Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates (Englisch)
- Neue Suche nach: Guo, Lilu
- Neue Suche nach: Suarez, Alirica I.
- Neue Suche nach: Braden, Michael R.
- Neue Suche nach: Gerdes, John M.
- Neue Suche nach: Thompson, Charles M.
- Neue Suche nach: Guo, Lilu
- Neue Suche nach: Suarez, Alirica I.
- Neue Suche nach: Braden, Michael R.
- Neue Suche nach: Gerdes, John M.
- Neue Suche nach: Thompson, Charles M.
In:
Bioorganic and Medicinal Chemistry Letters
;
20
, 3
;
1194-1197
;
2009
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ISSN:
- Aufsatz (Zeitschrift) / Elektronische Ressource
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Titel:Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates
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Beteiligte:Guo, Lilu ( Autor:in ) / Suarez, Alirica I. ( Autor:in ) / Braden, Michael R. ( Autor:in ) / Gerdes, John M. ( Autor:in ) / Thompson, Charles M. ( Autor:in )
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Erschienen in:Bioorganic and Medicinal Chemistry Letters ; 20, 3 ; 1194-1197
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Verlag:
- Neue Suche nach: Elsevier Ltd
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Erscheinungsdatum:02.12.2009
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Format / Umfang:4 pages
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ISSN:
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DOI:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Elektronische Ressource
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Sprache:Englisch
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Schlagwörter:
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Datenquelle:
Inhaltsverzeichnis – Band 20, Ausgabe 3
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- 1100
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Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP–ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cellsFerrigno, Federica / Branca, Danila / Kinzel, Olaf / Lillini, Samuele / Llauger Bufi, Laura / Monteagudo, Edith / Muraglia, Ester / Rowley, Michael / Schultz-Fademrecht, Carsten / Toniatti, Carlo et al. | 2009
- 1106
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Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitorsBoehringer, Markus / Fischer, Holger / Hennig, Michael / Hunziker, Daniel / Huwyler, Joerg / Kuhn, Bernd / Loeffler, Bernd M. / Luebbers, Thomas / Mattei, Patrizio / Narquizian, Robert et al. | 2009
- 1109
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Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesMattei, Patrizio / Boehringer, Markus / Di Giorgio, Patrick / Fischer, Holger / Hennig, Michael / Huwyler, Joerg / Koçer, Buelent / Kuhn, Bernd / Loeffler, Bernd M. / MacDonald, Alexander et al. | 2009
- 1114
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Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonistsDounay, Amy B. / Barta, Nancy S. / Campbell, Brian M. / Coleman, Corey / Collantes, Elizabeth M. / Denny, Lynne / Dutta, Satavisha / Gray, David L. / Hou, Dongfeng / Iyer, Rathna et al. | 2009
- 1118
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Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: A new step towards the design of high-affinity 5-HT1A ligandsDilly, Sébastien / Graulich, Amaury / Liégeois, Jean-François et al. | 2009
- 1124
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Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitorsSuzuki, Takayoshi / Tanaka, Rikako / Hamada, Shohei / Nakagawa, Hidehiko / Miyata, Naoki et al. | 2009
- 1128
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Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agentsAhmad, Saleem / Ngu, Khehyong / Miller, Keith J. / Wu, Ginger / Hung, Chen-pin / Malmstrom, Sarah / Zhang, Ge / O’Tanyi, Eva / Keim, William J. / Cullen, Mary Jane et al. | 2009
- 1134
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Discovery of C-imidazole azaheptapyridine FPT inhibitorsZhu, Hugh Y. / Cooper, Alan B. / Desai, Jagdish / Njoroge, George / Kirschmeier, Paul / Bishop, W. Robert / Strickland, Corey / Hruza, Alan / Doll, Ronald J. / Girijavallabhan, Viyyoor M. et al. | 2009
- 1137
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2,3-Diaminopyrazines as rho kinase inhibitorsHenderson, Alan J. / Hadden, Mark / Guo, Cheng / Douglas, Neema / Decornez, Helene / Hellberg, Mark R. / Rusinko, Andrew / McLaughlin, Marsha / Sharif, Naj / Drace, Colene et al. | 2009
- 1141
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Potent transglutaminase inhibitors, aryl β-aminoethyl ketonesOzaki, Shoichiro / Ebisui, Etsuko / Hamada, Kozo / Goto, Jun-Ichi / Suzuki, Akinobu Z. / Terauchi, Akiko / Mikoshiba, Katsuhiko et al. | 2009
- 1141
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Potent transglutaminase inhibitors, aryl b-aminoethyl ketonesOzaki, S. / Ebisui, E. / Hamada, K. / Goto, J. I. / Suzuki, A. Z. / Terauchi, A. / Mikoshiba, K. et al. | 2010
- 1145
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Label-free fluorescent real-time monitoring of adenylyl cyclaseRhee, Hyun-Woo / Kim, Kyoung-Shim / Han, Pyung-Lim / Hong, Jong-In et al. | 2009
- 1148
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Synthesis and structure–activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agentsLi, Wen-Shan / More, Shivaji V. / Wang, Chie-Hong / Jen, Ya Ching / Yao, Ching-Fa / Wang, Tein-Fu / Hung, Chin-Chun / Jao, Shu-Chuan et al. | 2009
- 1153
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Synthesis and application of a photoaffinity analog of dehydroepiandrosterone (DHEA)Olivo, Horacio F. / Perez-Hernandez, Nury / Liu, Dongmin / Iruthayanathan, Mary / O’Leary, Brianne / Homan, Laurie L. / Dillon, Joseph S. et al. | 2009
- 1156
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Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARa agonistsPingali, H. / Jain, M. / Shah, S. / Zaware, P. / Makadia, P. / Pola, S. / Thube, B. / Patel, D. / Patil, P. / Priyadarshini, P. et al. | 2010
- 1156
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Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARα agonistsPingali, Harikishore / Jain, Mukul / Shah, Shailesh / Zaware, Pandurang / Makadia, Pankaj / Pola, Suresh / Thube, Baban / Patel, Darshit / Patil, Pravin / Priyadarshini, Priyanka et al. | 2009
- 1162
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Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitorsPark, Jun-Seong / Kim, Dong Hyun / Lee, Jae Kyoung / Lee, Jin Young / Kim, Duck Hee / Kim, Han Kon / Lee, Hak-Ju / Kim, Ho Cheol et al. | 2009
- 1165
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The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogensYim, NamHui / Ha, Do Thi / Trung, Trinh Nam / Kim, Jin Pyo / Lee, SangMyung / Na, MinKyeun / Jung, HyunJu / Kim, Hyun Su / Kim, Young Ho / Bae, KiHwan et al. | 2009
- 1169
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Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptorEl-Haggar, Radwan / Kamikawa, Ken / Machi, Kazuya / Ye, Zhengmao / Ishino, Yuko / Tsumuraya, Takeshi / Fujii, Ikuo et al. | 2009
- 1173
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Heterocycle-substituted proline dipeptides as potent VLA-4 antagonistsReger, Thomas S. / Zunic, Jasmine / Stock, Nicholas / Wang, Bowei / Smith, Nicholas D. / Munoz, Benito / Green, Mitchell D. / Gardner, Michael F. / James, Joyce P. / Chen, Weichao et al. | 2009
- 1177
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Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1Rist, Øystein / Grimstrup, Marie / Receveur, Jean-Marie / Frimurer, Thomas M. / Ulven, Trond / Kostenis, Evi / Högberg, Thomas et al. | 2009
- 1181
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Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2Grimstrup, Marie / Rist, Øystein / Receveur, Jean-Marie / Frimurer, Thomas M. / Ulven, Trond / Mathiesen, Jesper M. / Kostenis, Evi / Högberg, Thomas et al. | 2009
- 1186
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5′-O-Dephosphorylated 2′,5′-oligoadenylate (2-5A) with 8-methyladenosine at the 2′-terminus activates human RNase LNagaoka, Kumi / Kitamura, Yoshiaki / Ueno, Yoshihito / Kitade, Yukio et al. | 2009
- 1186
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5prime-O-Dephosphorylated 2prime,5prime-oligoadenylate (2-5A) with 8-methyladenosine at the 2prime-terminus activates human RNase LNagaoka, K. / Kitamura, Y. / Ueno, Y. / Kitade, Y. et al. | 2010
- 1189
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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitorsRosner, Kristin E. / Guo, Zhuyan / Orth, Peter / Shipps, Gerald W. Jr. / Belanger, David B. / Chan, Tin Yau / Curran, Patrick J. / Dai, Chaoyang / Deng, Yongqi / Girijavallabhan, Vinay M. et al. | 2009
- 1189
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The discovery of novel tartrate-based TNF-a converting enzyme (TACE) inhibitorsRosner, K. E. / Guo, Z. / Orth, P. / Shipps, G. W. / Belanger, D. B. / Chan, T. Y. / Curran, P. J. / Dai, C. / Deng, Y. / Girijavallabhan, V. M. et al. | 2010
- 1194
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Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonatesGuo, Lilu / Suarez, Alirica I. / Braden, Michael R. / Gerdes, John M. / Thompson, Charles M. et al. | 2009
- 1198
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Synthesis of 4prime-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell linesWong, Y. / Osmond, G. / Brewer, K. I. / Tyler, D. S. / Andrus, M. B. et al. | 2010
- 1198
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Synthesis of 4′-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell linesWong, Yong / Osmond, Gregory / Brewer, Kenneth I. / Tyler, Douglas S. / Andrus, Merritt B. et al. | 2009
- 1202
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Simocyclinone D8 turns on against Gram-negative bacteria in a clinical settingRichter, Sara N. / Frasson, Ilaria / Palumbo, Manlio / Sissi, Claudia / Palù, Giorgio et al. | 2009
- 1205
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Chaperone-like activity of the acute-phase component human serum α1-acid glycoprotein: Inhibition of thermal- and chemical-induced aggregation of various proteinsZsila, Ferenc et al. | 2009
- 1205
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Chaperone-like activity of the acute-phase component human serum a1-acid glycoprotein: Inhibition of thermal- and chemical-induced aggregation of various proteinsZsila, F. et al. | 2010
- 1210
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Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidaseSaturnino, Carmela / Petrosino, Stefania / Ligresti, Alessia / Palladino, Chiara / Martino, Giovanni De / Bisogno, Tiziana / Marzo, Vincenzo Di et al. | 2009
- 1214
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Synthesis of novel 7-imino-2-thioxo-3,7-dihydro-2H-thiazolo [4,5-d] pyrimidine derivatives as adenosine A2A receptor antagonistsLuthra, Pratibha Mehta / Mishra, Chandra Bhushan / Jha, Pawan Kumar / Barodia, Sandeep Kumar et al. | 2009
- 1219
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Synthesis and evaluation of two series of 4′-aza-carbocyclic nucleosides as adenosine A2A receptor agonistsBeattie, David / Brearley, Andrew / Brown, Zarin / Charlton, Steven J. / Cox, Brian / Fairhurst, Robin A. / Fozard, John R. / Gedeck, Peter / Kirkham, Paul / Meja, Koremu et al. | 2009
- 1219
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Synthesis and evaluation of two series of 4prime-aza-carbocyclic nucleosides as adenosine A2A receptor agonistsBeattie, D. / Brearley, A. / Brown, Z. / Charlton, S. J. / Cox, B. / Fairhurst, R. A. / Fozard, J. R. / Gedeck, P. / Kirkham, P. / Meja, K. et al. | 2010
- 1225
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Novel small molecule bradykinin B1 receptor antagonists. Part 1: Benzamides and semicarbazidesSchaudt, Marco / Locardi, Elsa / Zischinsky, Gunther / Stragies, Roland / Pfeifer, Jochen R. / Gibson, Christoph / Scharn, Dirk / Richter, Uwe / Kalkhof, Holger / Dinkel, Klaus et al. | 2009
- 1229
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Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocyclesZischinsky, Gunther / Stragies, Roland / Schaudt, Marco / Pfeifer, Jochen R. / Gibson, Christoph / Locardi, Elsa / Scharn, Dirk / Richter, Uwe / Kalkhof, Holger / Dinkel, Klaus et al. | 2009
- 1233
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Novel small molecule bradykinin B1 receptor antagonists. Part 3: Hydroxyurea derivativesSchnatbaum, Karsten / Schaudt, Marco / Stragies, Roland / Pfeifer, Jochen R. / Gibson, Christoph / Locardi, Elsa / Scharn, Dirk / Richter, Uwe / Kalkhof, Holger / Dinkel, Klaus et al. | 2009
- 1237
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Benzimidazole- and indole-substituted 1,3′-bipyrrolidine benzamides as histamine H3 receptor antagonistsCole, Derek C. / Gross, Jonathan L. / Comery, Thomas A. / Aschmies, Suzan / Hirst, Warren D. / Kelley, Cody / Kim, Ji-In / Kubek, Katie / Ning, Xiaoping / Platt, Brian J. et al. | 2009
- 1237
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Benzimidazole- and indole-substituted 1,3prime-bipyrrolidine benzamides as histamine H3 receptor antagonistsCole, D. C. / Gross, J. L. / Comery, T. A. / Aschmies, S. / Hirst, W. D. / Kelley, C. / Kim, J. I. / Kubek, K. / Ning, X. / Platt, B. J. et al. | 2010
- 1241
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Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligandsGhosh, Arun K. / Gemma, Sandra / Simoni, Elena / Baldridge, Abigail / Walters, D. Eric / Ide, Kazuhiko / Tojo, Yasushi / Koh, Yasuhiro / Amano, Masayuki / Mitsuya, Hiroaki et al. | 2009
- 1247
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Hybrid anticancer agents: Isothiocyanate–progesterone conjugates as chemotherapeutic agents and insights into their cytotoxicitiesAdsule, Shreelekha / Banerjee, Sanjeev / Ahmed, Fakhara / Padhye, Subhash / Sarkar, Fazlul H. et al. | 2009
- 1252
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Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPARα selectiveBhurruth-Alcor, Yushma / Rost, Therese H. / Jorgensen, Michael R. / Rajender / Müller, Melanie / Skorve, Jon / Berge, Rolf K. / Miller, Andrew D. et al. | 2009
- 1252
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Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPARa selectiveBhurruth-Alcor, Y. / Rost, T. H. / Jorgensen, M. R. / Muller, M. / Skorve, J. / Berge, R. K. / Miller, A. D. et al. | 2010
- 1256
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Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056)Weng, Zhijie / Li, Jianqi et al. | 2009
- 1260
-
Solution structural investigation and conformation–activity relationship of BAM8-22 by NMR and molecular dynamics simulationsLv, Guohua / Dong, Shouliang et al. | 2009
- 1263
-
Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugsMao, Jialin / Yuan, Hai / Wang, Yuehong / Wan, Baojie / Pak, Dennis / He, Rong / Franzblau, Scott G. et al. | 2009
- 1269
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Piperazinyl pyrimidine derivatives as potent g-secretase modulatorsRivkin, A. / Ahearn, S. P. / Chichetti, S. M. / Kim, Y. R. / Li, C. / Rosenau, A. / Kattar, S. D. / Jung, J. / Shah, S. / Hughes, B. L. et al. | 2010
- 1269
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Piperazinyl pyrimidine derivatives as potent γ-secretase modulatorsRivkin, Alexey / Ahearn, Sean P. / Chichetti, Stephanie M. / Kim, Yoona R. / Li, Chaomin / Rosenau, Andrew / Kattar, Sam D. / Jung, Joon / Shah, Sanjiv / Hughes, Bethany L. et al. | 2009
- 1272
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Oxime Carbamate—Discovery of a series of novel FAAH inhibitorsSit, S.Y. / Conway, Charles M. / Xie, Kai / Bertekap, Robert / Bourin, Clotilde / Burris, Kevin D. et al. | 2009
- 1278
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Diaryl piperidines as CB1 receptor antagonistsScott, Jack D. / Li, Sarah W. / Wang, Hongwu / Xia, Yan / Jayne, Charles L. / Miller, Michael W. / Duffy, Ruth A. / Boykow, George C. / Kowalski, Timothy J. / Spar, Brian D. et al. | 2009
- 1284
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A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODHCowen, Deborah / Bedingfield, Paul / McConkey, Glenn A. / Fishwick, Colin W.G. / Johnson, A. Peter et al. | 2009
- 1288
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Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 9-oxo-9H-fluorene ringKemnitzer, William / Sirisoma, Nilantha / Jiang, Songchun / Kasibhatla, Shailaja / Crogan-Grundy, Candace / Tseng, Ben / Drewe, John / Cai, Sui Xiong et al. | 2009
- 1293
-
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategyVelcicky, Juraj / Feifel, Roland / Hawtin, Stuart / Heng, Richard / Huppertz, Christine / Koch, Guido / Kroemer, Markus / Moebitz, Henrik / Revesz, Laszlo / Scheufler, Clemens et al. | 2009
- 1298
-
Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonistsZhou, Changyou / Tang, Cheng / Chang, Eric / Ge, Min / Lin, Songnian / Cline, Eric / Tan, Carina P. / Feng, Yue / Zhou, Yun-Ping / Eiermann, George J. et al. | 2009
- 1302
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Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels–Alder chemistryYan, Shanshan / Miller, Marvin J. / Wencewicz, Timothy A. / Möllmann, Ute et al. | 2009
- 1306
-
Piperidine-derived γ-secretase modulatorsHall, Adrian / Elliott, Richard L. / Giblin, Gerard M.P. / Hussain, Ishrut / Musgrave, James / Naylor, Alan / Sasse, Rosemary / Smith, Beverley et al. | 2009
- 1306
-
Piperidine-derived g-secretase modulatorsHall, A. / Elliott, R. L. / Giblin, G. M. / Hussain, I. / Musgrave, J. / Naylor, A. / Sasse, R. / Smith, B. et al. | 2010
- 1312
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Gomphostenins: Two new antimalarial compounds from the leaves of Gomphostemma niveumSathe, Manisha / Kaushik, M.P. et al. | 2009
- IFC
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Editorial board| 2010