Selectivity in the Base-Catalyzed Hydrolysis of p-Nitrophenyl Esters within a Reversed-Phase Liquid Chromatography Column. (Reannouncement with New Availability Information)
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The -OH-catalyzed hydrolyses of p-nitrophenyl acetate (1) and hexanoate (2) were performed with excess -OH on a reversed-phase liquid chromatography column of macroporous 10-micrometer poly(styrene-divinylbenzene) under HPLC conditions in real time to give pseudo-first-order rate constants k(psi). The maximum value of k(psi), 1/k(psi), 2 was equal to or more than 5, and the reactivity difference was attributed to different rates of desorption of 1 and 2 from the polymer surface into the mobile phase, where -OH was localized.
Selectivity in the Base-Catalyzed Hydrolysis of p-Nitrophenyl Esters within a Reversed-Phase Liquid Chromatography Column. (Reannouncement with New Availability Information)