Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires (Unbekannt)
Freier Zugriff
- Neue Suche nach: Hsiao, Yi-Chun
- Neue Suche nach: Chen, Ying-Jiun J.
- Neue Suche nach: Goldstein, Leonard D.
- Neue Suche nach: Wu, Jia
- Neue Suche nach: Lin, Zhonghua
- Neue Suche nach: Schneider, Kellen
- Neue Suche nach: Chaudhuri, Subhra
- Neue Suche nach: Antony, Aju
- Neue Suche nach: Bajaj Pahuja, Kanika
- Neue Suche nach: Modrusan, Zora
- Neue Suche nach: Seshasayee, Dhaya
- Neue Suche nach: Seshagiri, Somasekar
- Neue Suche nach: Hötzel, Isidro
- Neue Suche nach: Hsiao, Yi-Chun
- Neue Suche nach: Chen, Ying-Jiun J.
- Neue Suche nach: Goldstein, Leonard D.
- Neue Suche nach: Wu, Jia
- Neue Suche nach: Lin, Zhonghua
- Neue Suche nach: Schneider, Kellen
- Neue Suche nach: Chaudhuri, Subhra
- Neue Suche nach: Antony, Aju
- Neue Suche nach: Bajaj Pahuja, Kanika
- Neue Suche nach: Modrusan, Zora
- Neue Suche nach: Seshasayee, Dhaya
- Neue Suche nach: Seshagiri, Somasekar
- Neue Suche nach: Hötzel, Isidro
In:
mAbs
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12
, 1
;
2020
- Aufsatz (Zeitschrift) / Elektronische Ressource
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Titel:Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires
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Beteiligte:Hsiao, Yi-Chun ( Autor:in ) / Chen, Ying-Jiun J. ( Autor:in ) / Goldstein, Leonard D. ( Autor:in ) / Wu, Jia ( Autor:in ) / Lin, Zhonghua ( Autor:in ) / Schneider, Kellen ( Autor:in ) / Chaudhuri, Subhra ( Autor:in ) / Antony, Aju ( Autor:in ) / Bajaj Pahuja, Kanika ( Autor:in ) / Modrusan, Zora ( Autor:in )
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Erschienen in:mAbs ; 12, 1
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Verlag:
- Neue Suche nach: Taylor & Francis
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Erscheinungsdatum:01.01.2020
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ISSN:
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DOI:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Elektronische Ressource
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Sprache:Unbekannt
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Schlagwörter:
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Datenquelle:
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VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosisLow, Sarah / Wu, Haixia / Jerath, Kavita / Tibolla, Annette / Fogal, Birgit / Conrad, Rebecca / Webb, Deborah / MacDougall, Margit / Kerr, Steven / Berger, Valentina et al. | 2020
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In situ antibody phage display yields optimal inhibitors of integrin α11/β1Gallo, Eugenio / Kelil, Abdellali / Bayliss, Peter E. / Jeganathan, Ajitha / Egorova, Olga / Ploder, Lynda / Adams, Jarrett J. / Giblin, Patricia / Sidhu, Sachdev S. et al. | 2020
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Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissuesConner, Kip P. / Pastuskovas, Cinthia V. / Soto, Marcus / Thomas, Veena A. / Wagner, Mylo / Rock, Dan A. et al. | 2020
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Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case studyXu, Jianlin / Xu, Xuankuo / Huang, Chao / Angelo, James / Oliveira, Christopher L. / Xu, Mengmeng / Xu, Xia / Temel, Deniz / Ding, Julia / Ghose, Sanchayita et al. | 2020
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A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumorsBishop, Michael W. / Hutson, Paul R. / Hank, Jacquelyn A. / Sondel, Paul M. / Furman, Wayne L. / Meagher, Michael M. / Navid, Fariba / Santana, Victor M. et al. | 2020
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Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemicQian, Kewen / Hu, Shi et al. | 2020
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Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependentBondza, Sina / ten Broeke, Toine / Nestor, Marika / Leusen, Jeanette H. W. / Buijs, Jos et al. | 2020
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Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activityCamacho, Raul C. / You, Seohee / D’Aquino, Katharine E. / Li, Wenyu / Wang, Yuanping / Gunnet, Joseph / Littrell, James / Qi, Jian Shen / Kang, Lijuan / Jian, Wenying et al. | 2020
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Development and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumabSchokker, Sandor / Fusetti, Fabrizia / Bonardi, Francesco / Molenaar, Remco J. / Mathôt, Ron A.A. / van Laarhoven, Hanneke W.M. et al. | 2020
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CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonismNelke, Johannes / Medler, Juliane / Weisenberger, Daniela / Beilhack, Andreas / Wajant, Harald et al. | 2020
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Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivoNadal, Lisa / Corbellari, Riccardo / Villa, Alessandra / Weiss, Tobias / Weller, Michael / Neri, Dario / De Luca, Roberto et al. | 2020
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Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodiesChuang, Gwo-Yu / Asokan, Mangaiarkarasi / Ivleva, Vera B. / Pegu, Amarendra / Yang, Eun Sung / Zhang, Baoshan / Chaudhuri, Rajoshi / Geng, Hui / Lin, Bob C. / Louder, Mark K. et al. | 2020
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Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometryGstöttner, Christoph / Reusch, Dietmar / Haberger, Markus / Dragan, Irina / Van Veelen, Peter / Kilgour, David P. A. / Tsybin, Yury O. / van der Burgt, Yuri E. M. / Wuhrer, Manfred / Nicolardi, Simone et al. | 2020
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Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studiesLi, Chunze / Zhang, Cindy / Li, Zao / Samineni, Divya / Lu, Dan / Wang, Bei / Chen, Shang-Chiung / Zhang, Rong / Agarwal, Priya / Fine, Bernard M. et al. | 2020
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Characterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysisShi, Rachel Liuqing / Xiao, Gang / Dillon, Thomas M. / Ricci, Margaret S. / Bondarenko, Pavel V. et al. | 2020
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Benchmarking biopharmaceutical process development and manufacturing cost contributions to R&DFarid, Suzanne S. / Baron, Max / Stamatis, Christos / Nie, Wenhao / Coffman, Jon et al. | 2020
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Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignanciesEvers, Mitchell / Ten Broeke, Toine / Jansen, J.H. Marco / Nederend, Maaike / Hamdan, Firas / Reiding, Karli R. / Meyer, Saskia / Moerer, Petra / Brinkman, Iris / Rösner, Thies et al. | 2020
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A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapyMiao, Xiaoniu / Luo, Yi / Huang, Xi / Lee, Suki M. Y. / Yuan, Zhijun / Tang, Yongzhou / Chen, Liandi / Wang, Chao / Wu, Fan / Xu, Yifeng et al. | 2020
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Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platformPekar, Lukas / Busch, Michael / Valldorf, Bernhard / Hinz, Steffen C. / Toleikis, Lars / Krah, Simon / Zielonka, Stefan et al. | 2020
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Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinityRos, Francesca / Offner, Sonja / Klostermann, Stefan / Thorey, Irmgard / Niersbach, Helmut / Breuer, Sebastian / Zarnt, Grit / Lorenz, Stefan / Puels, Juergen / Siewe, Basile et al. | 2020
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Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding siteHanf, Karl J. M. / Arndt, Joseph W. / Liu, YuTing / Gong, Bang Jian / Rushe, Mia / Sopko, Richelle / Massol, Ramiro / Smith, Benjamin / Gao, Yan / Dalkilic-Liddle, Isin et al. | 2020
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Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoiresSchmitz, Samuel / Soto, Cinque / Crowe, James E.Jr. / Meiler, Jens et al. | 2020
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Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometryRouby, G. / Tran, N. T. / Leblanc, Y. / Taverna, M. / Bihoreau, N. et al. | 2020
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Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristicsChen, Zhiqiang / Qian, Yueming / Song, Yuanli / Xu, Xuankuo / Tao, Li / Mussa, Nesredin / Ghose, Sanchayita / Li, Zheng Jian et al. | 2020
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Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipelineTuccori, Marco / Ferraro, Sara / Convertino, Irma / Cappello, Emiliano / Valdiserra, Giulia / Blandizzi, Corrado / Maggi, Fabrizio / Focosi, Daniele et al. | 2020