Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines (Unknown)
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In:
European journal of medicinal chemistry
;
103
;
226-237
;
2015
-
ISSN:
- Article (Journal) / Print
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Title:Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines
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Contributors:Dasari, Ramesh ( author ) / De Carvalho, Annelise ( author ) / Medellin, Derek C. ( author ) / Middleton, Kelsey N. ( author ) / Hague, Frédéric ( author ) / Volmar, Marie N.M. ( author ) / Frolova, Liliya V. ( author ) / Rossato, Mateus F. ( author ) / De La Chapa, Jorge J. ( author ) / Dybdal-Hargreaves, Nicholas F. ( author )
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Published in:European journal of medicinal chemistry ; 103 ; 226-237
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2015-01-01
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Size:12 pages
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ISSN:
-
Type of media:Article (Journal)
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Type of material:Print
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Language:Unknown
- New search for: 615.1
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615.1 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 103
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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4-Aminoquinoline derivatives as novel Mycobacterium tuberculosis GyrB inhibitors: Structural optimization, synthesis and biological evaluationMedapi, Brahmam / Suryadevara, Priyanka / Renuka, Janupally / Sridevi, Jonnalagadda Padma / Yogeeswari, Perumal / Sriram, Dharmarajan et al. | 2015
- 17
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Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activitiesLiu, Gang / Song, Shanshan / Shu, Shiqi / Miao, Zehong / Zhang, Ao / Ding, Chunyong et al. | 2015
- 29
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Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2Salerno, Silvia / Marini, Anna Maria / Fornaciari, Giacomo / Simorini, Francesca / La Motta, Concettina / Taliani, Sabrina / Sartini, Stefania / Da Settimo, Federico / García-Argáez, Aída Nelly / Gia, Ornella et al. | 2015
- 44
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Design, synthesis, and anticancer evaluation of long-chain alkoxylated mono-carbonyl analogues of curcuminWeng, Qiaoyou / Fu, Lili / Chen, Gaozhi / Hui, Junguo / Song, Jingjing / Feng, Jianpeng / Shi, Dengjian / Cai, Yuepiao / Ji, Jiansong / Liang, Guang et al. | 2015
- 56
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Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzymeAbdelsamie, Ahmed S. / Bey, Emmanuel / Gargano, Emanuele M. / van Koppen, Chris J. / Empting, Martin / Frotscher, Martin et al. | 2015
- 69
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Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerasesKhadka, Daulat Bikram / Tran, Giap Huu / Shin, Somin / Nguyen, Hang Thi Minh / Cao, Hue Thi / Zhao, Chao / Jin, Yifeng / Van, Hue Thi My / Chau, Minh Van / Kwon, Youngjoo et al. | 2015
- 80
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Discovery of novel VEGFR-2 inhibitors. Part 5: Exploration of diverse hinge-binding fragments via core-refining approachShan, Yuanyuan / Gao, Hongping / Shao, Xiaowei / Wang, Jinfeng / Pan, Xiaoyan / Zhang, Jie et al. | 2015
- 91
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Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitorsWang, Mei-Yan / Jin, Yuan-Yuan / Wei, Hui-Yu / Zhang, Li-Song / Sun, Su-Xia / Chen, Xiu-Bo / Dong, Wei-Li / Xu, Wei-Ren / Cheng, Xian-Chao / Wang, Run-Ling et al. | 2015
- 105
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Ynamide Click chemistry in development of triazole VEGFR2 TK modulatorsVojtičková, Margaréta / Dobiaš, Juraj / Hanquet, Gilles / Addová, Gabriela / Cetin-Atalay, Rengul / Yildirim, Deniz Cansen / Boháč, Andrej et al. | 2015
- 123
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Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4Madadi, Nikhil R. / Penthala, Narsimha R. / Howk, Kevin / Ketkar, Amit / Eoff, Robert L. / Borrelli, Michael J. / Crooks, Peter A. et al. | 2015
- 133
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Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystackGhani, Usman et al. | 2015
- 163
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Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitorsPallandre, Jean-René / Borg, Christophe / Rognan, Didier / Boibessot, Thibault / Luzet, Vincent / Yesylevskyy, Semen / Ramseyer, Christophe / Pudlo, Marc et al. | 2015
- 175
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Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonistsSwedberg, Joakim E. / Schroeder, Christina I. / Mitchell, Justin M. / Durek, Thomas / Fairlie, David P. / Edmonds, David J. / Griffith, David A. / Ruggeri, Roger B. / Derksen, David R. / Loria, Paula M. et al. | 2015
- 185
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Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitorsRuan, Ban-Feng / Cheng, Hui-Jie / Ren, Jing / Li, Hong-Lin / Guo, Lu-Lu / Zhang, Xing-Xing / Liao, Chenzhong et al. | 2015
- 191
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Structure–activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivoCaraballo, Rémi / Larsson, Mikael / Nilsson, Stefan K. / Ericsson, Madelene / Qian, Weixing / Nguyen Tran, Nam Phuong / Kindahl, Tomas / Svensson, Richard / Saar, Valeria / Artursson, Per et al. | 2015
- 210
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Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM)Elkamhawy, Ahmed / Viswanath, Ambily Nath Indu / Pae, Ae Nim / Kim, Hyeon Young / Heo, Jin-Chul / Park, Woo-Kyu / Lee, Chong-Ock / Yang, Heekyoung / Kim, Kang Ho / Nam, Do-Hyun et al. | 2015
- 223
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Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]de Lucia, Daniela / Lucio, Oscar Méndez / Musio, Biagia / Bender, Andreas / Listing, Monika / Dennhardt, Sophie / Koeberle, Andreas / Garscha, Ulrike / Rizzo, Roberta / Manfredini, Stefano et al. | 2015
- 226
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Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary aminesDasari, Ramesh / De Carvalho, Annelise / Medellin, Derek C. / Middleton, Kelsey N. / Hague, Frédéric / Volmar, Marie N.M. / Frolova, Liliya V. / Rossato, Mateus F. / De La Chapa, Jorge J. / Dybdal-Hargreaves, Nicholas F. et al. | 2015
- 238
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(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligandsKamińska, Katarzyna / Ziemba, Julia / Ner, Joanna / Schwed, Johannes Stephan / Łażewska, Dorota / Więcek, Małgorzata / Karcz, Tadeusz / Olejarz, Agnieszka / Latacz, Gniewomir / Kuder, Kamil et al. | 2015
- 252
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Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activatorsJain, Atul D. / Potteti, Haranatha / Richardson, Benjamin G. / Kingsley, Laura / Luciano, Julia P. / Ryuzoji, Aya F. / Lee, Hyun / Krunic, Aleksej / Mesecar, Andrew D. / Reddy, Sekhar P. et al. | 2015
- 269
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Discovery of highly potent renin inhibitors potentially interacting with the S3′ subsite of reninSun, Xiaowei / Wen, Xiaoan / Chen, Yan-yan / Shi, Chen / Gao, Chengzhe / Wu, Yong / Wang, Li-jun / Yang, Xiu-hong / Sun, Hongbin et al. | 2015
- 289
-
Synthesis and SAR of Imidazo[1,5-a]pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's diseaseNirogi, Ramakrishna / Mohammed, Abdul Rasheed / Shinde, Anil K. / Bogaraju, Narsimha / Gagginapalli, Shankar Reddy / Ravella, Srinivasa Rao / Kota, Laxman / Bhyrapuneni, Gopinadh / Muddana, Nageswara Rao / Benade, Vijay et al. | 2015
- 302
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New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's diseaseLuo, Xiao-Ting / Wang, Chun-Ming / Liu, Yun / Huang, Zhen-Guang et al. | 2015
- 312
-
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph–ephrin systemCastelli, Riccardo / Tognolini, Massimiliano / Vacondio, Federica / Incerti, Matteo / Pala, Daniele / Callegari, Donatella / Bertoni, Simona / Giorgio, Carmine / Hassan-Mohamed, Iftiin / Zanotti, Ilaria et al. | 2015
- 325
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3-Nitrotriazole-based piperazides as potent antitrypanosomal agentsPapadopoulou, Maria V. / Bloomer, William D. / Rosenzweig, Howard S. / O'Shea, Ivan P. / Wilkinson, Shane R. / Kaiser, Marcel et al. | 2015
- 335
-
Design, synthesis and biological evaluation of novel 1,2,4-triazolo [3,4-b][1,3,4] thiadiazines bearing furan and thiophene nucleusZhang, Bei / Li, Yan-Hong / Liu, Yang / Chen, Yu-Rong / Pan, En-Shan / You, Wen-Wei / Zhao, Pei-Liang et al. | 2015
- 343
-
Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitorsChen, Shaolei / Zhang, Tingjian / Wang, Jian / Wang, Fangyang / Niu, Handong / Wu, Chunfu / Wang, Shaojie et al. | 2015
- 354
-
Discovery of WQ-3810: Design, synthesis, and evaluation of 7-(3-alkylaminoazetidin-1-yl)fluoro-quinolones as orally active antibacterial agentsItoh, Kenji / Kuramoto, Yasuhiro / Amano, Hirotaka / Kazamori, Daichi / Yazaki, Akira et al. | 2015
- 361
-
Synthesis and structure-activity relationship study of benzofuran-based chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitorsMostofi, Manizheh / Mohammadi Ziarani, Ghodsi / Mahdavi, Mohammad / Moradi, Alireza / Nadri, Hamid / Emami, Saeed / Alinezhad, Heshmatollah / Foroumadi, Alireza / Shafiee, Abbas et al. | 2015
- 370
-
New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterizationde la Fuente Revenga, Mario / Herrera-Arozamena, Clara / Fernández-Sáez, Nerea / Barco, Gema / García-Orue, Itxaso / Sugden, David / Rivara, Silvia / Rodríguez-Franco, María Isabel et al. | 2015
- 374
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Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine fused chlorins as very active photodynamic agents for melanoma cellsPereira, Nelson A.M. / Laranjo, Mafalda / Pineiro, Marta / Serra, Arménio C. / Santos, Kathleen / Teixo, Ricardo / Abrantes, Ana Margarida / Gonçalves, Ana Cristina / Sarmento Ribeiro, Ana Bela / Casalta-Lopes, João et al. | 2015
- 381
-
Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazinesMarchand, Pascal / Bazin, Marc-Antoine / Pagniez, Fabrice / Rivière, Guillaume / Bodero, Lizeth / Marhadour, Sophie / Nourrisson, Marie-Renée / Picot, Carine / Ruchaud, Sandrine / Bach, Stéphane et al. | 2015
- 396
-
Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injuryWang, Ying-Ying / Gao, Yuan-Xue / Gao, Wei / Xu, Yuan / Xu, Ya-Zhou / Wang, Yun-Jie / Chang, Sai / Yu, Li-Gang / Zhang, Lu-Yong / Liao, Hong et al. | 2015
- 409
-
Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensisde Melos, Jorge Luiz R. / Torres-Santos, Eduardo Caio / Faiões, Viviane dos S. / de Nigris Del Cistia, Catarina / Sant'Anna, Carlos Maurício R. / Rodrigues-Santos, Cláudio Eduardo / Echevarria, Aurea et al. | 2015
- 418
-
Designing, synthesis of selective and high-affinity chalcone-benzothiazole hybrids as Brugia malayi thymidylate kinase inhibitors: In vitro validation and docking studiesSashidhara, Koneni V. / Avula, Srinivasa Rao / Doharey, Pawan Kumar / Singh, L. Ravithej / Balaramnavar, Vishal M. / Gupta, Jyoti / Misra-Bhattacharya, Shailja / Rathaur, Sushma / Saxena, Anil K. / Saxena, Jitendra Kumar et al. | 2015
- 429
-
Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities for α4β2 neuronal nicotinic acetylcholine receptorsDeligia, Francesco / Deiana, Valeria / Gotti, Cecilia / Lazzari, Paolo / Bottazzi, Mirko E.H. / Pucci, Luca / Fasoli, Francesca / Ragusa, Giulio / Pinna, Gerard A. / Murineddu, Gabriele et al. | 2015
- 438
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Converting maslinic acid into an effective inhibitor of acylcholinesterasesSchwarz, Stefan / Loesche, Anne / Lucas, Susana Dias / Sommerwerk, Sven / Serbian, Immo / Siewert, Bianka / Pianowski, Elke / Csuk, René et al. | 2015
- 446
-
Novel 1,4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studiesPingaew, Ratchanok / Prachayasittikul, Veda / Worachartcheewan, Apilak / Nantasenamat, Chanin / Prachayasittikul, Supaluk / Ruchirawat, Somsak / Prachayasittikul, Virapong et al. | 2015
- 460
-
Synthesis of small interfering RNAs containing acetal-type nucleoside analogs at their 3′-ends and analysis of their silencing activity and their ability to bind to the Argonaute2 PAZ domainInada, Natsumi / Nakamoto, Kosuke / Yokogawa, Takashi / Ueno, Yoshihito et al. | 2015
- 473
-
Discovery of novel, potent and low-toxicity angiotensin II receptor type 1 (AT1) blockers: Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazoles with a chiral centerHan, Xiao-Feng / He, Xing / Wang, Miao / Xu, Di / Hao, Li-Ping / Liang, Ai-Hua / Zhang, Jun / Zhou, Zhi-Ming et al. | 2015
- 488
-
Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genesMartí-Centelles, Rosa / Falomir, Eva / Murga, Juan / Carda, Miguel / Marco, J. Alberto et al. | 2015
- 497
-
Correlation of antioxidant activities with theoretical studies for new hydrazone compounds bearing a 3,4,5-trimethoxy benzyl moietyKareem, Huda S. / Ariffin, Azhar / Nordin, Nurdiana / Heidelberg, Thorsten / Abdul-Aziz, Azlina / Kong, Kin Weng / Yehye, Wageeh A. et al. | 2015
- 506
-
Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogsYan, Mi / Ma, Xiaodong / Dong, Ruiqian / Li, Xin / Zhao, Can / Guo, Zhenzhen / Shen, Yan / Liu, Fang / Ma, Ruixin / Ma, Shutao et al. | 2015
- 516
-
Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectivesTabrizi, Leila / McArdle, Patrick / Erxleben, Andrea / Chiniforoshan, Hossein et al. | 2015
- 530
-
Discovery and optimisation studies of antimalarial phenotypic hitsMital, Alka / Murugesan, Dinakaran / Kaiser, Marcel / Yeates, Clive / Gilbert, Ian H. et al. | 2015
- 539
-
An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysisTeo, Theodosia / Yang, Yuchao / Yu, Mingfeng / Basnet, Sunita K.C. / Gillam, Todd / Hou, Jinqiang / Schmid, Raffaella M. / Kumarasiri, Malika / Diab, Sarah / Albrecht, Hugo et al. | 2015
- 551
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Diethylstilbestrol-scaffold-based pregnane X receptor modulatorsHodnik, Žiga / Tomašič, Tihomir / Smodiš, Domen / D'Amore, Claudio / Mašič, Lucija Peterlin / Fiorucci, Stefano / Kikelj, Danijel et al. | 2015
- 563
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Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring BGagné-Boulet, Mathieu / Moussa, Hanane / Lacroix, Jacques / Côté, Marie-France / Masson, Jean-Yves / Fortin, Sébastien et al. | 2015
- 574
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Structure-activity relationship study using peptide arrays to optimize Api137 for an increased antimicrobial activity against Pseudomonas aeruginosaBluhm, Martina E.C. / Knappe, Daniel / Hoffmann, Ralf et al. | 2015
- 583
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Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XIIIbrahim, Hany S. / Abou-Seri, Sahar M. / Tanc, Muhammet / Elaasser, Mahmoud M. / Abdel-Aziz, Hatem A. / Supuran, Claudiu T. et al. | 2015
- 594
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Synthesis, characterization, crystal structure determination and biological screening of novel N-1 and C5 alkyl substituted scaffolds of pyrimidinePathan, Naziyanaz B. / Parvez, Ali / Bader, Ammar / Shaheen, Usama / Hadda, Taibi B. et al. | 2015
- 600
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Ligand binding studies, preliminary structure–activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductaseSrinivasan, Bharath / Tonddast-Navaei, Sam / Skolnick, Jeffrey et al. | 2015
- 615
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Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agentsChen, Tsung-Chih / Wu, Chia-Lun / Lee, Chia-Chung / Chen, Chun-Liang / Yu, Dah-Shyong / Huang, Hsu-Shan et al. | 2015
- iii
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Graphical contents list| 2015
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Editorial board| 2015