A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis (English)
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In:
JOURNAL OF MEDICINAL CHEMISTRY
;
53
, 6
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2589-2600
;
2010
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ISSN:
- Article (Journal) / Print
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Title:A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis
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Contributors:
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Published in:JOURNAL OF MEDICINAL CHEMISTRY ; 53, 6 ; 2589-2600
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Publisher:
- New search for: ACS AMERICAN CHEMICAL SOCIETY
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Publication date:2010-01-01
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Size:12 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 615
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 53, Issue 6
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 2333
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Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and CancerCombs, Andrew P. et al. | 2010
- 2345
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Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory DisordersGoldstein, David M. / Kuglstatter, Andreas / Lou, Yan / Soth, Michael J. et al. | 2010
- 2345
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Selective p38 alpha Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory DisordersGoldstein, D.M. / Kuglstatter, A. / Lou, Y. / Soth, M.J. et al. | 2010
- 2354
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N-Methyl Phenylalanine-Rich Peptides as Highly Versatile Blood−Brain Barrier ShuttlesMalakoutikhah, Morteza / Prades, Roger / Teixidó, Meritxell / Giralt, Ernest et al. | 2010
- 2364
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Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as α-Glucosidases InhibitorsFerreira, Sabrina B. / Sodero, Ana C. R. / Cardoso, Mariana F. C. / Lima, Emerson S. / Kaiser, Carlos R. / Silva, Floriano P. / Ferreira, Vitor F. et al. | 2010
- 2364
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Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as alpha -Glucosidases InhibitorsFerreira, S.B. / Sodero, A.C.R. / Cardoso, M.F.C. / Lima, E.S. / Kaiser, C.R. / Silva, F.P. / Ferreira, V.F. et al. | 2010
- 2376
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Fluorescent Epigenetic Small Molecule Induces Expression of the Tumor Suppressor Ras-Association Domain Family 1A and Inhibits Human Prostate XenograftSheikh, Kathryn D. / Banerjee, Partha P. / Jagadeesh, Shankar / Grindrod, Scott C. / Zhang, Li / Paige, Mikell / Brown, Milton L. et al. | 2010
- 2383
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Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1−7Fransson, Rebecca / Botros, Milad / Sköld, Christian / Nyberg, Fred / Lindeberg, Gunnar / Hallberg, Mathias / Sandström, Anja et al. | 2010
- 2390
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Synthesis and QSAR of Quinazoline Sulfonamides As Highly Potent Human Histamine H4 Receptor Inverse AgonistsSmits, Rogier A. / Adami, Maristella / Istyastono, Enade P. / Zuiderveld, Obbe P. / van Dam, Cindy M. E. / de Kanter, Frans J. J. / Jongejan, Aldo / Coruzzi, Gabriella / Leurs, Rob / de Esch, Iwan J. P. et al. | 2010
- 2401
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Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic Anhydrase Inhibitors: Synthesis, Biological Evaluation, and Enzyme−Ligand X-ray StudiesGitto, Rosaria / Agnello, Stefano / Ferro, Stefania / De Luca, Laura / Vullo, Daniela / Brynda, Jiri / Mader, Pavel / Supuran, Claudiu T. / Chimirri, Alba et al. | 2010
- 2409
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Synthesis and Biological Activities of 2-Amino-1-arylidenamino Imidazoles as Orally Active Anticancer AgentsLi, Wen-Tai / Hwang, Der-Ren / Song, Jen-Shin / Chen, Ching-Ping / Chuu, Jiunn-Jye / Hu, Chih-Bo / Lin, Heng-Liang / Huang, Chen-Lung / Huang, Chiung-Yi / Tseng, Huan-Yi et al. | 2010
- 2418
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Novel Diamidino-Substituted Derivatives of Phenyl Benzothiazolyl and Dibenzothiazolyl Furans and Thiophenes: Synthesis, Antiproliferative and DNA Binding PropertiesRacané, Livio / Tralić-Kulenović, Vesna / Kraljević Pavelić, Sandra / Ratkaj, Ivana / Peixoto, Paul / Nhili, Raja / Depauw, Sabine / Hildebrand, Marie-Paule / David-Cordonnier, Marie-Hélène / Pavelić, Krešimir et al. | 2010
- 2433
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Identification of 2-Anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead GenerationEgert-Schmidt, Anne-Marie / Dreher, Jan / Dunkel, Ute / Kohfeld, Simone / Preu, Lutz / Weber, Holger / Ehlert, Jan E. / Mutschler, Bettina / Totzke, Frank / Schächtele, Christoph et al. | 2010
- 2443
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Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease InhibitorMcCauley, John A. / McIntyre, Charles J. / Rudd, Michael T. / Nguyen, Kevin T. / Romano, Joseph J. / Butcher, John W. / Gilbert, Kevin F. / Bush, Kimberly J. / Holloway, M. Katharine / Swestock, John et al. | 2010
- 2464
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Prediction and Evaluation of Protein Farnesyltransferase Inhibition by Commercial DrugsDeGraw, Amanda J. / Keiser, Michael J. / Ochocki, Joshua D. / Shoichet, Brian K. / Distefano, Mark D. et al. | 2010
- 2472
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A Novel Insulin Secretagogue Based on a Dinucleoside Polyphosphate Scaffold(1)Eliahu, Shay et al. | 2010
- 2472
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A Novel Insulin Secretagogue Based on a Dinucleoside Polyphosphate ScaffoldEliahu, Shay / Barr, Haim M. / Camden, Jean / Weisman, Gary A. / Fischer, Bilha et al. | 2010
- 2482
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Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Zhang, Xian / He, Yantao / Liu, Sijiu / Yu, Zhihong / Jiang, Zhong-Xing / Yang, Zhenyun / Dong, Yuanshu / Nabinger, Sarah C. / Wu, Li / Gunawan, Andrea M. et al. | 2010
- 2494
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Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1Liu, Tao / Liu, Yu / Kao, Hung-Ying / Pei, Dehua et al. | 2010
- 2502
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Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic CompoundsTrabocchi, Andrea / Mannino, Claudia / Machetti, Fabrizio / De Bernardis, Flavia / Arancia, Silvia / Cauda, Roberto / Cassone, Antonio / Guarna, Antonio et al. | 2010
- 2510
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Synthesis and Evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D2 Receptor Ligands and the Discovery of the Dopaminergic Stabilizer 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16)Pettersson, Fredrik / Pontén, Henrik / Waters, Nicholas / Waters, Susanna / Sonesson, Clas et al. | 2010
- 2521
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5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT6 Receptor AntagonistsHaydar, Simon N. / Yun, Heedong / Andrae, Patrick M. / Mattes, James / Zhang, Jean / Kramer, Angela / Smith, Deborah L. / Huselton, Christine / Graf, Radka / Aschmies, Suzan et al. | 2010
- 2528
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Discovery of a Novel Series of Semisynthetic Vancomycin Derivatives Effective against Vancomycin-Resistant BacteriaNakama, Yuki / Yoshida, Osamu / Yoda, Masanori / Araki, Keisuke / Sawada, Yuri / Nakamura, Jun / Xu, Shu / Miura, Kenji / Maki, Hideki / Arimoto, Hirokazu et al. | 2010
- 2534
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1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Triple Reuptake InhibitorsMicheli, Fabrizio / Cavanni, Paolo / Arban, Roberto / Benedetti, Roberto / Bertani, Barbara / Bettati, Michela / Bettelini, Letizia / Bonanomi, Giorgio / Braggio, Simone / Checchia, Anna et al. | 2010
- 2552
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Development of Novel Adenosine Monophosphate-Activated Protein Kinase ActivatorsGuh, Jih-Hwa / Chang, Wei-Ling / Yang, Jian / Lee, Su-Lin / Wei, Shuo / Wang, Dasheng / Kulp, Samuel K. / Chen, Ching-Shih et al. | 2010
- 2562
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Structure−Activity Relationship of (N)-Methanocarba Phosphonate Analogues of 5′-AMP as Cardioprotective Agents Acting Through a Cardiac P2X ReceptorKumar, T. Santhosh / Zhou, Si-Yuan / Joshi, Bhalchandra V. / Balasubramanian, Ramachandran / Yang, Tiehong / Liang, Bruce T. / Jacobson, Kenneth A. et al. | 2010
- 2577
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Fragment-Based Deconstruction of Bcl-xL InhibitorsBarelier, Sarah / Pons, Julien / Marcillat, Olivier / Lancelin, Jean-Marc / Krimm, Isabelle et al. | 2010
- 2589
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A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and ApoptosisChen, Zhuo / Liang, Xin / Zhang, Huanying / Xie, Hua / Liu, Jianwen / Xu, Yufang / Zhu, Weiping / Wang, Yi / Wang, Xin / Tan, Shaoying et al. | 2010
- 2601
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Intramolecular Hydrogen Bonding in Medicinal ChemistryKuhn, Bernd / Mohr, Peter / Stahl, Martin et al. | 2010
- 2612
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Synthesis and Characterization of Rhenium and Technetium-99m Labeled InsulinSundararajan, Chitra / Besanger, Travis R. / Labiris, Renee / Guenther, Katharina J. / Strack, Thomas / Garafalo, Robert / Kawabata, Thomas T. / Finco-Kent, Deborah / Zubieta, Jon / Babich, John W. et al. | 2010
- 2622
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Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-α Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell ModelsNuti, Elisa / Casalini, Francesca / Avramova, Stanislava I. / Santamaria, Salvatore / Fabbi, Marina / Ferrini, Silvano / Marinelli, Luciana / La Pietra, Valeria / Limongelli, Vittorio / Novellino, Ettore et al. | 2010
- 2622
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Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor- alpha Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell ModelsNuti, E. / Casalini, F. / Avramova, S.I. / Santamaria, S. / Fabbi, M. / Ferrini, S. / Marinelli, L. / La Pietra, V. / Limongelli, V. / Novellino, E. et al. | 2010
- 2636
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Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual InhibitorVenkatesan, Aranapakam M. / Dehnhardt, Christoph M. / Delos Santos, Efren / Chen, Zecheng / Dos Santos, Osvaldo / Ayral-Kaloustian, Semiramis / Khafizova, Gulnaz / Brooijmans, Natasja / Mallon, Robert / Hollander, Irwin et al. | 2010
- 2646
-
Dopamine Receptor Ligands. Part 18: Modification of the Structural Skeleton of Indolobenzazecine-Type Dopamine Receptor AntagonistsRobaa, Dina / Enzensperger, Christoph / Abul Azm, Shams El Din / El Khawass, El Sayeda / El Sayed, Ola / Lehmann, Jochen et al. | 2010
- 2646
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Dopamine Receptor Ligands. Part 18:(1) Modification of the Structural Skeleton of Indolobenzazecine-Type Dopamine Receptor AntagonistsRobaa, Dina et al. | 2010
- 2651
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Noncovalent Tripeptidyl Benzyl- and Cyclohexyl-Amine Inhibitors of the Cysteine Protease Caspase-1Löser, Reik / Abbenante, Giovanni / Madala, Praveen K. / Halili, Maria / Le, Giang T. / Fairlie, David P. et al. | 2010
- 2656
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Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of Phosphodiesterase 5 (PDE5)Hughes, Robert O. / Rogier, D. Joseph / Jacobsen, E. Jon / Walker, John K. / MacInnes, Alan / Bond, Brian R. / Zhang, Lena L. / Yu, Ying / Zheng, Yi / Rumsey, Jeanne M. et al. | 2010
- 2661
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Discovery and SAR of Thiazolidine-2,4-dione Analogues as Insulin-like Growth Factor-1 Receptor (IGF-1R) Inhibitors via Hierarchical Virtual ScreeningLiu, Xiaofeng / Xie, Hua / Luo, Cheng / Tong, Linjiang / Wang, Yi / Peng, Ting / Ding, Jian / Jiang, Hualiang / Li, Honglin et al. | 2010
- 2666
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Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical CandidateShen, Hong C. / Ding, Fa-Xiang / Raghavan, Subharekha / Deng, Qiaolin / Luell, Silvi / Forrest, Michael J. / Carballo-Jane, Ester / Wilsie, Larissa C. / Krsmanovic, Mihajlo L. / Taggart, Andrew K. et al. | 2010
- 2671
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Book Review of Comprehensive Organic Name Reactions and ReagentsKerns, Robert J. et al. | 2010