Possible Involvement of Prostaglandins in Increases in Rat Plasma Adrenocorticotropic Hormone and Corticosterone Levels Induced by Radiation and Interleukin-1 Alpha Alone or Combined
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Possible Involvement of Prostaglandins in Increases in Rat Plasma Adrenocorticotropic Hormone and Corticosterone Levels Induced by Radiation and Interleukin-la Alone or Combined. KANDASAMY, S. B., THIAGARAJAN, A. B., AND HARRIS, A. H. (1995). Fundam. Appi. ToxicoL 25, 196-200. Exposing rats to 1-10 Gy of ionizing radiation increased plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels. In both irradiated and nonirradiated rats, recombinant human interleukin-l(apha) (rhIL- 1 apha) 1 hr before radiation/sham exposure enhanced plasma ACTH and CORT levels. Indomenthacin, a cyclooxygenase inhabitor, attenuated plasma ACTH and CORT levels induced by rediation.
Possible Involvement of Prostaglandins in Increases in Rat Plasma Adrenocorticotropic Hormone and Corticosterone Levels Induced by Radiation and Interleukin-1 Alpha Alone or Combined