Bioorganic and Medicinal Chemistry Letters
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
Table of contents
- 5325
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Graphical contents list| 2008
- 5347
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PASS-assisted exploration of antidepressant activity of 1,3,4-trisubstituted-β-lactam derivativesMittal, Munish / Goel, Rajesh K / Bhargava, Gaurav et al. | 2008
- 5347
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PASS-assisted exploration of antidepressant activity of 1,3,4-trisubstituted-b-lactam derivativesMittal, M. / Goel, R. K. / Bhargava, G. et al. | 2008
- 5350
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The ‘Ethereal’ nature of TLR4 agonism and antagonism in the AGP class of lipid A mimeticsBazin, Hélène G. / Murray, Tim J. / Bowen, William S. et al. | 2008
- 5355
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Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNAMei, Hui / Xing, Lei / Cai, Li et al. | 2008
- 5359
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Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilisLi, Meng / Chen, Zhi / Lin, Xiuping et al. | 2008
- 5364
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NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imagingRiss, Patrick J. / Kroll, Carsten / Nagel, Verena et al. | 2008
- 5368
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1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitorsZhan, Peng / Liu, Xinyong / Cao, Yuan et al. | 2008
- 5372
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Identification of novel inhibitors of extracellular signal-regulated kinase 2 based on the structure-based virtual screeningPark, Hwangseo / Bahn, Young Jae / Jeong, Dae Gwin et al. | 2008
- 5377
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Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.Lee, Dongha / Shin, Jongheon / Yoon, Kyung-Mi et al. | 2008
- 5381
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Quantitative structure–activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agentsChen, Ke-xian / Xie, Hai-ying / Li, Zu-guang et al. | 2008
- 5387
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Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapacholEyong, Kenneth O. / Kumar, Ponminor S. / Kuete, Victor et al. | 2008
- 5391
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Use of the X-ray structure of the β2-adrenergic receptor for drug discovery. Part 2: Identification of active compoundsSabio, Michael / Jones, Kenneth / Topiol, Sid et al. | 2008
- 5391
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Use of the X-ray structure of the b2-adrenergic receptor for drug discovery. Part 2: Identification of active compoundsSabio, M. / Jones, K. / Topiol, S. et al. | 2008
- 5396
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Human serum albumin as a catalyst of RNA cleavage: N-Homocysteinylation and N-phosphorylation by oligonucleotide affinity reagent alter the reactivity of the proteinGerasimova, Yuliya V. / Knorre, Dmitry D. / Shakirov, Makhmut M. et al. | 2008
- 5399
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Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasisReid, Caroline M. / Ebikeme, Charles / Barrett, Michael P. et al. | 2008
- 5402
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2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A2A antagonists with improved solubility and metabolic stabilityMoorjani, Manisha / Luo, Zhiyong / Lin, Emily et al. | 2008
- 5406
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Design and synthesis of sulfoximine based inhibitors for HIV-1 proteaseRaza, Abbas / Sham, Yuk Yin / Vince, Robert et al. | 2008
- 5411
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Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric moleculesRoy, Basab / Dutta, Sansa / Chowdhary, Anupma et al. | 2008
- 5415
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Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIAOslund, Rob C. / Cermak, Nathan / Verlinde, Christophe L.M.J. et al. | 2008
- 5420
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Synthesis of (3,4-dimethoxyphenoxy)alkylamino acetamides as orexin-2 receptor antagonistsCole, Andrew G. / Stroke, Ilana L. / Qin, Lan-Ying et al. | 2008
- 5424
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A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activityMagrioti, Victoria / Naxakis, George / Hadjipavlou-Litina, Dimitra et al. | 2008
- 5428
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The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitorsCheung, Mui / Harris, Philip A. / Badiang, Jennifer G. et al. | 2008
- 5431
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In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell linesBonesi, Marco / Tundis, Rosa / Deguin, Brigitte et al. | 2008
- 5435
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(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesNitta, Aiko / Fujii, Hideaki / Sakami, Satoshi et al. | 2008
- 5439
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Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesBridges, Thomas M. / Brady, Ashley E. / Phillip Kennedy, J. et al. | 2008
- 5443
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Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas—The effect of capping the distal basic piperidine nitrogenMiller, Nicole R. / Daniels, R. Nathan / Bridges, Thomas M. et al. | 2008
- 5448
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Synthesis and in vitro biological evaluation of ring B abeo-sterols as novel inhibitors of Mycobacterium tuberculosisWei, Xiaomei / Rodríguez, Abimael D. / Wang, Yuehong et al. | 2008
- 5451
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Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole leadCarlton, David L. / Collin-Smith, Lissa J. / Daniels, Alejandro J. et al. | 2008
- 5456
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‘Reverse’ α-ketoamide-based p38 MAP kinase inhibitorsMontalban, Antonio Garrido / Boman, Erik / Chang, Chau-Dung et al. | 2008
- 5456
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`Reverse' a-ketoamide-based p38 MAP kinase inhibitorsMontalban, A. G. / Boman, E. / Chang, C. D. et al. | 2008
- 5460
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2,4(5)-Diarylimidazoles: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2Rivara, Mirko / Baheti, Aparna R. / Fantini, Marco et al. | 2008
- 5463
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Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agentsTanaka, Kazuo / Kitamura, Narufumi / Morita, Masahito et al. | 2008
- 5466
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Carbonic anhydrase inhibitors: Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic/heterocyclic sulfonamides—in vitro and in vivo studiesKrungkrai, Jerapan / Krungkrai, Sudaratana R. / Supuran, Claudiu T. et al. | 2008
- 5472
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Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitorsIshida, Hiroshi / Isami, Shoichi / Matsumura, Tsutomu et al. | 2008
- 5478
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Microwave-assisted synthesis of unnatural amino acidsYoung, Douglas D. / Torres-Kolbus, Jessica / Deiters, Alexander et al. | 2008
- 5481
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Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureasJin, Jian / Wang, Yonghui / Shi, Dongchuan et al. | 2008
- 5487
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Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitorsAnderson, Malcolm / Andrews, David M. / Barker, Andy J. et al. | 2008
- 5493
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3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulatorsZhang, Lei / Rogers, Bruce N. / Duplantier, Allen J. et al. | 2008
- 5497
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Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluationDeng, Guanghui / Li, Weihua / Shen, Jianhua et al. | 2008
- 5503
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Using proton nuclear magnetic resonance to study the mode of ribonuclease A inhibition by competitive and noncompetitive inhibitorsGhosh, Kalyan Sundar / Debnath, Joy / Pathak, Tanmaya et al. | 2008
- 5507
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Synthesis and antibacterial activity of 4Prime-O-heteroarylcarbamoyl derivatives of macrolideXu, P. / Liu, L. / Jin, Z. p. et al. | 2008
- 5507
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Synthesis and antibacterial activity of 4″-O-heteroarylcarbamoyl derivatives of macrolideXu, Peng / Liu, Lu / Jin, Zhi-ping et al. | 2008
- 5512
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Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: Impending synergistic agentsBavikar, Sudhir N. / Salunke, Deepak B. / Hazra, Braja G. et al. | 2008
- 5518
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Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside–CoA bisubstrates as mechanistic probes for aminoglycoside N-6′-acetyltransferaseGao, Feng / Yan, Xuxu / Zahr, Omar et al. | 2008
- 5518
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Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6prime-acetyltransferaseGao, F. / Yan, X. / Zahr, O. et al. | 2008
- 5523
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Eicosapentaenoic-acid-derived isoprostanes: Synthesis and discovery of two major isoprostanesChang, Chih-Tsung / Patel, Pranav / Kang, Namin et al. | 2008
- 5528
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Optimization of a series of potent and selective ketone histone deacetylase inhibitorsPescatore, Giovanna / Kinzel, Olaf / Attenni, Barbara et al. | 2008
- 5533
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Design, synthesis and structure–activity relationship of simple bis-amides as potent inhibitors of GlyT1Jolidon, Synèse / Alberati, Daniela / Dowle, Adam et al. | 2008
- 5537
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Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole leadMoriarty, Kevin J. / Winters, Michael / Qiao, Lei et al. | 2008
- 5541
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5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)Winters, Michael P. / Robinson, Darius J. / Khine, Hnin Hnin et al. | 2008
- 5545
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Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)Moriarty, Kevin J. / Takahashi, Hidenori / Pullen, Steven S. et al. | 2008
- 5550
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Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitorsXu, Wenjian / Gray, David L. / Glase, Shelly A. et al. | 2008
- 5554
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Optimization and structure–activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitorGuay, Daniel / Boulet, Louise / Friesen, Richard W. et al. | 2008
- 5559
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Synthesis of potent water-soluble tissue transglutaminase inhibitorsGriffin, Martin / Mongeot, Alexandre / Collighan, Russell et al. | 2008
- 5563
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Synthesis and evaluation of novel 4-amino-4,6-androstadiene-3,17-dione: An analog of formestaneSharma, Sanjay K. / Zheng, Weizhong / Joshua, Alummoottil V. et al. | 2008
- 5567
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Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulatorsBohl, Casey E. / Wu, Zengru / Chen, Jiyun et al. | 2008
- 5571
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Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assayKemnitzer, William / Jiang, Songchun / Zhang, Hong et al. | 2008
- 5576
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Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeatsLi, Xinming / Ng, Magdeline Tao Tao / Wang, Yifan et al. | 2008
- 5581
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Novel 5-HT1A/1B/1D receptors antagonists with potent 5-HT reuptake inhibitory activitySerafinowska, Halina T. / Blaney, Frank E. / Lovell, Peter J. et al. | 2008
- 5586
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Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agentPingali, Harikishore / Jain, Mukul / Shah, Shailesh et al. | 2008
- 5591
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Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formationByun, Ji Hun / Kim, HyeYun / Kim, YoungSoo et al. | 2008
- 5591
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Aminostyrylbenzofuran derivatives as potent inhibitors for Ab fibril formationByun, J. H. / Kim, H. / Kim, Y. et al. | 2008
- 5594
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Development of mitochondria-targeted derivatives of resveratrolBiasutto, Lucia / Mattarei, Andrea / Marotta, Ester et al. | 2008
- 5598
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Synthesis and biological activity of enantiomeric pairs of 5-[(E)-cycloalk-2-enylidenemethyl]thiolactomycin congenersOhata, Kohei / Terashima, Shiro et al. | 2008
- 5601
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Small, non-peptide C5a receptor antagonists: Part 1Blagg, Julian / Mowbray, Charles / Pryde, David C. et al. | 2008
- 5605
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Small, non-peptide C5a receptor antagonists: Part 2Blagg, Julian / Mowbray, Charles / Pryde, David et al. | 2008
- 5609
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Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1Westaway, Susan M. / Thompson, Mervyn / Rami, Harshad K. et al. | 2008
- 5614
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Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituentsTakaishi, Kazuto / Izumi, Minoru / Baba, Naomichi et al. | 2008
- 5618
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Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part IZhang, Guobao / Ren, Pingda / Gray, Nathanael S. et al. | 2008
- 5622
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bis-Pyridinium cyclophanes: Novel ligands with high affinity for the blood–brain barrier choline transporterZhang, Zhenfa / Lockman, Paul R. / Mittapalli, Rajendar K. et al. | 2008
- 5626
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Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulatorsNiswender, Colleen M. / Lebois, Evan P. / Luo, Qingwei et al. | 2008
- 5631
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Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMPYan, Hongbin / Wang, Xiaolu / KuoLee, Rhonda et al. | 2008
- 5635
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Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituentsDragovich, Peter S. / Blazel, Julie K. / Ellis, David A. et al. | 2008
- 5635
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Novel HCV NS5B polymerase inhibitors derived from 4-(1prime,1prime-dioxo-1prime,4prime-dihydro-1primel6-benzo[1prime,2prime,4prime]thiadiazin-3prime-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituentsDragovich, P. S. / Blazel, J. K. / Ellis, D. A. et al. | 2008
- 5640
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Synthesis of nucleoside-based antiviral drugs in ionic liquidsKumar, Vineet / Malhotra, Sanjay V. et al. | 2008
- 5643
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Synthesis and activity of substituted carbamates as potentiators of the a4b2 nicotinic acetylcholine receptorSpringer, S. K. / Woodin, K. S. / Berry, V. et al. | 2008
- 5643
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Synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptorSpringer, Stephanie K. / Woodin, Katrina S. / Berry, Virginia et al. | 2008
- 5648
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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitorsFucini, Raymond V. / Hanan, Emily J. / Romanowski, Michael J. et al. | 2008
- 5653
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6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitorsBromidge, Steven M. / Bertani, Barbara / Borriello, Manuela et al. | 2008
- 5657
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Pholasin luminescence is enhanced by addition of dehydrocoelenterazineKuse, Masaki / Tanaka, Eiko / Nishikawa, Toshio et al. | 2008
- 5660
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DNA-templated click chemistry for creation of novel DNA binding moleculesImoto, Shuhei / Hirohama, Tomoya / Nagatsugi, Fumi et al. | 2008
- 5664
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Cu-free cycloaddition for identifying catalytic active adenylation domains of nonribosomal peptide synthetases by phage displayZou, Yekui / Yin, Jun et al. | 2008
- 5668
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Affinity labeling of the proteasome by a belactosin A derived inhibitorHasegawa, Makoto / Kinoshita, Kazuhiro / Nishimura, Chika et al. | 2008
- 5672
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Identification of novel protein kinase CK1 delta (CK1δ) inhibitors through structure-based virtual screeningCozza, Giorgio / Gianoncelli, Alessandra / Montopoli, Monica et al. | 2008
- 5672
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Identification of novel protein kinase CK1 delta (CK1d) inhibitors through structure-based virtual screeningCozza, G. / Gianoncelli, A. / Montopoli, M. et al. | 2008
- 5676
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Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor γLee, Yue-Zhi / Yang, Cheng-Wei / Kang, Iou-Jiun et al. | 2008
- 5676
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Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gLee, Y. Z. / Yang, C. W. / Kang, I. J. et al. | 2008
- 5680
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Novel design principle validated: Glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agentSomsák, László / Nagy, Veronika / Vidal, Sébastien et al. | 2008
- 5684
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Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitorsGhosh, Arun K. / Gong, Gangli / Grum-Tokars, Valerie et al. | 2008
- 5689
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Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective a2C adrenergic receptor antagonistPatel, S. D. / Habeski, W. M. / Min, H. et al. | 2008
- 5689
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Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective α2C adrenergic receptor antagonistPatel, Snahel D. / Habeski, Wendy M. / Min, Hyunsuk et al. | 2008
- 5694
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Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine KCa channel blockersGentles, Robert G. / Hu, Shuanghua / Huang, Yazhong et al. | 2008
- 5698
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Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonistsTrani, Giancarlo / Baddeley, Stuart M. / Briggs, Michael A. et al. | 2008
- 5701
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[18F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of β-amyloid fibrilsLee, Ji Hoon / Byeon, Seong Rim / Kim, YoungSoo et al. | 2008
- 5701
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[18F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of b-amyloid fibrilsLee, J. H. / Byeon, S. R. / Kim, Y. et al. | 2008
- I
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Instructions to contributors| 2008
- IFC
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Editorial board| 2008