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‘In Silico’ Simulation of Biological Processes [2002]

1
Chair's Introduction
4
Integrative Biological Modelling <fi>In Silico</fi>
26
Advances in Computing, and Their Impact on Scientific Computing
42
From Physics to Phenomenology. Levels of Description and Levels of Selection
53
Making Sense of Complex Phenomena in Biology
66
On Ontologies for Biologists: The Gene Ontology—Untangling the Web
84
General Discussion I: Model Validation
91
The KEGG Database
104
Bioinformatics of Cellular Signalling
119
General Discussion II: Standards of Communication
129
Imaging‐Based Integrative Models of the Heart: Closing the Loop between Experiment and Simulation
144
General Discussion III: Modelling Ca<sup>2+</sup> Signalling
151
The Virtual Cell Project
162
Modelling the Bacterial Chemotaxis Receptor Complex
182
The Heart Cell <fi>In Silico</fi>: Successes, Failures and Prospects
198
General Discussion IV
207
The IUPS Physiome Project
222
Using <fi>In Silico</fi> Biology to Facilitate Drug Development
244
Final Discussion: Is There a ‘Theoretical Biology’?
253
Index of Contributors
255
Subject Index
i
Front Matter
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