Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic (Englisch)
Freier Zugriff
- Neue Suche nach: Csonka, Dénes
- Neue Suche nach: Fishman, Vladislav
- Neue Suche nach: Natarajan, Jaya
- Neue Suche nach: Stieltjes, Hans
- Neue Suche nach: Armas, Danielle
- Neue Suche nach: Dishy, Victor
- Neue Suche nach: Perez Ruixo, Juan Jose
- Neue Suche nach: Csonka, Dénes
- Neue Suche nach: Fishman, Vladislav
- Neue Suche nach: Natarajan, Jaya
- Neue Suche nach: Stieltjes, Hans
- Neue Suche nach: Armas, Danielle
- Neue Suche nach: Dishy, Victor
- Neue Suche nach: Perez Ruixo, Juan Jose
In:
Pharmacology Research & Perspectives
;
9
, 5
;
2021
-
ISSN:
- Aufsatz (Zeitschrift) / Elektronische Ressource
-
Titel:Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic
-
Beteiligte:Csonka, Dénes ( Autor:in ) / Fishman, Vladislav ( Autor:in ) / Natarajan, Jaya ( Autor:in ) / Stieltjes, Hans ( Autor:in ) / Armas, Danielle ( Autor:in ) / Dishy, Victor ( Autor:in ) / Perez Ruixo, Juan Jose ( Autor:in )
-
Erschienen in:
-
Verlag:
-
Erscheinungsdatum:01.10.2021
-
Format / Umfang:10 pages
-
ISSN:
-
DOI:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Elektronische Ressource
-
Sprache:Englisch
-
Schlagwörter:
-
Datenquelle:
Inhaltsverzeichnis – Band 9, Ausgabe 5
Zeige alle Jahrgänge und Ausgaben
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
-
EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancersLuna Yolba, Raquel / Visentin, Virgile / Hervé, Caroline / Chiche, Johanna / Ricci, Jean‐Ehrland / Méneyrol, Jérôme / Paillasse, Michaël R. / Alet, Nathalie et al. | 2021
-
A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neuronsCosta, Blaise M. / Kwapisz, Lina Cortés / Mehrkens, Brittney / Bledsoe, Douglas N. / Vacca, Bryanna N. / Johnston, Tullia V. / Razzaq, Rehan / Manickam, Dhanasekaran / Klein, Bradley G. et al. | 2021
-
Strategies to apply 3Rs in preclinical testingGorzalczany, Susana B. / Rodriguez Basso, Angeles G. et al. | 2021
-
South American special issue: EditorialMonczor, Federico / Genaro, Ana et al. | 2021
-
Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population‐based assessmentYu, Ya‐Hui / Filion, Kristian B. / Reynier, Pauline / Platt, Robert W. / Yu, Oriana H. Y. / Grandi, Sonia M. et al. | 2021
-
Induced fit versus conformational selection: From rate constants to fluxes… and back to rate constantsVauquelin, Georges / Maes, Dominique et al. | 2021
-
Recombinant botulinum neurotoxin serotype A1 in vivo characterizationPérier, Cindy / Martin, Vincent / Cornet, Sylvie / Favre‐Guilmard, Christine / Rocher, Marie‐Noelle / Bindler, Julien / Wagner, Stéphanie / Andriambeloson, Emile / Rudkin, Brian B. / Marty, Rudy et al. | 2021
-
Issue Information| 2021
-
Corrigendum| 2021
-
Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantificationPedersen, Kata W. / Hansen, Jakob / Hasselstrøm, Jørgen B. / Jornil, Jakob R. et al. | 2021
-
An exploratory first‐in‐man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2‐ and 1‐week interval in patients with metastatic castration resistant prostate cancerVrouwe, Josephina P. M. / Kamerling, Ingrid M. C. / van Esdonk, Michiel J. / Metselaar, Josbert M. / Stuurman, Frederik E. / van der Pluijm, Gabri / Burggraaf, Jacobus / Osanto, Susanne et al. | 2021
-
Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disordersSagahón‐Azúa, Julia / Medellín‐Garibay, Susanna Edith / Chávez‐Castillo, Cinthya Eloisa / González‐Salinas, César Guillermo / Milán‐Segovia, Rosa del Carmen / Romano‐Moreno, Silvia et al. | 2021
-
Histamine in cancer immunology and immunotherapy. Current status and new perspectivesSarasola, María de la Paz / Táquez Delgado, Mónica A. / Nicoud, Melisa B. / Medina, Vanina A. et al. | 2021
-
Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteersNoda, Naoto / Takagaki, Takeshi / Yodo, Yasuhide / Horibuchi, Yuzo / Iino, Shuichi / Matsuki, Shunji / Ogama, Yoichiro / Kakuyama, Hiroyoshi et al. | 2021
-
Identification of the organic anion transporting polypeptides responsible for the hepatic uptake of the major metabolite of epyrifenacil, S‐3100‐CA, in miceSakurai, Kengo / Kuroda, Tomohiro / Abe, Jun / Toda, Hiroshi / Kitamoto, Sachiko et al. | 2021
-
Gut microbiota disorder caused by diterpenoids extracted from Euphorbia pekinensis aggravates intestinal mucosal damageWang, Kuilong / Xu, Xiaofen / Maimaiti, Aikebaier / Hao, Min / Sang, Xianan / Shan, Qiyuan / Wu, Xin / Cao, Gang et al. | 2021
-
Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemicCsonka, Dénes / Fishman, Vladislav / Natarajan, Jaya / Stieltjes, Hans / Armas, Danielle / Dishy, Victor / Perez Ruixo, Juan Jose et al. | 2021
-
[8]‐Gingerol exerts anti‐myocardial ischemic effects in rats via modulation of the MAPK signaling pathway and L‐type Ca2+ channelsXue, Yucong / Zhang, Muqing / Zheng, Bin / Zhang, Yuanyuan / Chu, Xi / Liu, Yu / Li, Ziliang / Han, Xue / Chu, Li et al. | 2021
-
Lumbriculus variegatus: A novel organism for in vivo pharmacology educationSeeley, Aidan / Bellamy, Caitlin / Davies, Nia A. / Wallace, Melisa J. et al. | 2021
-
Polypharmacology of clinical sodium glucose co‐transport protein 2 inhibitors and relationship to suspected adverse drug reactionsMatharu, Karan / Chana, Kiran / Ferro, Charles J. / Jones, Alan M. et al. | 2021
-
Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in ratsWang, Shuyao / Chen, Chun / Guan, Chi / Qiu, Liping / Zhang, Lei / Zhang, Shaofeng / Zhou, Hongyu / Du, Hongwen / Li, Chen / Wu, Yaqiong et al. | 2021
-
Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tractNader‐Macías, María Elena Fátima / De Gregorio, Priscilla Romina / Silva, Jessica Alejandra et al. | 2021
-
Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disordersPalumbo, María Laura / Moroni, Alejandro David / Quiroga, Sofía / Castro, María Micaela / Burgueño, Adriana Laura / Genaro, Ana María et al. | 2021
-
Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8Port, Andreas / Shaw, Jamie V. / Klopp‐Schulze, Lena / Bytyqi, Afrim / Vetter, Claudia / Hussey, Elizabeth / Mammasse, Nadra / Ona, Victor / Bachmann, Angelika / Strugala, Denis et al. | 2021
-
Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double‐blind, controlled trialLiu, Tianxiao / Lai, Ting / Chen, Jing / Lu, Yizhi / He, Fang / Chen, Yanhua / Xie, Yubo et al. | 2021
-
A framework for economic evaluation of therapeutic drug monitoring—guided dosing in oncologyErku, Daniel / Schneider, Jennifer / Scuffham, Paul et al. | 2021
-
Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animalsHeil, Luciana Boavista Barros / Cruz, Fernanda Ferreira / Antunes, Mariana Alves / Braga, Cassia Lisboa / Agra, Lais Costa / Bose Leão, Rebecca Madureira / Abreu, Soraia Carvalho / Pelosi, Paolo / Silva, Pedro Leme / Rocco, Patricia Rieken Macedo et al. | 2021
-
Benefits and adverse effects of sacubitril/valsartan in patients with chronic heart failure: A systematic review and meta‐analysisCharuel, Elodie / Menini, Thibault / Bedhomme, Sabrina / Pereira, Bruno / Piñol‐Domenech, Nathalie / Bouchant, Suzy / Boussageon, Rémy / Bœuf‐Gibot, Sylvaine / Vaillant‐Roussel, Helene et al. | 2021
-
A pharmacokinetics‐based approach to the monitoring of patient adherence to atorvastatin therapyKarvaly, Gellért Balázs / Karádi, István / Vincze, István / Neely, Michael N. / Trojnár, Eszter / Prohászka, Zoltán / Imreh, Éva / Vásárhelyi, Barna / Zsáry, András et al. | 2021
-
Mizagliflozin, a selective SGLT1 inhibitor, improves vascular cognitive impairment in a mouse model of small vessel diseaseIshida, Nanae / Saito, Maki / Sato, Sachiko / Tezuka, Yu / Sanbe, Atsushi / Taira, Eiichi / Hirose, Masamichi et al. | 2021
-
The use of GA‐RxODE (Genetics Algorithms and Running simulations from Ordinary Differential Equations‐based model) method to optimize bioequivalence studiesNuske, Ezequiel Omar / Morozov, Mikhail / Alejandro Serra, Héctor et al. | 2021
-
Pitolisant, a wake‐promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetolKrief, Stéphane / Berrebi‐Bertrand, Isabelle / Nagmar, Isabelle / Giret, Martin / Belliard, Simon / Perrin, David / Uguen, Marilyne / Robert, Philippe / Lecomte, Jeanne‐Marie / Schwartz, Jean‐Charles et al. | 2021
-
Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational studyPasta, Andrea / Borro, Paolo / Cremonini, Anna Laura / Formisano, Elena / Tozzi, Giulia / Cecchi, Stefano / Fresa, Raffaele / Labanca, Sara / Djahandideh, Afscin / Sukkar, Samir Giuseppe et al. | 2021
-
Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney diseaseSanaei‐Ardekani, Mohammad / Kamal, Shyreen / Handy, Whitney / Alam, Sidrah / Salaheldin, Aya / Moore, Anderson / Movafagh, Shahrzad et al. | 2021