Bioorganic and Medicinal Chemistry Letters
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
Table of contents
- 4961
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Graphical contents list| 2010
- 4983
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Hsp90 inhibition: Elimination of shock and stressDuerfeldt, Adam S. / Blagg, Brian S.J. et al. | 2010
- 4988
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Antimicrobial phenolic abietane diterpene from Lycopus europaeus L. (Lamiaceae)Radulović, Niko / Denić, Marija / Stojanović-Radić, Zorica et al. | 2010
- 4992
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Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonistsLange, Jos H.M. / Attali, Amos / van der Neut, Martina A.W. et al. | 2010
- 4999
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Synthesis of novel tetrahydroisoquinoline bronchodilatorsDalence-Guzmán, Maria F. / Toftered, Jörgen / Oltner, Viveca Thornqvist et al. | 2010
- 5004
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The synthesis and structure–activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonistsTing, Pauline C. / Lee, Joe F. / Albanese, Margaret M. et al. | 2010
- 5009
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Natural products-based insecticidal agents 7. Semisynthesis and insecticidal activity of novel 4a-alkyloxy-2-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivoXu, H. / Xiao, X. / Wang, Q. t. et al. | 2010
- 5009
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Natural products-based insecticidal agents 7. Semisynthesis and insecticidal activity of novel 4α-alkyloxy-2-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivoXu, Hui / Xiao, Xiao / Wang, Qing-tian et al. | 2010
- 5013
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Discovery of potent HIV integrase inhibitors active against raltegravir resistant virusesLe, Giang / Vandegraaff, Nick / Rhodes, David I. et al. | 2010
- 5019
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A stable analog of isochorismate for the study of MenD and other isochorismate-utilizing enzymesFang, Maohai / Langman, Blaine M. / Palmer, David R.J. et al. | 2010
- 5023
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Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamideDi Fiore, Anna / Truppo, Emanuela / Supuran, Claudiu T. et al. | 2010
- 5027
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Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinaseSampognaro, Anthony J. / Wittman, Mark D. / Carboni, Joan M. et al. | 2010
- 5031
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Development of 2-pyrrolidinyl-N-methyl pyrimidones as potent and orally bioavailable HIV integrase inhibitorsFerrara, Marco / Fiore, Fabrizio / Summa, Vincenzo et al. | 2010
- 5035
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Synthesis of pyrrolomorphinan derivatives as κ opioid agonistsFujii, Hideaki / Ida, Yoshihiro / Hanamura, Shinichi et al. | 2010
- 5035
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Synthesis of pyrrolomorphinan derivatives as k opioid agonistsFujii, H. / Ida, Y. / Hanamura, S. et al. | 2010
- 5039
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SAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stabilityGao, Donghong Amy / Xiong, Zhaoming / Heim-Riether, Alexander et al. | 2010
- 5044
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Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: Novel, potent, and selective series of Vasopressin1b receptor antagonistsArban, Roberto / Bianchi, Federica / Buson, Alberto et al. | 2010
- 5050
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Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I–XVInnocenti, Alessio / Gülçin, Ilhami / Scozzafava, Andrea et al. | 2010
- 5054
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InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivativesLakshmi, Neelakandan Vidhya / Thirumurugan, Prakasam / Noorulla, K.M. et al. | 2010
- 5062
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Synthesis and biological evaluation of oxoindolin-3-ylidene ethyl benzothiohydrazides as non-peptide TPO mimicsTang, Peng Cho / Lu, He Jun / Chen, Yi Qian et al. | 2010
- 5065
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Synthesis of selenophene derivatives as novel CHK1 inhibitorsHong, Pao-Chiung / Chen, Li-Jung / Lai, Tzu-Yun et al. | 2010
- 5069
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Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disordersGianotti, Massimo / Corti, Corrado / Fratte, Sonia Delle et al. | 2010
- 5074
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Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case studyChen, Austin / Dubé, Daniel / Dubé, Laurence et al. | 2010
- 5080
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Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptorAbdi, Muna H. / Beswick, Paul J. / Billinton, Andy et al. | 2010
- 5085
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Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activationTeng, Yuou / Iuchi, Katsuya / Iwasa, Eriko et al. | 2010
- 5089
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Inhibition of interleukin-1β converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketonesGalatsis, Paul / Caprathe, Bradley / Downing, Dennis et al. | 2010
- 5089
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Inhibition of interleukin-1b converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketonesGalatsis, P. / Caprathe, B. / Downing, D. et al. | 2010
- 5095
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Concise synthesis of Cannabisin GLi, Dawei / Li, Wenling / Wang, Qian et al. | 2010
- 5099
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Structure-based engineering of benzalacetone synthaseShimokawa, Yoshihiko / Morita, Hiroyuki / Abe, Ikuro et al. | 2010
- 5104
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Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogsGhosh, Arun K. / Dawson, Zachary L. / Moon, Deuk Kyu et al. | 2010
- 5108
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Development of methotrexate proline prodrug to overcome resistance by MDA-MB-231 cellsWu, Zhiqian / Shah, Anandkumar / Patel, Namrata et al. | 2010
- 5113
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Discovery of imidazo[1,2-b]pyridazine derivatives as IKKb inhibitors. Part 1: Hit-to-lead study and structure-activity relationshipShimizu, H. / Tanaka, S. / Toki, T. et al. | 2010
- 5113
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Discovery of imidazo[1,2-b]pyridazine derivatives as IKKβ inhibitors. Part 1: Hit-to-lead study and structure–activity relationshipShimizu, Hiroki / Tanaka, Shinji / Toki, Tadashi et al. | 2010
- 5119
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Introduction of guanidinium-modified deoxyuridine into the substrate binding regions of DNAzyme 10–23 to enhance target affinity: Implications for DNAzyme designLam, Curtis H. / Perrin, David M. et al. | 2010
- 5123
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Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitorsLing, Cui / Zheng, Zhibing / Jiang, Xian Cheng et al. | 2010
- 5126
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S-Benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenaseMatsuno, Kenji / Takai, Kazushige / Isaka, Yoshinobu et al. | 2010
- 5130
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Discovery of cannabinoid-1 receptor antagonists by virtual screeningLee, Gil Nam / Kim, Kwang Rok / Ahn, Sung-Hoon et al. | 2010
- 5133
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Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead explorationOza, Vibha / Ashwell, Susan / Brassil, Patrick et al. | 2010
- 5139
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Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activationFujii, Shuji / Ohsawa, Fuminori / Yamada, Shoya et al. | 2010
- 5143
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Fluorescent retinoid X receptor ligands for fluorescence polarization assayYamada, Shoya / Ohsawa, Fuminori / Fujii, Shuji et al. | 2010
- 5147
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Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonistsSchlegel, Kelly-Ann S. / Yang, Zhi-Qiang / Reger, Thomas S. et al. | 2010
- 5153
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Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive ratsGinn, John D. / Bosanac, Todd / Chen, Rhonda et al. | 2010
- 5157
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New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitorsMatos, Maria João / Viña, Dolores / Janeiro, Patricia et al. | 2010
- 5161
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Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists)Gerspacher, Marc / Altmann, Eva / Beerli, René et al. | 2010
- 5165
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Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonistsDavenport, Adam J. / Stimson, Christopher C. / Corsi, Massimo et al. | 2010
- 5170
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Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitorsBelanger, David B. / Curran, Patrick J. / Hruza, Alan et al. | 2010
- 5175
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Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)Engers, Darren W. / Gentry, Patrick R. / Williams, Richard et al. | 2010
- 5179
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Synthesis and evaluation of oryzalin analogs against Toxoplasma gondiiEndeshaw, Molla M. / Li, Catherine / Leon, Jessica de et al. | 2010
- 5184
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Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1b converting enzyme (ICE or caspase 1)Galatsis, P. / Caprathe, B. / Gilmore, J. et al. | 2010
- 5184
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Succinic acid amides as P2–P3 replacements for inhibitors of interleukin-1β converting enzyme (ICE or caspase 1)Galatsis, Paul / Caprathe, Bradley / Gilmore, John et al. | 2010
- 5191
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Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted deliveryThomas, Thommey P. / Choi, Seok Ki / Li, Ming-Hsin et al. | 2010
- 5195
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Synthesis and in vitro antibacterial activity of novel fluoroquinolone derivatives containing substituted piperidinesChai, Yun / Liu, Mingliang / Wang, Bo et al. | 2010
- 5199
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Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: Impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, a2A, D4.2, D3 and D2L receptorsResimont, M. / Liegeois, J. F. et al. | 2010
- 5199
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Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: Impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, α2A, D4.2, D3 and D2L receptorsRésimont, Mélissa / Liégeois, Jean-François et al. | 2010
- 5203
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Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activitiesGiraud, Francis / Marchand, Pascal / Carbonnelle, Delphine et al. | 2010
- 5207
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Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogsAldrich, Leslie N. / Stoops, Sydney L. / Crews, Brenda C. et al. | 2010
- 5212
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Design and synthesis of HCV agents with sequential triple inhibitory potentialsZhu, Tianmin / Fawzi, Mahdi B. / Flint, Michael et al. | 2010
- 5217
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X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitorsKuglstatter, Andreas / Ghate, Manjiri / Tsing, Stan et al. | 2010
- 5217
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X-ray crystal structure of JNK2 complexed with the p38a inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitorsKuglstatter, A. / Ghate, M. / Tsing, S. et al. | 2010
- 5221
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Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: A novel series of atypical antipsychotic agentsPark, Chul Min / Kim, So Young / Park, Woo Kyu et al. | 2010
- 5225
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An efficient one-pot synthesis of heterocycle-fused 1,2,3-triazole derivatives as anti-cancer agentsYan, Sheng-Jiao / Liu, Yong-Jiang / Chen, Yu-Lan et al. | 2010
- 5229
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Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activityKamal, Ahmed / Srikanth, Y.V.V. / Khan, M. Naseer A. et al. | 2010
- 5232
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Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agentsKamal, Ahmed / Reddy, J. Surendranadha / Ramaiah, M. Janaki et al. | 2010
- 5237
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Novel 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs)Yoon, Young Ae / Kim, Dong Hoon / Lee, Byoung Moon et al. | 2010
- 5241
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Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonistsSams, Anette Graven / Mikkelsen, Gitte Kobberøe / Larsen, Mogens et al. | 2010
- 5245
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Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological diseaseAbdellatif, Khaled R.A. / Velázquez, Carlos A. / Huang, Zhangjian et al. | 2010
- 5251
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Assessing the ability of a short fluorinated antifreeze glycopeptide and a fluorinated carbohydrate derivative to inhibit ice recrystallizationChaytor, Jennifer L. / Ben, Robert N. et al. | 2010
- 5255
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Synthesis and antituberculosis activity of new fatty acid amidesD’Oca, Caroline Da Ros Montes / Coelho, Tatiane / Marinho, Tamara Germani et al. | 2010
- 5258
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A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elementsJain, Disha / Koh, John T. et al. | 2010
- 5262
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Oxidative stimuli-responsive nanoprodrug of camptothecin kills glioblastoma cellsLee, Bong-Seop / Nalla, Aruna K. / Stock, Ilana R. et al. | 2010
- 5269
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Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonistsZhong, Min / Shen, Wang / Barr, Kenneth J. et al. | 2010
- 5274
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Factorizing the role of a critical leucine residue in the binding of substrate to human 20a-hydroxysteroid dehydrogenase (AKR1C1): Molecular modeling and kinetic studies of the Leu308Val mutant enzymeDhagat, U. / Endo, S. / Soda, M. et al. | 2010
- 5274
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Factorizing the role of a critical leucine residue in the binding of substrate to human 20α-hydroxysteroid dehydrogenase (AKR1C1): Molecular modeling and kinetic studies of the Leu308Val mutant enzymeDhagat, Urmi / Endo, Satoshi / Soda, Midori et al. | 2010
- 5277
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Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agentsYang, Su Hui / Van, Hue Thi My / Le, Thanh Nguyen et al. | 2010
- 5282
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Novel Notch-sparing γ-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist libraryKurosumi, Motonori / Nishio, Yoshino / Osawa, Satoko et al. | 2010
- 5282
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Novel Notch-sparing g-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist libraryKurosumi, M. / Nishio, Y. / Osawa, S. et al. | 2010
- 5286
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Biaryl substituted hydantoin compounds as TACE inhibitorsYu, Wensheng / Tong, Ling / Kim, Seong Heon et al. | 2010
- 5290
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Structure–activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloidsMcNulty, James / Nair, Jerald J. / Little, Jessamyn R.L. et al. | 2010
- 5295
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Identification of novel monoamine oxidase B inhibitors by structure-based virtual screeningGeldenhuys, Werner J. / Darvesh, Altaf S. / Funk, Max O. et al. | 2010
- 5299
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Preliminary studies of 3,4-dichloroaniline amides as antiparasitic agents: Structure–activity analysis of a compound library in vitro against Trichomonas vaginalisDornbush, Padraick J. / Cho, Cynric / Chang, Elizabeth S. et al. | 2010
- 5302
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A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β2-adrenoceptor agonists as inhaled long-acting bronchodilatorsBeattie, David / Bradley, Michelle / Brearley, Andrew et al. | 2010
- 5302
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A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of b2-adrenoceptor agonists as inhaled long-acting bronchodilatorsBeattie, D. / Bradley, M. / Brearley, A. et al. | 2010
- 5308
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Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studiesGreene, Nigel / Aleo, Michael D. / Louise-May, Shirley et al. | 2010
- 5313
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Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidateAnselm, Lilli / Banner, David W. / Benz, Jörg et al. | 2010
- 5320
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Construction of protein-modified TiO2 nanoparticles for use with ultrasound irradiation in a novel cell injuring methodOgino, Chiaki / Shibata, Naonori / Sasai, Ryosuke et al. | 2010
- 5326
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Labeling of nucleosides with fluorescent 6-chloro-2,3-napthalimideKatritzky, A.R. / Ozcan, S. / Todadze, E. et al. | 2010
- 5329
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Fragment-based discovery and optimization of BACE1 inhibitorsMadden, James / Dod, Jenny R. / Godemann, Robert et al. | 2010
- 5334
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Studies on the structure–activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agentsLi, Ben / Jones, Eric Dale / Zhou, Enkun et al. | 2010
- 5337
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Preparation of classical Re/99mTc(CO)3+ and novel 99mTc(CO)2(NO)2+ cores complexed with flavonol derivatives and their binding characteristics for Aβ(1–40) aggregatesYang, Yang / Zhu, Lin / Cui, Mengchao et al. | 2010
- 5337
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Preparation of classical Re/99mTc(CO)3+ and novel 99mTc(CO)2(NO)2+ cores complexed with flavonol derivatives and their binding characteristics for Ab(1-40) aggregatesYang, Y. / Zhu, L. / Cui, M. et al. | 2010
- 5345
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Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17α-hydroxylase/17,20-lyase (P45017α) derived from rat testicular microsomesOwen, Caroline P. / Shahid, Imran / Lee, Wai-Yee et al. | 2010
- 5345
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Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17a-hydroxylase/17,20-lyase (P45017a) derived from rat testicular microsomesOwen, C. P. / Shahid, I. / Lee, W. Y. et al. | 2010
- 5349
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Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agentsHossion, Abugafar M.L. / Otsuka, Nao / Kandahary, Rafiya K. et al. | 2010
- 5353
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Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activityBorcard, Françoise / Baud, Matthias / Bello, Claudia et al. | 2009
- 5357
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The action of bromoconduritol on ER glucosidase IITakeda, Yoichi / Totani, Kiichiro / Matsuo, Ichiro et al. | 2009
- 5360
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Corrigendum to “Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)” [Bioorg. Med. Chem. Lett. (2008) 554]Zhao, Zhijian / Wolkenberg, Scott E. / Sanderson, Philip E.J. et al. | 2010
- 5361
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Corrigendum to “Synthesis and structure–activity relationships of bengazole A analogs” [Bioorg. Med. Chem. Lett. 19 (2009) 2928]Mulder, Roger J. / Shafer, Cynthia M. / Dalisay, Doralyn S. et al. | 2009
- 5362
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Corrigendum to “1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: Novel synthesis via cyclization of N-acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-releasing factor-1 (CRF1) receptor antagonist activities” [Bioorg. Med. Chem. Lett. 11 (2001) 3165–3168]Chen, Chen / Dagnino, Raymond Jr. / Huang, Charles Q. et al. | 2009
- IFC
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Editorial board| 2010