NTP Developmental and Reproductive Toxicity Technical Report on the Prenatal Development Studies of 2-1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (CASRN 95737-68-1) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and New Zealand White (Hra:NZW SPF) Rabbits
(English)
2022
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2-((1?(4?Phenoxyphenoxy)propan?2?yl)oxy)pyridine (MPEP) is a juvenile hormone mimetic pesticide used to control a variety of insects, including tsetse flies, cockroaches, and whiteflies, and is added to potable water in Zika virus?endemic areas to control mosquitoes. It has been proposed that MPEP might contribute to the increased incidence of microcephaly in babies born to mothers who could be consuming MPEP in potable water. Because limited information is available about the potential hazard of MPEP to pregnant women, the National Toxicology Program (NTP) conducted prenatal developmental toxicity studies of MPEP to assess possible harm to the developing conceptus and pregnant animal. In these studies, time?mated Sprague Dawley (Hsd:Sprague Dawley® SD®) rats and New Zealand White (Hra:NZW SPF) rabbits were administered MPEP in corn oil by gavage once daily from implantation on gestation day (GD) 6 (rats) or GD 7 (rabbits) to the day before expected parturition (GD 20 for rats; GD 28 for rabbits). In the prenatal developmental toxicity study in rats, fetuses were examined for evidence of MPEP fetal toxicity. A dose range?finding study in rabbits was conducted, followed by a prenatal developmental toxicity study, to confirm the absence of a response in a second species. An assessment of maternal and fetal MPEP concentrations following exposure demonstrated maternal?fetal transfer of MPEP in both rats on GD 18 and rabbits on GD 28.
NTP Developmental and Reproductive Toxicity Technical Report on the Prenatal Development Studies of 2-1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (CASRN 95737-68-1) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and New Zealand White (Hra:NZW SPF) Rabbits