The possible role of methylglyoxal metabolism in cancer (Unbekannt)
Freier Zugriff
- Neue Suche nach: Alfarouk, Khalid O.
- Neue Suche nach: Alqahtani, Saad S.
- Neue Suche nach: Alshahrani, Saeed
- Neue Suche nach: Morgenstern, Jakob
- Neue Suche nach: Supuran, Claudiu T.
- Neue Suche nach: Reshkin, Stephan J.
- Neue Suche nach: Alfarouk, Khalid O.
- Neue Suche nach: Alqahtani, Saad S.
- Neue Suche nach: Alshahrani, Saeed
- Neue Suche nach: Morgenstern, Jakob
- Neue Suche nach: Supuran, Claudiu T.
- Neue Suche nach: Reshkin, Stephan J.
In:
Journal of Enzyme Inhibition and Medicinal Chemistry
;
36
, 1
;
2010-2015
;
2021
- Aufsatz (Zeitschrift) / Elektronische Ressource
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Titel:The possible role of methylglyoxal metabolism in cancer
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Beteiligte:Alfarouk, Khalid O. ( Autor:in ) / Alqahtani, Saad S. ( Autor:in ) / Alshahrani, Saeed ( Autor:in ) / Morgenstern, Jakob ( Autor:in ) / Supuran, Claudiu T. ( Autor:in ) / Reshkin, Stephan J. ( Autor:in )
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Erschienen in:Journal of Enzyme Inhibition and Medicinal Chemistry ; 36, 1 ; 2010-2015
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Verlag:
- Neue Suche nach: Taylor & Francis
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Erscheinungsdatum:01.01.2021
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Format / Umfang:6 pages
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ISSN:
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DOI:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Elektronische Ressource
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Sprache:Unbekannt
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Schlagwörter:
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Datenquelle:
Inhaltsverzeichnis – Band 36, Ausgabe 1
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In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosisDeb, Pran Kishore / Al-Shar’i, Nizar A. / Venugopala, Katharigatta N. / Pillay, Melendhran / Borah, Pobitra et al. | 2021
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Dietary inclusion of royal jelly modulates gene expression and activity of oxidative stress enzymes in zebrafishAksakal, Ercüment / Ekinci, Deniz / Supuran, Claudiu T. et al. | 2021
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Transition metal-catalysed A-ring C–H activations and C(sp2)–C(sp2) couplings in the 13α-oestrone series and in vitro evaluation of antiproliferative propertiesTraj, Péter / Abdolkhaliq, Ali Hazhmat / Németh, Anett / Dajcs, Sámuel Trisztán / Tömösi, Ferenc / Lanisnik-Rizner, Tea / Zupkó, István / Mernyák, Erzsébet et al. | 2021
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Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitorLi, Jiao / Zou, Wei / Yu, Koukou / Liu, Bing / Liang, Weifeng / Wang, Lisha / Lu, Yin / Jiang, Zequn / Wang, Aiyun / Zhu, Jiapeng et al. | 2021
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Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosisDostál, Jiří / Brynda, Jiří / Vaňková, Lucie / Zia, Syeda Rehana / Pichová, Iva / Heidingsfeld, Olga / Lepšík, Martin et al. | 2021
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Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducersKassab, Asmaa E. / Gedawy, Ehab M. / Hamed, Mohammed I. A. / Doghish, Ahmed S. / Hassan, Rasha A. et al. | 2021
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Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agentsDeplano, Alessandro / Karlsson, Jessica / Moraca, Federica / Svensson, Mona / Cristiano, Claudia / Morgillo, Carmine Marco / Fowler, Christopher J. / Russo, Roberto / Catalanotti, Bruno / Onnis, Valentina et al. | 2021
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Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studiesMishra, Chandra Bhushan / Mongre, Raj Kumar / Prakash, Amresh / Jeon, Raok / Supuran, Claudiu T. / Lee, Myeong-Sok et al. | 2021
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Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo modelsDettori, Ilaria / Fusco, Irene / Bulli, Irene / Gaviano, Lisa / Coppi, Elisabetta / Cherchi, Federica / Venturini, Martina / Di Cesare Mannelli, Lorenzo / Ghelardini, Carla / Nocentini, Alessio et al. | 2021
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Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibitionAbd El-Hameed, Rania H. / Mahgoub, Shahenda / El-Shanbaky, Hend M. / Mohamed, Mosaad S. / Ali, Sahar A. et al. | 2021
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Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cellsAl-Sanea, Mohammad M. / Al-Ansary, Ghada H. / Elsayed, Zainab M. / Maklad, Raed M. / Elkaeed, Eslam B. / Abdelgawad, Mohamed A. / Bukhari, Syed Nasir Abbas / Abdel-Aziz, Marwa M. / Suliman, Howayda / Eldehna, Wagdy M. et al. | 2021
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Effect of amino acids and amines on the activity of the recombinant ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territoriiDe Luca, Viviana / Petreni, Andrea / Carginale, Vincenzo / Scaloni, Andrea / Supuran, Claudiu T. / Capasso, Clemente et al. | 2021
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Identification of a novel SPT inhibitor WXP-003 by docking-based virtual screening and investigation of its anti-fungi effectWang, Xin / Yang, Xin / Sun, Xin / Qian, Yi / Fan, Mengyao / Zhang, Zhehao / Deng, Kaiyuan / Lou, Zaixiang / Pei, Zejun / Zhu, Jingyu et al. | 2021
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Flavonoids as inhibitors of human neutrophil elastaseJakimiuk, Katarzyna / Gesek, Jakub / Atanasov, Atanas G. / Tomczyk, Michał et al. | 2021
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Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell lineGonzález, Myriam / Ovejero-Sánchez, María / Vicente-Blázquez, Alba / Medarde, Manuel / González-Sarmiento, Rogelio / Peláez, Rafael et al. | 2021
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Inhibition of soluble epoxide hydrolase by phytochemical constituents of the root bark of Ulmus davidiana var. japonicaKim, Jang Hoon / Park, Ji Su / Lee, Yun Ji / Choi, Sena / Kim, Young Ho / Yang, Seo Young et al. | 2021
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Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoformsSupuran, Claudiu T. / Nocentini, Alessio / Yakubova, Elena / Savchuk, Nikolay / Kalinin, Stanislav / Krasavin, Mikhail et al. | 2021
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Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeaeNocentini, Alessio / Hewitt, Chad S. / Mastrolorenzo, Margaret D. / Flaherty, Daniel P. / Supuran, Claudiu T. et al. | 2021
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Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET predictionIbrahim, Tarek S. / Moustafa, Amr H. / Almalki, Ahmad J. / Allam, Rasha M. / Althagafi, Abdulhamid / Md, Shadab / Mohamed, Mamdouh F. A. et al. | 2021
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Inhibition of catechol-O-methyltransferase by natural pentacyclic triterpenes: structure–activity relationships and kinetic mechanismWang, Fang-Yuan / Wei, Gui-Lin / Fan, Yu-Fan / Zhao, Dong-Fang / Wang, Ping / Zou, Li-Wei / Yang, Ling et al. | 2021
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An anion and small molecule inhibition study of the β-carbonic anhydrase from Staphylococcus aureusUrbanski, Linda J. / Vullo, Daniela / Parkkila, Seppo / Supuran, Claudiu T. et al. | 2021
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Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducersAlsaif, Nawaf A. / Taghour, Mohammed S. / Alanazi, Mohammed M. / Obaidullah, Ahmad J. / Al-Mehizia, Abdulrahman A. / Alanazi, Manal M. / Aldawas, Saleh / Elwan, Alaa / Elkady, Hazem et al. | 2021
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Application of triazoles in the structural modification of natural productsGuo, Hong-Yan / Chen, Zheng-Ai / Shen, Qing-Kun / Quan, Zhe-Shan et al. | 2021
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4-Arylthiosemicarbazide derivatives as a new class of tyrosinase inhibitors and anti-Toxoplasma gondii agentsBekier, Adrian / Węglińska, Lidia / Paneth, Agata / Paneth, Piotr / Dzitko, Katarzyna et al. | 2021
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Piperazine skeleton in the structural modification of natural products: a reviewZhang, Run-Hui / Guo, Hong-Yan / Deng, Hao / Li, Jinzi / Quan, Zhe-Shan et al. | 2021
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Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1Chen, Wei / Chen, Qi / Kumar, Ashutosh / Jiang, Xi / Zhang, Kam Y. J. / Yang, Qing et al. | 2021
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Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cellsZhang, Yan / Wang, Qin / Li, Luolan / Le, Yi / Liu, Li / Yang, Jing / Li, Yongliang / Bao, Guochen / Yan, Longjia et al. | 2021
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Synthesis and biological evaluation of thiazolidinedione derivatives with high ligand efficiency to P. aeruginosa PhzSFroes, Thamires Quadros / Chaves, Bianca Trindade / Mendes, Marina Sena / Ximenes, Rafael Matos / da Silva, Ivanildo Mangueira / da Silva, Priscila Brandão Gomes / de Albuquerque, Julianna Ferreira Cavalcanti / Castilho, Marcelo Santos et al. | 2021
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Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?Deniz, Secil / Uysal, Tugba Kevser / Capasso, Clemente / Supuran, Claudiu T. / Ozensoy Guler, Ozen et al. | 2021
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Synthesis and biological evaluation of 4-phenoxy-phenyl isoxazoles as novel acetyl-CoA carboxylase inhibitorsWu, Xin / Yu, Yongbo / Huang, Tonghui et al. | 2021
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Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cellsForlani, Giuseppe / Sabbioni, Giuseppe / Ragno, Daniele / Petrollino, Davide / Borgatti, Monica et al. | 2021
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Of mitochondrion and COVID-19Alfarouk, Khalid Omer / Alhoufie, Sari T. S. / Hifny, Abdelhameed / Schwartz, Laurent / Alqahtani, Ali S. / Ahmed, Samrein B. M. / Alqahtani, Ali M. / Alqahtani, Saad S. / Muddathir, Abdel Khalig / Ali, Heyam et al. | 2021
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Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythiaZak, Krzysztof M. / Bostock, Mark J. / Waligorska, Irena / Thøgersen, Ida B. / Enghild, Jan J. / Popowicz, Grzegorz M. / Grudnik, Przemyslaw / Potempa, Jan / Ksiazek, Miroslaw et al. | 2021
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Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effectArlt, Birte / Mastrobuoni, Guido / Wuenschel, Jasmin / Astrahantseff, Kathy / Eggert, Angelika / Kempa, Stefan / Deubzer, Hedwig E. et al. | 2021
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Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine–hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancerAbdel-Atty, Mona M. / Farag, Nahla A. / Serya, Rabah A. T. / Abouzid, Khaled A. M. / Mowafy, Samar et al. | 2021
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Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agentsShawky, Ahmed M. / Ibrahim, Nashwa A. / Abdalla, Ashraf N. / Abourehab, Mohammed A. S. / Gouda, Ahmed M. et al. | 2021
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Targeting allosteric sites of human aromatase: a comprehensive in-silico and in-vitro workflow to find potential plant-based anti-breast cancer therapeuticsAlhadrami, Hani A. / Sayed, Ahmed M. / Melebari, Sami A. / Khogeer, Asem A. / Abdulaal, Wesam H. / Al-Fageeh, Mohamed B. / Algahtani, Mohammad / Rateb, Mostafa E. et al. | 2021
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Synthesis and biological evaluation of 2-arylbenzofuran derivatives as potential anti-Alzheimer’s disease agentsYun, Yinling / Miao, Yuhang / Sun, Xiaoya / Sun, Jie / Wang, Xiaojing et al. | 2021
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Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic miceGarai, János / Krekó, Marcell / Őrfi, László / Jakus, Péter Balázs / Rumbus, Zoltán / Kéringer, Patrik / Garami, András / Vámos, Eszter / Kovács, Dominika / Bagóné Vántus, Viola et al. | 2021
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Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivatorsKitagawa, Daniel A. S. / Rodrigues, Rafael B. / Silva, Thiago N. / dos Santos, Wellington V. / da Rocha, Vinicius C. V. / de Almeida, Joyce S. F. D. / Bernardo, Leandro B. / Carvalho-Silva, Taynara / Ferreira, Cintia N. / da Silva, Angelo A. T. et al. | 2021
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Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluationSalerno, Loredana / Vanella, Luca / Sorrenti, Valeria / Consoli, Valeria / Ciaffaglione, Valeria / Fallica, Antonino N. / Canale, Vittorio / Zajdel, Paweł / Pignatello, Rosario / Intagliata, Sebastiano et al. | 2021
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Ring size changes in the development of class I HDAC inhibitorsCho, Er-Chieh / Liu, Chi-Yuan / Tang, Di-Wei / Lee, Hsueh-Yun et al. | 2021
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Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitorsWang, Guangcheng / Fan, Meiyan / Liu, Wenjing / He, Min / Li, Yongjun / Peng, Zhiyun et al. | 2021
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Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidaseGhidini, Andrea / Scalvini, Laura / Palese, Francesca / Lodola, Alessio / Mor, Marco / Piomelli, Daniele et al. | 2021
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Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancerEldehna, Wagdy M. / Salem, Rofaida / Elsayed, Zainab M. / Al-Warhi, Tarfah / Knany, Hamada R. / Ayyad, Rezk R. / Traiki, Thamer Bin / Abdulla, Maha-Hamadien / Ahmad, Rehan / Abdel-Aziz, Hatem A. et al. | 2021
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Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agentWu, Jun / Hu, Hongyu / Ao, Mingtao / Cui, Zhenzhen / Zhou, Xiaoping / Qin, Jingbo / Guo, Yafei / Chen, Jingwei / Xue, Yuhua / Fang, Meijuan et al. | 2021
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Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinasesMokhtar, Mohamed / Alghamdi, Khadijah S. / Ahmed, Nesreen S. / Bakhotmah, Dina / Saleh, Tamer S. et al. | 2021
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Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzymeVenugopala, Katharigatta N. / Chandrashekharappa, Sandeep / Deb, Pran Kishore / Tratrat, Christophe / Pillay, Melendhran / Chopra, Deepak / Al-Shar’i, Nizar A. / Hourani, Wafa / Dahabiyeh, Lina A. / Borah, Pobitra et al. | 2021
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Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling studyFares, Salma / Selim, Khalid B. / Goda, Fatma E. / El-Sayed, Magda A. A. / AlSaif, Nawaf A. / Hefnawy, Mohamed M. / Abdel-Aziz, Alaa A.-M. / El-Azab, Adel S. et al. | 2021
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Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivativesSinreih, Maša / Jójárt, Rebeka / Kele, Zoltán / Büdefeld, Tomaž / Paragi, Gábor / Mernyák, Erzsébet / Rižner, Tea Lanišnik et al. | 2021
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Diaryl azo derivatives as anti-diabetic and antimicrobial agents: synthesis, in vitro, kinetic and docking studiesTahir, Tehreem / Shahzad, Mirza Imran / Tabassum, Rukhsana / Rafiq, Muhammad / Ashfaq, Muhammad / Hassan, Mubashir / Kotwica-Mojzych, Katarzyna / Mojzych, Mariusz et al. | 2021
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Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking studyAbdel-Aziz, Alaa A.-M. / El-Azab, Adel S. / AlSaif, Nawaf A. / Obaidullah, Ahmad J. / Al-Obaid, Abdulrahman M. / Al-Suwaidan, Ibrahim A. et al. | 2021
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Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastomaZhang, Lishun / Yang, Zichao / Sang, Huiting / Jiang, Ying / Zhou, Mingfeng / Huang, Chuan / Huang, Chunhui / Wu, Xiaoyun / Zhang, Tingting / Zhang, Xingmei et al. | 2021
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Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepinesCruz-López, Olga / Ner, Matilde / Nerín-Fonz, Francho / Jiménez-Martínez, Yaiza / Araripe, David / Marchal, Juan A. / Boulaiz, Houria / Gutiérrez-de-Terán, Hugo / Campos, Joaquín M. / Conejo-García, Ana et al. | 2021
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Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancerDing, Lijuan / Wei, Feng / Wang, Nanya / Sun, Yue / Wang, Qiang / Fan, Xia / Qi, Ling / Wang, Shudong et al. | 2021
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New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011–2021) focussing on structure–activity relationship (SAR) and docking insightsElkamhawy, Ahmed / Ali, Eslam M. H. / Lee, Kyeong et al. | 2021
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CO2 permeability of the rat erythrocyte membrane and its inhibitionAl-Samir, Samer / Prill, Maximilian / Supuran, Claudiu T. / Gros, Gerolf / Endeward, Volker et al. | 2021
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Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agentsMzezewa, Sheunopa C. / Omoruyi, Sylvester I. / Zondagh, Luke S. / Malan, Sarel F. / Ekpo, Okobi E. / Joubert, Jacques et al. | 2021
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New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking studyMaccallini, Cristina / Gallorini, Marialucia / Sisto, Francesca / Akdemir, Atilla / Ammazzalorso, Alessandra / De Filippis, Barbara / Fantacuzzi, Marialuigia / Giampietro, Letizia / Carradori, Simone / Cataldi, Amelia et al. | 2021
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Synthesis and biological evaluations of oleanolic acid indole derivatives as hyaluronidase inhibitors with enhanced skin permeabilityHe, Hao / Li, Huifang / Akanji, Toyosi / Niu, Shengli / Luo, Zhujun / Li, Dongli / Seeram, Navindra P. / Wu, Panpan / Ma, Hang et al. | 2021
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Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitorsWang, Guangcheng / Liu, Wenjing / Fan, Meiyan / He, Min / Li, Yongjun / Peng, Zhiyun et al. | 2021
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