Primary Anastomosis Versus End-Ostomy in Left-Sided Colonic and Proximal Rectal Cancer Surgery in the Elderly Dutch Population: A Propensity Score Matched Analysis (Englisch)
Freier Zugriff
- Neue Suche nach: van Loon, Yu Ting
- Weitere Informationen zu van Loon, Yu Ting:
- https://orcid.org/0000-0002-9978-1091
- Neue Suche nach: van Erning, Felice N.
- Neue Suche nach: Maas, Huub A.
- Neue Suche nach: Stassen, Laurents P. S.
- Neue Suche nach: Zimmerman, David D. E.
- Neue Suche nach: van Loon, Yu Ting
- Weitere Informationen zu van Loon, Yu Ting:
- https://orcid.org/0000-0002-9978-1091
- Neue Suche nach: van Erning, Felice N.
- Neue Suche nach: Maas, Huub A.
- Neue Suche nach: Stassen, Laurents P. S.
- Neue Suche nach: Zimmerman, David D. E.
In:
Annals of Surgical Oncology
;
28
, 12
; 7450-7460
;
2021
-
ISSN:
- Aufsatz (Zeitschrift) / Elektronische Ressource
-
Titel:Primary Anastomosis Versus End-Ostomy in Left-Sided Colonic and Proximal Rectal Cancer Surgery in the Elderly Dutch Population: A Propensity Score Matched Analysis
-
Beteiligte:van Loon, Yu Ting ( Autor:in ) / van Erning, Felice N. ( Autor:in ) / Maas, Huub A. ( Autor:in ) / Stassen, Laurents P. S. ( Autor:in ) / Zimmerman, David D. E. ( Autor:in )
-
Erschienen in:Annals of Surgical Oncology ; 28, 12 ; 7450-7460
-
Verlag:
- Neue Suche nach: Springer International Publishing
- Neue Suche nach: Springer
-
Erscheinungsort:Berlin [u.a.]
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Erscheinungsdatum:2021
-
ISSN:
-
ZDBID:
-
DOI:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Elektronische Ressource
-
Sprache:Englisch
- Neue Suche nach: 44.81 / 44.65
- Weitere Informationen zu Basisklassifikation
-
Klassifikation:
-
Datenquelle:
Inhaltsverzeichnis – Band 28, Ausgabe 12
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- 7506
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Early Identification of Residual Disease After Neuroendocrine Tumor Resection Using a Liquid Biopsy Multigenomic mRNA Signature (NETest)Modlin, Irvin M. / Kidd, Mark / Oberg, Kjell / Falconi, Massimo / Filosso, Pier Luigi / Frilling, Andrea / Malczewska, Anna / Salem, Ronald / Toumpanakis, Christos / Laskaratos, Faidon-Marios et al. | 2021
- 7518
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ASO Author Reflections: A Genomic Blood Test (NETest) that Informs you if the Patient has a Recurrence at the First Postoperative VisitModlin, Irvin M. et al. | 2021
- 7520
-
Multimodality Treatment Improves Locoregional Control, Progression-Free and Overall Survival in Patients with Anaplastic Thyroid Cancer: A Retrospective Cohort Study Comparing Oncological Outcomes and Morbidity between Multimodality Treatment and Limited TreatmentJonker, Pascal K. C. / Turchini, John / Kruijff, Schelto / Lin, Jia Feng / Gill, Anthony J. / Eade, Thomas / Aniss, Ahmad / Clifton-Bligh, Roderick / Learoyd, Diana / Robinson, Bruce et al. | 2021
- 7531
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ASO Author Reflections: Multimodality Treatment in Anaplastic Thyroid Cancer: Improving Survival Outcomes and Balancing Treatment Related ComplicationsJonker, Pascal K. C. / Sywak, Mark et al. | 2021
- 7533
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Is Postoperative Adjuvant Radioactive Iodine Ablation Therapy Always Necessary for Intermediate-Risk Papillary Thyroid Cancer Patients With Central Neck Metastasis?Han, Kyujin / Noh, Hae Min / Jeong, Ha Min / Lim, Young Chang et al. | 2021
- 7545
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Evaluation of Minimal Important Difference and Responder Definition in the EORTC QLQ-PAN26 Module for Assessing Health-Related Quality of Life in Patients with Surgically Resected Pancreatic AdenocarcinomaReni, Michele / Braverman, Julia / Hendifar, Andrew / Li, Chung-Pin / Macarulla, Teresa / Oh, Do-Youn / Riess, Hanno / Tempero, Margaret / Lu, Brian / Marcus, James et al. | 2021
- 7555
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Chemotherapy After Diagnosis of Malignant Bowel Obstruction is Associated with Superior Survival for Medicare Patients with Advanced MalignancyBateni, Sarah B. / Gingrich, Alicia A. / Kirane, Amanda R. / Sauder, Candice A. M. / Gholami, Sepideh / Bold, Richard J. / Meyers, Frederick J. / Canter, Robert J. et al. | 2021
- 7564
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ASO Author Reflections: The Central Role of Chemotherapy in Patients with Advanced Cancer Recently Diagnosed with Malignant Bowel ObstructionBateni, Sarah B. / Canter, Robert J. et al. | 2021
- 7566
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Impact of Residential Racial Integration on Postoperative Outcomes Among Medicare Beneficiaries Undergoing Resection for CancerParo, Alessandro / Dalmacy, Djhenne / Madison Hyer, J. / Tsilimigras, Diamantis I. / Diaz, Adrian / Pawlik, Timothy M. et al. | 2021
- 7575
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ASO Author Reflections: Impact of Residential Racial Integration on Postoperative Outcomes Among Medicare Beneficiaries Undergoing Resection for CancerParo, Alessandro / Pawlik, Timothy M. et al. | 2021
- 7577
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Development and Validation of a Short Version of the Metric for the Observation of Decision-Making in Multidisciplinary Tumor Boards: MODe-LiteLamb, B. W. / Miah, S. / Skolarus, T. A. / Stewart, G. D. / Green, J. S. A. / Sevdalis, N. / Soukup, T. et al. | 2021
- 7589
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ASO Author Reflections: The Pursuit of Digitalised Quality Improvement Assessment Tools for Cancer Multidisciplinary TeamsLamb, Benjamin W. / Miah, S. / Soukup, T. et al. | 2021
- 7591
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Association Between Adjuvant Therapy and Survival in Stage II–III Endometrial Cancer: Influence of Malignant Peritoneal CytologyMatsuo, Koji / Matsuzaki, Shinya / Nusbaum, David J. / Roman, Lynda D. / Wright, Jason D. / Harter, Philipp / Klar, Maximilian et al. | 2021
- 7604
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ASO Author Reflections: Malignant Peritoneal Cytology, Adjuvant Therapy Choice, and Survival in Advanced Endometrial CancerMatsuzaki, Shinya / Miller, Heather / Klar, Maximilian / Matsuo, Koji et al. | 2021
- 7606
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Clinical Significance of Mesenteric Lymph Node Involvement in the Pattern of Liver Metastasis in Patients with Ovarian CancerTanaka, Kana / Shimada, Yoshifumi / Nishino, Koji / Yoshihara, Kosuke / Nakano, Masato / Kameyama, Hitoshi / Enomoto, Takayuki / Wakai, Toshifumi et al. | 2021
- 7614
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ASO Author Reflections: Clinical Significance of Mesenteric Lymph Node Involvement in Patients with Ovarian CancerShimada, Yoshifumi / Tanaka, Kana / Nishino, Koji / Yoshihara, Kosuke / Nakano, Masato / Kameyama, Hitoshi / Enomoto, Takayuki / Wakai, Toshifumi et al. | 2021
- 7616
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Status of Surgical Management of Borderline Ovarian Tumors in France: are Recommendations Being Followed? Multicentric French Study by the FRANCOGYN GroupLecointre, Lise / Bund, Virginie / Sangnier, Eva / Ouldamer, Lobna / Bendifallah, Sofiane / Koskas, Martin / Bolze, Pierre-Adrien / Collinet, Pierre / Canlorbe, Geoffroy / Touboul, Cyril et al. | 2021
- 7624
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Multi-Institutional Development and External Validation of a Nomogram for Prediction of Extrahepatic Recurrence After Curative-Intent Resection for Hepatocellular CarcinomaWei, Tao / Zhang, Xu-Feng / Xue, Feng / Bagante, Fabio / Ratti, Francesca / Marques, Hugo P. / Silva, Silvia / Soubrane, Olivier / Lam, Vincent / Poultsides, George A. et al. | 2021
- 7634
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ASO Author Reflections: Multi-institutional Development and External Validation of a Nomogram for Prediction of Extrahepatic Recurrence After Curative-Intent Resection for Hepatocellular CarcinomaZhang, Xu-Feng / Pawlik, Timothy M. et al. | 2021
- 7636
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Infiltrative Tumor Borders in Colorectal Liver Metastasis: Should We Enlarge Margin Size?Jayme, Vitoria Ramos / Fonseca, Gilton Marques / Amaral, Isaac Massaud Amim / Coelho, Fabricio Ferreira / Kruger, Jaime Arthur Pirola / Jeismann, Vagner Birk / Pinheiro, Rafael Soares Nunes / de Mello, Evandro Sobroza / Herman, Paulo et al. | 2021
- 7647
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Prediction of Prognosis for cHCC-CC Patients After Surgery: Comparison of Tumor Marker Score Based on AFP, CEA, CA19-9, and Other Clinical StagesHou, Gui-Min / Liu, Hai-ling / Wu, Hong / Zeng, Yong et al. | 2021
- 7661
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ASO Author Reflections: Tumor Marker Score Based on Conventional Tumor Markers (AFP, CEA, and CA19-9) Predicts Prognosis Well for cHCC-CC Patients After SurgeryHou, Gui-Min / Zeng, Yong et al. | 2021
- 7663
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Prognostic Impact of Surgical Intervention After Lenvatinib Treatment for Advanced Hepatocellular CarcinomaShindoh, Junichi / Kawamura, Yusuke / Kobayashi, Yuta / Kobayashi, Masahiro / Akuta, Norio / Okubo, Satoshi / Suzuki, Yoshiyuki / Hashimoto, Masaji et al. | 2021
- 7673
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Serum α-Fetoprotein Levels at Time of Recurrence Predict Post-Recurrence Outcomes Following Resection of Hepatocellular CarcinomaTsilimigras, Diamantis I. / Moris, Dimitrios / Hyer, J. Madison / Bagante, Fabio / Ratti, Francesca / Marques, Hugo P. / Soubrane, Olivier / Lam, Vincent / Poultsides, George A. / Popescu, Irinel et al. | 2021
- 7684
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ASO Author Reflections: AFP Levels at the Time of Recurrence Predict Post-recurrence Outcomes Irrespective of Modality Used to Treat RecurrenceTsilimigras, Diamantis I. / Pawlik, Timothy M. et al. | 2021
- 7686
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Long-Term Outcomes of Anatomic Versus Nonanatomic Resection in Hepatocellular Carcinoma Patients with Bile Duct Tumor Thrombus: A Propensity Score Matching AnalysisWu, Jia-Yi / Sun, Ju-Xian / Bai, Yan-Nan / Huang, Xiao-Xiao / Wu, Jun-Yi / Wei, Yong-Gang / Zhang, Zhi-Bo / Zhou, Jian-Yin / Wang, Yao-Dong / Cheng, Shu-Qun et al. | 2021
- 7696
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ASO Author Reflections: Treatment for Hepatocellular Carcinoma with Bile Duct Tumor Thrombus—Anatomic Resection Should Be RecommendedWu, Jia-Yi / Sun, Ju-Xian / Cheng, Shu-Qun / Yan, Mao-Lin et al. | 2021
- 7698
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Failure to Cure Patients with Colorectal Liver Metastases: The Impact of the Liver SurgeonVega, Eduardo A. / Salehi, Omid / Nicolaescu, Diana / Dussom, Edward-Michael / Alarcon, Sylvia V. / Kozyreva, Olga / Simonds, Jana / Schnipper, Deborah / Conrad, Claudius et al. | 2021
- 7707
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Do We Still Need Liver Surgeons in the Treatment of Colorectal Liver Metastases?Vega, Eduardo A. / Freeman, Richard / Conrad, Claudius et al. | 2021
- 7709
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A Prognostic Scoring System to Predict Survival Outcome of Resectable Colorectal Liver Metastases in this Modern EraLiu, Wei / Zhang, Wei / Xu, Ye / Li, Yu-Hong / Xing, Bao-Cai et al. | 2021
- 7719
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Surgery for Bismuth-Corlette Type 4 Perihilar Cholangiocarcinoma: Results from a Western Multicenter Collaborative GroupRuzzenente, Andrea / Bagante, Fabio / Olthof, Pim B. / Aldrighetti, Luca / Alikhanov, Ruslan / Cescon, Matteo / Koerkamp, Bas Groot / Jarnagin, William R. / Nadalin, Silvio / Pratschke, Johann et al. | 2021
- 7730
-
The Role of Surgery in the Treatment of Bismuth–Corlette Type IV Perihilar CholangiocarcinomaAlaimo, Laura / Bagante, Fabio / Ruzzenente, Andrea et al. | 2021
- 7731
-
Repeat hepatectomy versus radiofrequency ablation in management of recurrent hepatocellular carcinoma: an average treatment effect analysisChua, Darren W. / Koh, Ye-Xin / Syn, Nicholas L. / Chuan, Tan Yu / Yao, Teo Jin / Lee, Ser-Yee / Goh, Brian K. P. / Cheow, Peng-Chung / Chung, Alexander Y. / Chan, Chung-Yip et al. | 2021
- 7741
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Kasai-Like Portoenterostomy for Multiple Biliary Duct Reconstruction After Extended Liver Resection of Perihilar CholangiocarcinomaMimmo, Antonio / Tzedakis, Stylianos / Guéroult, Pierre / Belabbas, Dihia / Jeddou, Heithem / Boudjema, Karim et al. | 2021
- 7742
-
Minimally Invasive Versus Open Pancreatectomy for Right-Sided and Left-Sided G1/G2 Nonfunctioning Pancreatic Neuroendocrine Tumors: A Multicenter Matched Analysis with an Inverse Probability of Treatment-Weighting MethodHwang, Ho Kyoung / Song, Ki Byung / Park, Minsu / Kwon, Wooil / Jang, Jin-Young / Heo, Jin Seok / Choi, Dong Wook / Kang, Chang Moo / Park, Joon Seong / Hong, Tae Ho et al. | 2021
- 7759
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Impact of Neoadjuvant Therapy on Survival Following Margin-Positive Resection for Pancreatic CancerChopra, Asmita / Zenati, Mazen / Hogg, Melissa E. / Zeh, Herbert J. / Bartlett, David L. / Bahary, Nathan / Zureikat, Amer H. / Beane, Joal D. et al. | 2021
- 7770
-
ASO Author Reflections: Impact of Neoadjuvant Therapy on Survival After Margin-Positive Resection for Pancreatic CancerChopra, Asmita / Beane, Joal D. et al. | 2021
- 7772
-
Coagulopathy and Venous Thromboembolic Events Following Cytoreductive Surgery and Hyperthermic Intraperitoneal ChemotherapyDranichnikov, Paul / Mahteme, Haile / Cashin, Peter H. / Graf, Wilhelm et al. | 2021
- 7783
-
ASO Author Reflections: Changes in Coagulation Biomarkers and the Risk for Venous Thromboembolism After Cytoreductive Surgery and Hyperthermic Intraperitoneal ChemotherapyDranichnikov, Paul et al. | 2021
- 7784
-
Safe Anastomoses without Ostomies in Cytoreductive Surgery with Heated Intraperitoneal Chemotherapy: Technical Considerations and ModificationsBarrios, Pedro / Ramos, Isabel / Crusellas, Oriol / Sabia, Domenico / Mompart, Sergio / Bijelic, Lana et al. | 2021
- 7793
-
A Near-Zero Anastomotic Leak Rate in Cytoreductive Surgery with Heated Intraperitoneal Chemotherapy is AchievableBarrios, Pedro / Ramos, Isabel / Bijelic, Lana et al. | 2021
- 7795
-
Differences in Sociodemographic Disparities Between Patients Undergoing Surgery for Advanced Colorectal or Ovarian CancerGoldberg, Ellen M. / Berger, Yaniv / Sood, Divya / Kurnit, Katherine C. / Kim, Josephine S. / Lee, Nita K. / Yamada, S. Diane / Turaga, Kiran K. / Eng, Oliver S. et al. | 2021
- 7807
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ASO Author Reflections: Disparities in Access to Cytoreductive SurgeryGoldberg, Ellen M. / Eng, Oliver S. et al. | 2021
- 7809
-
Managing Recurrent Pseudomyxoma Peritonei in 430 Patients After Complete Cytoreduction and HIPEC: A Dilemma for Patients and SurgeonsAhmadi, Nima / Kostadinov, Danko / Sakata, Shinichiro / Ball, William Robert / Gandhi, Jamish / Carr, Norman John / Tzivanakis, Alexios / Dayal, Sanjeev Paul / Mohamed, Faheez / Cecil, Thomas Desmond et al. | 2021
- 7821
-
ASO Author Reflections: Managing Recurrent Pseudomyxoma Peritonei in 430 Patients After Complete Cytoreduction and HIPECAhmadi, Nima / Moran, Brendan J. et al. | 2021
- 7823
-
Perioperative Inpatient Opioid Consumption Following Autologous Free-Flap Breast Reconstruction Patients: An Examination of Risk and Patient-Reported OutcomesNelson, Jonas A. / Polanco, Thais O. / Shamsunder, Meghana G. / Coriddi, Michelle / Matros, Evan / Hicks, Madeleine E. V. / Disa, Joseph J. / Mehrara, Babak J. / Allen, Robert J. / Dayan, Joseph H. et al. | 2021
- 7834
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Use of Vascularized Fibular Epiphyseal Transfer with Massive Bone Allograft for Proximal Humeral Reconstruction in Children with Bone SarcomaLu, Yajie / Xiao, Xin / Li, Minghui / Chen, Guojing / Huang, Mengquan / Ji, Chuanlei / Wang, Zhen / Li, Jing et al. | 2021
- 7842
-
Development and Psychometric Validation of the BREAST-Q Sensation Module for Women Undergoing Post-Mastectomy Breast ReconstructionTsangaris, Elena / Klassen, Anne F. / Kaur, Manraj N. / Voineskos, Sophocles / Bordeleau, Louise / Zhong, Toni / Broyles, Justin / Pusic, Andrea L. et al. | 2021
- 7854
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Analysis of Differentiation Changes and Outcomes at Time of First Recurrence of Retroperitoneal Liposarcoma by Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)Nessim, Carolyn / Raut, Chandrajit P. / Callegaro, Dario / Barretta, Francesco / Miceli, Rosalba / Fairweather, Mark / Blay, Jean-Yves / Strauss, Dirk / Rutkowski, Piotr / Ahuja, Nita et al. | 2021
- 7864
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Impact of Secondary Aneurysmal Bone Cysts on Survival of Patients with Enneking Stage IIB Extremity Osteosarcoma: A Propensity Score Matching AnalysisZhou, Chenliang / Qian, Guowei / Wang, Yiyun / Li, Hongtao / Yu, Wenxi / Zheng, Shuier / Shen, Zan / Wang, Yonggang et al. | 2021
- 7873
-
Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: An Updated Consensus Approach from the Transatlantic Australasian RPS Working GroupSwallow, Carol J. / Strauss, Dirk C. / Bonvalot, Sylvie / Rutkowski, Piotr / Desai, Anant / Gladdy, Rebecca A. / Gonzalez, Ricardo / Gyorki, David E. / Fairweather, Mark / van Houdt, Winan J. et al. | 2021
- 7889
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ASO Author Reflections: Standardization in the Management of Retroperitoneal Sarcoma Through International CollaborationGyorki, David E. / Roland, Christina L. et al. | 2021
- 7891
-
Late Local Recurrence and Metastasis in Soft Tissue Sarcoma of the Extremities and Trunk Wall: Better Outcome After Treatment of Late Events Compared with Earlyvon Konow, Arvid / Ghanei, Iman / Styring, Emelie / Vult von Steyern, Fredrik et al. | 2021
- 7903
-
Staging and Surveillance of Myxoid Liposarcoma: Follow-up Assessment and the Metastatic Pattern of 169 Patients Suggests Inadequacy of Current Practice StandardsVisgauss, Julia D. / Wilson, David A. / Perrin, David L / Colglazier, Roy / French, Robert / Mattei, Jean-Camille / Griffin, Anthony M. / Wunder, Jay S. / Ferguson, Peter C. et al. | 2021
- 7912
-
Disease-free Interval Is Associated with Oncologic Outcomes in Patients with Recurrent Gastrointestinal Stromal TumorSutton, Thomas L. / Walker, Brett S. / Billingsley, Kevin G. / Sheppard, Brett C. / Corless, Christopher L. / Heinrich, Michael C. / Mayo, Skye C. et al. | 2021
- 7921
-
ASO Author Reflections: The Disease-Free Interval is Associated with Oncologic Outcomes for Patients with Recurrent Gastrointestinal Stromal TumorSutton, Thomas L. / Heinrich, Michael C. / Mayo, Skye C. et al. | 2021
- 7923
-
Management of Soft Tissue Sarcomas in Extremities: Variation in Treatment Recommendations and Surveillance According to Specialty and ContinentAcem, Ibtissam / Smit, Merel M. / Verhoef, Cornelis / van Houdt, Winan J. / Haas, Rick L. / van der Hage, Jos A. / Grünhagen, Dirk J. / van de Sande, Michiel A. J. et al. | 2021
- 7937
-
ASO Author Reflections: Towards Patient-Tailored Management of Extremity Soft Tissue SarcomaAcem, I. / van de Sande, M. A. J. / Verhoef, C. et al. | 2021
- 7939
-
Cumulative Burden of Postoperative Complications in Patients Undergoing Surgery for Primary Retroperitoneal SarcomaTirotta, Fabio / Parente, Alessandro / Hodson, James / Desai, Anant / Almond, L. Max / Ford, Samuel J. et al. | 2021
- 7950
-
Containing Cumulative Postoperative Morbidity in Patients with Retroperitoneal Sarcoma May Improve Long-Term PrognosisTirotta, Fabio / Ford, Samuel J. et al. | 2021
- 7952
-
Nutritional Predictors of Wound Infection in Patients with Lower Extremity Soft Tissue SarcomaKline, Adam / Kamalapathy, Pramod / Bruce, Katharine / Raskin, Kevin / Schwab, Joseph / Lozano-Calderón, Santiago et al. | 2021
- 7961
-
Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database StudyEvans, Daniel R. / Lazarides, Alexander L. / Cullen, Mark M. / Visgauss, Julia D. / Somarelli, Jason A. / Blazer, Dan G. / Brigman, Brian E. / Eward, William C. et al. | 2021
- 7973
-
MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular CarcinomaEl-mezayen, Hatem / Yamamura, Kensuke / Yusa, Toshihiko / Nakao, Yosuke / Uemura, Norio / Kitamura, Fumimasa / Itoyama, Rumi / Yamao, Takanobu / Higashi, Takaaki / Hayashi, Hiromitsu et al. | 2021
- 7983
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Diagnostic Immunostaining and Tumor Markers Predict the Prognosis of Esophageal Neuroendocrine Cell Carcinoma PatientsSohda, Makoto / Saeki, Hiroshi / Kuwano, Hiroyuki / Miyazaki, Tatsuya / Yokobori, Takehiko / Sano, Akihiko / Sakai, Makoto / Kakeji, Yoshihiro / Toh, Yasushi / Doki, Yuichiro et al. | 2021
- 7990
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Clinical Significance of Serum Squamous Cell Carcinoma Antigen for Patients with Recurrent Esophageal Squamous Cell CarcinomaKanie, Yasukazu / Okamura, Akihiko / Maruyama, Suguru / Sakamoto, Kei / Fujiwara, Daisuke / Kanamori, Jun / Imamura, Yu / Watanabe, Masayuki et al. | 2021
- 7997
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ASO Author Reflections: Serum Squamous Cell Carcinoma Antigen in Recurrent Esophageal Squamous Cell CarcinomaKanie, Yasukazu / Okamura, Akihiko / Watanabe, Masayuki et al. | 2021
- 7999
-
Mucinous Colorectal Cancer is Associated With Expression of the TIM-3 Immune Checkpoint Independently of Microsatellite Instability (MSI) StatusO’Connell, Emer / Salvucci, Manuela / Reynolds, Ian S. / McNamara, Deborah A. / Burke, John P. / Prehn, Jochen H. M. et al. | 2021