Seaman, Michael S. / Freire, Ernesto et al. | 2016
- 335
-
Discovery of 3‑Substituted 1H‑Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective AntagonistsChen, Huayan / Yang, Hui / Wang, Zhilong / Xie, Xin / Nan, Fajun et al. | 2016