1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors (English)
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In:
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
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20
, 10
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3125-3128
;
2010
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ISSN:
- Article (Journal) / Print
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Title:1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
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Contributors:Tollefson, M. B. ( author ) / Acker, B. A. ( author ) / Jacobsen, E. J. ( author ) / Hughes, R. O. ( author ) / Walker, J. K. ( author ) / Fox, D. N. ( author ) / Palmer, M. J. ( author ) / Freeman, S. K. ( author ) / Yu, Y. ( author ) / Bond, B. R. ( author )
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Published in:BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS ; 20, 10 ; 3125-3128
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2010-01-01
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Size:4 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 572.5
- Further information on Dewey Decimal Classification
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Classification:
DDC: 572.5 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 20, Issue 10
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 3007
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Graphical contents list| 2010
- 3017
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5-Functionalized indazoles as glucocorticoid receptor agonistsBai, Mei / Carr, Grant / DeOrazio, Russell J. / Friedrich, Thomas D. / Dobritsa, Svetlana / Fitzpatrick, Kevin / Guzzo, Peter R. / Kitchen, Douglas B. / Lynch, Michael A. / Peace, Denise et al. | 2010
- 3021
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Novel Tween® 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastomaMasotti, Andrea / Vicennati, Paola / Alisi, Anna / Marianecci, Carlotta / Rinaldi, Federica / Carafa, Maria / Ortaggi, Giancarlo et al. | 2010
- 3026
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Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activityMiller, John F. / Gudmundsson, Kristjan S. / Richardson, Leah D’Aurora / Jenkinson, Stephen / Spaltenstein, Andrew / Thomson, Michael / Wheelan, Pat et al. | 2010
- 3031
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Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agentsBera, Smritilekha / Zhanel, George G. / Schweizer, Frank et al. | 2010
- 3036
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A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen)Fauq, Abdul H. / Maharvi, Ghulam M. / Sinha, Dola et al. | 2010
- 3039
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Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubilityNieman, James A. / Nair, Sajiv K. / Heasley, Steven E. / Schultz, Brenda L. / Zerth, Herbert M. / Nugent, Richard A. / Chen, Ke / Stephanski, Kevin J. / Hopkins, Todd A. / Knechtel, Mary L. et al. | 2010
- 3043
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Cyclopeptide Smac mimetics as antagonists of IAP proteinsSun, Haiying / Liu, Liu / Lu, Jianfeng / Qiu, Su / Yang, Chao-Yie / Yi, Han / Wang, Shaomeng et al. | 2010
- 3047
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Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, IIShen, Yongchun / Du, Hong / Kotake, Makoto / Matsushima, Tomohiro / Goto, Masaki / Shirota, Hiroshi / Gusovsky, Fabian / Li, Xiangyi / Jiang, Yimin / Schiller, Shawn et al. | 2010
- 3050
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Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19)Muftuoglu, Yagmur / Mustata, Gabriela et al. | 2010
- 3065
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Synthesis of novel benzocoumarin derivatives as lipid lowering agentsSashidhara, Koneni V. / Rosaiah, Jammikuntla N. / Kumar, Abdhesh / Bhatia, Gitika / Khanna, A.K. et al. | 2010
- 3070
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Complexes of 2-hydroxyacetophenone semicarbazones: A novel series of superoxide dismutase mimeticsSafavi, Maliheh / Foroumadi, Alireza / Nakhjiri, Maryam / Abdollahi, Mohammad / Shafiee, Abbas / Ilkhani, Hoda / Ganjali, Mohammad Reza / Hosseinimehr, Seyed Jalal / Emami, Saeed et al. | 2010
- 3074
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Design, synthesis and SAR of phenylamino-substituted 5,11-dihydro-dibenzo[a,d]cyclohepten-10-ones and 11H-dibenzo[b,f]oxepin-10-ones as p38 MAP kinase inhibitorsDorn, Angelika / Schattel, Verena / Laufer, Stefan et al. | 2010
- 3078
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Synthesis and anticancer evaluation of α-lipoic acid derivativesZhang, Shi-Jie / Ge, Qiu-Fu / Guo, Dian-Wu / Hu, Wei-Xiao / Liu, Hua-Zhang et al. | 2010
- 3078
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Synthesis and anticancer evaluation of a-lipoic acid derivativesZhang, S. J. / Ge, Q. F. / Guo, D. W. / Hu, W. X. / Liu, H. Z. et al. | 2010
- 3084
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Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen speciesXu, Wei / Huang, Han-chang / Lin, Chang-jun / Jiang, Zhao-Feng et al. | 2010
- 3089
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3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitorsSethi, Kalyan K. / Verma, Saurabh M. / Prasanthi, Naru / Sahoo, Suvendu K. / Parhi, Rabi N. / Suresh, P. et al. | 2010
- 3094
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First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitorsHu, Honggang / Liao, Hongli / Zhang, Jun / Wu, Weifeng / Yan, Jufang / Yan, Yonghong / Zhao, Qingjie / Zou, Yan / Chai, Xiaoyun / Yu, Shichong et al. | 2010
- 3098
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The synthesis of novel fluorescent purine analogues modified by azacrown ether at C6Guo, Hai-Ming / Wu, Jing / Niu, Hong-Ying / Wang, Dong-Chao / Zhang, Feng / Qu, Gui-Rong et al. | 2010
- 3103
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Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomographySchönberger, Matthias / Leggett, Carmine / Kim, Sung Won / Hooker, Jacob M. et al. | 2010
- 3107
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Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonistChen, Xiangyang / Pierce, Betsy / Naing, Win / Grapperhaus, Margaret L. / Phillion, Dennis P. et al. | 2010
- 3112
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Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activityLi, Wei / Dang, Yongjun / Liu, Jun O. / Yu, Biao et al. | 2010
- 3116
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Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonistsRotstein, David M. / Melville, Chris R. / Padilla, Fernando / Cournoyer, Dick / Lee, Eun K. / Lemoine, Remy / Petersen, Ann C. / Setti, Lina Q. / Wanner, Jutta / Chen, Lijing et al. | 2010
- 3120
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1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitorsTollefson, Michael B. / Acker, Brad A. / Jacobsen, E.J. / Hughes, Robert O. / Walker, John K. / Fox, David N.A. / Palmer, Michael J. / Freeman, Sandra K. / Yu, Ying / Bond, Brian R. et al. | 2010
- 3125
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1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitorsTollefson, Michael B. / Acker, Brad A. / Jacobsen, E.J. / Hughes, Robert O. / Walker, John K. / Fox, David N.A. / Palmer, Michael J. / Freeman, Sandra K. / Yu, Ying / Bond, Brian R. et al. | 2010
- 3129
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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead effortsBrnardic, Edward J. / Fraley, Mark E. / Garbaccio, Robert M. / Layton, Mark E. / Sanders, John M. / Culberson, Chris / Jacobson, Marlene A. / Magliaro, Brian C. / Hutson, Pete H. / O’Brien, Julie A. et al. | 2010
- 3134
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Cooperative binding of a quinoline derivative to an RNA stem loop containing a dangling endRamisetty, Sreenivasa Rao / Baranger, Anne M. et al. | 2010
- 3138
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Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activityBressi, Jerome C. / Jong, Ron de / Wu, Yiqin / Jennings, Andy J. / Brown, Jason W. / O’Connell, Shawn / Tari, Leslie W. / Skene, Robert J. / Vu, Phong / Navre, Marc et al. | 2010
- 3142
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Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamidesBressi, Jerome C. / Jennings, Andy J. / Skene, Robert / Wu, Yiqin / Melkus, Robert / Jong, Ron De / O’Connell, Shawn / Grimshaw, Charles E. / Navre, Marc / Gangloff, Anthony R. et al. | 2010
- 3146
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Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinaseJerome, Kevin D. / Hepperle, Michael E. / Walker, John K. / Xing, Li / Devraj, Rajesh V. / Benson, Alan G. / Baldus, John E. / Selness, Shaun R. et al. | 2010
- 3150
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Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicitySatyanarayana, Mavurapu / Kim, Young-Ah / Rzuczek, Suzanne G. / Pilch, Daniel S. / Liu, Angela A. / Liu, Leroy F. / Rice, Joseph E. / LaVoie, Edmond J. et al. | 2010
- 3155
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Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, IIIShen, Yongchun / Boivin, Roch / Yoneda, Naoki / Du, Hong / Schiller, Shawn / Matsushima, Tomohiro / Goto, Masaki / Shirota, Hiroshi / Gusovsky, Fabian / Lemelin, Charles et al. | 2010
- 3158
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Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leadsHuang, Yifang / Strobel, Eric D. / Ho, Chih Y. / Reynolds, Charles H. / Conway, Kelly A. / Piesvaux, Jennifer A. / Brenneman, Douglas E. / Yohrling, George J. / Moore Arnold, H. / Rosenthal, Daniel et al. | 2010
- 3161
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Synthesis and structure–activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptorChambers, Laura J. / Stevens, Alexander J. / Moses, Andrew P. / Michel, Anton D. / Walter, Daryl S. / Davies, David J. / Livermore, David G. / Fonfria, Elena / Demont, Emmanuel H. / Vimal, Mythily et al. | 2010
- 3165
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Design, synthesis and evaluation of progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug effluxZeinyeh, Waël / Alameh, Ghina / Radix, Sylvie / Grenot, Catherine / Dumontet, Charles / Walchshofer, Nadia et al. | 2010
- 3169
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Novel 1,3,5-triphenyl-2-pyrazolines as anti-infective agentsSivakumar, P.M. / Prabhu Seenivasan, S. / Kumar, Vanaja / Doble, Mukesh et al. | 2010
- 3173
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Chiral NG-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivityGhorai, Prasanta / Kraus, Anja / Birnkammer, Tobias / Geyer, Roland / Bernhardt, Günther / Dove, Stefan / Seifert, Roland / Elz, Sigurd / Buschauer, Armin et al. | 2010
- 3177
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The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidinesGangjee, Aleem / Namjoshi, Ojas A. / Ihnat, Michael A. / Buchanan, Aaron et al. | 2010
- 3182
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Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-oneVelaparthi, Upender / Saulnier, Mark G. / Wittman, Mark D. / Liu, Peiying / Frennesson, David B. / Zimmermann, Kurt / Carboni, Joan M. / Gottardis, Marco / Li, Aixin / Greer, Ann et al. | 2010
- 3186
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Corrigendum to “Neolignans from Piper kadsura and their anti-neuroinflammatory activity” [Bioorg. Med. Chem. Lett. 20 (2010) 409]Kim, Ki Hyun / Choi, Jung Wook / Ha, Sang Keun / Kim, Sun Yeou / Lee, Kang Ro et al. | 2010
- IFC
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Editorial board| 2010