Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor (English)
- New search for: Muthukaman, N.
- New search for: Deshmukh, S.
- New search for: Sarode, N.
- New search for: Tondlekar, S.
- New search for: Tambe, M.
- New search for: Pisal, D.
- New search for: Shaikh, M.
- New search for: Kattige, V. G.
- New search for: Honnegowda, S.
- New search for: Karande, V.
- New search for: Muthukaman, N.
- New search for: Deshmukh, S.
- New search for: Sarode, N.
- New search for: Tondlekar, S.
- New search for: Tambe, M.
- New search for: Pisal, D.
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In:
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS ONLINE
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26
, 24
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5977-5984
;
2016
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ISSN:
- Article (Journal) / Print
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Title:Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor
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Contributors:Muthukaman, N. ( author ) / Deshmukh, S. ( author ) / Sarode, N. ( author ) / Tondlekar, S. ( author ) / Tambe, M. ( author ) / Pisal, D. ( author ) / Shaikh, M. ( author ) / Kattige, V. G. ( author ) / Honnegowda, S. ( author ) / Karande, V. ( author )
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Published in:BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS ONLINE ; 26, 24 ; 5977-5984
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2016-01-01
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Size:8 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 572.5
- Further information on Dewey Decimal Classification
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Classification:
DDC: 572.5 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 26, Issue 24
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 5843
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Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolismMotoyama, Takayuki / Osada, Hiroyuki et al. | 2016
- 5851
-
Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugsBurke, Philip J. / Wong, Lai Chun / Jenkins, Terence C. / Knox, Richard J. / Meikle, Ian T. / Stanforth, Stephen P. et al. | 2016
- 5855
-
The discovery of quinoline based single-ligand human H1 and H3 receptor antagonistsProcopiou, Panayiotis A. / Ancliff, Rachael A. / Gore, Paul M. / Hancock, Ashley P. / Hodgson, Simon T. / Holmes, Duncan S. / Keeling, Steven P. / Looker, Brian E. / Parr, Nigel A. / Rowedder, James E. et al. | 2016
- 5860
-
3-Cyano-6-(5-methyl-3-pyrazoloamino) pyridines (Part 2): A dual inhibitor of Aurora kinase and tubulin polymerizationMorioka, Masahiko et al. | 2016
- 5863
-
Marine sponge alkaloids as a source of anti-bacterial adjuvantsMelander, Roberta J. / Liu, Hong-bing / Stephens, Matthew D. / Bewley, Carole A. / Melander, Christian et al. | 2016
- 5867
-
Synthesis and carbonic anhydrase inhibitory properties of novel chalcone substituted benzenesulfonamidesArslan, Tayfun / Türkoğlu, Emir Alper / Şentürk, Murat / Supuran, Claudiu T. et al. | 2016
- 5871
-
Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potentialDegnan, Andrew P. / Maxwell, Darrell / Balakrishnan, Anand / Brown, Jeffrey M. / Easton, Amy / Gulianello, Michael / Hanumegowda, Umesh / Hill-Drzewi, Melissa / Miller, Regina / Santone, Kenneth S. et al. | 2016
- 5877
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Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptorSchrader, Thomas O. / Kasem, Michelle / Ren, Albert / Feichtinger, Konrad / Al Doori, Bilal / Wei, Jing / Wu, Chunrui / Dang, Huong / Le, Minh / Gatlin, Joel et al. | 2016
- 5883
-
N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the ratPenthala, Narsimha Reddy / Janganati, Venumadhav / Alpe, Terri L. / Apana, Scott M. / Berridge, Marc S. / Crooks, Peter A. / Borrelli, Michael J. et al. | 2016
- 5887
-
Development of 1-aryl-3-furanyl/thienyl-imidazopyridine templates for inhibitors against hypoxia inducible factor (HIF)-1 transcriptional activityFuse, Shinichiro / Ohuchi, Toshiaki / Asawa, Yasunobu / Sato, Shinichi / Nakamura, Hiroyuki et al. | 2016
- 5891
-
Development of a triazole class of highly potent Porcn inhibitorsYou, Lin / Zhang, Chengwei / Yarravarapu, Nageswari / Morlock, Lorraine / Wang, Xiaolei / Zhang, Lishu / Williams, Noelle S. / Lum, Lawrence / Chen, Chuo et al. | 2016
- 5896
-
Discovery of novel N-phenyl 1,4-dihydropyridines with a dual mode of antimycobacterial activityLentz, Fabian / Hemmer, Marc / Reiling, Norbert / Hilgeroth, Andreas et al. | 2016
- 5899
-
Discovery of SOAT2 inhibitors from synthetic small moleculesKobayashi, Keisuke / Ohshiro, Taichi / Tomoda, Hiroshi / Yin, Feng / Cui, Hai-Lei / Chouthaiwale, Pandurang V. / Tanaka, Fujie et al. | 2016
- 5902
-
Synthesis of peptide nucleic acids (PNA) with a crosslinking agent to RNA and effective inhibition of dicerAkisawa, Takuya / Yamada, Ken / Nagatsugi, Fumi et al. | 2016
- 5907
-
Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPIFarahat, Abdelbasset A. / Bennett-Vaughn, Cheree / Mineva, Ekaterina M. / Kumar, Arvind / Wenzler, Tanja / Brun, Reto / Liu, Yang / Wilson, W. David / Boykin, David W. et al. | 2016
- 5911
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Design, synthesis and transfection efficiency of a novel redox-sensitive polycationic amphiphilePuchkov, Pavel A. / Shmendel, Elena V. / Luneva, Anastasya S. / Morozova, Nina G. / Zenkova, Marina A. / Maslov, Mikhail A. et al. | 2016
- 5916
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Discovery of new chemical entities as potential leads against Mycobacterium tuberculosisLu, Xiaoyun / Tang, Jian / Liu, Zhiyong / Li, Minke / Zhang, Tianyu / Zhang, Xiantao / Ding, Ke et al. | 2016
- 5920
-
Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moietiesWei, Zhi-Yu / Chi, Ke-Qiang / Yu, Zhan-Kui / Liu, Hong-Yan / Sun, Liang-Peng / Zheng, Chang-Ji / Piao, Hu-Ri et al. | 2016
- 5926
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Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potencyFarand, Julie / Mai, Nicholas / Chandrasekhar, Jayaraman / Newby, Zachary E. / Van Veldhuizen, Josh / Loyer-Drew, Jennifer / Venkataramani, Chandrasekar / Guerrero, Juan / Kwok, Amy / Li, Ning et al. | 2016
- 5931
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Exploring the anti-biofilm activity of cinnamic acid derivatives in Candida albicansDe Vita, Daniela / Simonetti, Giovanna / Pandolfi, Fabiana / Costi, Roberta / Di Santo, Roberto / D’Auria, Felicia Diodata / Scipione, Luigi et al. | 2016
- 5936
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Synthesis and fungicidal activity of 1,1-diaryl tertiary alcoholsLi, Xiuyun / Han, Xiaoqiang / He, Mengmeng / Xiao, Yumei / Qin, Zhaohai et al. | 2016
- 5943
-
Radical scavenging and antibacterial activity of caffemides against gram positive, gram negative and clinical drug resistance bacteriaMisra, Kaushik / Maity, Himadri Sekhar / Nag, Ahindra / Sonawane, Avinash et al. | 2016
- 5947
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Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)Lam, Betty / Arikawa, Yasuyoshi / Cramlett, Joshua / Dong, Qing / de Jong, Ron / Feher, Victoria / Grimshaw, Charles E. / Farrell, Pamela J. / Hoffman, Isaac D. / Jennings, Andy et al. | 2016
- 5951
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Discovery of 1,3-diethyl-7-methyl-8-(phenoxymethyl)-xanthine derivatives as novel adenosine A1 and A2A receptor antagonistsHarmse, Rozanne / van der Walt, Mietha M. / Petzer, Jacobus P. / Terre’Blanche, Gisella et al. | 2016
- 5956
-
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activityYasuda, Daisuke / Nakajima, Mao / Yuasa, Akihiro / Obata, Rika / Takahashi, Kyoko / Ohe, Tomoyuki / Ichimura, Yoshinobu / Komatsu, Masaaki / Yamamoto, Masayuki / Imamura, Riyo et al. | 2016
- 5960
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Design, development of new synthetic methodology, and biological evaluation of substituted quinolines as new anti-tubercular leadsTanwar, Babita / Kumar, Asim / Yogeeswari, Perumal / Sriram, Dharmarajan / Chakraborti, Asit K. et al. | 2016
- 5967
-
Flavans with potential anti-inflammatory activities from Zephyranthes candidaZhan, Guanqun / Zhou, Junfei / Liu, Tingting / Zheng, Guijuan / Aisa, Haji Akber / Yao, Guangmin et al. | 2016
- 5971
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Synthesis and biological evaluation of allylated mono-carbonyl analogues of curcumin (MACs) as anti-cancer agents for cholangiocarcinomaQiu, Chenyu / Hu, Yan / Wu, Ke / Yang, Ke / Wang, Nan / Ma, Yue / Zhu, Heping / Zhang, Yi / Zhou, Yunfang / Chen, Chao et al. | 2016
- 5977
-
Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitorMuthukaman, Nagarajan / Deshmukh, Sanjay / Sarode, Neelam / Tondlekar, Shital / Tambe, Macchindra / Pisal, Dnyandeo / Shaikh, Mahamadhanif / Kattige, Vidya G. / Honnegowda, Srinivasa / Karande, Vikas et al. | 2016
- 5985
-
One-step radiosynthesis of 18F-IRS: A novel radiotracer targeting mutant EGFR in NSCLC for PET/CT imagingXiao, Zunyu / Song, Yan / Wang, Kai / Sun, Xilin / Shen, Baozhong et al. | 2016
- 5989
-
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA bindingRanjan, Nihar / Arya, Dev P. et al. | 2016
- 5995
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Dimeric sesquiterpene and thiophenes from the roots of Echinops latifoliusJin, Qinghao / Lee, Jin Woo / Jang, Hari / Choi, Ji Eun / Kim, Hyung Sik / Lee, Dongho / Hong, Jin Tae / Lee, Mi Kyeong / Hwang, Bang Yeon et al. | 2016
- IFC
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Editorial board| 2016