Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators (Englisch)
Freier Zugriff
- Neue Suche nach: El-Behairy, Mohammed Farrag
- Neue Suche nach: Abd-Allah, Walaa Hamada
- Neue Suche nach: Khalifa, Mohamed M.
- Neue Suche nach: Nafie, Mohamed S.
- Neue Suche nach: Saleh, Mohamed A.
- Neue Suche nach: Abdel-Maksoud, Mohammed S.
- Neue Suche nach: Al-Warhi, Tarfah
- Neue Suche nach: Eldehna, Wagdy M.
- Neue Suche nach: Al‐Karmalawy, Ahmed A.
- Neue Suche nach: El-Behairy, Mohammed Farrag
- Neue Suche nach: Abd-Allah, Walaa Hamada
- Neue Suche nach: Khalifa, Mohamed M.
- Neue Suche nach: Nafie, Mohamed S.
- Neue Suche nach: Saleh, Mohamed A.
- Neue Suche nach: Abdel-Maksoud, Mohammed S.
- Neue Suche nach: Al-Warhi, Tarfah
- Neue Suche nach: Eldehna, Wagdy M.
- Neue Suche nach: Al‐Karmalawy, Ahmed A.
In:
Journal of Enzyme Inhibition and Medicinal Chemistry
;
38
, 1
;
2023
- Aufsatz (Zeitschrift) / Elektronische Ressource
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Titel:Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators
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Beteiligte:El-Behairy, Mohammed Farrag ( Autor:in ) / Abd-Allah, Walaa Hamada ( Autor:in ) / Khalifa, Mohamed M. ( Autor:in ) / Nafie, Mohamed S. ( Autor:in ) / Saleh, Mohamed A. ( Autor:in ) / Abdel-Maksoud, Mohammed S. ( Autor:in ) / Al-Warhi, Tarfah ( Autor:in ) / Eldehna, Wagdy M. ( Autor:in ) / Al‐Karmalawy, Ahmed A. ( Autor:in )
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Erschienen in:
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Verlag:
- Neue Suche nach: Taylor & Francis
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Erscheinungsdatum:31.12.2023
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ISSN:
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DOI:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Elektronische Ressource
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Sprache:Englisch
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Schlagwörter:
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Datenquelle:
Inhaltsverzeichnis – Band 38, Ausgabe 1
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Correction| 2023
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Reply letter to Dr. Wojtasek regarding: Oxidation of flavonoids by tyrosinase and by o-quinones–comment on "Flavonoids as tyrosinase inhibitors in in silico and in vitro models: basic framework of SAR using a statistical modelling approach” published by K. Jakimiuk, S. Sari, R. Milewski, C.T. Supuran, D. Söhretoglu, and M. Tomczyk (J Enzyme Inhib Med Chem 2022;37:427-436)Tomczyk, Michał / on behalf of all co-authors et al. | 2023
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New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrasesCuffaro, Doretta / Di Leo, Riccardo / Ciccone, Lidia / Nocentini, Alessio / Supuran, Claudiu T. / Nuti, Elisa / Rossello, Armando et al. | 2023
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In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancerChang, Chao-Di / Chao, Min-Wu / Lee, Hsueh-Yun / Liu, Yi-Ting / Tu, Huang-Ju / Lien, Ssu-Ting / Lin, Tony Eight / Sung, Tzu-Ying / Yen, Shih-Chung / Huang, Sing-Han et al. | 2023
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Inhibition studies with simple and complex (in)organic anions of the γ-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri, MscCAγGiovannuzzi, Simone / De Luca, Viviana / Capasso, Clemente / Supuran, Claudiu T. et al. | 2023
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Research progress of natural products and their derivatives against Alzheimer’s diseaseLiu, Jin-Ying / Guo, Hong-Yan / Quan, Zhe-Shan / Shen, Qing-Kun / Cui, Hong / Li, Xiaoting et al. | 2023
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Design, biological evaluation, and molecular modelling insights of cupressic acid derivatives as promising anti-inflammatory agentsSoliman, Amal F. / Elimam, Diaaeldin M. / El-Senduny, Fardous F. / Alossaimi, Manal A. / Alamri, Mubarak / Abdel Bar, Fatma M. et al. | 2023
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Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitorsRamzan, Farhat / Nabi, Syed Ayaz / Lone, Mehak Saba / Bonardi, Alessandro / Hamid, Aabid / Bano, Sameena / Sharma, Kalicharan / Shafi, Syed / Samim, Mohammed / Javed, Kalim et al. | 2023
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Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluationKothayer, Hend / Rezq, Samar / Abdelkhalek, Ahmed S. / Romero, Damian G. / Elbaramawi, Samar S. et al. | 2023
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Styrylquinazoline derivatives as ABL inhibitors selective for different DFG orientationsMalarz, Katarzyna / Mularski, Jacek / Pacholczyk, Marcin / Musiol, Robert et al. | 2023
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Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitorsGiovannuzzi, Simone / Bonardi, Alessandro / Gratteri, Paola / Nocentini, Alessio / Supuran, Claudiu T. et al. | 2023
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Synthesis and anticancer properties of celastrol derivatives involved in the inhibition of VEGFSong, Mingxia / Wen, Jiantao / Hua, Yi / Zhu, Yangnv / Xia, Qishan / Guo, Qiaoyue / Luo, Yiqin / Deng, Xianqing / Huang, Yushan et al. | 2023
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Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)Abo Al-Hamd, Mahmoud G. / Tawfik, Haytham O. / Abdullah, Omeima / Yamaguchi, Koki / Sugiura, Masaharu / Mehany, Ahmed B. M. / El-Hamamsy, Mervat H. / El-Moselhy, Tarek F. et al. | 2023
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Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosisHemeda, Loah R. / El Hassab, Mahmoud A. / Abdelgawad, Mohamed A. / Khaleel, Eman F. / Abdel-Aziz, Marwa M. / Binjubair, Faizah A. / Al-Rashood, Sara T. / Eldehna, Wagdy M. / El-Ashrey, Mohamed K. et al. | 2023
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The NMR studies of CMP inhibition of polysialylationLu, Bo / Liao, Si-Ming / Liu, Xue-Hui / Liang, Shi-Jie / Huang, Jun / Lin, Mei / Meng, Li / Wang, Qing-Yan / Huang, Ri-Bo / Zhou, Guo-Ping et al. | 2023
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Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffoldRomagnoli, Romeo / De Ventura, Tiziano / Manfredini, Stefano / Baldini, Erika / Supuran, Claudiu T. / Nocentini, Alessio / Brancale, Andrea / Varricchio, Carmine / Bortolozzi, Roberta / Manfreda, Lorenzo et al. | 2023
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Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancerSharma, Sachin / Chandra, Kavya / Naik, Aliva / Sharma, Anamika / Sharma, Ram / Thakur, Amandeep / Grewal, Ajmer Singh / Dhingra, Ashwani K. / Banerjee, Arnab / Liou, Jing Ping et al. | 2023
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Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer’s diseaseDu, Hongtao / Song, Jinzhi / Ma, Fang / Gao, Hongxin / Zhao, Xinyan / Mao, Renjun / He, Xiaolong / Yan, Yan et al. | 2023
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Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agentsMaestro, Ines / Madruga, Enrique / Boya, Patricia / Martínez, Ana et al. | 2023
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Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levelsAl-Harbi, Laila M. / Al-Harbi, Eman A. / Okasha, Rawda M. / El-Eisawy, R. A. / El-Nassag, Mohammed A. A. / Mohamed, Hany M. / Fouda, Ahmed M. / Elhenawy, Ahmed A. / Mora, Ahmed / El-Agrody, Ahmed M. et al. | 2023
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An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65Poli, Giulio / Demontis, Gian Carlo / Sodi, Andrea / Saba, Alessandro / Rizzo, Stanislao / Macchia, Marco / Tuccinardi, Tiziano et al. | 2023
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Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agentsAl-Sanea, Mohammad M. / Hamdi, Abdelrahman / Brogi, Simone / S. Tawfik, Samar / Othman, Dina I. A. / Elshal, Mahmoud / Ur Rahman, Hidayat / Parambi, Della G. T. / M. Elbargisy, Rehab / Selim, Samy et al. | 2023
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Design, synthesis, molecular modelling and antitumor evaluation of S-glucosylated rhodanines through topo II inhibition and DNA intercalationKhodair, Ahmed I. / Alzahrani, Fatimah M. / Awad, Mohamed K. / Al-Issa, Siham A. / Al-Hazmi, Ghaferah H. / Nafie, Mohamed S. et al. | 2023
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Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studiesOthman, Dina I. A. / Hamdi, Abdelrahman / Tawfik, Samar S. / Elgazar, Abdullah A. / Mostafa, Amany S. et al. | 2023
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Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activityEl-Damasy, Ashraf K. / Jin, Heewon / Park, Jung Woo / Kim, Hyun Ji / Khojah, Hanan / Seo, Seon Hee / Lee, Ju-Hyeon / Bang, Eun-Kyoung / Keum, Gyochang et al. | 2023
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Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitorsAstrain-Redin, Nora / Paoletti, Niccolò / Plano, Daniel / Bonardi, Alessandro / Gratteri, Paola / Angeli, Andrea / Sanmartin, Carmen / Supuran, Claudiu T. et al. | 2023
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Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivityAllam, Heba Abdelrasheed / Albakry, Mohamed E. / Mahmoud, Walaa R. / Bonardi, Alessandro / Moussa, Shaimaa A. / Mohamady, Samy / Abdel-Aziz, Hatem A. / Supuran, Claudiu T. / Ibrahim, Hany S. et al. | 2023
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Discovery of potent heat shock protein 90 (Hsp90) inhibitors: structure-based virtual screening, molecular dynamics simulation, and biological evaluationXu, Yonghua / Zou, Yunting / Zhou, Shasha / Niu, Miao-Miao / Zhang, Yan / Li, Jindong / Xu, Zhen / Yang, Li et al. | 2023
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A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer’s diseaseDarvesh, Sultan / Banfield, Scott / Dufour, Maeve / Forrestall, Katrina L. / Maillet, Hillary / Reid, G. Andrew / Sands, Dane / Pottie, Ian R. et al. | 2023
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Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutantEl-Damasy, Ashraf K. / Kim, Hyun Ji / Park, Jung Woo / Nam, Yunju / Hur, Wooyoung / Bang, Eun-Kyoung / Keum, Gyochang et al. | 2023
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Carbonic anhydrase inhibitory activity of phthalimide-capped benzene sulphonamide derivativesShilkar, Deepak / Mohd Siddique, Mohd Usman / Bua, Silvia / Yasmin, Sabina / Patil, Mrunali / Timiri, Ajay Kumar / Supuran, Claudiu T. / Jayaprakash, Venkatesan et al. | 2023
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Semisynthesis and anti-cancer properties of novel honokiol derivatives in human nasopharyngeal carcinoma CNE-2Z cellsLi, Bo-Han / Ma, Hui / Zhu, Jing / Chen, Jie / Dai, Yi-Qun / Zhang, Xiao-Jing / Li, Hong-Mei / Wu, Cheng-Zhu et al. | 2023
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Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacyBurmistrov, Vladimir V. / Morisseau, Christophe / Danilov, Dmitry V. / Gladkikh, Boris P. / D’yachenko, Vladimir S. / Zefirov, Nikolay A. / Zefirova, Olga N. / Butov, Gennady M. / Hammock, Bruce D. et al. | 2023
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New spiro-indeno[1,2-b]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insightsBarakat, Assem / Alshahrani, Saeed / Al-Majid, Abdullah Mohammed / Alamary, Abdullah Saleh / Haukka, Matti / Abu-Serie, Marwa M. / Domingo, Luis R. / Ashraf, Sajda / Ul-Haq, Zaheer / Nafie, Mohamed S. et al. | 2023
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Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3Kα inhibitorsChen, Rui / Wang, Zhongyuan / Sima, Lijie / Cheng, Hu / Luo, Bilan / Wang, Jianta / Guo, Bing / Mao, Shunyi / Zhou, Zhixu / Peng, Jingang et al. | 2023
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Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and βTan, Kathrin / Jäger, Christian / Geissler, Stefanie / Schlenzig, Dagmar / Buchholz, Mirko / Ramsbeck, Daniel et al. | 2023
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TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivativesLi, Aiyun / Guan, Li / Su, Wanzhen / Zhao, Ning / Song, Xuwen / Wang, Jin / Tang, Xiaoxiao / Li, Weize / Jiao, Xiangying et al. | 2023
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Adiponectin – stratification biomarker in diastolic cardiac dysfunctionDincă, Valeriu-Gabi / Diaconu, Adriana / Coculescu, Bogdan-Ioan / Dincă, Alexandra-Ligia / Ciuc, Diana Mihaela / Bîrlă, Rodica Daniela / Marica, Cristian Daniel / Tudorache, Sorin Ioan / Manole, Gheorghe / Coculescu, Elena Claudia et al. | 2023
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Design, synthesis, and biological evaluation of benzoheterocyclic sulfoxide derivatives as quorum sensing inhibitors in Pseudomonas aeruginosaMao, Shen / Li, Qiaoqiang / Yang, Zhikun / Li, Yasheng / Ye, Xinyi / Wang, Hong et al. | 2023
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WRH-2412 alleviates the progression of hepatocellular carcinoma through regulation of TGF-β/β-catenin/α-SMA pathwayElewa, Mohammed A. F. / Eldehna, Wagdy M. / Hamdan, Ahmed M. E. / Abd El-kawi, Samraa H. / El-Kalaawy, Asmaa M. / Majrashi, Taghreed A. / Barghash, Reham F. / Abdel-Aziz, Hatem A. / Hashem, Khalid S. / Al-Gayyar, Mohammed M. H. et al. | 2023
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Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VIIFiorentino, Francesco / Nocentini, Alessio / Rotili, Dante / Supuran, Claudiu T. / Mai, Antonello et al. | 2023
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Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanomaPeng, Xiaopeng / Yu, Ziwen / Surineni, Goverdhan / Deng, Bulian / Zhang, Meizhu / Li, Chuan / Sun, Zhiqiang / Pan, Wanyi / Liu, Yao / Liu, Shenglan et al. | 2023
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Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell linesSon, Seohyun / Elkamhawy, Ahmed / Gul, Anam Rana / Al‐Karmalawy, Ahmed A. / Alnajjar, Radwan / Abdeen, Ahmed / Ibrahim, Samah F. / Alshammari, Saud O. / Alshammari, Qamar A. / Choi, Won Jun et al. | 2023
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Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hopeAl-Omari, Mothana K. / Elaarag, Mai / Al-Zoubi, Raed M. / Al-Qudimat, Ahmad R. / Zarour, Ayman A. / Al-Hurani, Enas A. / Fares, Zainab E. / Alkharraz, Leena M. / Shkoor, Mohanad / Bani-Yaseen, Abdulilah D. et al. | 2023
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Discovery of an effective anti-inflammatory agent for inhibiting the activation of NF-κBYan, Yaoyao / Lv, Qi / Zhou, Feilong / Jian, Yujie / Xinhua, Liu / Chen, Xing / Hu, Yong et al. | 2023
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Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studiesBedewy, Walaa A. / Mohamed, Mosaad S. / Abdelhameed, Ahmed M. / Elsawy, Mohamed A. / Al-Muhur, Mohammed / Ashida, Noriyuki / Abdalla, Ashraf N / Elwaie, Tamer A. / Nagamatsu, Tomohisa / Ali, Hamed I. et al. | 2023
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Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s diseaseChen, Ping / Geng, Xiaofei et al. | 2023
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Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202RLiu, Siming / Huang, Chuan / Huang, Chunhui / Huang, Yaqi / Yu, Yonghuan / Wu, Guowu / Guo, Fengqiu / Jiang, Ying / Wan, Shanhe / Zhu, Zhengguang et al. | 2023
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PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1–AKT–mTOR/Bcl2 pathwayZhang, Hua / Zhou, Shi-Jia / Shen, Chen-Feng / Zhou, Yong-Nan / Wu, Cai-Yun / Zhu, Meng-Yu / Yu, Qi-Meng / Awadasseid, Annoor / Wu, Yan-Ling / Zhang, Wen et al. | 2023
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Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitorsTang, Kun / Li, Huan-Huan / Wu, Chengyao / Zhang, Shi-Long / Yang, Jian-Guo / Tang, Wenjian / Qin, Hua-Li et al. | 2023
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Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferationKim, Jang Hoon / Park, Yea-In / Hur, Mok / Park, Woo Tae / Moon, Youn-Ho / Huh, Yun-Chan / Kim, Tae IL / Kang, Min Hye / Kang, Jong Seong / Cho, Chong Woon et al. | 2023
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Peptide foldamer-based inhibitors of the SARS-CoV-2 S protein–human ACE2 interactionMarković, Violeta / Shaik, Jeelan Basha / Ożga, Katarzyna / Ciesiołkiewicz, Agnieszka / Lizandra Perez, Juan / Rudzińska-Szostak, Ewa / Berlicki, Łukasz et al. | 2023
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Novel N-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulationsHaffez, Hesham / Elsayed, Nosaiba A. / Ahmed, Marwa F. / Fatahala, Samar S. / Khaleel, Eman F. / Badi, Rehab Mustafa / Elkaeed, Eslam B. / El Hassab, Mahmoud A. / Hammad, Sherif F. / Eldehna, Wagdy M. et al. | 2023
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New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activityTan, Daopeng / Wang, Jianmei / Wang, Xianting / Qin, Lin / Du, Yimei / Zhao, Changkuo / Liu, Peijun / Zhang, Qianru / Ma, Feifei / Xie, Jian et al. | 2023
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Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XIIEl-Damasy, Ashraf K. / Kim, Hyun Ji / Nocentini, Alessio / Seo, Seon Hee / Eldehna, Wagdy M. / Bang, Eun-Kyoung / Supuran, Claudiu T. / Keum, Gyochang et al. | 2023
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Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salarisAspatwar, Ashok / Bonardi, Alessandro / Aisala, Heidi / Zueva, Ksenia / Primmer, Craig R / Lumme, Jaakko / Parkkila, Seppo / Supuran, Claudiu T. et al. | 2023
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2-((1H-Benzo[d]imidazol-2-yl)amino)benzo[d]thiazole-6-sulphonamides: a class of carbonic anhydrase II and VII-selective inhibitorsAbdoli, Morteza / Supuran, Claudiu T. / Žalubovskis, Raivis et al. | 2023
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Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer’s diseaseYang, Huali / Jia, Hongwei / Deng, Minghui / Zhang, Kaicheng / Liu, Yaoyang / Liu, Yang / Cheng, Maosheng / Xiao, Wei et al. | 2023
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Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cellsMalina, Jaroslav / Kostrhunova, Hana / Song, Hualong / Scott, Peter / Brabec, Viktor et al. | 2023
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Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studiesAl-Karmalawy, Ahmed A. / El-Gamil, Dalia S. / El-Shesheny, Rabeh / Sharaky, Marwa / Alnajjar, Radwan / Kutkat, Omnia / Moatasim, Yassmin / Elagawany, Mohamed / Al-Rashood, Sara T. / Binjubair, Faizah A. et al. | 2023
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A novel RRGW derived peptide is a promising inhibitor of BoNT/AMa, Wantong / Wang, Lulu / Tan, Xiangmin / Wang, Xin / Yang, Chunyan / Wang, Yu / Liu, Ziye / Liu, Bo / Zhu, Hai / Zhi, Dejuan et al. | 2023
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Discovery of dual S-RBD/NRP1-targeting peptides: structure-based virtual screening, synthesis, biological evaluation, and molecular dynamics simulation studiesHu, Chunfang / Guo, Ting / Zou, Yunting / Gao, Junyi / Gao, Yi / Niu, Miaomiao / Xia, Yang / Shen, Xiaozhou / Li, Jindong et al. | 2023
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Discovery and biological evaluation of novel CARM1/HDAC2 dual-targeting inhibitors with anti-prostate cancer agentsLiang, Sudong / Geng, Yifei / Niu, Miao-Miao / Zhang, Yan / He, Weiping / Li, Jindong / Yang, Li / Xu, Zhen et al. | 2023
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Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophagesGhany, Lina M. A. Abdel / Beshay, Botros Y. / Youssef Moustafa, Amal M. / Maghrabi, Ali Hassan Ahmed / Ali, Eman Hussain Khalifa / Saleem, Rasha Mohammed / Zaki, Islam / Ryad, Noha et al. | 2023
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2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoformsSequeira, Lisa / Distinto, Simona / Meleddu, Rita / Gaspari, Marco / Angeli, Andrea / Cottiglia, Filippo / Secci, Daniela / Onali, Alessia / Sanna, Erica / Borges, Fernanda et al. | 2023
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Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agentsYuan, Ying-Hui / Mao, Nian-Dong / Duan, Ji-Long / Zhang, Hang / Garrido, Carmen / Lirussi, Frédéric / Gao, Yuan / Xie, Tian / Ye, Xiang-Yang et al. | 2023
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Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agentsKhalil, Ahmed F. / El-Moselhy, Tarek F. / El-Bastawissy, Eman A. / Abdelhady, Rasha / Younis, Nancy S. / El-Hamamsy, Mervat H. et al. | 2023
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Synthesis, kinetic studies and in-silico investigations of novel quinolinyl-iminothiazolines as alkaline phosphatase inhibitorsMustafa, Muhammad Naeem / Channar, Pervaiz Ali / Sarfraz, Muhammad / Saeed, Aamer / Ejaz, Syeda Abida / Aziz, Mubashir / Alasmary, Fatmah Ali / Alsoqair, Hanadi Yaqob / Raza, Hussain / Kim, Song Ja et al. | 2023
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Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoniHaapanen, Susanna / Angeli, Andrea / Tolvanen, Martti / Emameh, Reza Zolfaghari / Supuran, Claudiu T. / Parkkila, Seppo et al. | 2023
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Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitorsElsayed, Zainab M. / Almahli, Hadia / Nocentini, Alessio / Ammara, Andrea / Supuran, Claudiu T. / Eldehna, Wagdy M. / Abou-Seri, Sahar M. et al. | 2023
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Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitorsAhn, Myunghwan / Park, Seung Eun / Choi, Jiyeon / Choi, Jiahn / Choi, Doyoung / An, Dongju / Jeon, Hayoung / Oh, Soowhan / Lee, Kiho / Kim, Jaehoon et al. | 2023
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Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifoliaEl-Nashar, Heba A. S. / Sayed, Ahmed M. / El-Sherief, Hany A. M. / Rateb, Mostafa E. / Akil, Lina / Khadra, Ibrahim / Majrashi, Taghreed A. / Al-Rashood, Sara T. / Binjubair, Faizah A. / El Hassab, Mahmoud A. et al. | 2023
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Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationshipsFantacuzzi, Marialuigia / D’Agostino, Ilaria / Carradori, Simone / Liguori, Francesco / Carta, Fabrizio / Agamennone, Mariangela / Angeli, Andrea / Sannio, Filomena / Docquier, Jean-Denis / Capasso, Clemente et al. | 2023
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Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitorsMahnashi, Mater / Alshahrani, Mohammed Merae / Al Ali, Amer / Asiri, Abdulaziz / Abou-Salim, Mahrous A. et al. | 2023
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Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activityMourad, Mai A. E. / Abo Elmaaty, Ayman / Zaki, Islam / Mourad, Ahmed A. E. / Hofni, Amal / Khodir, Ahmed E. / Aboubakr, Esam M. / Elkamhawy, Ahmed / Roh, Eun Joo / Al-Karmalawy, Ahmed A. et al. | 2023
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Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insightsHamdi, Abdelrahman / Yaseen, Muhammad / Ewes, Wafaa A. / Bhat, Mashooq Ahmad / Ziedan, Noha I. / El-Shafey, Hamed W. / Mohamed, Ahmed A. B. / Elnagar, Mohamed R. / Haikal, Abdullah / Othman, Dina I. A. et al. | 2023
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Discovery of novel arylamide derivatives containing piperazine moiety as inhibitors of tubulin polymerisation with potent liver cancer inhibitory activityShi, Xiao-Yi / Jiao, Huang / Zhang, Jia-Kai / Tian, Xin-Yi / Guo, Dan-Feng / Gao, Jie / Jia, Mei-Qi / Song, Jian / Zhang, Sai-Yang / Fu, Xiang-Jing et al. | 2023
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Potent inhibition of human tyrosinase inhibitor by verproside from the whole plant of Pseudolysimachion rotundum var. subintegrumJung, Sunin / Woo, So-Yeun / Park, Mi Hyeon / Kim, Doo-Young / Lee, Su Ui / Oh, Sei-Ryang / Kim, Mun-Ock / Lee, Jinhyuk / Ryu, Hyung Won et al. | 2023
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Promising inhibition of diabetes-related enzymes and antioxidant properties of Ptilostemon casabonae leaves extractSanna, Cinzia / Fais, Antonella / Era, Benedetta / Delogu, Giovanna L. / Sanna, Enrico / Dazzi, Laura / Rosa, Antonella / Marengo, Arianna / Rubiolo, Patrizia / De Agostini, Antonio et al. | 2023
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Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilitiesEl-Miligy, Mostafa M. M. / Abdelaziz, Marwa E. / Fahmy, Salwa M. / Ibrahim, Tamer M. / Abu-Serie, Marwa M. / Mahran, Mona A. / Hazzaa, Aly A. et al. | 2023
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Recent progress in chemistry and bioactivity of monoterpenoid indole alkaloids from the genus gelsemium: a comprehensive reviewWang, Lin / Chen, Siyu / Gao, Xun / Liang, Xiao / Lv, Weichen / Zhang, Dongfang / Jin, Xin et al. | 2023
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New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer’s diseaseCzarnecka, Kamila / Girek, Małgorzata / Kręcisz, Paweł / Skibiński, Robert / Łątka, Kamil / Jończyk, Jakub / Bajda, Marek / Szymczyk, Piotr / Galita, Grzegorz / Kabziński, Jacek et al. | 2023
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Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cellsNegri, Aide / Marozzi, Marina / Trisciuoglio, Daniela / Rotili, Dante / Mai, Antonello / Rizzi, Federica et al. | 2023
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New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico studyAl-Sanea, Mohammad M. / Hamdi, Abdelrahman / Mohamed, Ahmed A. B. / El-Shafey, Hamed W. / Moustafa, Mahmoud / Elgazar, Abdullah A. / Eldehna, Wagdy M. / Ur Rahman, Hidayat / Parambi, Della G. T. / Elbargisy, Rehab M. et al. | 2023
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The importance of including the C-terminal domain of PTP1B1-400 to identify potential antidiabetic inhibitorsCoronell-Tovar, Andrea / Cortés-Benítez, Francisco / González-Andrade, Martin et al. | 2023
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Different chemical proteomic approaches to identify the targets of lapatinibKovačević, Tatjana / Nujić, Krunoslav / Cindrić, Mario / Dragojević, Snježana / Vinter, Adrijana / Hozić, Amela / Mesić, Milan et al. | 2023
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Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulationsBao, Huayin / Wang, Wei / Sun, Haibo / Chen, Jianzhong et al. | 2023
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Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFRL858R/T790M inhibitorsFu, Jianfang / Yu, Jie / Zhang, Xiang / Chang, Yaoyao / Fan, Hongze / Dong, Mengzhen / Li, Mengjia / Liu, Yue / Hu, Jinxing et al. | 2023
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Chemical composition, seasonal variation and antiaging activities of essential oil from Callistemon subulatus leaves growing in EgyptRabie, Omyma / El-Nashar, Heba A. S. / Majrashi, Taghreed A. / Al‐Warhi, Tarfah / El Hassab, Mahmoud A. / Eldehna, Wagdy M. / Mostafa, Nada M. et al. | 2023
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Latest advances in dual inhibitors of acetylcholinesterase and monoamine oxidase B against Alzheimer’s diseaseZou, Dajiang / Liu, Renzheng / Lv, Yangjing / Guo, Jianan / Zhang, Changjun / Xie, Yuanyuan et al. | 2023
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The multifaceted nature of plant acid phosphatases: purification, biochemical features, and applicationsSharma, Lokesh / Kahandal, Amol / Kanagare, Anant / Kulkarni, Atul / Tagad, Chandrakant K. et al. | 2023
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Design, synthesis and evaluation of quinoline-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer’s diseaseChen, Hongsong / Mi, Jing / Li, Sen / Liu, Zhengwei / Yang, Jing / Chen, Rui / Wang, Yujie / Ban, Yujuan / Zhou, Yi / Dong, Wu et al. | 2023
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Effect of in vitro simulated digestion on the anti-Helicobacter Pylori activity of different Propolis extractsGoverna, Paolo / Romagnoli, Giulia / Albanese, Paola / Rossi, Federico / Manetti, Fabrizio / Biagi, Marco et al. | 2023
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Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XIIMahammad Ghouse, Shaik / Bahatam, Kavyaraj / Angeli, Andrea / Pawar, Gaurav / Chinchilli, Krishna Kartheek / Yaddanapudi, Venkata Madhavi / Mohammed, Arifuddin / Supuran, Claudiu T. / Nanduri, Srinivas et al. | 2023
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Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds–synthesis, biological activity, and structural evaluationStępnicki, Piotr / Wronikowska-Denysiuk, Olga / Zięba, Agata / Targowska-Duda, Katarzyna M. / Bartyzel, Agata / Wróbel, Martyna Z. / Wróbel, Tomasz M. / Szałaj, Klaudia / Chodkowski, Andrzej / Mirecka, Karolina et al. | 2023
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Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovaniHassan, Ahmed H. E. / Bayoumi, Waleed A. / El-Sayed, Selwan M. / Phan, Trong-Nhat / Kim, Yeon Ju / Lee, Chae Hyeon / Cho, Soo Bin / Oh, Taegeun / Ham, Gyeongpyo / Mahmoud, Kazem et al. | 2023
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Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main proteaseElNaggar, Mai H. / Elgazar, Abdullah A. / Gamal, Ghada / Hamed, Shimaa M. / Elsayed, Zainab M. / El-Ashrey, Mohamed K. / Abood, Amira / El Hassab, Mahmoud A. / Soliman, Ahmed M. / El-Domany, Ramadan A. et al. | 2023
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Application of the Mannich reaction in the structural modification of natural productsPu, Miao-Xia / Guo, Hong-Yan / Quan, Zhe-Shan / Li, Xiaoting / Shen, Qing-Kun et al. | 2023
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Lavandula angustifolia mill. (Lamiaceae) ethanol extract and its main constituents as promising agents for the treatment of metabolic disorders: chemical profile, in vitro biological studies, and molecular dockingTundis, Rosa / Grande, Fedora / Occhiuzzi, Maria A. / Sicari, Vincenzo / Loizzo, Monica R. / Cappello, Anna R. et al. | 2023
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Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analoguesNuti, Francesca / Larregola, Maud / Staśkiewicz, Agnieszka / Retzl, Bernhard / Tomašević, Nataša / Macchia, Lorenzo / Street, Maria E. / Jewgiński, Michał / Lequin, Olivier / Latajka, Rafal et al. | 2023
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New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studiesFadaly, Wael A. A. / Zidan, Taha H. / Kahk, Nesma M. / Mohamed, Fatma E. A. / Abdelhakeem, Marwa M. / Khalil, Rehab G. / Nemr, Mohamed T. M. et al. | 2023
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New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling studyFadaly, Wael A. A. / Nemr, Mohamed T. M. / Zidan, Taha H. / Mohamed, Fatma E. A. / Abdelhakeem, Marwa M. / Abu Jayab, Nour N. / Omar, Hany A. / Abdellatif, Khaled R. A. et al. | 2023
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Selected strategies to fight pathogenic bacteriaPlotniece, Aiva / Sobolev, Arkadij / Supuran, Claudiu T. / Carta, Fabrizio / Björkling, Fredrik / Franzyk, Henrik / Yli-Kauhaluoma, Jari / Augustyns, Koen / Cos, Paul / De Vooght, Linda et al. | 2023
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ALDEFLUOR activity, ALDH isoforms, and their clinical significance in cancersDuan, Jiang-Jie / Cai, Jiao / Gao, Lei / Yu, Shi-Cang et al. | 2023
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Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and IIIvanova, Jekaterīna / Abdoli, Morteza / Nocentini, Alessio / Žalubovskis, Raivis / Supuran, Claudiu T. et al. | 2023
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Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell linesRykowski, Sebastian / Gurda-Woźna, Dorota / Fedoruk-Wyszomirska, Agnieszka / Orlicka-Płocka, Marta / Kowalczyk, Aleksandra / Stączek, Paweł / Denel-Bobrowska, Marta / Biniek-Antosiak, Katarzyna / Rypniewski, Wojciech / Wyszko, Eliza et al. | 2023
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Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activitiesChu, Jung-Chun / Tseng, Hui-Ju / Lee, Sung-Bau / Hsu, Kai-Cheng / Hsin, Ling-Wei / Liang, Ru-Hao / Lin, Tony Eight / Gao, Nain-Chu / Chen, Liang-Chieh / Lu, Wan-Hsun et al. | 2023
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Development of novel salicylic acid–donepezil–rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer’s diseaseZhou, Yi / He, Ying / Teng, Xue / Mi, Jing / Yang, Jing / Wei, Rongrui / Liu, Wenmin / Ma, Qinge / Tan, Zhenghuai / Sang, Zhipei et al. | 2023
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α-Glucosidase inhibition by green, white and oolong teas: in vitro activity and computational studiesEsposito, Fabio / Pala, Nicolino / Carcelli, Mauro / Boateng, Samuel T. / D’Aquila, Paolo S. / Mariani, Alberto / Satta, Sandro / Chamcheu, Jean Christopher / Sechi, Mario / Sanna, Vanna et al. | 2023
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Aryl derivatives of 3H-1,2-benzoxaphosphepine 2-oxides as inhibitors of cancer-related carbonic anhydrase isoforms IX and XIIBalašova, Anastasija / Pustenko, Aleksandrs / Nocentini, Alessio / Vullo, Daniela / Supuran, Claudiu T. / Žalubovskis, Raivis et al. | 2023
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Design, synthesis and evaluation of dihydro-1H-indene derivatives as novel tubulin polymerisation inhibitors with anti-angiogenic and antitumor potencyXu, Shengtao / Sun, Yijun / Wang, Peng / Tan, Yuchen / Shi, Lei / Chen, Jian et al. | 2023
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The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replicationBianconi, Elisa / Gidari, Anna / Souma, Maria / Sabbatini, Samuele / Grifagni, Deborah / Bigiotti, Carlo / Schiaroli, Elisabetta / Comez, Lucia / Paciaroni, Alessandro / Cantini, Francesca et al. | 2023
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Synthesis, biological evaluation, and computational studies of N-benzyl pyridinium–curcumin derivatives as potent AChE inhibitors with antioxidant activityAl-Rifai, Nafisah M. / Al-Khalileh, Nemeh M. / Zahra, Jalal A. / El-Barghouthi, Musa I. / Darras, Fouad H. et al. | 2023
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Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamatesGiovannuzzi, Simone / Marapaka, Anil Kumar / Abutaleb, Nader S. / Carta, Fabrizio / Liang, Hsin-Wen / Nocentini, Alessio / Pisano, Luigi / Seleem, Mohamed N. / Flaherty, Daniel P. / Supuran, Claudiu T. et al. | 2023
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Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluationLiu, Wei / He, Youyou / Guo, Zhongjie / Wang, Miaomiao / Han, Xiaodong / Jia, Hairui / He, Jin / Miao, Shanshan / Wang, Shengzheng et al. | 2023
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Dual-target ligand discovery for Alzheimer’s disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregationEl-Hussieny, Marwa / Abd-El-Maksoud, Mansoura A. / Soliman, Fouad M. / Fouad, Marwa A. / El-Ashrey, Mohamed K. et al. | 2023
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Purification and characterisation of glutathione reductase from scorpionfish (scorpaena porcus) and investigation of heavy metal ions inhibitionIşık, Kübra / Soydan, Ercan et al. | 2023
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Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s diseaseHafez, Donia E. / Dubiel, Mariam / La Spada, Gabriella / Catto, Marco / Reiner-Link, David / Syu, Yu-Ting / Abdel-Halim, Mohammad / Hwang, Tsong-Long / Stark, Holger / Abadi, Ashraf H. et al. | 2023
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Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insightsBadawi, Waleed A. / Rashed, Mahmoud / Nocentini, Alessio / Bonardi, Alessandro / Abd-Alhaseeb, Mohammad M. / Al-Rashood, Sara T. / Veerakanellore, Giri Babu / Majrashi, Taghreed A. / Elkaeed, Eslam B. / Elgendy, Bahaa et al. | 2023
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Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapyWang, Ze / Zhao, Li / Zhang, Bo / Feng, Jiahe / Wang, Yule / Zhang, Bin / Jin, Haixiao / Ding, Lijian / Wang, Ning / He, Shan et al. | 2023
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Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinaseHassan, Ahmed H. E. / Oh, Yeon Il / Lee, Chae Hyeon / Kim, Yeon Ju / Cho, Soo Bin / Alam, Md. Maqusood / Park, Sang-Eun / Chung, Kyung-Sook / Lee, Kyung-Tae / Lee, Yong Sup et al. | 2023
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Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivativesXia, Meng-Yu / Cai, Yu-Xiang / Chen, Jun-Xian / Zhao, Xin / Dong, Hong-Mei / Yang, Zai-Chang et al. | 2023
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Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomeraseGarcía-Torres, Itzhel / De la Mora-De la Mora, Ignacio / López-Velázquez, Gabriel / Cabrera, Nallely / Flores-López, Luis Antonio / Becker, Ingeborg / Herrera-López, Juliana / Hernández, Roberto / Pérez-Montfort, Ruy / Enríquez-Flores, Sergio et al. | 2023
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Fragment-based design, synthesis and biological evaluation of theophylline derivatives as ATAD2 inhibitors in BT-549 cellsYao, Dahong / You, Jieshu / Yang, Xuetao / Zhang, Jin / Yao, Xiaojun et al. | 2023
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Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cellsKim, Hyeong jae / Hong, Jeong Hee et al. | 2023