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8‐acetoxy‐trisulfopyrene as the first activatable fluorogenic probe for add‐and‐read assessment of Organic anion‐transporting polypeptides, OATP1B1, OATP1B3, and OATP2B1
Wiley | 2021|essential in drug development and is recommended by international regulatory agencies, the FDA, EMA, and PMDA. In general, radiolabeled indicators ...Keywords: drug interaction -
10th international symposium on the synthesis and applications of isotopes and isotopically labelled compounds—WBA–new methods and applications and WBA–instrumentation and regulatory, Sessions 5 & 6: Monday, June 15, 2009
Wiley | 2010|Predicting human radiation Dosimetry for clinical radiolabelled drug development studies was discussed
... -
A bifunctional anti-PCSK9 scFv/Exendin-4 fusion protein exhibits enhanced lipid-lowering effects via targeting multiple signaling pathways in HFD-fed mice
Elsevier | 2023|component, has become one of the most important representatives of macromolecular drugs for disease treatment since that monotherapy itself might ...Keywords: Food and Drug Administration, sterol regulatory element-binding protein -
A comparison of molecular representations for lipophilicity quantitative structure–property relationships with results from the SAMPL6 logP Prediction Challenge
Springer Verlag | 2020|Effective representation of a molecule is required to develop useful quantitative structure–property
...Publisher: Springer International Publishing, Cham -
A Critical N-Nitrosamine Impurity of Anticoagulant Drug, Rivaroxaban: Synthesis, Characterization, Development of LC–MS/MS Method for Nanogram Level Quantification
Springer Verlag | 2022|levels of carcinogenic potential N-nitrosamine impurities has been a severe apprehension in recent years. The regulatory ... -
Alcoholic Hepatitis: Pathogenesis, Diagnosis and Treatment
Bentham Science Publishers | 2016|), represents a thorny problem in the clinical practice. In severe forms of acute AH, some specific drug treatments, including glucorticoids or ...Keywords: Clinical Trials & Regulatory Affairs -
Analytical Quality by Design Approach for a Stability-Indicating Method to Determine Apixaban and Its Related Impurities
Springer Verlag | 2020|process understanding and control. Analytical QbD (AQbD) is widely used when it comes to the development and optimization of analytical methods ...Keywords: Drug impurities -
An orally administered butyrate-releasing xylan derivative reduces inflammation in dextran sulphate sodium-induced murine colitis
Elsevier | 2019|) inhibition. XylB reduces inflammatory intestinal damage in mice, suggesting that it would be a potential drug for the treatment of UC and could be ...Keywords: crude powder of water-insoluble xylan, regulatory T cell, butyryl esterification of xylan, degree of substitution, determination of myeloperoxidase, mammalian target of rapamycin, phosphorylated mammalian target of rapamycin, mammalian homologue of yeast autophagy-related gene 6, phylogenetic investigation of communities by reconstruction of unobserved states -
An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)
Springer Verlag | 2021|determination of individual enantiomeric drug molecules is a necessity especially for clinical, analytical, and regulatory purposes. Among ... -
An Update on Design and Pharmacology of Dendritic Poly(l-lysine)
Online Contents | 2018|in a new drug application category of various regulatory bodies. As dendritic poly(l-lysine) scaffold is biocompatible unlike many other ... -
A review on the advances in the extraction methods and structure elucidation of Poria cocos polysaccharide and its pharmacological activities and drug carrier applications
Elsevier | 2022|, etc. There is the potential application of PCP as drug carriers. The review provides a comprehensive summary of the latest extraction and ...Keywords: Drug carrier application -
A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy
Elsevier | 2021|drug resistance through both aerobic glycolysis and non-metabolic pathways. In this review, the functions and regulatory roles of PKM2 are ... -
Aspect of adhesives in transdermal drug delivery systems
Tema Archive | 2014|effective amount of drug across the skin. The quality attribute of the adhesives in TDDS is indispensible for fabrication design and important to ... -
Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Elsevier | 2020|Multi-detector AF4 for characterization of nanomedicines is reviewed ...Keywords: regulatory framework -
A Validated Stability-Indicating and Stereoselective HPLC Method for the Determination of Lenalidomide Enantiomers in Bulk Form and Capsules
Online Contents | 2016|International Conference on Harmonization/Food and Drug Administration regulatory requirements, was utilized successfully for the determination of LDM ... -
Bionic lipoprotein loaded with chloroquine-mediated blocking immune escape improves antitumor immunotherapy
Elsevier | 2023|. However, immune escape and the immunosuppressive microenvironment of tumor usually limit the efficiency of tumor immunotherapy. Therefore ... -
Breast cancer stem cells: Biology and therapeutic implications
Elsevier | 2018|. The role of CSCs in metastasis, angiogenesis, drug resistance and tumor recurrence ...Keywords: CBF1/Suppressor of Hairless/LAG1, Suppressor of fused, epithelial splicing regulatory proteins, Drug resistance -
Cancer stem cell antigens as targets for new combined anti-cancer therapies
Elsevier | 2020|. CSCs are an obstacle to the success of immune checkpoint inhibitors (ICIs ...Keywords: Food and Drug Administration, regulatory T cells -
Cancer stem cells
Elsevier | 2012|surface markers such as CD44, CD24, and CD133 are often used to identify and enrich CSCs. A regulatory network consisting of microRNAs and Wnt/β ...
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