The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors (English)
- New search for: Smith, Garrick P.
- New search for: Badolo, Lassina
- New search for: Chell, Victoria
- New search for: Chen, I-Jen
- New search for: Christensen, Kenneth Vielsted
- New search for: David, Laurent
- New search for: Daechsel, Justus Alfred
- New search for: Hentzer, Morten
- New search for: Herzig, Martin Christian
- New search for: Mikkelsen, Gitte Kobberøe
- New search for: Watson, Stephen P.
- New search for: Williamson, Douglas S.
- New search for: Smith, Garrick P.
- New search for: Badolo, Lassina
- New search for: Chell, Victoria
- New search for: Chen, I-Jen
- New search for: Christensen, Kenneth Vielsted
- New search for: David, Laurent
- New search for: Daechsel, Justus Alfred
- New search for: Hentzer, Morten
- New search for: Herzig, Martin Christian
- New search for: Mikkelsen, Gitte Kobberøe
- New search for: Watson, Stephen P.
- New search for: Williamson, Douglas S.
In:
Bioorganic & medicinal chemistry letters
;
27
, 18
;
4500-4505
;
2017
-
ISSN:
- Article (Journal) / Print
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Title:The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors
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Contributors:Smith, Garrick P. ( author ) / Badolo, Lassina ( author ) / Chell, Victoria ( author ) / Chen, I-Jen ( author ) / Christensen, Kenneth Vielsted ( author ) / David, Laurent ( author ) / Daechsel, Justus Alfred ( author ) / Hentzer, Morten ( author ) / Herzig, Martin Christian ( author ) / Mikkelsen, Gitte Kobberøe ( author )
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Published in:Bioorganic & medicinal chemistry letters ; 27, 18 ; 4500-4505
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2017-01-01
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Size:6 pages
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ISSN:
-
Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 572
- Further information on Dewey Decimal Classification
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Classification:
DDC: 572 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 27, Issue 18
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4221
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Antibiotic adjuvants – A strategy to unlock bacterial resistance to antibioticsGonzález-Bello, Concepción et al. | 2017
- 4229
-
Recent advances in JAK3 inhibition: Isoform selectivity by covalent cysteine targetingForster, Michael / Gehringer, Matthias / Laufer, Stefan A. et al. | 2017
- 4238
-
Pyrrolo[2,1-f][1,2,4]triazines: From C-nucleosides to kinases and back again, the remarkable journey of a versatile nitrogen heterocycleOtt, Gregory R. / Favor, David A. et al. | 2017
- 4247
-
Current approaches to the treatment of Parkinson’s DiseaseEllis, J. Michael / Fell, Matthew J. et al. | 2017
- 4256
-
Recent progresses in biomedical applications of aptamer-functionalized systemsDing, Fei / Gao, Yangguang / He, Xianran et al. | 2017
- 4270
-
Novel α,β-unsaturated amide derivatives bearing α-amino phosphonate moiety as potential antiviral agentsLan, Xianmin / Xie, Dandan / Yin, Limin / Wang, Zhenzhen / Chen, Jin / Zhang, Awei / Song, Baoan / Hu, Deyu et al. | 2017
- 4274
-
Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile coreBewley, Blake R. / Spearing, Paul K. / Weiner, Rebecca L. / Luscombe, Vincent B. / Zhan, Xiaoyan / Chang, Sichen / Cho, Hyekyung P. / Rodriguez, Alice L. / Niswender, Colleen M. / Conn, P. Jeffrey et al. | 2017
- 4280
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Synthesis and electronic properties of ester substituted 1,4-dicyanodibenzodioxins and evaluation of anti-proliferative activity of all isomeric 1,2-, 2,3- and 1,4-dicyanodibenzodioxins against HeLa cell lineBanerjee, Subhadeep / Chattopadhyay, Anjan / Fernandes, Joseph R.D. / Banerjee, Arnab / Phadte, Apeksha Ashok / Savardekar, Akanksha Vinod / Singh, Keisham Sarjit et al. | 2017
- 4285
-
Cation exchange assisted binding-elution strategy for enzymatic synthesis of human milk oligosaccharides (HMOs)Zhu, Hailiang / Wu, Zhigang / Gadi, Madhusudhan Reddy / Wang, Shuaishuai / Guo, Yuxi / Edmunds, Garrett / Guan, Wanyi / Fang, Junqiang et al. | 2017
- 4288
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Efficacious cellular codelivery of doxorubicin and EGFP siRNA mediated by the composition of PLGA and PEI protected gold nanoparticlesKumar, Krishan / Vulugundam, Gururaja / Jaiswal, Pradeep Kumar / Shyamlal, Bharti Rajesh Kumar / Chaudhary, Sandeep et al. | 2017
- 4294
-
Synthesis and biological evaluation of pyridinium-functionalized carbazole derivatives as promising antibacterial agentsWang, Pei-Yi / Fang, He-Shu / Shao, Wu-Bin / Zhou, Jian / Chen, Zhuo / Song, Bao-An / Yang, Song et al. | 2017
- 4298
-
Synthesis and antiviral evaluation of novel 1,3,4-oxadiazole/thiadiazole-chalcone conjugatesGan, Xiuhai / Hu, Deyu / Chen, Zhuo / Wang, Yanjiao / Song, Baoan et al. | 2017
- 4302
-
Small molecule inhibitors of bacterial transcription complex formationWenholz, Daniel S. / Zeng, Ming / Ma, Cong / Mielczarek, Marcin / Yang, Xiao / Bhadbhade, Mohan / Black, David St. C. / Lewis, Peter J. / Griffith, Renate / Kumar, Naresh et al. | 2017
- 4309
-
Quinazoline-1-deoxynojirimycin hybrids as high active dual inhibitors of EGFR and α-glucosidaseZhang, Yaling / Gao, Hongliang / Liu, Renjie / Liu, Juan / Chen, Li / Li, Xiabing / Zhao, Lijun / Wang, Wei / Li, Baolin et al. | 2017
- 4314
-
Synthesis of novel forskolin isoxazole derivatives with potent anti-cancer activity against breast cancer cell linesBurra, Srinivas / Voora, Vani / Rao, Ch. Prasad / Vijay Kumar, P. / Kancha, Rama Krishna / David Krupadanam, G.L. et al. | 2017
- 4319
-
Evaluation of tetraether lipid-based liposomal carriers for encapsulation and retention of nucleoside-based drugsPaolucci, Valentina / Leriche, Geoffray / Koyanagi, Takaoki / Yang, Jerry et al. | 2017
- 4323
-
The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitorsAlexandre, François-René / Badaroux, Eric / Bilello, John P. / Bot, Stéphanie / Bouisset, Tony / Brandt, Guillaume / Cappelle, Sylvie / Chapron, Christopher / Chaves, Dominique / Convard, Thierry et al. | 2017
- 4331
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Synthesis and optimization of 4,5,6,7-tetrahydrooxazolo[4,5-c]pyridines as potent and orally-active metabotropic glutamate receptor 5 negative allosteric modulatorsHirose, Wataru / Kato, Yoshihiro / Natsutani, Itaru / Takata, Makoto / Kitaichi, Maiko / Imai, Satoki / Hayashi, Shun / Arai, Yukiyo / Hoshino, Kohei / Yoshida, Kohzo et al. | 2017
- 4336
-
Synthesis of some monosaccharide-related ester derivatives as insecticidal and acaricidal agentsHuang, Xiaobo / Zhang, Bingchuan / Xu, Hui et al. | 2017
- 4341
-
Photodynamic inactivation of multiresistant bacteria (KPC) using zinc(II)phthalocyaninesMiretti, Mariana / Clementi, Romina / Tempesti, Tomas C. / Baumgartner, María T. et al. | 2017
- 4345
-
Structural characterization of a new steroidal saponin from Agave angustifolia var. Marginata and a preliminary investigation of its in vivo antiulcerogenic activity and in vitro membrane permeability propertyPereira, Gabriela Moysés / Ribeiro, Marcela Gonçalves / da Silva, Bernadete Pereira / Parente, José Paz et al. | 2017
- 4350
-
Design, synthesis, and biological activity of 5′-phenyl-1,2,5,6-tetrahydro-3,3′-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptorsJin, Yafei / Huang, Xiaoqin / Papke, Roger L. / Jutkiewicz, Emily M. / Showalter, Hollis D. / Zhan, Chang-Guo et al. | 2017
- 4354
-
Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agentsRioux, Benjamin / Pouget, Christelle / Fidanzi-Dugas, Chloë / Gamond, Aurélie / Laurent, Aurélie / Semaan, Josiane / Pinon, Aline / Champavier, Yves / Léger, David Y. / Liagre, Bertrand et al. | 2017
- 4358
-
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybridsAbdelall, Eman K.A. / Abdelhamid, Abdou O. / Azouz, Amany A. et al. | 2017
- 4370
-
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis modelLiang, Jun / Van Abbema, Anne / Balazs, Mercedesz / Barrett, Kathy / Berezhkovsky, Leo / Blair, Wade S. / Chang, Christine / Delarosa, Donnie / DeVoss, Jason / Driscoll, Jim et al. | 2017
- 4377
-
Design, synthesis and preliminary antiproliferative activity studies of new diheteroaryl thioether derivativesLi, Zhong-Hua / Liu, Xue-Qi / Zhao, Tao-Qian / Geng, Peng-Fei / Liu, Ying / Zhao, Bing / Guo, Wen-Ge / Yu, Bin / Liu, Hong-Min et al. | 2017
- 4383
-
Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonistsLee, Sunho / Kim, Changhoon / Ann, Jihyae / Thorat, Shivaji A. / Kim, Eunhye / Park, Jongmi / Choi, Sun / Blumberg, Peter M. / Frank-Foltyn, Robert / Bahrenberg, Gregor et al. | 2017
- 4389
-
Cytotoxic effect of sanguiin H-6 on MCF-7 and MDA-MB-231 human breast carcinoma cellsPark, Eun-Ji / Lee, Dahae / Baek, Seon-Eun / Kim, Ki Hyun / Kang, Ki Sung / Jang, Tae Su / Lee, Hye Lim / Song, Ji Hoon / Yoo, Jeong-Eun et al. | 2017
- 4393
-
Synthesis, antimicrobial activity, structure-activity relationship and cytotoxic studies of a new series of functionalized (Z)-3-(2-oxo-2-substituted ethylidene)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-onesSharma, Ritu / Yadav, Lalit / Lal, Jaggi / Jaiswal, Pradeep K. / Mathur, Manas / Swami, Ajit K. / Chaudhary, Sandeep et al. | 2017
- 4399
-
Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitorsPark, Sun Jun / Kim, Eunjin / Yoo, Miyoun / Lee, Joo-Youn / Park, Chi Hoon / Hwang, Jong Yeon / Ha, Jae Du et al. | 2017
- 4405
-
Characterization of a highly selective inhibitor of the Aurora kinasesFerguson, Fleur M. / Doctor, Zainab M. / Chaikuad, Apirat / Sim, Taebo / Kim, Nam Doo / Knapp, Stefan / Gray, Nathanael S. et al. | 2017
- 4409
-
Design, synthesis, anti-inflammatory activity, and molecular docking studies of perimidine derivatives containing triazoleZhang, Hong-Jian / Wang, Xiu-Zhi / Cao, Qi / Gong, Guo-Hua / Quan, Zhe-Shan et al. | 2017
- 4415
-
Rational design, synthesis and preliminary antitumor activity evaluation of a chlorambucil derivative with potent DNA/HDAC dual-targeting inhibitory activityXie, Rui / Li, Yan / Tang, Pingwah / Yuan, Qipeng et al. | 2017
- 4421
-
Arylamidonaphtalene sulfonate compounds as a novel class of heparanase inhibitorsRondanin, Riccardo / Fochi, Sara / Baruchello, Riccardo / Bernardi, Tatiana / Oliva, Paola / Semeraro, Floriana / Simoni, Daniele / Giannini, Giuseppe et al. | 2017
- 4426
-
Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD+) synthetase inhibitors as potential antitubercular agentsWang, Xu / Ahn, Yong-Mo / Lentscher, Adam G. / Lister, Julia S. / Brothers, Robert C. / Kneen, Malea M. / Gerratana, Barbara / Boshoff, Helena I. / Dowd, Cynthia S. et al. | 2017
- 4431
-
Elucidation of a carboxylate O-methyltransferase NcmP in nocamycin biosynthetic pathwayMo, Xuhua / Gui, Chun / Wang, Qingji et al. | 2017
- 4436
-
Synthesis, conformational study and antiviral activity of l-like neplanocin derivativesChen, Qi / Davidson, Amber et al. | 2017
- 4440
-
A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3)Pan, Xiaolei / Iyer, Kavita A. / Liu, Hebing / Sweet, Douglas H. / Dukat, Małgorzata et al. | 2017
- 4446
-
On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cellsGontijo, Talita B. / de Freitas, Rossimiriam P. / Emery, Flavio S. / Pedrosa, Leandro F. / Vieira Neto, José B. / Cavalcanti, Bruno C. / Pessoa, Claudia / King, Aaron / de Moliner, Fabio / Vendrell, Marc et al. | 2017
- 4457
-
Synthesis of 3-[4-(dimethylamino)phenyl]alkyl-2-oxindole derivatives and their effects on neuronal cell deathFuruta, Kyoji / Kawai, Yu / Mizuno, Yosuke / Hattori, Yurika / Koyama, Hiroko / Hirata, Yoko et al. | 2017
- 4462
-
Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realmLlona-Minguez, Sabin / Fayezi, Shabnam / Alihemmati, Alireza / Juárez-Jiménez, Jordi / Piedrafita, F. Javier / Helleday, Thomas et al. | 2017
- 4467
-
Aminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicityMagalhães, Álvaro F. / Graça, Vânia C. / Calhelha, Ricardo C. / Ferreira, Isabel C.F.R. / Santos, Paulo F. et al. | 2017
- 4471
-
1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agentsCooper, Alan B. / Ciblat, Stephane / Shipps, Gerald / Levine, Jedd / Kostura, Matthew / Oza, Vibha / Constantineau-Forget, Lea / Dery, Martin / Grand-Maitre, Chantal / Bruneau-Latour, Nicolas et al. | 2017
- 4478
-
Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptideHattori, Takayuki / Okitsu, Koyo / Yamazaki, Norikazu / Ohoka, Nobumichi / Shibata, Norihito / Misawa, Takashi / Kurihara, Masaaki / Demizu, Yosuke / Naito, Mikihiko et al. | 2017
- 4482
-
1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathyXiu, Zhi-Ming / Wang, Li-Ping / Fu, Jun / Xu, Jia / Liu, Li et al. | 2017
- 4488
-
Discovery of potent and selective CDK8 inhibitors through FBDD approachHan, Xingchun / Jiang, Min / Zhou, Chengang / Zhou, Zheng / Xu, Zhiheng / Wang, Lisha / Mayweg, Alexander V. / Niu, Rui / Jin, Tai-Guang / Yang, Song et al. | 2017
- 4493
-
Synthesis, estrogen receptor binding affinity and molecular docking of pyrimidine-piperazine-chromene and -quinoline conjugatesParveen, Iram / Ahmed, Naseem / Idrees, Danish / Khan, Parvez / Hassan, Md. Imtaiyaz et al. | 2017
- 4500
-
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitorsSmith, Garrick P. / Badolo, Lassina / Chell, Victoria / Chen, I-Jen / Christensen, Kenneth Vielsted / David, Laurent / Daechsel, Justus Alfred / Hentzer, Morten / Herzig, Martin Christian / Mikkelsen, Gitte Kobberøe et al. | 2017
- 4506
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Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructureNong, Wenqian / Zhao, Anran / Wei, Jinrui / Lin, Xiao / Wang, Lisheng / Lin, Cuiwu et al. | 2017
- 4512
-
Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA)Forrester, Sean G. / Foster, Joshua / Robert, Sebastien / Salim, Lidya / Desaulniers, Jean-Paul et al. | 2017
- 4514
-
Modified biphenyl Hsp90 C-terminal inhibitors for the treatment of cancerForsberg, Leah K. / Liu, Weiya / Holzbeierlein, Jeffrey / Blagg, Brian S.J. et al. | 2017
- IFC
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Editorial board| 2017