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The Atmospheric Research and Exposure Assessment Laboratory (AREAL), Office of Research and Development (ORD), U.S. Environmental Protection Agency (EPA), is initiating a research program to collect fundamental information on the key parameters and factors that influence indoor air quality and comfort in randomly selected General Services Administration (GSA) owned and operated large office buidlings. A standardized week-long investigative protocol will be employed in each building a minimum of three times during different seasons over the next 3-5 years to characterize the key physical parameters of the selected GSA buildings and randomly selected test areas; measure key comfort and environmental parameters inside and outside the building; characterize the heating, ventilating, and air conditioning (HVAC) system(s); and collect occupant response data associated with their perceptions of indoor air quality.