1-(3-Deoxy-3-fluoro-β-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies (Englisch)
- Neue Suche nach: Tsirkone, Vicky G.
- Neue Suche nach: Tsoukala, Evangelia
- Neue Suche nach: Lamprakis, Christos
- Neue Suche nach: Manta, Stella
- Neue Suche nach: Hayes, Joseph M.
- Neue Suche nach: Skamnaki, Vicky T.
- Neue Suche nach: Drakou, Christina
- Neue Suche nach: Zographos, Spyros E.
- Neue Suche nach: Komiotis, Dimitri
- Neue Suche nach: Leonidas, Demetres D.
- Neue Suche nach: Tsirkone, Vicky G.
- Neue Suche nach: Tsoukala, Evangelia
- Neue Suche nach: Lamprakis, Christos
- Neue Suche nach: Manta, Stella
- Neue Suche nach: Hayes, Joseph M.
- Neue Suche nach: Skamnaki, Vicky T.
- Neue Suche nach: Drakou, Christina
- Neue Suche nach: Zographos, Spyros E.
- Neue Suche nach: Komiotis, Dimitri
- Neue Suche nach: Leonidas, Demetres D.
In:
Bioorganic and Medicinal Chemistry
;
18
, 10
;
3413-3425
;
2010
-
ISSN:
- Aufsatz (Zeitschrift) / Elektronische Ressource
-
Titel:1-(3-Deoxy-3-fluoro-β-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies
-
Beteiligte:Tsirkone, Vicky G. ( Autor:in ) / Tsoukala, Evangelia ( Autor:in ) / Lamprakis, Christos ( Autor:in ) / Manta, Stella ( Autor:in ) / Hayes, Joseph M. ( Autor:in ) / Skamnaki, Vicky T. ( Autor:in ) / Drakou, Christina ( Autor:in ) / Zographos, Spyros E. ( Autor:in ) / Komiotis, Dimitri ( Autor:in ) / Leonidas, Demetres D. ( Autor:in )
-
Erschienen in:Bioorganic and Medicinal Chemistry ; 18, 10 ; 3413-3425
-
Verlag:
- Neue Suche nach: Elsevier Ltd
-
Erscheinungsdatum:01.04.2010
-
Format / Umfang:13 pages
-
ISSN:
-
DOI:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Elektronische Ressource
-
Sprache:Englisch
-
Schlagwörter:GP , glycogen phosphorylase, 1,4-α-d-glucan: orthophosphate α-glucosyltransferase (EC 2.4.1.1) , GPb , rabbit muscle glycogen phosphorylase b , GPa , rabbit muscle glycogen phosphorylase a , hlGPa , human liver glycogen phosphorylase a , PLP , pyridoxal 5′-phosphate , glucose , α-d-glucose , Glc-1-P , α-d-glucose 1-phosphate , Glycogen phosphorylase , Diabetes , X-ray crystallography , Structure-assisted inhibitor design , Glide docking , Quantum mechanics polarized ligand (QPLD) docking , Tautomers
-
Datenquelle:
Inhaltsverzeichnis – Band 18, Ausgabe 10
Zeige alle Jahrgänge und Ausgaben
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
- 3353
-
Graphical contents list| 2010
- 3361
-
Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthaseJarmuła, Adam / Frączyk, Tomasz / Cieplak, Piotr / Rode, Wojciech et al. | 2010
- 3371
-
Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivativesAbdelhafez, Omaima M. / Amin, Kamelia M. / Batran, Rasha Z. / Maher, Timothy J. / Nada, Somaia A. / Sethumadhavan, Shalini et al. | 2010
- 3379
-
Bioactive norditerpenoids from the soft coral Sinularia gyrosaCheng, Shi-Yie / Chuang, Cheng-Ta / Wen, Zhi-Hong / Wang, Shang-Kwei / Chiou, Shu-Fen / Hsu, Chi-Hsin / Dai, Chang-Feng / Duh, Chang-Yih et al. | 2010
- 3387
-
Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitorsBüttner, Anita / Cottin, Thomas / Xu, Jing / Tzagkaroulaki, Lito / Giannis, Athanassios et al. | 2010
- 3403
-
Structure–activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinaseKim, Young Ah / Rawal, Ravindra K. / Yoo, Jakyung / Sharon, Ashoke / Jha, Ashok K. / Chu, Chung K. / Rais, Reem H. / Al Safarjalani, Omar N. / Naguib, Fardos N.M. / el Kouni, Mahmoud H. et al. | 2010
- 3413
-
1-(3-Deoxy-3-fluoro-β-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studiesTsirkone, Vicky G. / Tsoukala, Evangelia / Lamprakis, Christos / Manta, Stella / Hayes, Joseph M. / Skamnaki, Vicky T. / Drakou, Christina / Zographos, Spyros E. / Komiotis, Dimitri / Leonidas, Demetres D. et al. | 2010
- 3413
-
1-(3-Deoxy-3-fluoro-b-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studiesTsirkone, V. G. / Tsoukala, E. / Lamprakis, C. / Manta, S. / Hayes, J. M. / Skamnaki, V. T. / Drakou, C. / Zographos, S. E. / Komiotis, D. / Leonidas, D. D. et al. | 2010
- 3426
-
Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT1 melatoninergic ligandsMésangeau, Christophe / Pérès, Basile / Descamps-François, Carole / Chavatte, Philippe / Audinot, Valérie / Coumailleau, Sophie / Boutin, Jean A. / Delagrange, Philippe / Bennejean, Caroline / Renard, Pierre et al. | 2010
- 3437
-
Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor α and β agonistsPoutiainen, Pekka K. / Venäläinen, Tuomas A. / Peräkylä, Mikael / Matilainen, Juha M. / Väisänen, Sami / Honkakoski, Paavo / Laatikainen, Reino / Pulkkinen, Juha T. et al. | 2010
- 3437
-
Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor a and b agonistsPoutiainen, P. K. / Venalainen, T. A. / Perakyla, M. / Matilainen, J. M. / Vaisanen, S. / Honkakoski, P. / Laatikainen, R. / Pulkkinen, J. T. et al. | 2010
- 3448
-
Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agentsLing, Yong / Ye, Xiaolei / Ji, Hui / Zhang, Yihua / Lai, Yisheng / Peng, Sixun / Tian, Jide et al. | 2010
- 3457
-
Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteinsPei, Zhichao / Gustavsson, Tobias / Roth, Robert / Frejd, Torbjörn / Hägerhäll, Cecilia et al. | 2010
- 3467
-
Isolation and characterization of enantioselective DNA aptamers for ibuprofenKim, Yeon Seok / Hyun, Chang Jun / Kim, In Ae / Gu, Man Bock et al. | 2010
- 3474
-
RNA interference with 2′,4′-bridged nucleic acid analoguesAbdur Rahman, S.M. / Sato, Hiroyuki / Tsuda, Naoto / Haitani, Sunao / Narukawa, Keisuke / Imanishi, Takeshi / Obika, Satoshi et al. | 2010
- 3474
-
RNA interference with 2prime,4prime-bridged nucleic acid analoguesAbdur Rahman, S. M. / Sato, H. / Tsuda, N. / Haitani, S. / Narukawa, K. / Imanishi, T. / Obika, S. et al. | 2010
- 3481
-
Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitorsLeiris, Simon J. / Khdour, Omar M. / Segerman, Zachary J. / Tsosie, Krystal S. / Chapuis, Jean-Charles / Hecht, Sidney M. et al. | 2010
- 3494
-
Novel estrone mimetics with high 17β-HSD1 inhibitory activityOster, Alexander / Klein, Tobias / Werth, Ruth / Kruchten, Patricia / Bey, Emmanuel / Negri, Matthias / Marchais-Oberwinkler, Sandrine / Frotscher, Martin / Hartmann, Rolf W. et al. | 2010
- 3494
-
Novel estrone mimetics with high 17b-HSD1 inhibitory activityOster, A. / Klein, T. / Werth, R. / Kruchten, P. / Bey, E. / Negri, M. / Marchais-Oberwinkler, S. / Frotscher, M. / Hartmann, R. W. et al. | 2010
- 3506
-
Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activityBiagini, Pierfrancesco / Biancalani, Claudio / Graziano, Alessia / Cesari, Nicoletta / Giovannoni, Maria Paola / Cilibrizzi, Agostino / Piaz, Vittorio Dal / Vergelli, Claudia / Crocetti, Letizia / Delcanale, Maurizio et al. | 2010
- 3518
-
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthaseTalukdar, Arindam / Morgunova, Ekaterina / Duan, Jianxin / Meining, Winfried / Foloppe, Nicolas / Nilsson, Lennart / Bacher, Adelbert / Illarionov, Boris / Fischer, Markus / Ladenstein, Rudolf et al. | 2010
- 3535
-
Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinansCzakó, Barbara / Marton, János / Berényi, Sándor / Gach, Katarzyna / Fichna, Jakub / Storr, Martin / Tóth, Géza / Sipos, Attila / Janecka, Anna et al. | 2010
- 3543
-
Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agentsBelluti, Federica / Fontana, Gabriele / Bo, Laura Dal / Carenini, Nives / Giommarelli, Chiara / Zunino, Franco et al. | 2010
- 3551
-
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazolesBranowska, Danuta / Farahat, Abdelbasset A. / Kumar, Arvind / Wenzler, Tanja / Brun, Reto / Liu, Yang / Wilson, W. David / Boykin, David W. et al. | 2010
- 3559
-
NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and IIEkinci, Deniz / Çavdar, Hüseyin / Talaz, Oktay / Şentürk, Murat / Supuran, Claudiu T. et al. | 2010
- 3564
-
Targeting a ruthenium complex to the nucleus with short peptidesPuckett, Cindy A. / Barton, Jacqueline K. et al. | 2010
- 3570
-
Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-dionesThirupathi Reddy, Y. / Narsimha Reddy, P. / Koduru, Srinivas / Damodaran, Chendil / Crooks, Peter A. et al. | 2010
- 3575
-
Synthesis and biological activity of N4-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agentsGangjee, Aleem / Kurup, Sonali / Ihnat, Michael A / Thorpe, Jessica E. / Shenoy, Satyendra S. et al. | 2010
- 3588
-
Design of new potent and selective secretory phospholipase A2 inhibitors. 6-Synthesis, structure–activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivativesMeddad-Belhabich, Nadia / Aoun, Darina / Djimdé, Atimé / Redeuilh, Catherine / Dive, Georges / Massicot, France / Chau, François / Heymans, Françoise / Lamouri, Aazdine et al. | 2010
- 3601
-
In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et PerrNgoumfo, Rostand M. / Jouda, Jean-Bosco / Mouafo, Ferdinand T. / Komguem, Justin / Mbazoa, Céline D. / Shiao, Tze Chieh / Choudhary, Mohammed I. / Laatsch, Hartmut / Legault, Jean / Pichette, André et al. | 2010
- 3606
-
Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148Mackman, Richard L. / Ray, Adrian S. / Hui, Hon C. / Zhang, Lijun / Birkus, Gabriel / Boojamra, Constantine G. / Desai, Manoj C. / Douglas, Janet L. / Gao, Ying / Grant, Deborah et al. | 2010
- 3618
-
Silica-supported fluoroboric acid (HBF4–SiO2) catalyzed highly productive synthesis of thiomorpholides as activators of l-asparaginase as well as the antioxidant agentBandgar, Babasaheb P. / Gawande, Shrikant S. / Warangkar, Suchita C. / Totre, Jalinder V. et al. | 2010
- 3625
-
Corrigendum to “Chemo-enzymatic synthesis of 1,4-oxazepanyl sugar as potent inhibitor of chitinase” [Bioorg. Med. Chem. 14 (2006) 2446]Huang, Gang-Liang / Zhang, Da-Wei / Zhao, Hong-Juan / Zhang, Hou-Cheng / Wang, Peng-George et al. | 2009
- IFC
-
Editorial board| 2010