Bioorganic and Medicinal Chemistry Letters
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
Table of contents
- 1465
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Graphical contents list| 2010
- 1485
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S1P receptor mediated activity of FTY720 phosphate mimicsHögenauer, Klemens / Hinterding, Klaus / Nussbaumer, Peter et al. | 2010
- 1488
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Dioxo-triazines as a novel series of cathepsin K inhibitorsRankovic, Zoran / Cai, Jiaqiang / Fradera, Xavier et al. | 2010
- 1491
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The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5Schiemann, Kai / Finsinger, Dirk / Zenke, Frank et al. | 2010
- 1496
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Iodine scanning of a phenazine inhibitor of vacuolar sortingSurpin, Marci / Zou, Yunfan / Xiong, Chiyi et al. | 2010
- 1500
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Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41Zhou, Guangyan / Wu, Dong / Hermel, Evan et al. | 2010
- 1504
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Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell linesRudys, Simonas / Ríos-Luci, Carla / Pérez-Roth, Eduardo et al. | 2010
- 1507
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Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptorsFulton, Brian S. / Knapp, Brian L. / Bidlack, Jean M. et al. | 2010
- 1510
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Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophoreJha, Amitabh / Mukherjee, Chandrani / Prasad, Ashok K. et al. | 2010
- 1516
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Discovery of a novel series of potent S1P1 agonistsCrosignani, Stefano / Bombrun, Agnes / Covini, David et al. | 2010
- 1520
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New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoidesTamura, Satoru / Kubata, Bruno Kilunga / Syamsurizal et al. | 2010
- 1524
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Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitorsRankovic, Zoran / Cai, Jiaqiang / Kerr, Jennifer et al. | 2010
- 1528
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Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activityDing, Yan / Liang, Chun / Kim, Jun Ho et al. | 2010
- 1532
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Synthesis of physostigmine analogues and evaluation of their anticholinesterase activitiesZhan, Zha-Jun / Bian, Hong-Ling / Wang, Jian-Wei et al. | 2010
- 1535
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Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studiesNiu, Chuansheng / Ho, Douglas M. / Zask, Arie et al. | 2010
- 1539
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Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonistsSifferlen, Thierry / Boss, Christoph / Cottreel, Emmanuelle et al. | 2010
- 1543
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Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding modeMeyers, Marvin J. / Pelc, Matthew / Kamtekar, Satwik et al. | 2010
- 1548
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Carbonic anhydrase inhibitors. Inhibition of transmembrane isoforms IX, XII, and XIV with less investigated anions including trithiocarbonate and dithiocarbamateInnocenti, Alessio / Scozzafava, Andrea / Supuran, Claudiu T. et al. | 2010
- 1551
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Azabicyclic sulfonamides as potent 11β-HSD1 inhibitorsShah, Unmesh / Boyle, Craig D. / Chackalamannil, Samuel et al. | 2010
- 1551
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Azabicyclic sulfonamides as potent 11b-HSD1 inhibitorsShah, U. / Boyle, C. D. / Chackalamannil, S. et al. | 2010
- 1555
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Structure–activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril coresFensome, Andrew / Goldberg, Joel / McComas, Casey C. et al. | 2010
- 1559
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Azole-based inhibitors of AKT/PKB for the treatment of cancerZeng, Qingping / Allen, John G. / Bourbeau, Matthew P. et al. | 2010
- 1565
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Radiosynthesis of novel carbon-11-labeled triaryl ligands for cannabinoid-type 2 receptorFujinaga, Masayuki / Kumata, Katsushi / Yanamoto, Kazuhiko et al. | 2010
- 1569
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C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclizationRobinson, Ralph P. / Mascitti, Vincent / Boustany-Kari, Carine M. et al. | 2010
- 1573
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Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell linesLee, Junghun / Kim, Hwan / Yu, Hana et al. | 2010
- 1578
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Biochemical analysis of cellular target of S-trityl-l-cysteine derivatives using affinity matrixShimizu, Makiko / Ishii, Hirosuke / Ogo, Naohisa et al. | 2010
- 1581
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Acidic elements in histamine H3 receptor antagonistsSander, Kerstin / von Coburg, Yvonne / Camelin, Jean-Claude et al. | 2010
- 1585
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N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptaseMitchell, Michael L. / Son, Jong Chan / Lee, Ill Young et al. | 2010
- 1589
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N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptaseMitchell, Michael L. / Son, Jong Chan / Guo, Hongyan et al. | 2010
- 1593
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SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitorsRamtohul, Yeeman K. / Black, Cameron / Chan, Chi-Chung et al. | 2010
- 1598
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Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae FlosTamura, Satoru / Yang, Gang-Ming / Yasueda, Natsuko et al. | 2010
- 1601
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Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogsKurasaki, Haruaki / Okamoto, Iwao / Morita, Nobuyoshi et al. | 2010
- 1604
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Selective inducible microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from an oxicam templateWang, Jane / Limburg, David / Carter, Jeff et al. | 2010
- 1610
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Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffoldsBallet, Steven / Marczak, Ewa D. / Feytens, Debby et al. | 2010
- 1614
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Design, synthesis and biological evaluation of estradiol–chlorambucil hybrids as anticancer agentsGupta, Atul / Saha, Pijus / Descôteaux, Caroline et al. | 2010
- 1619
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Metabolic activation of N-thiazol-2-yl benzamide as glucokinase activators: Impacts of glutathione trapping on covalent bindingIino, Tomoharu / Hashimoto, Noriaki / Hasegawa, Takuro et al. | 2010
- 1623
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Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agentsBairwa, Ranjeet / Kakwani, Manoj / Tawari, Nilesh R. et al. | 2010
- 1626
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Effect of 3′-end capping of aptamer with various 2′,4′-bridged nucleotides: Enzymatic post-modification toward a practical use of polyclonal aptamersKasahara, Yuuya / Kitadume, Shunsuke / Morihiro, Kunihiko et al. | 2010
- 1626
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Effect of 3prime-end capping of aptamer with various 2prime,4prime-bridged nucleotides: Enzymatic post-modification toward a practical use of polyclonal aptamersKasahara, Y. / Kitadume, S. / Morihiro, K. et al. | 2010
- 1630
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Novel 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-one derivatives as potential anti-cancer agentsDevegowda, Vani N. / Kim, Jung Hyun / Han, Ki-Cheol et al. | 2010
- 1634
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Discovery of potent and selective bicyclic A2B adenosine receptor antagonists via bioisosteric amide replacementEastwood, Paul / Gonzalez, Jacob / Paredes, Sergio et al. | 2010
- 1638
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Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonistsGrimstrup, Marie / Receveur, Jean-Marie / Rist, Øystein et al. | 2010
- 1642
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Stereospecific synthesis of oximes and oxime ethers of 3-azabicycles: A SAR study towards antimicrobial agentsParthiban, Paramasivam / Rathika, Paramasivam / Ramkumar, Venkatachalam et al. | 2010
- 1648
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The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanismJain, Harsh V. / Rasheed, Roshni / Kalman, Thomas I. et al. | 2010
- 1652
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2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeuticsZeng, Qingping / Bourbeau, Matthew P. / Wohlhieter, G. Erich et al. | 2010
- 1657
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3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulatorsBernotas, Ronald C. / Antane, Schuyler / Shenoy, Rajesh et al. | 2010
- 1661
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3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3βArnost, Michael / Pierce, Al / Haar, Ernst ter et al. | 2010
- 1661
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3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3bArnost, M. / Pierce, A. / Haar, E. t. et al. | 2010
- 1665
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Synthetic atpenin analogs: Potent mitochondrial inhibitors of mammalian and fungal succinate-ubiquinone oxidoreductaseSelby, Thomas P. / Hughes, Kenneth A. / Rauh, James J. et al. | 2010
- 1669
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Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitorsIoannidis, Stephanos / Lamb, Michelle L. / Almeida, Lynsie et al. | 2010
- 1674
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Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maravirocLemoine, Rémy C. / Petersen, Ann C. / Setti, Lina et al. | 2010
- 1677
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2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)Bursavich, Matthew G. / Parker, Daniel P. / Willardsen, J. Adam et al. | 2010
- 1680
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Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38a mitogen-activated protein kinaseWurz, R. P. / Pettus, L. H. / Henkle, B. et al. | 2010
- 1680
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Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinaseWurz, Ryan P. / Pettus, Liping H. / Henkle, Bradley et al. | 2010
- 1685
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Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound libraryGlass, LaTeca S. / Bapat, Aditi / Kelley, Mark R. et al. | 2010
- 1689
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Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitorsNair, Latha G. / Bogen, Stephane / Ruan, Sumei et al. | 2010
- 1693
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Discovery of potent and bioavailable GSK-3β inhibitorsGong, Leyi / Hirschfeld, Don / Tan, Yun-Chou et al. | 2010
- 1693
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Discovery of potent and bioavailable GSK-3b inhibitorsGong, L. / Hirschfeld, D. / Tan, Y. C. et al. | 2010
- 1697
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Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A2B adenosine receptor antagonistsEastwood, Paul / Gonzalez, Jacob / Paredes, Sergio et al. | 2010
- 1701
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Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acidsInnocenti, Alessio / Leewattanapasuk, Worraanong / Manole, Gheorghe et al. | 2010
- 1701
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Carbonic anhydrase activators: Activation of the b-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acidsInnocenti, A. / Leewattanapasuk, W. / Manole, G. et al. | 2010
- 1705
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Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressantKang, Suk Youn / Park, Eun-Jung / Park, Woo-Kyu et al. | 2010
- 1712
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LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivatorsMita, Yusuke / Dodo, Kosuke / Noguchi-Yachide, Tomomi et al. | 2010
- 1718
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Design, synthesis, evaluation and QSAR analysis of N1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitorsTakahashi, Jun / Hijikuro, Ichiro / Kihara, Takeshi et al. | 2010
- 1721
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Design, synthesis and evaluation of carbamate-modified (−)-N1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitorsTakahashi, Jun / Hijikuro, Ichiro / Kihara, Takeshi et al. | 2010
- 1724
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2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitorsGerspacher, Marc / Furet, Pascal / Pissot-Soldermann, Carole et al. | 2010
- 1728
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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonistsTroxler, Thomas / Hurth, Konstanze / Schuh, Karl-Heinrich et al. | 2010
- 1735
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Exploration of a new series of PAR1 antagonistsPlanty, Bruno / Pujol, Chantal / Lamothe, Marie et al. | 2010
- 1740
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Novel tetrahydrochinoline derived CETP inhibitorsSchmeck, Carsten / Gielen-Haertwig, Heike / Vakalopoulos, Alexandros et al. | 2010
- 1744
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SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitorsZimmermann, Kurt / Wittman, Mark D. / Saulnier, Mark G. et al. | 2010
- 1749
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Synthesis and in vitro evaluation of 18F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PETRobins, Edward G. / Zhao, Yongjun / Khan, Imtiaz et al. | 2010
- 1752
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Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB1 receptor antagonistsLange, Jos H.M. / van der Neut, Martina A.W. / den Hartog, Arnold P. et al. | 2010
- 1758
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Identification of piperazine-bisamide GHSR antagonists for the treatment of obesityYu, Ming / Lizarzaburu, Mike / Beckmann, Holger et al. | 2010
- 1763
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Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis implicationsMusilek, Kamil / Komloova, Marketa / Zavadova, Vlasta et al. | 2010
- 1767
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Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureusLee, Kyungae / Campbell, Jennifer / Swoboda, Jonathan G. et al. | 2010
- 1771
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Structure–activity relationships of bacterial outer-membrane permeabilizers based on polymyxin B heptapeptidesUrakawa, Hirotoshi / Yamada, Keiichi / Komagoe, Keiko et al. | 2010
- 1776
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Selection of inhibitory peptides for Aurora-A kinase from a phage-displayed library of helix–loop–helix peptidesFujiwara, Daisuke / Ye, Zhengmao / Gouda, Masaki et al. | 2010
- 1779
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Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitorsZhu, Hong / Young, Mary B. / Nantermet, Philippe G. et al. | 2010
- 1783
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Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugsCoughlin, John E. / Padmanabhan, Seetharamaiyer / Zhang, Guangrong et al. | 2010
- 1787
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Podophyllotoxin analogues active versus Trypanosoma bruceiUddin, Md. Jashim / Smithson, David C. / Brown, Kristin M. et al. | 2010
- 1792
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Use of polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline for the preparation of a hapten–protein conjugate for antibody developmentSathe, Manisha / Derveni, Mariliza / Allen, Marjorie et al. | 2009
- 1796
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Corrigendum to “Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding” [Bioorg. Med. Chem. Lett. 20 (2010) 657]Kuduk, Scott D. / Di Marco, Christina N. / Cofre, Victoria et al. | 2010
- 1797
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Corrigendum to “Discovery of novel taspine derivatives as antiangiogenic agents” [Bioorg. Med. Chem. Lett. 20 (2010) 718]Zhang, Jie / Zhang, Yanmin / Zhang, Sanqi et al. | 2010
- 1798
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Corrigendum to "Development of photoaffinity probes for g-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker" [Bioorg. Med. Chem. Lett. 19 (2009) 6869]Yokoshima, S. / Abe, Y. / Watanabe, N. et al. | 2010
- 1798
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Corrigendum to “Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker” [Bioorg. Med. Chem. Lett. 19 (2009) 6869]Yokoshima, Satoshi / Abe, Yuzo / Watanabe, Naoto et al. | 2010
- 1800
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Corrigendum to “Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists” [Bioorg. Med. Chem. Lett. 19 (2009) 6801]Sun, Zhong-Yue / Zhu, Zhaoning / Ye, Yuanzan et al. | 2010
- IFC
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Editorial board| 2010