Potent and selective thiophene urea-templated inhibitors of S6K (English)
- New search for: Ye, P.
- New search for: Kuhn, C.
- New search for: Juan, M.
- New search for: Sharma, R.
- New search for: Connolly, B.
- New search for: Alton, G.
- New search for: Liu, H.
- New search for: Stanton, R.
- New search for: Kablaoui, N. M.
- New search for: Ye, P.
- New search for: Kuhn, C.
- New search for: Juan, M.
- New search for: Sharma, R.
- New search for: Connolly, B.
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In:
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
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21
, 2
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849-852
;
2011
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ISSN:
- Article (Journal) / Print
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Title:Potent and selective thiophene urea-templated inhibitors of S6K
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Contributors:Ye, P. ( author ) / Kuhn, C. ( author ) / Juan, M. ( author ) / Sharma, R. ( author ) / Connolly, B. ( author ) / Alton, G. ( author ) / Liu, H. ( author ) / Stanton, R. ( author ) / Kablaoui, N. M. ( author )
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Published in:BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS ; 21, 2 ; 849-852
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2011-01-01
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Size:4 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 572.5
- Further information on Dewey Decimal Classification
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Classification:
DDC: 572.5 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 21, Issue 2
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 607
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Graphical contents list| 2011
- 622
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Efficient synthesis of trisaccharide saponins and their tumor cell killing effects through oncotic necrosisGao, Jian / Li, Xia / Gu, Guofeng / Sun, Bin / Cui, Min / Ji, Mei / Lou, Hong-Xiang et al. | 2010
- 628
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Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modificationZaware, Pandurang / Shah, Shailesh R. / Pingali, Harikishore / Makadia, Pankaj / Thube, Baban / Pola, Suresh / Patel, Darshit / Priyadarshini, Priyanka / Suthar, Dinesh / Shah, Maanan et al. | 2010
- 628
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Modulation of PPAR subtype selectivity. Part 2: Transforming PPARa/g dual agonist into a selective PPAR agonist through bioisosteric modificationZaware, P. / Shah, S. R. / Pingali, H. / Makadia, P. / Thube, B. / Pola, S. / Patel, D. / Priyadarshini, P. / Suthar, D. / Shah, M. et al. | 2011
- 633
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Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpaKiem, Phan Van / Cuong, Nguyen Xuan / Nhiem, Nguyen Xuan / Thu, Vu Kim / Ban, Ninh Khac / Minh, Chau Van / Tai, Bui Huu / Hai, Truong Nam / Lee, Sang Hyun / Jang, Hae Dong et al. | 2010
- 638
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Discovery of selective irreversible inhibitors for EGFR-T790MZhou, Wenjun / Ercan, Dalia / Jänne, Pasi A. / Gray, Nathanael S. et al. | 2010
- 644
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Synthesis and structure–activity relationships of novel benzoxaboroles as a new class of antimalarial agentsZhang, Yong-Kang / Plattner, Jacob J. / Freund, Yvonne R. / Easom, Eric E. / Zhou, Yasheen / Gut, Jiri / Rosenthal, Philip J. / Waterson, David / Gamo, Francisco-Javier / Angulo-Barturen, Inigo et al. | 2010
- 652
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8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylaseMařák, David / Otmar, Miroslav / Votruba, Ivan / Dračínský, Martin / Krečmerová, Marcela et al. | 2010
- 655
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Imidazolylchromanone oxime ethers as potential anticonvulsant agents: Anticonvulsive evaluation in PTZ-kindling model of epilepsy and SAR studyEmami, Saeed / Kebriaeezadeh, Abbas / Ahangar, Nematollah / Khorasani, Reza et al. | 2010
- 660
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2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilinesZificsak, Craig A. / Theroff, Jay P. / Aimone, Lisa D. / Albom, Mark S. / Angeles, Thelma S. / Brown, Rebecca A. / Galinis, Deborah / Grobelny, Jennifer V. / Herbertz, Torsten / Husten, Jean et al. | 2010
- 664
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Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulatorsQin, Jun / Dhondi, Pawan / Huang, Xianhai / Mandal, Mihirbaran / Zhao, Zhiqiang / Pissarnitski, Dmitri / Zhou, Wei / Aslanian, Robert / Zhu, Zhaoning / Greenlee, William et al. | 2010
- 664
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Discovery of fused 5,6-bicyclic heterocycles as g-secretase modulatorsQin, J. / Dhondi, P. / Huang, X. / Mandal, M. / Zhao, Z. / Pissarnitski, D. / Zhou, W. / Aslanian, R. / Zhu, Z. / Greenlee, W. et al. | 2011
- 670
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Tetrahydroquinoline derivatives as opioid receptor antagonistsZhang, Cunyu / Westaway, Susan M. / Speake, Jason D. / Bishop, Michael J. / Goetz, Aaron S. / Carballo, Luz Helena / Hu, Mike / Epperly, Andrea H. et al. | 2010
- 677
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Synthetic analogs of daidzein, having more potent osteoblast stimulating effectYadav, Dinesh K. / Gautam, Abnish K. / Kureel, Jyoti / Srivastava, Kamini / Sahai, Mahendra / Singh, Divya / Chattopadhyay, Naibedya / Maurya, Rakesh et al. | 2010
- 682
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Synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivativesMokale, Santosh N. / Elgire, R.D. / Sakle, Nikhil / Shinde, Devanand B. et al. | 2010
- 686
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New azoles with antifungal activity: Design, synthesis, and molecular dockingChai, Xiaoyun / Zhang, Jun / Cao, Yongbing / Zou, Yan / Wu, Qiuye / Zhang, Dazhi / Jiang, Yuanying / Sun, Qingyan et al. | 2010
- 690
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Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.Shao, Chang-Lun / Wang, Chang-Yun / Wei, Mei-Yan / Gu, Yu-Cheng / She, Zhi-Gang / Qian, Pei-Yuan / Lin, Yong-Cheng et al. | 2010
- 694
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Synthesis and biological evaluation of novel dihydro-aryl/alkylsulfanyl-cyclohexylmethyl-oxopyrimidines (S-DACOs) as high active anti-HIV agentsHe, Yan-Ping / Long, Jin / Zhang, Shui-Shuan / Li, Cong / Lai, Christopher Cong / Zhang, Chun-Sheng / Li, Da-Xiong / Zhang, De-Hua / Wang, Hua / Cai, Qing-Qing et al. | 2010
- 698
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1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT6 serotonin receptor ligandsPark, Chul Min / Choi, Jin Il / Choi, Jung Hwan / Kim, So Young / Park, Woo Kyu / Seong, Churl Min et al. | 2010
- 704
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Quencher-free molecular beacon: Enhancement of the signal-to-background ratio with graphene oxideYi, Jeong Wu / Park, Jaesung / Singh, N. Jiten / Lee, Il Joon / Kim, Kwang S. / Kim, Byeang Hyean et al. | 2010
- 707
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Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitorsGaspar, Alexandra / Reis, Joana / Fonseca, André / Milhazes, Nuno / Viña, Dolores / Uriarte, Eugenio / Borges, Fernanda et al. | 2010
- 710
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Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillataBertucci, Anthony / Innocenti, Alessio / Scozzafava, Andrea / Tambutté, Sylvie / Zoccola, Didier / Supuran, Claudiu T. et al. | 2010
- 715
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Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3′-overhang regions and its RNAi activityMasud, Mohammad Mehedi / Masuda, Tomokazu / Inoue, Yusuke / Kuwahara, Masayasu / Sawai, Hiroaki / Ozaki, Hiroaki et al. | 2010
- 715
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Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3prime-overhang regions and its RNAi activityMasud, M. M. / Masuda, T. / Inoue, Y. / Kuwahara, M. / Sawai, H. / Ozaki, H. et al. | 2011
- 718
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New Hedgehog/GLI signaling inhibitors from Excoecaria agallochaRifai, Yusnita / Arai, Midori A. / Sadhu, Samir K. / Ahmed, Firoj / Ishibashi, Masami et al. | 2010
- 723
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Synthesis of 3′-azido-3′-deoxythymidine (AZT)—Cinchona alkaloid conjugates via click chemistry: Toward novel fluorescent markers and cytostatic agentsBaraniak, Dagmara / Kacprzak, Karol / Celewicz, Lech et al. | 2010
- 723
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Synthesis of 3prime-azido-3prime-deoxythymidine (AZT)-Cinchona alkaloid conjugates via click chemistry: Toward novel fluorescent markers and cytostatic agentsBaraniak, D. / Kacprzak, K. / Celewicz, L. et al. | 2011
- 727
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Chemical affinity matrix-based identification of prohibitin as a binding protein to anti-resorptive sulfonyl amidine compoundsChang, Sung-Youn / Bae, Su Jung / Lee, Myung Yun / Baek, Seung-hwa / Chang, Sukbok / Kim, Seong Hwan et al. | 2010
- 730
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Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogsScott, Latanya M. / Chen, Liwei / Daniel, Kenyon G. / Brooks, Wesley H. / Guida, Wayne C. / Lawrence, Harshani R. / Sebti, Said M. / Lawrence, Nicholas J. / Wu, Jie et al. | 2010
- 734
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The identification of substituted benzothiophene derivatives as PGE2 subtype 4 receptor antagonists: From acid to non-acidLi, Lianhai / Mathieu, Marie-Claude / Denis, Danielle / Therien, Alex G. / Wang, Zhaoyin et al. | 2010
- 738
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The synthesis and biological evaluation of 1-C-alkyl-l-arabinoiminofuranoses, a novel class of a-glucosidase inhibitorsNatori, Y. / Imahori, T. / Murakami, K. / Yoshimura, Y. / Nakagawa, S. / Kato, A. / Adachi, I. / Takahata, H. et al. | 2011
- 738
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The synthesis and biological evaluation of 1-C-alkyl-l-arabinoiminofuranoses, a novel class of α-glucosidase inhibitorsNatori, Yoshihiro / Imahori, Tatsushi / Murakami, Keiichi / Yoshimura, Yuichi / Nakagawa, Shinpei / Kato, Atsushi / Adachi, Isao / Takahata, Hiroki et al. | 2010
- 742
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Exploration of SAR regarding glucose moiety in novel C-aryl glucoside inhibitors of SGLT2Park, Eun-Jung / Kong, Younggyu / Lee, Jun Sung / Lee, Sung-Han / Lee, Jinhwa et al. | 2010
- 747
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2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species–mitochondria pathwayHan, Young-Min / Shin, Dae-Seop / Lee, Yu-Jin / Ismail, Ismail Ahmed / Hong, Su-Hyung / Han, Dong Cho / Kwon, Byoung-Mog et al. | 2010
- 752
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Modulation of i-motif thermodynamic stability by the introduction of UNA (unlocked nucleic acid) monomersPasternak, Anna / Wengel, Jesper et al. | 2010
- 756
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A novel transition state analog inhibitor of guanase based on azepinomycin ring structure: Synthesis and biochemical assessment of enzyme inhibitionChakraborty, Saibal / Shah, Niti H. / Fishbein, James C. / Hosmane, Ramachandra S. et al. | 2010
- 760
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6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitorsNagasawa, Johnny Y. / Song, Jenny / Chen, Huanming / Kim, Hong-Woo / Blazel, Julie / Ouk, Samedy / Groschel, Bettina / Borges, Virginia / Ong, Voon / Yeh, Li-Tain et al. | 2010
- 764
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Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluationMesenzani, Ornella / Massarotti, Alberto / Giustiniano, Mariateresa / Pirali, Tracey / Bevilacqua, Valentina / Caldarelli, Antonio / Canonico, Pierluigi / Sorba, Giovanni / Novellino, Ettore / Genazzani, Armando A. et al. | 2010
- 769
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Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivativesEpifano, Francesco / Sosa, Silvio / Tubaro, Aurelia / Marcotullio, M. Carla / Curini, Massimo / Genovese, Salvatore et al. | 2010
- 773
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Quinazolinones as γ-secretase modulatorsFischer, Christian / Shah, Sanjiv / Hughes, Bethany L. / Nikov, George N. / Crispino, Jamie L. / Middleton, Richard E. / Szewczak, Alexander A. / Munoz, Benito / Shearman, Mark S. et al. | 2010
- 773
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Quinazolinones as g-secretase modulatorsFischer, C. / Shah, S. / Hughes, B. L. / Nikov, G. N. / Crispino, J. L. / Middleton, R. E. / Szewczak, A. A. / Munoz, B. / Shearman, M. S. et al. | 2011
- 777
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Non-covalent inhibitors of rhinovirus 3C proteaseBaxter, Andrew / Chambers, Mark / Edfeldt, Fredrik / Edman, Karl / Freeman, Adrian / Johansson, Cristian / King, Sarah / Morley, Andy / Petersen, Jens / Rawlins, Phil et al. | 2010
- 781
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Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinasesFink, Brian E. / Norris, Derek / Mastalerz, Harold / Chen, Ping / Goyal, Bindu / Zhao, Yufen / Kim, Soong-Hoon / Vite, Gregory D. / Lee, Francis Y. / Zhang, Hongjian et al. | 2010
- 786
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In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalconesGutteridge, Clare E. / Hoffman, Marshall M. / Bhattacharjee, Apurba K. / Milhous, Wilbur K. / Gerena, Lucia et al. | 2010
- 790
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13C-labeled indolequinone-DTPA-Gd conjugate for NMR probing cytochrome:P450 reductase-mediated one-electron reductionKomatsu, Hirokazu / Tanabe, Kazuhito / Nishimoto, Sei-ichi et al. | 2010
- 794
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Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictusBandyopadhyay, Prabal / Guha, Lopamudra / Seenivasagan, T. / Sathe, Manisha / Sharma, Pratibha / Parashar, B.D. / Kaushik, M.P. et al. | 2010
- 798
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Antioxidant activity of N-acyl chitosan oligosaccharide with same substituting degreeSun, Tao / Zhu, Yun / Xie, Jing / Yin, Xuhong et al. | 2010
- 801
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Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesisSundaram, Krithika / Dhagat, Urmi / Endo, Satoshi / Chung, Roland / Matsunaga, Toshiyuki / Hara, Akira / El-Kabbani, Ossama et al. | 2010
- 805
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Structure based evolution of a novel series of positive modulators of the AMPA receptorJamieson, Craig / Maclean, John K.F. / Brown, Christopher I. / Campbell, Robert A. / Gillen, Kevin J. / Gillespie, Jonathan / Kazemier, Bert / Kiczun, Michael / Lamont, Yvonne / Lyons, Amanda J. et al. | 2010
- 812
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The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824Bollo, Soledad / Núñez-Vergara, Luis J. / Kang, Sunhee / Zhang, Liang / Boshoff, Helena I. / Barry, Clifton E. III / Squella, Juan A. / Dowd, Cynthia S. et al. | 2010
- 818
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QSAR of adenosine receptor antagonists: Exploring physicochemical requirements for binding of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives with human adenosine A3 receptor subtypePran Kishore, D. / Balakumar, C. / Raghuram Rao, A. / Roy, Partha Pratim / Roy, Kunal et al. | 2010
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Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffoldZhao, Yunxue / Liu, Min / Chagnault, Vincent / Wang, Juying / Zhang, Xiumei / Murphy, Paul V. et al. | 2010
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Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screeningGiordanetto, Fabrizio / Kull, Bengt / Dellsén, Anita et al. | 2010
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New furin inhibitors based on weakly basic amidinohydrazonesSielaff, Frank / Than, Manuel E. / Bevec, Dorian / Lindberg, Iris / Steinmetzer, Torsten et al. | 2010
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Azaindoles as potent CRTH2 receptor antagonistsSimard, Daniel / Leblanc, Yves / Berthelette, Carl / Zaghdane, M. Helmi / Molinaro, Carmela / Wang, Zhaoyin / Gallant, Michel / Lau, Stephen / Thao, Trinh / Hamel, Martine et al. | 2010
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Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus PseudoceratinaXu, Min / Andrews, Kathy T. / Birrell, Geoff W. / Tran, Truc Linh / Camp, David / Davis, Rohan A. / Quinn, Ronald J. et al. | 2010
- 849
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Potent and selective thiophene urea-templated inhibitors of S6KYe, Ping / Kuhn, Cyrille / Juan, Miret / Sharma, Rahul / Connolly, Brendan / Alton, Gordon / Liu, Hu / Stanton, Robert / Kablaoui, Natasha M. et al. | 2010
- 853
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Discovery of novel ureas and thioureas of 3-decladinosyl-3-hydroxy 15-membered azalides active against efflux-mediated resistant Streptococcus pneumoniaeBukvić Krajačić, Mirjana / Dumić, Miljenko / Novak, Predrag / Cindrić, Mario / Koštrun, Sanja / Fajdetić, Andrea / Alihodžić, Sulejman / Brajša, Karmen / Kujundžić, Nedjeljko et al. | 2010
- 857
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Molecular recognition and enhancement of aqueous solubility and bioactivity of CD437 by β-cyclodextrinMishur, Robert J. / Griffin, Matthew E. / Battle, Cooper H. / Shan, Bin / Jayawickramarajah, Janarthanan et al. | 2010
- 857
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Molecular recognition and enhancement of aqueous solubility and bioactivity of CD437 by b-cyclodextrinMishur, R. J. / Griffin, M. E. / Battle, C. H. / Shan, B. / Jayawickramarajah, J. et al. | 2011
- 861
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Discovery of a series of potent arylthiadiazole H3 antagonistsXiao, Dong / Palani, Anandan / Sofolarides, Michael / Huang, Ying / Aslanian, Robert / Vaccaro, Henry / Hong, Liwu / McKittrick, Brian / West, Robert E. Jr. / Williams, Shirley M. et al. | 2010
- 865
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Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonistsPettersson, Martin / Campbell, Brian M. / Dounay, Amy B. / Gray, David L. / Xie, Longfei / O’Donnell, Christopher J. / Stratman, Nancy C. / Zoski, Kim / Drummond, Elena / Bora, Gary et al. | 2010
- 869
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A potent and selective indole N-type calcium channel (Cav2.2) blocker for the treatment of painTyagarajan, Sriram / Chakravarty, Prasun K. / Park, Min / Zhou, Bishan / Herrington, James B. / Ratliff, Kevin / Bugianesi, Randall M. / Williams, Brande / Haedo, Rodolfo J. / Swensen, Andrew M. et al. | 2010
- 874
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A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2Bu, Yanyan / Shi, Tao / Meng, Minghui / Kong, Guiping / Tian, Yingpu / Chen, Quancheng / Yao, Xinsheng / Feng, Gensheng / Cheng, Haifeng / Lu, Zhongxian et al. | 2010
- 879
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Corrigendum to “Use of anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads for capture of respiratory syncytial virus” [Bioorg. Med. Chem. Lett. 19 (2009) 4488–4491]Sakudo, Akikazu / Baba, Koichi / Tsukamoto, Megumi / Ikuta, Kazuyoshi et al. | 2010
- 880
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Corrigendum to “Tailored α-methylene-γ-butyrolactones and their effects on growth suppression in pancreatic carcinoma cells” [Bioorg. Med. Chem. Lett. 20 (2010) 6620–6623]Ramachandran, P. Veeraraghavan / Pratihar, Debarshi / Nair, Hari Narayanan G. / Walters, Matthew / Smith, Sadie / Yip-Schneider, Michele T. / Wu, Huangbing / Schmidt, C. Max et al. | 2010
- 880
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Corrigendum to "Tailored a-methylene-g-butyrolactones and their effects on growth suppression in pancreatic carcinoma cells" [Bioorg. Med. Chem. Lett. 20 (2010) 6620-6623]Ramachandran, P. V. / Pratihar, D. / Nair, H. N. / Walters, M. / Smith, S. / Yip-Schneider, M. T. / Wu, H. / Schmidt, C. M. et al. | 2011
- IFC
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Editorial board| 2011