2,3,5-Trisubstituted pyridines as selective AKT inhibitors—Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity (Englisch)
- Neue Suche nach: Lin, Hong
- Neue Suche nach: Yamashita, Dennis S.
- Neue Suche nach: Zeng, Jin
- Neue Suche nach: Xie, Ren
- Neue Suche nach: Wang, Wenyong
- Neue Suche nach: Nidarmarthy, Sirishkumar
- Neue Suche nach: Luengo, Juan I.
- Neue Suche nach: Rhodes, Nelson
- Neue Suche nach: Knick, Victoria B.
- Neue Suche nach: Choudhry, Anthony E.
- Neue Suche nach: Lai, Zhihong
- Neue Suche nach: Minthorn, Elisabeth A.
- Neue Suche nach: Strum, Susan L.
- Neue Suche nach: Wood, Edgar R.
- Neue Suche nach: Elkins, Patricia A.
- Neue Suche nach: Concha, Nestor O.
- Neue Suche nach: Heerding, Dirk A.
- Neue Suche nach: Lin, Hong
- Neue Suche nach: Yamashita, Dennis S.
- Neue Suche nach: Zeng, Jin
- Neue Suche nach: Xie, Ren
- Neue Suche nach: Wang, Wenyong
- Neue Suche nach: Nidarmarthy, Sirishkumar
- Neue Suche nach: Luengo, Juan I.
- Neue Suche nach: Rhodes, Nelson
- Neue Suche nach: Knick, Victoria B.
- Neue Suche nach: Choudhry, Anthony E.
- Neue Suche nach: Lai, Zhihong
- Neue Suche nach: Minthorn, Elisabeth A.
- Neue Suche nach: Strum, Susan L.
- Neue Suche nach: Wood, Edgar R.
- Neue Suche nach: Elkins, Patricia A.
- Neue Suche nach: Concha, Nestor O.
- Neue Suche nach: Heerding, Dirk A.
In:
Bioorganic and Medicinal Chemistry Letters
;
20
, 2
;
673-678
;
2009
-
ISSN:
- Aufsatz (Zeitschrift) / Elektronische Ressource
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Titel:2,3,5-Trisubstituted pyridines as selective AKT inhibitors—Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity
-
Beteiligte:Lin, Hong ( Autor:in ) / Yamashita, Dennis S. ( Autor:in ) / Zeng, Jin ( Autor:in ) / Xie, Ren ( Autor:in ) / Wang, Wenyong ( Autor:in ) / Nidarmarthy, Sirishkumar ( Autor:in ) / Luengo, Juan I. ( Autor:in ) / Rhodes, Nelson ( Autor:in ) / Knick, Victoria B. ( Autor:in ) / Choudhry, Anthony E. ( Autor:in )
-
Erschienen in:Bioorganic and Medicinal Chemistry Letters ; 20, 2 ; 673-678
-
Verlag:
- Neue Suche nach: Elsevier Ltd
-
Erscheinungsdatum:16.11.2009
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Format / Umfang:6 pages
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ISSN:
-
DOI:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Elektronische Ressource
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Sprache:Englisch
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Schlagwörter:
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Datenquelle:
Inhaltsverzeichnis – Band 20, Ausgabe 2
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Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1prime-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4prime-piperidine]Uto, Y. / Kiyotsuka, Y. / Ueno, Y. / Miyazawa, Y. / Kurata, H. / Ogata, T. / Deguchi, T. / Yamada, M. / Watanabe, N. / Konishi, M. et al. | 2010
- 755
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Fluorinated piperidine acetic acids as g-secretase modulatorsStanton, M. G. / Hubbs, J. / Sloman, D. / Hamblett, C. / Andrade, P. / Angagaw, M. / Bi, G. / Black, R. M. / Crispino, J. / Cruz, J. C. et al. | 2010
- 755
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Fluorinated piperidine acetic acids as γ-secretase modulatorsStanton, Matthew G. / Hubbs, Jed / Sloman, David / Hamblett, Christopher / Andrade, Paula / Angagaw, Minilik / Bi, Grace / Black, Regina M. / Crispino, Jamie / Cruz, Jonathan C. et al. | 2009
- 759
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The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2D’Alessandro, Pier L. / Corti, Corrado / Roth, Adelheid / Ugolini, Annarosa / Sava, Anna / Montanari, Dino / Bianchi, Federica / Garland, Stephen L. / Powney, Ben / Koppe, Emma L. et al. | 2009
- 763
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Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profilesNishizawa, Rena / Nishiyama, Toshihiko / Hisaichi, Katsuya / Hirai, Keisuke / Habashita, Hiromu / Takaoka, Yoshikazu / Tada, Hideaki / Sagawa, Kenji / Shibayama, Shiro / Maeda, Kenji et al. | 2009
- 767
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Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substratesKrzysiak, Amanda J. / Aditya, Animesh V. / Hougland, James L. / Fierke, Carol A. / Gibbs, Richard A. et al. | 2009
- 771
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Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]Robarge, Kirk D. / Brunton, Shirley A. / Castanedo, Georgette M. / Cui, Yong / Dina, Michael S. / Goldsmith, Richard / Gould, Stephen E. / Guichert, Oivin / Gunzner, Janet L. / Halladay, Jason et al. | 2009
- 772
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Corrigendum to “N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration” [Bioorg. Med. Chem. Lett. 19 (2009) 5078]Wakenhut, Florian / Allan, Gill A. / Fish, Paul V. / Fray, M. Jonathan / Harrison, Anthony C. / McCoy, Rachel / Phillips, Stephen C. / Ryckmans, Thomas / Stobie, Alan / Westbrook, Dominique et al. | 2009
- 773
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Corrigendum to “Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 6307]Boezio, Alessandro A. / Berry, Loren / Albrecht, Brian K. / Bauer, David / Bellon, Steven F. / Bode, Christiane / Chen, April / Choquette, Deborah / Dussault, Isabelle / Fang, Mei et al. | 2009
- IFC
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Editorial board| 2009