(12) J 9hW(1-M JN)?Vt2~iEP) l (19) P d PIT, R. ~(10) 1 K"|WhiVi4 Y (43) d VTW O 2022/147877 A1 2022 4 7 ) 14 (14.07.2022) WIPO I PCT (51) M pt i]j T : 100 3 202, 402, 502k, Guangdong 519031 A61L 24/08 (2006.01) A61L 24/00 (2006.01) (CN)o .~ES!lJ (WANG, Jianjin); t 3 (21) p :PCT/CN2021/075416 iM X4M ITP ,A#Ri \2WA M100 3AK202, 402, 502, Guangdong 519031 (22)M j pi i : 2021 2 ] 5 H (05.02.2021) (CN) o I -2W(GUO,Aijun); (25) $ig #: tfiftZ4lt Ft94tiH I $10oo (26) Qfliif: 3%202, 402, 5022, Guangdong 519031 (CN)o (74) {tjI A: f- 1)tl M t $ - PFtT$ phR 'i (30)f~ty] (JIAQUANWIPLAW); t2 Ai$ iT5 202110008377.1 2021 4 1Aj5H (05.01.2021) CN P1 (JIAUN H W)I 100+ [Id F 3T N F 1 A )Q (71) $i : t 4q P1 - I, - 4 f R (f} pR 910, Guangdong 510627 (CN)o 1]i (HONEST MEDICAL CHINA CO., LTD.) [CN/ (81) CN]; + # t \2 N fgt)$): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, 402, 5 $4 f Guangdong 5103100 ( 320'BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, 402, 502,Guangdong519031(CN)° CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, (72) & PA )A : ;7 jIi-4(TANG, Shunqing); F_ 3T J A GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, IT, = r i M t 4EX $ , IT 4 tiLR i \ JJP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, (54) Title: STARCH-BASED FLUFFY PARTICLES AND PREPARATION METHOD THEREFOR AND APPLICATION THERE (54)lRZ A : 9 t) $ ti2Kt4Liff) (57) Abstract: Starch-based fluffy particles and a preparation method therefor and an application thereof, relating to the technical field of hemostatic materials. The preparation method for the starch-based fluffy particles comprises the following Steps: (1) adding water into starch or modified starch for gelatinization to obtain starch paste; (2) adding the starch paste into an organic solvent, performing stir ring, standing and centrifugation, and collecting a precipitate; and (3) perform ing freeze drying, crushing and sieving on the precipitate in sequence to prepare the starch-based fluffy particles. The starch-based fluffy particles are porous and fluffy, are large in particle gap, have excellent water absorption speed, water ab sorption rate and degradation rate, and can achieve the purpose of rapid and effi cient hemostasis; and the starch-based fluffy particles are free of addition of com ponents such as a dispersing agent, an emulsifying agent, or a cross-linking agent -i 2 and have the characteristics of safety and reliability, so that the hemostatic require ment of an in-vivo environment is also satisfied. -(5 7) I tt:AV l tt W, V-R-A $ 1 irT ItiA -(1)A tt4ZliRA kj Cl)Jl2VK]itr2, t~flt t ; (2) t;()It X~i %4+~~f O4H FFIA,Jk"WK:0t N ~t~titi 0 ffi~ t&$itii$L RU>Trtii', 1B~fk, Nt A-A t ,V Wj ft ~ L t qA-A t ,VT LAWt 5, 3# HW In'N4 A ±-pl~.,W~r T 9tJFltifA W O 2022/147877 A 1 ||||||||1I||I||||I|I|I|||||||I||||||||i||I|||I||||||||||||||||||||||||||||| LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, WS, ZA, ZM, ZWc (84) p W AT-~tl~t~l Mfi): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), kil (AM, AZ, BY, KG, KZ, RU, TJ, TM), [III (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). -A 1j2(4. 17 1 (R -~ ~ 1t *- (3))