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Phosphatidylinositol-3-kinase as a putative target for anticancer action of clotrimazole
Online Contents | 2015|of CTZ because the drug does not affect the interaction of the PI3K regulatory subunit and the insulin receptor substrate (IRS)-1 ... -
A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy
Elsevier | 2021|drug resistance through both aerobic glycolysis and non-metabolic pathways. In this review, the functions and regulatory roles of PKM2 are ... -
Deuterated active pharmaceutical ingredients: A science‐based proposal for synthesis, analysis, and control. Part 1: Framing the problem
Wiley | 2019|chemistry, analytical chemistry, and drug metabolism and pharmacokinetics have been meeting under the auspices of IQ to define and address these ...Keywords: International Consortium for Innovation & Quality, drug substance -
Mechanisms Underlying the Health Benefits of Plant Sterol and Stanol Ester Consumption
Online Contents | 2015|addition, they might influence the functioning of our immune system via a changed activity of the regulatory T-cells. This combination of effects ...Keywords: Immune System - drug effects -
Identification and characterization of a flexile G-quadruplex in the distal promoter region of stemness gene REX1
Elsevier | 2023|R1WT to be a promising drug target. The endogenous existence of R1WT was confirmed by BG4 antibody derived chromatin immunoprecipitation ... -
The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives
Elsevier | 2023|. Despite advances in the structure and pharmacology of RNA methylation regulators that have improved drug discovery, regulating these proteins by ... -
Role of Metal-Organic Frameworks (MOFs) in treating and diagnosing microbial infections
Elsevier | 2024|Abstract This review article highlights the innovative role of metal ... -
HILIC–MS Determination of Genotoxic Impurity of 2-Chloro-N-(2-Chloroethyl)Ethanamine in the Vortioxetine Manufacturing Process
Online Contents | 2016|In the last decade, pharmaceutical regulatory agencies are focused on monitoring and evaluation of trace-level genotoxic impurities (GTIs ... -
Probing the structures of G protein-coupled receptors with mass spectrometry-based techniques
Elsevier | 2022|regulate numerous physiological processes in the human body, and represent one of the largest protein families as targets for drug development for ... -
Preparation methods, structural characteristics, and biological activity of polysaccharides from Platycodon grandiflorus
Elsevier | 2023|, anticancer, antiangiogenic, and immune regulatory properties. Incorporating the principles of traditional Chinese medicine, carrier concepts, and ...Keywords: Drug target
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