Regulatory peptides
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Table of contents
- 1
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Chairman's opening remarksOtsuka, Masanori et al. | 1993
- 4
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Opening addressPernow, Bengt et al. | 1993
- 9
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Characterisation, CNS distribution and function of NK2 receptors studied using potent NK2 receptor antagonistsHagan, R.M. / Beresford, I.J.M. / Stables, J. et al. | 1993
- 20
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Discovery of CP-96,345 and its characterization in disease models involving substance PLowe, John A III / Drozda, Susan E / Michael Snider, R et al. | 1993
- 24
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Antinociceptive properties and inhibition of neurogenic inflammation with potent SP antagonists belonging to perhydroisoindolonesGarret, Claude / Carruette, Anne / Fardin, Véronique et al. | 1993
- 31
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SR 48968, a neurokinin A (NK2) receptor antagonistEmonds-Alt, Xavier / Advenier, Charles / Croci, Tiziano et al. | 1993
- 37
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Signal transduction and ligand-binding domains of the tachykinin receptorsNakanishi, Shigetada / Nakajima, Yoshiaki / Yokota, Yoshifumi et al. | 1993
- 43
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Mapping the ligand binding site of the NK-1 receptorFong, Tung Ming / Huang, Ruey-Ruey C. / Yu, Hong et al. | 1993
- 49
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Binding epitopes for peptide and non-peptide ligands on the NK1 (substance P) receptorGether, Ulrik / Johansen, Teit E. / Michael Snider, R. et al. | 1993
- 59
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Structure, expression and second messenger-mediated regulation of the human and rat substance P receptors and their genesKrause, J.E. / Bu, J.-Y. / Takeda, Y. et al. | 1993
- 67
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3.3 kb of 5′ flanking DNA from the rat preprotachykinin gene directs high level expression of a reporter gene in microinjected dorsal root ganglion neurons but not in transgenic miceHarmar, A.J. / Mulderry, P.K. / Al-Shawi, R. et al. | 1993
- 70
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Cytokines regulate substance P expression in sympathetic neuronsKessler, John A. / Freidin, Mona M. / Kalberg, Christopher et al. | 1993
- 76
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Coexistence and interaction of neuropeptides with substance P in primary sensory neurons, with special reference to galaninHökfelt, T. / Zhang, X. / Verge, V. et al. | 1993
- 81
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Four novel tachykinins in frog (Rana catesbeiana) brain and intestineKangawa, Kenji / Kozawa, Hitoo / Hino, Jun et al. | 1993
- 89
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Arthropod venoms affecting cell signalling systemNakajima, Terumi et al. | 1993
- 93
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Galanin analogues: agonist and antagonistYanaihara, Noboru / Mochizuki, Tohru / Takatsuka, Naoki et al. | 1993
- 102
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Effects of l-glutamate, substance P and substance P(1–7) on cardiovascular regulation in the nucleus tractus solitariusHall, Michael E. / Greer, Robert A. / Stewart, John M. et al. | 1993
- 110
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Signal transduction mechanisms of substance P effects on ion channelsNakajima, Yasuko / Koyano, Konomi / Velimirovic, Bratislav M. et al. | 1993
- 114
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Substance P receptor (NK-1) in the central nervous system: possible functions from a morphological aspectKiyama, Hiroshi / Maeno, Hiroshi / Tohyama, Masaya et al. | 1993
- 124
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Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2 and NK3 tachykinin receptorsGlowinski, J. / Kemel, M.L. / Desban, M. et al. | 1993
- 129
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Substance P in the retina and primary visual centers: its projection and plasticity after deafferentationSenba, Emiko / Miguell-Hidalgo, Jose Javier et al. | 1993
- 138
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Participation of substance P in spinal physiological responses to peripheral aversive stimulationHenry, James L. et al. | 1993
- 144
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Release of tachykinins and its metabolism in the airwayKohrogi, H. / Yamaguchi, T. / Kawano, O. et al. | 1993
- 150
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Upregulation, release and axonal transport of substance P and calcitonin gene-related peptide in adjuvant inflammation and regulatory function of nerve growth factorDonnerer, J. / Schuligoi, R. / Stein, C. et al. | 1993
- 155
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Organization of substance P primary sensory neurons: ultrastructural and physiological correlatesCuello, A.C. / Ribeiro-da-Silva, A. / Ma, W. et al. | 1993
- 165
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The differential roles of substance P and neurokinin A in spinal cord hyperexcitability and neurogenic inflammationWiesenfeld-Hallin, Zsuzsanna / Xu, Xiao-Jun et al. | 1993
- 174
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Substance P and substance P receptor histochemistry in human neurodegenerative diseasesKowall, N.W. / Quigley, B.J. Jr. / Krause, J.E. et al. | 1993
- 189
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Autoradiographic localisation and characterisation of substance P binding sites in rat kneesWalsh, David A. / Salmon, Michael / Wharton, John et al. | 1993
- 193
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Preprotachykinin mRNA expression in the synovial tissue of chronic arthritisHashimoto, Sanshiro / Yamanaka, Kensuke / Inoue, Akio et al. | 1993
- 195
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A role for the C-terminal fragment of substance P, SP7−11 in the pathogenesis of arthritisHalliday, Dale A. / McNeil, Julian D. / Betts, William H. et al. | 1993
- 198
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Substance P-induced inflammation in the rat knee joint is mediated by neurokinin 1 (NK1) receptorsLam, F.Y. / Ferrell, W.R. / Scott, D.T. et al. | 1993
- 202
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The proportion of CGRP-immunoreactive and SP-mRNA containing dorsal root ganglion cells is increased by a unilateral inflammation of the ankle joint of the ratHanesch, Ulrike / Pfrommer, Ursula / Grubb, Blair D. et al. | 1993
- 204
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Maintained peptidergic innervation of the knee joint in an animal model of antigen-induced arthritisTheriault, E. / Marshall, K.W. / Homonko, D.A. et al. | 1993
- 208
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Capsaicin pretreatment increases inflammatory response to intratracheal instillation of endotoxin in ratsLong, N.C. / Frevert, C.W. / Shore, S.A. et al. | 1993
- 211
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Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivityClark Lantz, R. / Lemen, Richard J. / Dey, Richard D. et al. | 1993
- 214
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Tachykinins, via NK1 receptor activation, play a relevant role in plasma protein extravasation evoked by allergen challenge in the airways of sensitized guinea-pigsBertrand, Claude / Geppetti, Pierangelo / Baker, Jonathan et al. | 1993
- 217
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Characterization of NK-2 binding sites in rabbit lung tissueMillard, Susan / Yamamura, Henry / Bloom, John et al. | 1993
- 220
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Involvement of substance P present in small-diameter afferent fibers in microcirculatory hemodynamics of the rat hind instepYonehara, Norifumi / Takiuchi, Sou / Imai, Yasuo et al. | 1993
- 223
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Effect of substance P on the expression of an adhesion molecule ICAM-1 in human vascular endothelial cellsNakagawa, Noriaki / Iwamoto, Itsuo / Yoshida, Sho et al. | 1993
- 225
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Role of leukotriene B4 in substance P-induced granulocyte infiltration in mouse skinIwamoto, Itsuo / Tomoe, Sanae / Yoshida, Sho et al. | 1993
- 228
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Mechanism for substance P-induced activation of human neutrophils and eosinophilsIwamoto, Itsuo / Nakagawa, Noriaki / Yamazaki, Hiroomi et al. | 1993
- 231
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Topical indomethacin decreases substance P immunoreactivity in human ocular aqueous humorKieselbach, Gerhard / Troger, Josef / Kaehler, Christian et al. | 1993
- 233
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Relations of contractile hyperreactivity to tachykinins in rabbit tracheaSakai, Yasushi / Inoue, Kazuaki / Homma, Ikuo et al. | 1993
- 236
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Neurokinin A, but not neurokinin B and substance P, induces codeine-resistant coughs in awake guinea-pigsTakahama, Kazuo / Fuchikami, Junichi / Isohama, Yoichiro et al. | 1993
- 238
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Involvement of substance P in the paroxysmal cough of pertussisYoshihara, Shigemi / Kanno, Noriko / Ando, Tamotsu et al. | 1993
- 241
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Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomachKatori, M. / Ohno, T. / Nishiyama, K. et al. | 1993
- 244
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A study on the peptidergic nerves (VIP, substance P) in the colon of patients with diverticular diseaseTomita, Ryouichi / Munakata, Keimei / Aoki, Nobuhiko et al. | 1993
- 247
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Immunohistochemical study of substance P in the substantia nigra of multiple system atrophyNomura, Hiroshi / Konno, Hidehiko / Takase, Sadao et al. | 1993
- 251
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The role of substance P in the pathogenesis of experimental allergic neuritisWu, Shujian / Chen, Juan / Xu, Chengtao et al. | 1993
- 254
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Peptide-immunoreactive neuronal structures in the human celiac/superior mesenteric ganglionic complex (CSM)Del Fiacco, Marina / Floris, Alessandra / Lai, Maria Letizia et al. | 1993
- 257
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Multiple actions of substance P and other tachykinins on sympathetic neurons in rat prevertebral gangliaKonishi, S. / Song, S.-Y. / Yamakuni, T. et al. | 1993
- 260
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Role of substance P in regulating sympatho-adrenal function in conscious ratsShimatsu, Akira / Ishikawa, Yasuhiro / Kasai, Kyomi et al. | 1993
- 263
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Comparison of effects of morphine and CP-96,345, a substance P antagonist, administered intrathecally on the somatosympathetic reflex discharges in anesthetized ratsAdachi, Takehiko / Sato, Akio / Sato, Yuko et al. | 1993
- 266
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Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345Prabhakar, N. R. / Snider, R. M. / Lowe, J. A. et al. | 1993
- 266
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Selective blockage of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345Prabhakar, N.R. / Snider, R.M. / Lowe, J.A. III et al. | 1993
- 269
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Potentiation of sensory tachykininergic and parasympathetic cholinergic transmission by epidermal growth factorMuramatsu, Ikunobu / Hollenberg, Morley D. et al. | 1993
- 272
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SP/CGRP-immunoreactive nerves in the tracheal epithelium of rats: immunohistochemical and ultrastructural studyTerada, Masaki / Iwanaga, Toshihiko / Fujita, Tsuneo et al. | 1993
- 275
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Regional differences in contractile responses to tachykinin agonists and to electrical field stimulation are dependent on distribution of proteinase activityFunayama, Norio / Shinkai, Michiko / Takayanagi, Issei et al. | 1993
- 278
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Does substance P release mediate NANC nerve-mediated responses to field stimulation and ligands, in the rabbit isolated sphincter pupillae?Hall, Judith M. / Mitchell, Debra / Morton, Ian K.M. et al. | 1993
- 282
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Pharmacological analysis of receptors involved in tachykininergic contraction induced by electrical transmural stimulation in the rabbit iris sphincter muscleKunitomo, Masaru / Imaizumi, Noriko / Sameshima, Emiko et al. | 1993
- 285
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Pharmacological properties of a slow C-fiber response induced by stimulation of greater splanchnic nerve in an isolated spinal cord-nerve preparation of the newborn ratYanagisawa, Mitsuhiko / Hosoki, Rumiko / Otsuka, Masanori et al. | 1993
- 287
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Functional characterization of neurokinin receptors with agonists and antagonistsRegoli, D. / Nguyen, Q.T. / Jukic, D. et al. | 1993
- 290
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Differential SAR of quinuclidine SP antagonists between rat and human-type receptorsSnider, R.M. / Longo, K.P. / Zorn, S.H. et al. | 1993
- 293
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Role of NK-1 receptor in central cardiovascular regulation in rats: studies on a novel non-peptide antagonist, CP-96,345, of substance P NK-1 receptorSaigo, Aki / Takano, Yukio / Saito, Ryo et al. | 1993
- 297
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Involvement of tachykinin and CGRP receptors in the cardio-pulmonary effects evoked by capsaicin in the guinea-pigSatoh, Hiroyuki / Delay-Goyet, Philippe / Lundberg, Jan M. et al. | 1993
- 300
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Variations in affinities for the NK1 receptor: differences between the non-peptide substance P antagonists RP 67580 and CP-96,345 and the agonist septideFardin, Véronique / Foucault, Frédéric / Bock, Marie Dominique et al. | 1993
- 304
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Differences in the potency of CP-96345 and RP-67580, two new non-peptide antagonists selective for NK1 receptors, in inhibiting responses evoked by stimulation of sensory nervesDelay-Goyet, P. / Satoh, H. / Stjaerne, P. et al. | 1993
- 304
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Differences in the potency o non-peptide antagonists selective for NK1 receptors, in inhibiting responses evoked by stimulation of sensory nervesDelay-Goyet, Philippe / Satoh, Hiroyuki / Stjärne, Per et al. | 1993
- 307
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Evidence for NK-1 receptor subtypes from in vivo bronchopulmonary and cardiovascular studiesFloch, Anne / Massa, Nicole / Thiry, Chantal et al. | 1993
- 309
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Blockade of cutaneous nerve-evoked responses by GR71251 in the isolated spinal cord preparation of newborn ratGuo, J.-Z. / Yoshioka, K. / Yanagisawa, M. et al. | 1993
- 311
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On the presence of NK2 receptor subtypes in peripheral and central tissuesWatling, K.J. / Guard, S. / Krause, J.E. et al. | 1993
- 314
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In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonistGiuliani, Sandro / Patacchini, Riccardo / Giachetti, Antonio et al. | 1993
- 317
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Characterization of the cardiovascular and behavioral effects of centrally administered neuropeptide K in the conscious ratPrat, Alexandre / Picard, Pierre / Domenico, Regoli et al. | 1993
- 321
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Novel substance P analogues inhibit circular muscle contraction of guinea pig ileum and depolarization of new born rat spinal cord induced by substance PMochizuki, Tohru / Ohshima, Keiichi / Kuwahara, Atukazu et al. | 1993
- 326
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A selective and extremely potent antagonist of the neurokinin-1 receptorSakurada, Tsukasa / Manome, Yoichi / Tan-No, Koichi et al. | 1993
- 329
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CP-99,994, a nonpeptide antagonist of the tachykinin NK1 receptorMcLean, S. / Snider, R.M. / Desai, M.C. et al. | 1993
- 332
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Design of a novel dipeptide substance P antagonist FK888Hagiwara, Daijiro / Miyake, Hiroshi / Igari, Norihiro et al. | 1993
- 335
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The pharmacological properties of FK888, a novel dipeptide NK1 antagonistMurai, Masako / Maeda, Yasue / Yamaoka, Makiko et al. | 1993
- 338
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Inhibitory effects of substance P analogs on the activation of GTP-binding regulatory proteins by receptorsMukai, Hidehito / Higashijima, Tsutomu et al. | 1993
- 340
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[3H]Substance P binds to two high-affinity sites in bovine retinaHauser, Kathleen L. / Heid, Jakob / Bittiger, Helmut et al. | 1993
- 343
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Spantide-induced antinociception in the opioid mechanismTan-No, Koichi / Sakurada, Tsukasa / Yamada, Toshihide et al. | 1993
- 346
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Different behavioral profiles of the non-peptide substance P (NK-1) antagonists CP-96,345 and RP 67580Saria, Alois / Troger, Josef / Zernig, Gerald et al. | 1993
- 349
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Increased synthesis of neurokinin B and enkephalin after chronic haloperidol treatmentMarksteiner, J. / Saria, A. / Miller, C.H. et al. | 1993
- 352
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Effects of subacute repeated injections of phencyclidine and MK-801 on substance P content in the rat brainMitsushio, H. / Shirayama, Y. / Nishikawa, T. et al. | 1993
- 354
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Substance P-evoked release of amino acid transmitters from the newborn rat spinal cordMaehara, T. / Suzuki, H. / Yoshioka, K. et al. | 1993
- 357
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N-terminally extended tachykinins in human cerebrospinal fluidToresson, Gudrun / Brodin, Ernst / Bertilsson, Leif et al. | 1993
- 360
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The mechanism of central pressor actions of tachykinin NK-3 receptor in the paraventricular nucleus of the hypothalamus in ratsTakano, Yukio / Nakayama, Yasuhisa / Matsumoto, Takafumi et al. | 1993
- 364
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In vivo characterization of tachykinin receptors responsible for the central cardiovascular effects of substance P and neurokinin ACulman, J. / Tschöpe, C. / Picard, A. et al. | 1993
- 367
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Tachykinins depress a calcium-dependent potassium conductance in sympathetic preganglionic neuronsInokuchi, H. / Yoshimura, M. / Polosa, C. et al. | 1993
- 370
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Expression of and proto-oncogenes in the rat spinal cord and the effects of noxious stimulationMurakoshi, Takayuki / Hamasaki, Hiroko / Ikawa, Yoji et al. | 1993
- 373
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Effect of the nonpeptide NK-1 receptor antagonist CP-96,345 on the morphine withdrawal response of guinea-pigsChahl, Loris A. / Johnston, P.A. et al. | 1993
- 376
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Neurokinin-1, -2 and -3 receptors are candidates for a role in the opiate withdrawal response in guinea-pigsJohnston, P.A. / Chahl, Loris A. et al. | 1993
- 379
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Substance P-evoked circular muscle contractions have a close connection with serotonergic neurons in guinea-pig ileumOhmori, Toshiaki / Kuwahara, Atsukazu / Ozaki, Tsuyoshi et al. | 1993
- 381
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Effect of CP-96,345 on the [Met5]enkephalin washout withdrawal response of the guinea-pig isolated ileumChahl, Loris A. / Kavanagh, C.A. et al. | 1993
- 383
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Stimulation and propagation of the ascending enteric reflex contraction: role of tachykinins and acetylcholineHolzer, P. / Maggi, C.A. et al. | 1993
- 386
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Tachykinin NK-1 and NK-2 receptors in the circular muscle of the guinea-pig proximal colonSanticioli, Paolo / Giuliani, Sandro / Bartho, Lorand et al. | 1993
- 389
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Spinal effects of selective NK-1 and NK-2 receptor antagonists on bladder motility in anesthetized ratsMaggi, C.A. / Lecci, A. / Garret, C. et al. | 1993
- 392
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Intrathecal administration of NK1 receptor antagonist, CP96345, inhibits the micturition reflex in the ratKawatani, M. / Matsumoto, G. / Birder, L.A. et al. | 1993
- 396
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Tachykinin receptors in the rat isolated uterusFisher, L. / Pennefather, J.N. / Hall, S. et al. | 1993
- 399
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Effect of tachykinins on the acetylcholine output stimulated by nicotine from guinea-pig bladderShinkai, Michiko / Takayanagi, Issei et al. | 1993
- 402
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Substance P/calcitonin gene-related peptide (CGRP)-immunoreactive nerve terminals in the whole mount preparations of the dog urethraIwanaga, Toshihiko / Tamaki, Makoto / Adachi, Isamu et al. | 1993
- 405
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Participation of spinal cord substance P in hyperalgesia induced by repeated cold stressKuraishi, Yasushi / Satoh, Masamichi et al. | 1993
- 407
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Primary afferent-evoked slow EPSPs and responses to substance P of dorsal horn neurons in the adult rat spinal cord slicesYoshimura, Megumu / Shimizu, Toko / Yajiri, Yohichi et al. | 1993
- 410
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Substance P-containing primary afferent receives inhibitory modulation directly from enkephalin- and GABA-containing interneurons in the dorsal horn of the chickenAtsumi, S. / Sakamoto, H. / Kawate, T. et al. | 1993
- 413
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The effects of NK-1 and NK-2 receptor antagonists on the capsaicin evoked synaptic response in the rat spinal cord in vitroUrban, Laszlo / Dray, Andy / Nagy, Istvan et al. | 1993
- 415
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Desensitizing mechanism of capsaicin and nonanoyl vanillylamide on the vascular nociceptive response in the guinea pigKawamura, Shunsuke / Kume, Hiroko / Yonezawa, Akihiko et al. | 1993
- 418
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Interactions between excitatory amino acids and tachykinins and long-term changes of synaptic responses in the rat spinal dorsal hornRandic, M. / Jiang, M.C. / Rusin, K.I. et al. | 1993
- 421
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The amino-terminus of substance P mimics and MK-801 attenuates the effects of capsaicin on nociception and kainic acid-induced behavior in the mouseLarson, Alice A. / Sun, Xiaofeng et al. | 1993
- 424
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Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK~1 receptors or by presynaptic action of opioid receptor agonistsMoussaoui, S. / Carruette, A. / Garret, C. et al. | 1993
- 424
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Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynpatic action of opioid receptor agonistsMoussaoui, Saliha / Curruette, Anne / Garret, Claude et al. | 1993
- 426
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Receptor characterization of the spinal action of neurokinins on nociception: a three receptor hypothesisCouture, Réjean / Boucher, Sylvie / Picard, Pierre et al. | 1993
- 430
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Is the selective non-peptide NK-1 receptor antagonist CP96,345 a peripherally acting analgesic?Berge, O.-G. / Ståhlberg, M. et al. | 1993
- 433
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Non-specific activity of in models of pain and inflammationNagahisa, Atsushi / Asai, Rinko / Kanai, Yoshihito et al. | 1993
- 437
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Effect of CP-96,345 a non-peptide substance P antagonist, capsaicin, resiniferatoxin and ruthenium red on nociceptionSzolcsányi, J. / Nagy, J. / Pethö, G. et al. | 1993
- 440
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Antiinflammatory and analgesic activity of CP-96,345: on orally active non-peptide substance P receptor antagonistNagahisa, Atsushi / Kanai, Yoshihito / Suga, Osamu et al. | 1993
- 440
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Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonistNagahisa, A. / Kanai, Y. / Suga, O. et al. | 1993
- 444
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Investigations of the expression and post-translational processing of the preprotachykinin-I (PPT-I) gene by rat pancreatic, insulin-producing tumor cell-linesMcGregor, G.P. / Fehmann, C. / Hartel, R. et al. | 1993
- 447
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The roles of the putative third cytoplasmic loop and cytoplasmic carboxyl tail of NK-1 and NK-2 receptors in agonist stimulated second messenger responses in stably transfected CHO cellsBlount, Paul / Krause, James E. et al. | 1993
- 450
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Substance P-induced elevation of intracellular calcium in transfected Chinese hamster ovary cells: role of inositol trisphosphateMochizuki-Oda, Noriko / Nakajima, Yoshiaki / Nakanishi, Shigetada et al. | 1993
- 453
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Do substance P agonists insert into the lipid membrane?Hölzemann, Günter / Greiner, Hartmut E. / Harting, Jürgen et al. | 1993
- 455
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A novel, selective radioligand, [125I]-[Lys5, Tyr(I2)7, Meleu9, Nle10]-NKA(4–10), for the tachykinin NK-2 receptorBadgery-Parker, Tim / Zeng, Xiang-Ping / Lavielle, Solange et al. | 1993
- 458
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Potentiating effect of peptidase inhibitors on a C fiber-evoked response in the isolated spinal cord preparation of the neonatal ratSuzuki, H. / Seno, N. / Hosoki, R. et al. | 1993
- 461
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Concluding remarksLemberk, Fred et al. | 1993
- 463
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Author index| 1993
- 472
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Key word index| 1993
- ii
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Editorial Board| 1993
- xix
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PrefaceOtsuka, Masanori / Kanazawa, Ichiro / Nakanishi, Shigetada et al. | 1993
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Proceedings of the International Symposium on SUBSTANCE P AND RELATED PEPTIDES - Pain, Inflammation, Visceral and CNS Functions - 3-6 November 1992, Shizuoka, Japan| 1993