Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase (English)
- New search for: Ye, B.
- New search for: Bauman, J.
- New search for: Chen, M.
- New search for: Davey, D.
- New search for: Khim, S. K.
- New search for: King, B.
- New search for: Kirkland, T.
- New search for: Kochanny, M.
- New search for: Liang, A.
- New search for: Lentz, D.
- New search for: Ye, B.
- New search for: Bauman, J.
- New search for: Chen, M.
- New search for: Davey, D.
- New search for: Khim, S. K.
- New search for: King, B.
- New search for: Kirkland, T.
- New search for: Kochanny, M.
- New search for: Liang, A.
- New search for: Lentz, D.
In:
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
;
18
, 14
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3891-3894
;
2008
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ISSN:
- Article (Journal) / Print
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Title:Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase
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Contributors:Ye, B. ( author ) / Bauman, J. ( author ) / Chen, M. ( author ) / Davey, D. ( author ) / Khim, S. K. ( author ) / King, B. ( author ) / Kirkland, T. ( author ) / Kochanny, M. ( author ) / Liang, A. ( author ) / Lentz, D. ( author )
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Published in:BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS ; 18, 14 ; 3891-3894
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2008-01-01
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Size:4 pages
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ISSN:
-
Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 572.5
- Further information on Dewey Decimal Classification
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Classification:
DDC: 572.5 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 18, Issue 14
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 3819
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Graphical contents list| 2008
- 3844
-
Synthesis and structure–activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: A novel series of 5-HT2C receptor antagonistsPark, Chul Min / Kim, So Young / Park, Woo Kyu / Park, No Sang / Seong, Churl Min et al. | 2008
- 3848
-
Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonistsBetschmann, Patrick / Bettencourt, Brian / Donnelly-Roberts, Diana / Friedman, Michael / George, Jonathan / Hirst, Gavin / Josephsohn, Nathan / Konopacki, Donald / Li, Biqin / Maull, John et al. | 2008
- 3852
-
Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonistsGong, Yong / Barbay, J. Kent / Buntinx, Mieke / Li, Jian / Wauwe, Jean Van / Claes, Concha / Lommen, Guy Van / Hornby, Pamela J. / He, Wei et al. | 2008
- 3856
-
Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibitionSchnute, Mark E. / Brideau, Roger J. / Collier, Sarah A. / Cudahy, Michele M. / Hopkins, Todd A. / Knechtel, Mary L. / Oien, Nancee L. / Sackett, Robert S. / Scott, Allen / Stephan, Mari L. et al. | 2008
- 3860
-
Synthesis and discovery of autophagy inducers for A549 and H460 lung cancer cells, novel 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carbohydrazide derivativesFan, Chuan-Dong / Zhao, Bao-Xiang / Wei, Fang / Zhang, Gai-Hua / Dong, Wen-Liang / Miao, Jun-Ying et al. | 2008
- 3860
-
Synthesis and discovery of autophagy inducers for A549 and H460 lung cancer cells, novel 1-(2prime-hydroxy-3prime-aroxypropyl)-3-aryl-1H-pyrazole-5-carbohydrazide derivativesFan, C. D. / Zhao, B. X. / Wei, F. / Zhang, G. H. / Dong, W. L. / Miao, J. Y. et al. | 2008
- 3865
-
4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitorsPace, Paola / Spieser, Stéphane A.H. / Summa, Vincenzo et al. | 2008
- 3870
-
Antileukemic activity of aminoparthenolide analogsNasim, Shama / Crooks, Peter A. et al. | 2008
- 3874
-
Activation of CFTR by UCCF-029 and genisteinAl-Nakkash, Layla / Springsteel, Mark F. / Kurth, Mark J. / Nantz, Michael H. et al. | 2008
- 3878
-
Cyclobranol: A substrate for C25-methyl sterol side chains and potent mechanism-based inactivator of plant sterol methyltransferaseWang, Junqing / Nes, W. David et al. | 2008
- 3882
-
Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonistKumar Srivastava, Brijesh / Soni, Rina / Patel, Jayendra Z. / Jha, Satadru / Shedage, Sandeep A. / Gandhi, Neha / Sairam, Kalapatapu V.V.M. / Pawar, Vishwanath / Sadhwani, Nisha / Mitra, Prasenjit et al. | 2008
- 3887
-
Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivativesHutchinson, Douglas K. / Rosenberg, Teresa / Klein, Larry L. / Bosse, Todd D. / Larson, Daniel P. / He, Wenping / Jiang, Wen W. / Kati, Warren M. / Kohlbrenner, William E. / Liu, Yaya et al. | 2008
- 3891
-
Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolaseYe, Bin / Bauman, John / Chen, Ming / Davey, David / Khim, Seock-Kyu / King, Beverly / Kirkland, Thomas / Kochanny, Monica / Liang, Amy / Lentz, Dao et al. | 2008
- 3895
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Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitorsKhim, Seock-Kyu / Bauman, John / Evans, Jarred / Freeman, Beverly / King, Beverly / Kirkland, Thomas / Kochanny, Monica / Lentz, Dao / Liang, Amy / Mendoza, Lisa et al. | 2008
- 3899
-
T-type Ca2+ channel blockers suppress the growth of human cancer cellsHeo, Jae Ho / Seo, Han Na / Choe, Yun Jeong / Kim, Sujin / Oh, Chun Rim / Kim, Young Deuk / Rhim, Hyewhon / Choo, Dong Joon / Kim, Jungahn / Lee, Jae Yeol et al. | 2008
- 3902
-
Synthesis and cytotoxicity of aurilide analogsSuenaga, Kiyotake / Kajiwara, Shuri / Kuribayashi, Satomi / Handa, Tomohisa / Kigoshi, Hideo et al. | 2008
- 3906
-
Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligandPark, Jeong-Ju / Lee, Ji Hyung / Ghosh, Subhash C. / Bricard, Gabriel / Venkataswamy, Manjunatha M. / Porcelli, Steven A. / Chung, Sung-Kee et al. | 2008
- 3910
-
Detection of structure-switching in G-quadruplexes using end-stacking abilitySeo, Young Jun / Lee, Il Joon / Kim, Byeang Hyean et al. | 2008
- 3914
-
Gallic acid-based indanone derivatives as anticancer agentsSaxena, Hari Om / Faridi, Uzma / Srivastava, Suchita / Kumar, J.K. / Darokar, M.P. / Luqman, Suaib / Chanotiya, C.S. / Krishna, Vinay / Negi, Arvind S. / Khanuja, S.P.S. et al. | 2008
- 3919
-
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligandsRaval, Saurin / Raval, Preeti / Bandyopadhyay, Debdutta / Soni, Krunal / Yevale, Digambar / Jogiya, Digvijay / Modi, Honey / Joharapurkar, Amit / Gandhi, Neha / Jain, Mukul R. et al. | 2008
- 3919
-
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor b (TR-b) selective ligandsRaval, S. / Raval, P. / Bandyopadhyay, D. / Soni, K. / Yevale, D. / Jogiya, D. / Modi, H. / Joharapurkar, A. / Gandhi, N. / Jain, M. R. et al. | 2008
- 3925
-
Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluationTegley, Christopher M. / Viswanadhan, Vellarkad N. / Biswas, Kaustav / Frohn, Michael J. / Peterkin, Tanya A.N. / Chang, Catherine / Bürli, Roland W. / Dao, Jennifer H. / Veith, Henrike / Rogers, Norma et al. | 2008
- 3925
-
Discovery of novel hydroxy-thiazoles as HIF-a prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluationTegley, C. M. / Viswanadhan, V. N. / Biswas, K. / Frohn, M. J. / Peterkin, T. A. / Chang, C. / Burli, R. W. / Dao, J. H. / Veith, H. / Rogers, N. et al. | 2008
- 3929
-
A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligandsLiu, Kevin G. / Lo, Jennifer R. / Comery, Thomas A. / Zhang, Guo Ming / Zhang, Jean Y. / Kowal, Dianne M. / Smith, Deborah L. / Di, Li / Kerns, Edward H. / Schechter, Lee E. et al. | 2008
- 3932
-
Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screeningFinn, John / Stidham, Mark / Hilgers, Mark / G. C., Kedar et al. | 2008
- 3938
-
Carbonic anhydrase inhibitors: Thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Innocenti, Alessio / Maresca, Alfonso / Scozzafava, Andrea / Supuran, Claudiu T. et al. | 2008
- 3942
-
Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymeraseMenear, Keith A. / Adcock, Claire / Alonso, Francisco Cuenca / Blackburn, Kristel / Copsey, Louise / Drzewiecki, Jan / Fundo, Alexandra / Le Gall, Armelle / Gomez, Sylvie / Javaid, Hashim et al. | 2008
- 3946
-
Natural products in parallel synthesis: Triazole libraries of nonactic acidLuesse, Sarah B. / Wells, Gregg / Nayek, Abhijit / Smith, Adrienne E. / Kusche, Brian R. / Bergmeier, Stephen C. / McMills, Mark C. / Priestley, Nigel D. / Wright, Dennis L. et al. | 2008
- 3950
-
Urotensin-II receptor antagonists: Synthesis and SAR of N-cyclic azaalkyl benzamidesJin, Jian / An, Ming / Sapienza, Anthony / Aiyar, Nambi / Naselsky, Diane / Sarau, Henry M. / Foley, James J. / Salyers, Kevin L. / Knight, Steven D. / Keenan, Richard M. et al. | 2008
- 3955
-
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituentZhu, Gui-Dong / Gandhi, Viraj B. / Gong, Jianchun / Thomas, Sheela / Luo, Yan / Liu, Xuesong / Shi, Yan / Klinghofer, Vered / Johnson, Eric F. / Frost, David et al. | 2008
- 3959
-
Discovery of selective and nonpeptidic cathepsin S inhibitorsIrie, Osamu / Ehara, Takeru / Iwasaki, Atsuko / Yokokawa, Fumiaki / Sakaki, Junichi / Hirao, Hajime / Kanazawa, Takanori / Teno, Naoki / Horiuchi, Miyuki / Umemura, Ichiro et al. | 2008
- 3963
-
A serine protease inhibitor from hemolymph of green mussel, Perna viridisKhan, M.S. / Goswami, U. / Rojatkar, S.R. / Khan, M.I. et al. | 2008
- 3968
-
A simple and efficient approach to the synthesis of 4H-furo[3,4-b]pyrans via a three-component reaction of isocyanidesShaabani, Ahmad / Soleimani, Ebrahim / Sarvary, Afshin / Rezayan, Ali Hossein et al. | 2008
- 3971
-
Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphinesSi, Yu-Gui / Gardner, Matthew P. / Tarazi, Frank I. / Baldessarini, Ross J. / Neumeyer, John L. et al. | 2008
- 3974
-
Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR)Das, Bhaskar C. / Madhukumar, Ankanahlli V. / Anguiano, Jaime / Kim, Sean / Sinz, Michael / Zvyaga, Tatyana A. / Power, Eoin C. / Ganellin, C. Robin / Mani, Sridhar et al. | 2008
- 3978
-
Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistryCancilla, Mark T. / He, Molly M. / Viswanathan, Nina / Simmons, Robert L. / Taylor, Meggin / Fung, Amy D. / Cao, Kathy / Erlanson, Daniel A. et al. | 2008
- 3982
-
Synthesis and cytotoxic activity of benzopyran-based platinum(II) complexesGupta, Atul / Mandal, Sanat K. / Leblanc, Valérie / Descôteaux, Caroline / Asselin, Éric / Bérubé, Gervais et al. | 2008
- 3988
-
Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclastsKim, Seong Hwan / Jhon, Dong Joo / Song, Jong Hwan / No, Jae Sung / Kang, Nam Sook et al. | 2008
- 3992
-
Hypaphorine, an indole alkaloid from Erythrina velutina, induced sleep on normal miceOzawa, Masaaki / Honda, Kazuki / Nakai, Izumi / Kishida, Akio / Ohsaki, Ayumi et al. | 2008
- 3995
-
Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloningHe, Qing-Li / Jiang, Hui / Zhang, Feng / Chen, Hai-Bao / Tang, Gong-Li et al. | 2008
- 3999
-
Translocation of an Aib-containing peptide through cell membranesWada, Shun-ichi / Hitora, Yasunari / Tanaka, Reiko / Urata, Hidehito et al. | 2008
- 4002
-
Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivativesGhosh, Samir / Tiwari, Pallavi / Pandey, Shashi / Misra, Anup Kumar / Chaturvedi, Vinita / Gaikwad, Anil / Bhatnagar, Shalini / Sinha, Sudhir et al. | 2008
- 4006
-
Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinaseKim, Dae-Kee / Lim, Jin-Hwi / Lee, Jung A. / Dewang, Purushottam M. et al. | 2008
- 4006
-
Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38a mitogen-activated protein kinaseKim, D. K. / Lim, J. H. / Lee, J. A. / Dewang, P. M. et al. | 2008
- 4011
-
Tentacle type peptides as artificial lectins against sulfated Lewis X and AHyun, Soonsil / Lee, Eun Hye / Park, Jihye / Yu, Jaehoon et al. | 2008
- 4015
-
A new sesquiterpene lactone from the roots of Saussurea lappa: Structure–anticancer activity studyRobinson, A. / Kumar, T. Vijay / Sreedhar, E. / Naidu, V.G.M. / Krishna, Sistla Rama / Babu, K. Suresh / Srinivas, P.V. / Rao, J. Madhusudana et al. | 2008
- 4018
-
Designing rapid onset selective serotonin re-uptake inhibitors. 2: Structure–activity relationships of substituted (aryl)benzylaminesMiddleton, Donald S. / Andrews, Mark / Glossop, Paul / Gymer, Geoffrey / Hepworth, David / Jessiman, Alan / Johnson, Patrick S. / MacKenny, Malcolm / Pitcher, Michael J. / Rooker, Tony et al. | 2008
- 4022
-
Discovery of new Gram-negative antivirulence drugs: Structure and properties of novel E. coli WaaC inhibitorsMoreau, F. / Desroy, N. / Genevard, J.M. / Vongsouthi, V. / Gerusz, V. / Le Fralliec, G. / Oliveira, C. / Floquet, S. / Denis, A. / Escaich, S. et al. | 2008
- 4027
-
Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonistsHall, Adrian / Billinton, Andy / Bristow, Alan K. / Brown, Susan H. / Chowdhury, Anita / Cutler, Leanne / Giblin, Gerard M.P. / Goldsmith, Paul / Hayhow, Thomas G. / Kilford, Ian R. et al. | 2008
- 4033
-
Structure, antimicrobial activity and DNA-binding properties of the cobalt(II)–sparfloxacin complexEfthimiadou, Eleni K. / Karaliota, Alexandra / Psomas, George et al. | 2008
- 4038
-
Using hydroxymethylphenoxy derivates with the SPOT technology to generate peptides with authentic C-terminiAy, Bernhard / Landgraf, Katja / Streitz, Mathias / Fuhrmann, Stephan / Volkmer, Rudolf / Boisguerin, Prisca et al. | 2008
- 4044
-
Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cellsYamamoto, Yukihiro / Hosokawa, Masashi / Kurihara, Hideyuki / Maoka, Takashi / Miyashita, Kazuo et al. | 2008
- 4047
-
Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreusKang, Hahk-Soo / Kim, Kyoung-Rok / Jun, Eun-Mi / Park, Soon-Hye / Lee, Tae-Soo / Suh, Joo-Won / Kim, Jong-Pyung et al. | 2008
- 4051
-
N-Demethylation of nocathiacin I via photo-oxidationLi, Wenying / Huang, Stella / Liu, Xiaohong / Leet, John E. / Cantone, Joseph L. / Lam, Kin S. et al. | 2008
- 4054
-
Discovery of novel 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinoline-1(2H)-ones as potent and selective inhibitors of KDR: Synthesis, SAR, and pharmacokinetic propertiesChoquette, Deborah / Teffera, Yohannes / Polverino, Anthony / Harmange, Jean-Christophe et al. | 2008
- 4059
-
N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustardJiang, Yongying / Hu, Longqin et al. | 2008
- 4064
-
Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activityZhang, Yanan / Gilmour, Brian P. / Navarro, Hernán A. / Runyon, Scott P. et al. | 2008
- 4068
-
Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitorsEvans, Karen A. / Li, Yue H. / Coppo, Frank T. / Graybill, Todd L. / Cichy-Knight, Maria / Patel, Mehul / Gale, Jennifer / Li, Hu / Thrall, Sara H. / Tew, David et al. | 2008
- 4072
-
(d)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagoguesLi, Jun / Chen, Stephanie Y. / Murphy, Brian J. / Flynn, Neil / Seethala, Ramakrishna / Slusarchyk, Dorothy / Yan, Mujing / Sleph, Paul / Zhang, Hongjian / Humphreys, William G. et al. | 2008
- 4075
-
Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitorsZimmermann, Kurt / Wittman, Mark D. / Saulnier, Mark G. / Velaparthi, Upender / Langley, David R. / Sang, Xiaopeng / Frennesson, David / Carboni, Joan / Li, Aixin / Greer, Ann et al. | 2008
- 4081
-
On the antibiotic activity of oxazolomycinBagwell, Claire L. / Moloney, Mark G. / Thompson, Amber L. et al. | 2008
- 4087
-
Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitorsSattigeri, Jitendra A. / Andappan, Murugaiah M.S. / Kishore, Kaushal / Thangathirupathy, Srinivasan / Sundaram, Sinduja / Singh, Shuchita / Sharma, Suchitra / Davis, Joseph A. / Chugh, Anita / Bansal, Vinay S. et al. | 2008
- 4092
-
Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microgliaJin, Guo Hua / Ha, Sang Keun / Park, Hye Min / Kang, Bomi / Kim, Sun Yeou / Kim, Hee-Do / Ryu, Jae-Ha / Jeon, Raok et al. | 2008
- 4095
-
Novel hexacyclic camptothecin derivatives. Part 1: Synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ringWang, Sheng / Li, Yuyan / Liu, Yonghui / Lu, Aijun / You, Qidong et al. | 2008
- 4098
-
Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffoldSharma, Sameer / Rodriguez, Alice L. / Conn, P. Jeffrey / Lindsley, Craig W. et al. | 2008
- 4102
-
Synthesis and in vivo evaluation of 11-substituted estradiol derivatives as anti-implantation agentsDwivedy, Indra / Gupta, Atul / Grover, Arvinder / Srivastava, Vandana / Singh, Man Mohan / Ray, Suprabhat et al. | 2008
- 4106
-
Correlation between reduction potentials and inhibitions of Epstein–Barr virus activation by anthraquinone derivativesKoyama, Junko / Nisino, Yu / Morita, Izumi / Kobayashi, Norihiro / Osakai, Toshiyuki / Tokuda, Harukuni et al. | 2008
- 4110
-
Enantioselective synthesis of (R)-(+)- and (S)-(−)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulationPyo, Mi Kyung / Lee, Duck-Hyung / Kim, Doo-Hyun / Lee, Ji-Hye / Moon, Jong-Cheon / Chang, Ki Churl / Yun-Choi, Hye Sook et al. | 2008
- 4115
-
Isosteric exchange of the acylsulfonamide moiety in Abbott’s Bcl-XL protein interaction antagonistDömling, Alexander / Antuch, Walfrido / Beck, Barbara / Schauer-Vukašinović, Vesna et al. | 2008
- 4118
-
Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor XaQiao, Jennifer X. / Cheney, Daniel L. / Alexander, Richard S. / Smallwood, Angela M. / King, Sarah R. / He, Kan / Rendina, Alan R. / Luettgen, Joseph M. / Knabb, Robert M. / Wexler, Ruth R. et al. | 2008
- 4124
-
Identification of novel non-peptide CXCR4 antagonists by ligand-based design approachUeda, Satoshi / Kato, Manabu / Inuki, Shinsuke / Ohno, Hiroaki / Evans, Barry / Wang, Zi-xuan / Peiper, Stephen C. / Izumi, Kazuki / Kodama, Eiichi / Matsuoka, Masao et al. | 2008
- 4130
-
Reduction in post-prandial hyperglycemic excursion through α-glucosidase inhibition by β-acetamido carbonyl compoundsTiwari, Ashok K. / Kumbhare, Ravindra M. / Agawane, Sachin B. / Ali, Amtul Z. / Kumar, K. Vijay et al. | 2008
- 4130
-
Reduction in post-prandial hyperglycemic excursion through a-glucosidase inhibition by b-acetamido carbonyl compoundsTiwari, A. K. / Kumbhare, R. M. / Agawane, S. B. / Ali, A. Z. / Kumar, K. V. et al. | 2008
- 4133
-
Novel H3 receptor antagonists with improved pharmacokinetic profilesSantora, Vincent J. / Covel, Jonathan A. / Hayashi, Rena / Hofilena, Brian J. / Ibarra, Jason B. / Pulley, Michelle D. / Weinhouse, Michael I. / Semple, Graeme / Ren, Albert / Pereira, Guilherme et al. | 2008
- 4137
-
Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseasesChen, Ning / Bürli, Roland W. / Neira, Susana / Hungate, Randall / Zhang, Dawei / Yu, Violeta / Nguyen, Yen / Tudor, Yanyan / Plant, Matthew / Flynn, Shaun et al. | 2008
- 4142
-
Molecular recognition of a DNA:RNA hybrid: Sub-nanomolar binding by a neomycin–methidium conjugateShaw, Nicholas N. / Xi, Hongjuan / Arya, Dev P. et al. | 2008
- 4146
-
Imidazopyridines as VLA-4 integrin antagonistsPhillips, David J. / Davenport, Richard J. / Demaude, Thierry A. / Galleway, Fiona P. / Jones, Mark W. / Knerr, Laurent / Perry, Benjamin G. / Ratcliffe, Andrew J. et al. | 2008
- 4150
-
Imidazolidin-4-one peptidomimetic derivatives of primaquine: Synthesis and antimalarial activityVale, Nuno / Matos, Joana / Gut, Jiri / Nogueira, Fátima / do Rosário, Virgílio / Rosenthal, Philip J. / Moreira, Rui / Gomes, Paula et al. | 2008
- 4154
-
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leadsVan der Veken, Pieter / De Meester, Ingrid / Dubois, Véronique / Soroka, Anna / Van Goethem, Sebastiaan / Maes, Marie-Berthe / Brandt, Inger / Lambeir, Anne-Marie / Chen, Xin / Haemers, Achiel et al. | 2008
- 4159
-
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitorsVan Goethem, Sebastiaan / Van der Veken, Pieter / Dubois, Véronique / Soroka, Anna / Lambeir, Anne-Marie / Chen, Xin / Haemers, Achiel / Scharpé, Simon / De Meester, Ingrid / Augustyns, Koen et al. | 2008
- 4163
-
3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitorsUrbach, Allan / Muccioli, Giulio G. / Stern, Eric / Lambert, Didier M. / Marchand-Brynaert, Jacqueline et al. | 2008
- 4168
-
Discovery of a novel, potent and orally active series of γ-lactams as selective NK1 antagonistsPaliwal, Sunil / Reichard, Gregory A. / Shah, Sapna / Wrobleski, Michelle Laci / Wang, Cheng / Stengone, Carmine / Tsui, Hon-Chung / Xiao, Dong / Duffy, Ruth A. / Lachowicz, Jean E. et al. | 2008
- 4168
-
Discovery of a novel, potent and orally active series of g-lactams as selective NK1 antagonistsPaliwal, S. / Reichard, G. A. / Shah, S. / Wrobleski, M. L. / Wang, C. / Stengone, C. / Tsui, H. C. / Xiao, D. / Duffy, R. A. / Lachowicz, J. E. et al. | 2008
- 4172
-
Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agentsFadeyi, Olugbeminiyi O. / Adamson, Saudat T. / Myles, E. Lewis / Okoro, Cosmas O. et al. | 2008
- 4177
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Design, synthesis of novel peptidomimetic derivatives of 4-HPR for rhabdoid tumorsDas, Bhaskar C. / Smith, Melissa E. / Kalpana, Ganjam V. et al. | 2008
- 4181
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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymeraseKim, Sun Hee / Tran, Martin T. / Ruebsam, Frank / Xiang, Alan X. / Ayida, Benjamin / McGuire, Helen / Ellis, David / Blazel, Julie / Tran, Chinh V. / Murphy, Douglas E. et al. | 2008
- 4186
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Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitorsSiu, Tony / Liang, Jun / Arruda, Jeannie / Li, Yiwei / Jones, Raymond E. / Defeo-Jones, Deborah / Barnett, Stanley F. / Robinson, Ronald G. et al. | 2008
- 4191
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The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activitySiu, Tony / Li, Yiwei / Nagasawa, Johnny / Liang, Jun / Tehrani, Lida / Chua, Peter / Jones, Raymond E. / Defeo-Jones, Deborah / Barnett, Stanley F. / Robinson, Ronald G. et al. | 2008
- 4195
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Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A novel class of 5-lipoxygenase inhibitorsChowdhury, Morshed Alam / Chen, Hua / Abdellatif, Khaled R.A. / Dong, Ying / Petruk, Kenneth C. / Knaus, Edward E. et al. | 2008
- 4199
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Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonistsShah, Unmesh / Boyle, Craig D. / Chackalamannil, Samuel / Neustadt, Bernard R. / Lindo, Neil / Greenlee, William J. / Foster, Carolyn / Arik, Leyla / Zhai, Ying / Ng, Kwokei et al. | 2008
- 4204
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Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonistsShah, Unmesh / Lankin, Claire M. / Boyle, Craig D. / Chackalamannil, Samuel / Greenlee, William J. / Neustadt, Bernard R. / Cohen-Williams, Mary E. / Higgins, Guy A. / Ng, Kwokei / Varty, Geoffrey B. et al. | 2008
- 4210
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Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitorsVerissimo, Edite / Berry, Neil / Gibbons, Peter / Cristiano, M. Lurdes S. / Rosenthal, Philip J. / Gut, Jiri / Ward, Stephen A. / O’Neill, Paul M. et al. | 2008
- 4215
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Synthesis and screening of small molecule inhibitors of anthrax edema factorJimenez, Maria Estrella / Bush, Kathryn / Pawlik, Jennifer / Sower, Laurie / Peterson, Johnny W. / Gilbertson, Scott R. et al. | 2008
- 4219
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Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034Bogen, S. / Arasappan, A. / Pan, W. / Ruan, S. / Padilla, A. / Saksena, A.K. / Girijavallabhan, V. / Njoroge, F.G. et al. | 2008
- 4224
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Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI)Wu, Dongpei / Pontillo, Joseph / Ching, Brett / Hudson, Sarah / Gao, Yinghong / Fleck, Beth A. / Gogas, Kathleen / Wade, Warren S. et al. | 2008
- 4228
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Spiroleptosphol isolated from Leptosphaeria doliolumHashimoto, Masaru / Tsushima, Taro / Murakami, Takanori / Nomiya, Masahiro / Takada, Noboru / Tanaka, Kazuaki et al. | 2008
- 4232
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Discovery of a novel series of Notch-sparing γ-secretase inhibitorsKreft, Anthony / Harrison, Boyd / Aschmies, Suzan / Atchison, Kevin / Casebier, David / Cole, Derek C. / Diamantidis, George / Ellingboe, John / Hauze, Diane / Hu, Yun et al. | 2008
- 4232
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Discovery of a novel series of Notch-sparing g-secretase inhibitorsKreft, A. / Harrison, B. / Aschmies, S. / Atchison, K. / Casebier, D. / Cole, D. C. / Diamantidis, G. / Ellingboe, J. / Hauze, D. / Hu, Y. et al. | 2008
- 4237
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Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitorsHamblin, J. Nicole / Angell, Tony D.R. / Ballantine, Stuart P. / Cook, Caroline M. / Cooper, Anthony W.J. / Dawson, John / Delves, Christopher J. / Jones, Paul S. / Lindvall, Mika / Lucas, Fiona S. et al. | 2008
- 4242
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Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitorsJanetka, James W. / Almeida, Lynsie / Ashwell, Susan / Brassil, Patrick J. / Daly, Kevin / Deng, Chun / Gero, Thomas / Glynn, Roberta E. / Horn, Candice L. / Ioannidis, Stephanos et al. | 2008
- 4249
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Enhanced anti-influenza A virus activity of (−)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: Effect of alkyl chain lengthMori, Shuichi / Miyake, Shinya / Kobe, Takayoshi / Nakaya, Takaaki / Fuller, Stephen D. / Kato, Nobuo / Kaihatsu, Kunihiro et al. | 2008
- 4253
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Corrigendum to “2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists” [Bioorg. Med. Chem. Lett. 18 (2008) 2103–2108]Shireman, Brock T. / Dvorak, Curt A. / Rudolph, Dale A. / Bonaventure, Pascal / Nepomuceno, Diane / Dvorak, Lisa / Miller, Kirsten L. / Lovenberg, Timothy W. / Carruthers, Nicholas I. et al. | 2008
- 4254
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Corrigendum to “N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1)” [Bioorg. Med. Chem. Lett. 18 (2008) 2730–2734]Jetter, Michele C. / McNally, James J. / Youngman, Mark A. / McDonnell, Mark E. / Dubin, Adrienne E. / Nasser, Nadia / Zhang, Sui-Po / Codd, Ellen E. / Colburn, Ray W. / Stone, Dennis R. et al. | 2008
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Instructions to contributors| 2008
- IFC
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Editorial board| 2008