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The purpose of the study was to obtain quantitative correlations between chronic exposure to 100 ppm carbon monoxide and physiologic parameters of the cardiovascule system and blood of normal monkeys, and monkeys with induced myocardial infarction. Pathologic effects on other body organs (heart, lungs, liver, kidneys, adrenals and brain) were also investigated. Experimental infarctions were induced by selectively depositing polystyrene microspheres (300) into the left coronary artery using direct coronary catheterization with the aid of image intensifying flouroscopy. Successful infarction was reflected by characteristic changes in the ECG, blood pressure, WBC, and serum enzymes (LDH, CKP, GOT). Normal and infarcted animals were exposed continuously (23 hours per day) for three months and six months. Air breathing control normal and infarcted animals were housed in separated quarters removed from the chamber area. ECGs of infarcted and non-infarcted animals breathing carbon monoxide displayed increased P wave amplitudes. The incidence of T wave inversion was higher in infarcted than non-infarcted animals.