Bioorganic and Medicinal Chemistry Letters
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
Table of contents
- 7273
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Graphical contents list| 2012
- 7297
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Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitorHwang, Jong Yeon / Windisch, Marc Peter / Jo, Suyeon et al. | 2012
- 7302
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The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffoldBonn, Peter / Brink, D. Mikael / Fägerhag, Jonas et al. | 2012
- 7306
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Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)Qian, Wen-Jian / Park, Jung-Eun / Lee, Kyung S. et al. | 2012
- 7309
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6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitorsZhao, Xue Zhi / Maddali, Kasthuraiah / Smith, Steven J. et al. | 2012
- 7314
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Structure–activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic actionThur, Yithachu / Bhalerao, Amit / Munshi, Zaki et al. | 2012
- 7322
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Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine spongeHe, Rui / Wakimoto, Toshiyuki / Egami, Yoko et al. | 2012
- 7322
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Heterologously expressed b-hydroxyl fatty acids from a metagenomic library of a marine spongeHe, R. / Wakimoto, T. / Egami, Y. et al. | 2012
- 7326
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Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitorsTerao, Yoshito / Suzuki, Hideo / Yoshikawa, Masato et al. | 2012
- 7330
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Synthesis, characterization and biological studies of diosgenyl analoguesHuang, Baozhan / Du, Dan / Zhang, Rui et al. | 2012
- 7335
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Identification of novel mPGES-1 inhibitors through screening of a chemical libraryPark, Sung-Jun / Han, Seong-Gu / Ahsan, Hafiz Muhammad et al. | 2012
- 7340
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Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar K i range: Oxygenated N-(2-[1,1′-biphenyl]-4-ylethyl) analogues of 8-CACWentland, Mark P. / Jo, Sunjin / Gargano, Joseph M. et al. | 2012
- 7340
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Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: Oxygenated N-(2-[1,1prime-biphenyl]-4-ylethyl) analogues of 8-CACWentland, M. P. / Jo, S. / Gargano, J. M. et al. | 2012
- 7345
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Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: Effect of dimerisation on phosphatase inhibitionSarkis, Manal / Tran, Diem Ngan / Kolb, Stéphanie et al. | 2012
- 7351
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Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groupsLi, Xianfeng / Liu, Yang / Zhang, Yong-Kang et al. | 2012
- 7357
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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolitesTichenor, Mark S. / Keith, John M. / Jones, William M. et al. | 2012
- 7363
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Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug effluxYu, Melvin J. / Zheng, Wanjun / Tendyke, Karen et al. | 2012
- 7367
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Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase BVan der Walt, Mietha M. / Terre’Blanche, Gisella / Lourens, Anna C.U. et al. | 2012
- 7371
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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated effluxRzasa, Robert M. / Hu, Essa / Rumfelt, Shannon et al. | 2012
- 7376
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Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the ratHunt, Hazel J. / Ray, Nicholas C. / Hynd, George et al. | 2012
- 7381
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Discovery of a novel series of 4-quinolone JNK inhibitorsGong, Leyi / Tan, Yun-Chou / Boice, Genevieve et al. | 2012
- 7388
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Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffoldRodriguez, Alice L. / Zhou, Ya / Williams, Richard et al. | 2012
- 7393
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New diterpene furanoids from the Antarctic lichen Huea spCui, Yinglan / Yim, Joung Han / Lee, Dong-Sung et al. | 2012
- 7397
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Design and synthesis of procollagen C-proteinase inhibitorsTurtle, Eric / Chow, Nicholas / Yang, Charles et al. | 2012
- 7402
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Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolidesChen, Xiaozhuo / Xu, Peng / Xu, Yanpeng et al. | 2012
- 7406
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Synthesis and biological evaluation of 99mTc(CO)3(His–CB) as a tumor imaging agentWang, Jianjun / Yang, Jing / Duan, Xiaojiang et al. | 2012
- 7410
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Development of a dual functional luminescent sensor for zinc ion based on a peptidic architectureHirayama, Tasuku / Taki, Masayasu / Akaoka, Kazushi et al. | 2012
- 7414
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Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosisJeankumar, Variam Ullas / Chandran, Manoj / Samala, Ganesh et al. | 2012
- 7418
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A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolothiazoles as antimycobacterial agentsAlmansour, Abdulrahman I. / Ali, Sadath / Ali, Mohamed Ashraf et al. | 2012
- 7422
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Structure-related cytotoxic activity of derivatives from kulokekahilide-2, a cyclodepsipeptide in Hawaiian marine molluskUmehara, Masahiro / Negishi, Takayuki / Tashiro, Tomoko et al. | 2012
- 7426
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Molecular hybridization of bioactives: Synthesis and antitubercular evaluation of novel dibenzofuran embodied homoisoflavonoids via Baylis–Hillman reactionYempala, Thirumal / Sriram, Darmarajan / Yogeeswari, Perumal et al. | 2012
- 7431
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Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N 1-arylsulfonyl indole derivatives as 5-HT6 receptor ligandsNirogi, Ramakrishna V.S. / Badange, Rajeshkumar / Kambhampati, Ramasastri et al. | 2012
- 7436
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Compounds from the heartwood of Caesalpinia sappan and their anti-inflammatory activityMin, Byung Sun / Cuong, To Dao / Hung, Tran Manh et al. | 2012
- 7440
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Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitorsDai, Hou-ling / Gao, Li-xin / Yang, Ying et al. | 2012
- 7444
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Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)sSawada, Hiromi / Okazaki, Miki / Morita, Daichi et al. | 2012
- 7448
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Functional assay for shiga-like toxin via detection by antibody capture and multivalent galabiose bindingvan Hattum, Hilde / van der Zwaluw, Kim / Visser, Gerben M. et al. | 2012
- 7451
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Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitorsSong, Yu Min / Ha, Young Mi / Kim, Jin-Ah et al. | 2012
- 7456
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Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitorsLee, Kyeong / Goo, Ja-Il / Jung, Hwa Young et al. | 2012
- 7461
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Synthesis of C3-arylated-3-deazauridine derivatives with potent anti-HSV-1 activitiesLalut, Julien / Tripoteau, Ludovic / Marty, Christel et al. | 2012
- 7465
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Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti-neuroinflammatory effectsWoo, Kyeong Wan / Moon, Eunjung / Park, So Young et al. | 2012
- 7471
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Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptorsGealageas, Ronan / Schneider, Séverine / Humbert, Jean-Paul et al. | 2012
- 7475
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Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-chloroimidazole embodied 4-azafluorenones via molecular hybridization approachAddla, Dinesh / Bhima / Sridhar, Balasubramanian et al. | 2012
- 7481
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Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probeSuganami, Akiko / Toyota, Taro / Okazaki, Shigetoshi et al. | 2012
- 7486
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Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitorsChiba, Takashi / Ohwada, Jun / Sakamoto, Hiroshi et al. | 2012
- 7490
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Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activityGuo, Zhi Kai / Liu, Shou Bai / Jiao, Rui Hua et al. | 2012
- 7494
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Selection of a screening panel of rhinoviral serotypesTomkinson, Nick / Wenlock, Mark / McCrae, Christopher et al. | 2012
- 7499
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Synthesis of novel mono and bis-indole conduritol derivatives and their α/β-glycosidase inhibitory effectsÇavdar, Hüseyin / Talaz, Oktay / Ekinci, Deniz et al. | 2012
- 7499
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Synthesis of novel mono and bis-indole conduritol derivatives and their a/b-glycosidase inhibitory effectsCavdar, H. / Talaz, O. / Ekinci, D. et al. | 2012
- 7504
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Azabenzthiazole inhibitors of leukotriene A4 hydrolaseTanis, Virginia M. / Bacani, Genesis M. / Blevitt, Jonathan M. et al. | 2012
- 7512
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Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffoldTremblay, Martin / Bonneau, Pierre / Bousquet, Yves et al. | 2012
- 7518
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7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitorsCheung, Adrian Wai-Hing / Banner, Bruce / Bose, Jolly et al. | 2012
- 7523
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Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitorsBhattacharya, Samit K. / Aspnes, Gary E. / Bagley, Scott W. et al. | 2012
- 7530
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Synthesis and biological evaluation of novel spin labeled 18b-glycyrrhetinic acid derivativesLiu, Y. / Qian, K. / Wang, C. Y. et al. | 2012
- 7530
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Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivativesLiu, Yingqian / Qian, Keduo / Wang, Chih-Ya et al. | 2012
- 7534
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Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitorsOka, Yusuke / Yabuuchi, Tetsuya / Fujii, Yasuyuki et al. | 2012
- 7534
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Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase g inhibitorsOka, Y. / Yabuuchi, T. / Fujii, Y. et al. | 2012
- 7539
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Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivativesMohan, Sahoo Biswa / Ravi Kumar, B.V.V. / Dinda, S.C. et al. | 2012
- 7543
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Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemiaKhanna, Smriti / Burudkar, Sandeep / Bajaj, Komal et al. | 2012
- 7547
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Synthesis and structure–activity relationship studies of cytotoxic vinorelbine amide analoguesHu, Lingjun / Song, Weibin / Meng, Yuhui et al. | 2012
- 7551
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Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)Wada, Naohisa / Fujii, Hideaki / Koyano, Koji et al. | 2012
- 7555
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Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s diseaseLee, Yun Suk / Kim, Hee / Kim, Young-Ho et al. | 2012
- 7562
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Synthesis of chiral hydroxylated enones as potential anti-tumor agentsShing, Tony K.M. / Wu, Ho T. / Kwok, H.F. et al. | 2012
- 7566
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An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a]pyrimidines derivativesChobe, Santosh S. / Dawane, Bhaskar S. / Tumbi, Khaled M. et al. | 2012
- 7573
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Azo-reductase activated budesodine prodrugs for colon targetingMarquez Ruiz, Juan F. / Kedziora, Kinga / O’Reilly, Mary et al. | 2012
- 7578
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Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensationVolkova, Maria S. / Jensen, Katherine C. / Lozinskaya, Natalia A. et al. | 2012
- 7582
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Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugateSuneela, Dhaneshwar / Dipmala, Patil et al. | 2012
- 7588
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Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: Preponderant role of the phenyl ester substituents on the piperidin-4-one oxime coreHarini, Salakatte Thammaiah / Kumar, Honnaiah Vijay / Rangaswamy, Javarappa et al. | 2012
- 7593
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Impact of protein binding cavity volume (PCV) and ligand volume (LV) in rigid and flexible docking of protein–ligand complexesSaranya, N. / Jeyakanthan, J. / Selvaraj, S. et al. | 2012
- 7598
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Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimersPhothongkam, Supannee / Chancharunee, Sirirat / Saovapakhiran, Angkana et al. | 2012
- 7602
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(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effectsMuratake, Hideaki / Ito, Ai / Toda, Takahiro et al. | 2012
- 7605
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Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug–drug interactionPalmer, Cynthia / Pairish, Mason / Kephart, Susan et al. | 2012
- 7610
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Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agentPandey, Suresh K. / Pan, Shawn / Kant, Ritu et al. | 2012
- 7610
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Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic a4b2 receptor imaging agentPandey, S. K. / Pan, S. / Kant, R. et al. | 2012
- 7615
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Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitorsZhang, Qingwei / Xia, Zhiren / Mitten, Michael J. et al. | 2012
- 7623
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Uronosyl phosphonate-based sialidase inhibitor synthesis and conformational analysisBhatt, Beenu / Thomson, Robin J. / von Itzstein, Mark et al. | 2012
- 7627
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Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2Labadie, Sharada / Dragovich, Peter S. / Barrett, Kathy et al. | 2012
- 7634
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Modification of a promiscuous inhibitor shifts the inhibition from g-secretase to FLT-3Amombo, G. M. / Kramer, T. / Lo Monte, F. et al. | 2012
- 7634
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Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3Amombo, Ghislaine Marlyse Okala / Kramer, Thomas / Lo Monte, Fabio et al. | 2012
- 7641
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Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2Bakmiwewa, Supun M. / Fatokun, Amos A. / Tran, Anh et al. | 2012
- 7647
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Structure requirements for anaerobe processing of azo compounds: Implications for prodrug designGavin, Jason / Ruiz, Juan F. Marquez / Kedziora, Kinga et al. | 2012
- 7653
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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitorsForsyth, Timothy / Kearney, Patrick C. / Kim, Byung Gyu et al. | 2012
- 7659
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Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agentsLiu, Ying-Qian / Dai, Wei / Wang, Chih-Ya et al. | 2012
- 7662
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Synthesis and structure–activity relationships of fibrate-based analogues inside PPARsGiampietro, Letizia / D’Angelo, Alessandra / Giancristofaro, Antonella et al. | 2012
- 7667
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2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer’s diseaseGu, Jiamin / Anumala, Upendra Rao / Lo Monte, Fabio et al. | 2012
- 7672
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Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonistsAguilar, Nuria / Mir, Marta / Grima, Pedro M. et al. | 2012
- 7677
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Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitorsMori, Yutaka / Ogawa, Yasuyuki / Mochizuki, Akiyoshi et al. | 2012
- 7683
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Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agentsLu, Chuanjun / Guo, Yueyan / Li, Jianheng et al. | 2012
- 7688
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Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moietyQi, Qing-Rong / Pan, Jia / Guo, Xiao-Qiang et al. | 2012
- 7693
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Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisationFournier-Dit-Chabert, Jérémie / Vinader, Victoria / Santos, Ana Rita et al. | 2012
- 7697
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Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletonsFujii, Hideaki / Nakajima, Ryo / Akiyama, Junko et al. | 2012
- 7702
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Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part IFurber, Mark / Alcaraz, Lilian / Luckhurst, Christopher et al. | 2012
- 7707
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Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearanceFurber, Mark / Alcaraz, Lilian / Luckhurst, Christopher et al. | 2012
- 7711
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Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologiesFujii, Hideaki / Imaide, Satomi / Hirayama, Shigeto et al. | 2012
- 7711
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Essential structure of opioid k receptor agonist nalfurafine for binding to the k receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologiesFujii, H. / Imaide, S. / Hirayama, S. et al. | 2012
- 7715
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Fluorescent nitrile-based inhibitors of cysteine cathepsinsFrizler, Maxim / Mertens, Matthias D. / Gütschow, Michael et al. | 2012
- 7719
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Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSAAnnadurai, Sivakumar / Martinez, Rogelio / Canney, Daniel J. et al. | 2012
- 7726
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1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activityHung, Hsin-Yi / Ohkoshi, Emika / Goto, Masuo et al. | 2012
- 7730
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Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivativesZhao, Zhigang / Shi, Zhichuan / Liu, Min et al. | 2012
- 7735
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Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolidPersch, Elke / Basile, Teodora / Bockelmann, Svenja et al. | 2012
- 7739
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Synthesis and antimycobacterial activity of calpinactam derivativesNagai, Kenichiro / Koyama, Nobuhiro / Sato, Noriko et al. | 2012
- 7742
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Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agentThiyagarajan, Anandarajan / Salim, Mohammed T.A. / Balaraju, Tuniki et al. | 2012
- 7748
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Corrigendum to “POMA analyses as new efficient bioinformatics’ platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues” [Bioorg. Med. Chem. Lett. 22 (2012) 7029–7035]Ahsan, Mohamed Jawed / Govindasamy, Jeyabalan / Khalilullah, Habibullah et al. | 2012
- 7749
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Corrigendum to “Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives” [Bioorg. Med. Chem. Lett. 22 (2012) 4122–4126]Kim, Taejung / Lee, Woojung / Jeong, Kyu Hyuk et al. | 2012
- 7749
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Corrigendum to "Total synthesis and dual PPARa/g agonist effects of Amorphastilbol and its synthetic derivatives" [Bioorg. Med. Chem. Lett. 22 (2012) 4122-4126]Kim, T. / Lee, W. / Jeong, K. H. et al. | 2012
- 7750
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Corrigendum to “Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes” [Bioorg. Med. Chem. Lett. 22 (2012) 6218–6223]Du, Xiaohui / Kim, Yong-Jae / Lai, SuJen et al. | 2012
- IFC
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Editorial board| 2012