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Activated carbon and fiberglass are widely used in air filtration industry. Nanotechnology field is booming in an exceptionally impressive manner. Nanofibers are one of the unique materials which have one order of magnitude smaller than conventional fibers. The high surface-to-volume ratio, low resistance and enhanced filtration performance make nanofibers an attractive material for many applications such as healthcare, energy and air filtration. Recent advancements in the removal of volatile organic compounds (VOC), nanoparticles and airborne bacterial contaminates in the air are highlighted. The aerosol filtration performances of nanofibers are also presented. The enhanced activity of nanofibers due to the nanosize and their applications such as in protective clothing are highlighted.