Bioorganic and Medicinal Chemistry Letters
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
Table of contents
- 2005
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Graphical contents list| 2004
- 2025
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The design, preparation and SAR of novel small molecule sodium (Na+) channel blockersAshwell, Mark A / Lapierre, Jean-Marc / Kaplan, Alan et al. | 2004
- 2031
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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the α2δ subunit of voltage-gated calcium channelsHu, Tao / Stearns, Brian A / Campbell, Brian T et al. | 2004
- 2031
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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo(3,4-d)pyridazine derivatives as high-affinity ligands of the a2d subunit of voltage-gated calcium channelsHu, Tao et al. | 2004
- 2035
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Highly diastereoselective inverse electron demand (IED) Diels–Alder reaction mediated by chiral salen–AlCl complex: the first, target-oriented synthesis of pyranoquinolines as potential antibacterial agentsMagesh, Chinnian J / Makesh, Sarasu V / Perumal, Paramasivan T et al. | 2004
- 2041
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Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue designSun, Lichun / Vasilevich, Natalya I / Fuselier, Joseph A et al. | 2004
- 2047
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Biaryl amide glucagon receptor antagonistsKurukulasuriya, Ravi / Sorensen, Bryan K / Link, James T et al. | 2004
- 2051
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Synthesis and biochemical properties of E-ring modified luotonin A derivativesCagir, Ali / Jones, Shannon H / Eisenhauer, Brian M et al. | 2004
- 2055
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N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: Structure–activity relationship of the benzoyl moietyBurdick, Daniel J / Marsters, James C Jr. / Aliagas-Martin, Ignacio et al. | 2004
- 2061
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Antibacterial activity of glycine betaine analogues: involvement of osmoportersCosquer, Anne / Ficamos, Morgane / Jebbar, Mohamed et al. | 2004
- 2067
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DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acidsBürli, Roland W. / Kaizerman, Jacob A. / Duan, Jian-Xin et al. | 2004
- 2073
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N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitorsJia, Zhaozhong J / Su, Ting / Zuckett, Jingmei F et al. | 2004
- 2079
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Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonistsAkritopoulou-Zanze, Irini / Patel, Jyoti R / Hartandi, Kresna et al. | 2004
- 2083
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Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor1 (CRF1) receptor antagonistsHuang, Charles Q / Grigoriadis, Dimitri E / Liu, Zhengyu et al. | 2004
- 2087
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Macrocyclic proteoglycan mimics. Potent inhibition of cell adhesion by a bundle of chondroitin sulfate chains assembled on the calix[4]resorcarene platformTomita, Naotoshi / Sando, Shinsuke / Sera, Takashi et al. | 2004
- 2091
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Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolaseKim, Hea Ok / Yoo, Su Jeong / Ahn, Hee Sung et al. | 2004
- 2095
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Use of apple seed meal as a new source of b-glucosidase for enzymatic glucosylation of 4-substituted benzyl alcohols and tyrosol in monophasic aqueous-dioxane mediumMin Tong, Ai et al. | 2004
- 2095
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Use of apple seed meal as a new source of β-glucosidase for enzymatic glucosylation of 4-substituted benzyl alcohols and tyrosol in monophasic aqueous-dioxane mediumMin Tong, Ai / Ya Lu, Wen / He Xu, Jian et al. | 2004
- 2099
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Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5′-sulfonamide moiety of phenyl ringKim, Dae-Kee / Young Lee, Ju / Park, Hyun-Ju et al. | 2004
- 2099
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Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5prime-sulfonamide moiety of phenyl ringKim, D. K. / Young Lee, J. / Park, H. J. et al. | 2004
- 2105
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Styrylheterocycles as a novel class inhibitor of cyclooxygenase-2-mediated prostaglandin E2 productionLee, Sang Kook / Park, Eun-Jung / Lee, Eunjung et al. | 2004
- 2109
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N,N-Dialkyl-4-((8-azabicyclo(3.2.1)-oct-3-ylidene)phenylmethyl)benz- amides, potent, selective d opioid agonistsCarson, John R. et al. | 2004
- 2109
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N,N-Dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective δ opioid agonistsCarson, John R / Coats, Steven J / Codd, Ellen E et al. | 2004
- 2113
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N-Alkyl-4-((8-azabicyclo(3.2.1)-oct-3-ylidene)phenylmethyl)benzamid- es, (micro) and d opioid agonists: a (micro) addressCarson, John R. et al. | 2004
- 2113
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N-Alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, m and d opioid agonists: a m addressCarson, J. R. / Coats, S. J. / Codd, E. E. et al. | 2004
- 2113
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N-Alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, μ and δ opioid agonists: a μ addressCarson, John R. / Coats, Steven J. / Codd, Ellen E. et al. | 2004
- 2117
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Synthesis and monoamine transporter affinity of 3'-analogs of 2-b-carbomethoxy-3-b-(4'-iodophenyl)tropane (b-CIT)Bois, Frederic et al. | 2004
- 2117
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Synthesis and monoamine transporter affinity of 3′-analogs of 2-β-carbomethoxy-3-β-(4′-iodophenyl)tropane (β-CIT)Bois, Frederic / Baldwin, Ronald M / Kula, Nora S et al. | 2004
- 2117
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Synthesis and monoamine transporter affinity of 3prime-analogs of 2-b-carbomethoxy-3-b-(4prime-iodophenyl)tropane (b-CIT)Bois, F. / Baldwin, R. M. / Kula, N. S. et al. | 2004
- 2121
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Novel pyrazolopyrimidine derivatives as GSK-3 inhibitorsPeat, Andrew J / Boucheron, Joyce A / Dickerson, Scott H et al. | 2004
- 2127
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Novel GSK-3 inhibitors with improved cellular activityPeat, Andrew J / Garrido, Dulce / Boucheron, Joyce A et al. | 2004
- 2131
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Efficient synthesis of -DDBChang, Junbiao / Guo, Xiaohe / Cheng, Senxiang et al. | 2004
- 2131
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Efficient synthesis of g-DDBChang, Junbiao et al. | 2004
- 2137
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Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferaseLiu, Xiao-hui / Prestwich, Glenn D. et al. | 2004
- 2141
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Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P1prime groupNantermet, P. G. / Barrow, J. C. / Lindsley, S. R. et al. | 2004
- 2141
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Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P1′ groupNantermet, Philippe G / Barrow, James C / Lindsley, Stacey R et al. | 2004
- 2147
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Design and synthesis of conformationally frozen peptide nucleic acid backbone: chiral piperidine PNA as a hexitol nucleic acid surrogateLonkar, Pallavi S. / Kumar, Vaijayanti A. et al. | 2004
- 2151
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Capped dipeptide phenethylamide inhibitors of the HCV NS3 proteaseNizi, Emanuela / Koch, Uwe / Ontoria, Jesus M et al. | 2004
- 2155
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Synthesis and inhibition of Src kinase activity by 7-ethenyl and 7-ethynyl-4-anilino-3-quinolinecarbonitrilesBarrios Sosa, Ana Carolina / Boschelli, Diane H / Ye, Fei et al. | 2004
- 2159
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2′,3′-Didehydro-2′,3′-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditionsShi, Junxing / Ray, Adrian S / Mathew, Judy S et al. | 2004
- 2159
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2prime,3prime-Didehydro-2prime,3prime-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditionsShi, J. / Ray, A. S. / Mathew, J. S. et al. | 2004
- 2163
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The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere templateKath, John C / DiRico, Amy P / Gladue, Ronald P et al. | 2004
- 2169
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Potent small molecule CCR1 antagonistsKath, John C / Brissette, William H / Brown, Matthew F et al. | 2004
- 2175
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Novel CCR1 antagonists with improved metabolic stabilityBrown, Matthew F / Avery, Mike / Brissette, William H et al. | 2004
- 2181
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Betulinic acid and its derivatives as anti-angiogenic agentsMukherjee, Rama / Jaggi, Manu / Rajendran, Praveen et al. | 2004
- 2185
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Novel pyrrole-containing progesterone receptor modulatorsCollins, Mark A / Hudak, Valerie / Bender, Reinhold et al. | 2004
- 2191
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Preparation of highly active α-chymotrypsin for catalysis in organic mediaRoy, Ipsita / Gupta, Munishwar N et al. | 2004
- 2191
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Preparation of highly active a-chymotrypsin for catalysis in organic mediaRoy, Ipsita et al. | 2004
- 2195
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2,3-Diarylpyran-4-ones: a new series of selective cyclooxygenase-2 inhibitorsHyup Joo, Yung / Kwan Kim, Jin / Kang, Seon-Hwa et al. | 2004
- 2199
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Structure–activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenaseLeitão, Andrei / Andricopulo, Adriano D / Oliva, Glaucius et al. | 2004
- 2205
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Glycosyltransferase activity can be selectively modulated by chemical modifications of acceptor substratesGalan, M.Carmen / Dodson, Christopher S / Venot, Andre P et al. | 2004
- 2209
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Discovery of novel nonsteroidal glucocorticoid receptor modulatorsLink, J.T / Sorensen, Bryan K / Patel, Jyoti et al. | 2004
- 2213
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Synthesis and antitumor evaluation of benzoylphenylurea analogsGurulingappa, Hallur / Amador, Maria L / Zhao, Ming et al. | 2004
- 2217
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Thioxanthene-derived analogs as s1 receptor ligandsGlennon, Richard A. et al. | 2004
- 2217
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Thioxanthene-derived analogs as σ1 receptor ligandsGlennon, Richard A / Ismaiel, Abd M / Ablordeppey, Seth et al. | 2004
- 2221
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Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate librariesLiu, Ligong / Ping Li, Cai / Cochran, Siska et al. | 2004
- 2227
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Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptaseBisacchi, Gregory S / Slusarchyk, William A / Bolton, Scott A et al. | 2004
- 2233
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Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitorsSutton, James C / Bolton, Scott A / Davis, Malcolm E et al. | 2004
- 2241
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Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarinsCurini, Massimo / Epifano, Francesco / Maltese, Federica et al. | 2004
- 2245
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Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitorsByth, Kate F / Culshaw, Janet D / Green, Stephen et al. | 2004
- 2249
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Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitorsByth, Kate F / Cooper, Nicola / Culshaw, Janet D et al. | 2004
- 2253
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Synthesis and anti-HCMV activity of 1-acyl-b-lactams and 1-acylazetidines derived from phenylalanineGerona-Navarro, Guillermo et al. | 2004
- 2253
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Synthesis and anti-HCMV activity of 1-acyl-β-lactams and 1-acylazetidines derived from phenylalanineGerona-Navarro, Guillermo / Pérez de Vega, Ma Jesús / Garcı́a-López, Ma Teresa et al. | 2004
- 2257
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Novel halogenated nitrobenzylthioinosine analogs as es nucleoside transporter inhibitorsGupte, Amol / Buolamwini, John K et al. | 2004
- 2261
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Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cellsKang, Sam Sik / Lee, Ji Yeon / Choi, Yoo Keum et al. | 2004
- 2265
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5-Lipoxygenase inhibitors with histamine H1 receptor antagonist activityLewis, Timothy A / Bayless, Lynn / Eckman, Joseph B et al. | 2004
- 2269
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Synthesis and structure–activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonistsRowbottom, Martin W / Tucci, Fabio C / Zhu, Yun-Fei et al. | 2004
- 2275
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Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatumHegde, Vinod R / Pu, Haiyan / Patel, Mahesh et al. | 2004
- 2279
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Structural determinants for high 5-HT2A receptor affinity of spiro[9,10-dihydroanthracene]-9,3′-pyrrolidine (SpAMDA)Peddi, Srinivas / Roth, Bryan L / Glennon, Richard A et al. | 2004
- 2279
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Structural determinants for high 5-HT2A receptor affinity of spiro[9,10-dihydroanthracene]-9,3prime-pyrrolidine (SpAMDA)Peddi, S. / Roth, B. L. / Glennon, R. A. et al. | 2004
- 2285
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Tight binding ligand approach to oligosaccharide-grafted proteinTotani, Kiichiro / Matsuo, Ichiro / Ito, Yukishige et al. | 2004
- 2291
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Analysis of structure–activity relationships for the ‘B-region’ of N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activityLee, Jeewoo / Kang, Sang-Uk / Choi, Hyun-Kyung et al. | 2004
- 2291
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Analysis of structure-activity relationships for the `B-region' of N-(3-acyloxy-2-benzylpropyl)-Nprime-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activityLee, J. / Kang, S. U. / Choi, H. K. et al. | 2004
- 2299
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Synthesis and biological evaluation of benzamides and benzamidines: structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinaseAsano, Toru / Yoshikawa, Tomohiro / Nakamura, Hiroyuki et al. | 2004
- 2303
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Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-bGong, Baoqing et al. | 2004
- 2303
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Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-βGong, Baoqing / Hong, Feng / Kohm, Cory et al. | 2004
- 2309
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A simple method for predicting serum protein binding of compounds from IC50 shift analysis for in vitro assaysRusnak, David W. / Lai, Zhihong / Lansing, Timothy J. et al. | 2004
- 2313
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Chemiluminescence quenching of pteroic acid–N-sulfonyl-acridinium-9-carboxamide conjugates by folate binding proteinAdamczyk, Maciej / Fino, James R / Mattingly, Phillip G et al. | 2004
- 2319
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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzymeThérien, Michel / Skorey, Kathryn / Zamboni, Robert et al. | 2004
- 2323
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Amidines as amide bond replacements in VLA-4 antagonistsKamenecka, Theodore M / Park, You-Jung / Lin, Linus S et al. | 2004
- 2327
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Synthesis and structure-activity relationship of 3-arylbenzoxazines as selective estrogen receptor b agonistsYang, Wu et al. | 2004
- 2327
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Synthesis and structure–activity relationship of 3-arylbenzoxazines as selective estrogen receptor β agonistsYang, Wu / Wang, Yufeng / Ma, Zhengping et al. | 2004
- 2331
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Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4Lin, Linus S / Lanza, Thomas J Jr. / Castonguay, Laurie A et al. | 2004
- 2335
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Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analoguesBurlingame, Mark A / Shaw, Simon J / Sundermann, Kurt F et al. | 2004
- 2339
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Studies on intestinal permeability of cirrhotic patients by analysis lactulose and mannitol in urine with HPLC/RID/MSLiu, Hongxia / Zhang, Shusheng / Yu, Ajuan et al. | 2004
- 2345
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3-Hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonistsColotta, Vittoria / Catarzi, Daniela / Varano, Flavia et al. | 2004
- 2351
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Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discoveredVullo, Daniela / Scozzafava, Andrea / Pastorekova, Silvia et al. | 2004
- 2357
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Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamideAbbate, Francesco / Casini, Angela / Scozzafava, Andrea et al. | 2004
- 2363
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New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agentsPerzyna, Aurore / Klupsch, Frédérique / Houssin, Raymond et al. | 2004
- 2367
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Indoline derivatives as 5-HT2C receptor agonistsBentley, J.M / Adams, D.R / Bebbington, D et al. | 2003
- 2371
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Corrigendum to "Aza-bicyclic amino acid sulfonamides as a4b1/a4b7 integrin antagonists"Dyatkin, A. B. / Hoekstra, W. J. / Kinney, W. A. et al. | 2004
- 2371
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Corrigendum to “Aza-bicyclic amino acid sulfonamides as α4β1/α4β7 integrin antagonists”Dyatkin, Alexey B / Hoekstra, William J / Kinney, William A et al. | 2003
- 2371
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Corrigendum to "Aza-bicyclic amino acid sulfonamides as a4b1-a4b7 integrin antagonists" - (Bioorg. Med. Chem. Lett. 14 (2004) 591)Dyatkin, Alexey B. et al. | 2004
- 2373
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Erratum to “α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents”Jain, R / Sundram, A / Lopez, S et al. | 2004
- 2373
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Erratum to "a-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents"Jain, R. / Sundram, A. / Lopez, S. et al. | 2004
- 2373
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Erratum to "a-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents" - (Bioorg. Med. Chem. Lett. 13 (2003) 4223)Jain, R. et al. | 2004
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Editorial board| 2004
- I
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Contributors to this issue| 2004
- V
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Instructions to contributors| 2004