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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
American Chemical Society | 2018| -
Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment
American Chemical Society | 2020| -
Structural Impact of Mutation D614G in SARS-CoV‑2 Spike Protein: Enhanced Infectivity and Therapeutic Opportunity
American Chemical Society | 2020| -
INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
American Chemical Society | 2017| -
Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV‑2
American Chemical Society | 2020| -
Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp2)–C(sp3) Cross-Coupling Methods by Library Synthesis
American Chemical Society | 2020| -
Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor
American Chemical Society | 2017| -
Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor
American Chemical Society | 2020| -
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity
American Chemical Society | 2018| -
Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
American Chemical Society | 2020| -
De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease
American Chemical Society | 2019| -
Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin
American Chemical Society | 2017| -
Transforming Computational Drug Discovery with Machine Learning and AI
American Chemical Society | 2018| -
Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase
American Chemical Society | 2020|
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