Bioorganic and Medicinal Chemistry Letters
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
Table of contents
- 4517
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Graphical contents list| 2009
- 4538
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Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivativesLee, Chaewoon / Lee, Jin Moo / Lee, Na-Ra et al. | 2009
- 4542
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Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activityWang, Xiaofang / Creek, Darren J. / Schiaffo, Charles E. et al. | 2009
- 4546
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3,4-Disubstituted benzofuran P1prime MMP-13 inhibitors: Optimization of selectivity and reduction of protein bindingLi, W. / Hu, Y. / Li, J. et al. | 2009
- 4546
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3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein bindingLi, Wei / Hu, Yonghan / Li, Jianchang et al. | 2009
- 4551
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Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agentsPiatnitski Chekler, Eugene L. / Butera, John A. / Di, Li et al. | 2009
- 4555
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Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonistsDidiuk, Mary T. / Griffith, David A. / Benbow, John W. et al. | 2009
- 4560
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Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPDWan, Zehong / Laine, Dramane I. / Yan, Hongxing et al. | 2009
- 4563
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The discovery of azepane sulfonamides as potent 11β-HSD1 inhibitorsNeelamkavil, Santhosh F. / Boyle, Craig D. / Chackalamannil, Samuel et al. | 2009
- 4563
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The discovery of azepane sulfonamides as potent 11b-HSD1 inhibitorsNeelamkavil, S. F. / Boyle, C. D. / Chackalamannil, S. et al. | 2009
- 4566
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Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitorsChioua, Mourad / Samadi, Abdelouahid / Soriano, Elena et al. | 2009
- 4570
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Synthesis and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting significant antiproliferative activity against breast cancer cell linesMao, Wei-wei / Wang, Ting-ting / Zeng, He-ping et al. | 2009
- 4574
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Design and synthesis of novel nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors from caffeic acid phenethyl esterWang, Peng / Liu, Chuan / Sanches, Tino et al. | 2009
- 4579
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Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar templateFish, Paul V. / Wakenhut, Florian / Ryckmans, Thomas et al. | 2009
- 4584
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C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer propertiesTung, Nguyen Huu / Minh, Chau Van / Ha, Tran Thu et al. | 2009
- 4589
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Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonistsKishino, Hiroyuki / Moriya, Minoru / Sakuraba, Shunji et al. | 2009
- 4594
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Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agentsGowda, N.R. Thimme / Kavitha, C.V. / Chiruvella, Kishore K. et al. | 2009
- 4601
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Isoplatensimycin: Synthesis and biological evaluationJang, Ki Po / Kim, Chan Hyuk / Na, Seong Wook et al. | 2009
- 4603
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Synthesis and opioid receptor activity of indolopropellanesLi, Fuying / Gaob, Linghuan / Yin, Chenlei et al. | 2009
- 4607
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Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: Part 1Nakao, Akira / Ohkawa, Nobuyuki / Nagasaki, Takayoshi et al. | 2009
- 4611
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Synthesis and biological evaluation of imidazole derivatives as novel NOP/ORL1 receptor antagonists: Exploration and optimization of alternative pyrazole structureSugimoto, Yuichi / Kobayashi, Kensuke / Asai, Masanori et al. | 2009
- 4617
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Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: Improving cell based activity by the quaternarization of a chiral centerNizi, Emanuela / Orsale, Maria Vittoria / Crescenzi, Benedetta et al. | 2009
- 4622
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Design of selective Cathepsin inhibitorsBethel, Paul A. / Gerhardt, Stefan / Jones, Emma V. et al. | 2009
- 4626
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Synthesis and structure–activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agentsHu, Laixing / Kully, Maureen L. / Boykin, David W. et al. | 2009
- 4630
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Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitorsLucas, Matthew C. / Carter, David S. / Cai, Hai-Ying et al. | 2009
- 4634
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Discovery of a novel protein kinase B inhibitor by structure-based virtual screeningMedina-Franco, Jose L. / Giulianotti, Marc A. / Yu, Yongping et al. | 2009
- 4639
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Discovery of CYT997: a structurally novel orally active microtubule targeting agentBurns, Christopher J. / Harte, Michael F. / Bu, Xianyong et al. | 2009
- 4643
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Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquidsKumar, Vineet / Malhotra, Sanjay V. et al. | 2009
- 4647
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Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitisStearns, Brian A. / Baccei, Christopher / Bain, Gretchen et al. | 2009
- 4652
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Glycolipid ester-type heterodimers from Ipomoea tyrianthina and their pharmacological activityLeón-Rivera, Ismael / Mirón-López, Gumersindo / Estrada-Soto, Samuel et al. | 2009
- 4657
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Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregationParlow, John J. / Burney, Mary W. / Case, Brenda L. et al. | 2009
- 4664
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Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonistsWashburn, David G. / Hoang, Tram H. / Frazee, James S. et al. | 2009
- 4669
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Polyethylenimine effectively induces, stabilizes, and regulates intramolecular G-quadruplexesSun, Hongxia / Zhou, Qiuju / Xiang, Junfeng et al. | 2009
- 4673
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Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitorsSato, Yoshiyuki / Onozaki, Yu / Sugimoto, Tetsuya et al. | 2009
- 4679
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Discovery of highly potent and selective biphenylacylsulfonamide-based β3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the β2-adrenergic receptor: Part 6Hattori, Kouji / Orita, Masaya / Toda, Susumu et al. | 2009
- 4679
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Discovery of highly potent and selective biphenylacylsulfonamide-based b3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the b2-adrenergic receptor: Part 6Hattori, K. / Orita, M. / Toda, S. et al. | 2009
- 4684
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Ulmosides A and B: Flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphataseRawat, Preeti / Kumar, Manmeet / Sharan, Kunal et al. | 2009
- 4688
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C5-Modified nucleosides exhibiting anticancer activityLee, Yoon-Suk / Park, Sun Min / Kim, Hwan Mook et al. | 2009
- 4692
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Substituted pyrimidines as cannabinoid CB1 receptor ligandsKim, Min Ju / Kim, Jong Yup / Seo, Hee Jeong et al. | 2009
- 4698
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Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17a-hydroxylase/17,20-lyase (P-45017a)Ahmed, S. / Shahid, I. / Dhanani, S. et al. | 2009
- 4698
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Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17α-hydroxylase/17,20-lyase (P-45017α)Ahmed, Sabbir / Shahid, Imran / Dhanani, Sachin et al. | 2009
- 4702
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Semi-synthesis and anti-proliferative activity evaluation of novel analogues of HonokiolLuo, Youfu / Xu, Yongbin / Chen, Lijuan et al. | 2009
- 4706
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Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assayNishizaki, Yosuke / Ishimoto, Yoichi / Hotta, Yudai et al. | 2009
- 4711
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Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimicWångsell, Fredrik / Russo, Francesco / Sävmarker, Jonas et al. | 2009
- 4715
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Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitorsOlimpieri, Francesca / Tambaro, Simone / Fustero, Santos et al. | 2009
- 4720
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Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitorPark, Byung Sun / El-Deeb, Ibrahim M. / Yoo, Kyung Ho et al. | 2009
- 4724
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Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38a mitogen-activated protein kinaseWurz, R. P. / Pettus, L. H. / Xu, S. et al. | 2009
- 4724
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Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinaseWurz, Ryan P. / Pettus, Liping H. / Xu, Shimin et al. | 2009
- 4729
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Identification of MK-1925: A selective, orally active and brain-penetrable opioid receptor-like 1 (ORL1) antagonistKobayashi, Kensuke / Tsujita, Tomohiro / Ito, Hirokatsu et al. | 2009
- 4733
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FXR agonist activity of conformationally constrained analogs of GW 4064Akwabi-Ameyaw, Adwoa / Bass, Jonathan Y. / Caldwell, Richard D. et al. | 2009
- 4740
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The identification of potent, orally bioavailable tricyclic CGRP receptor antagonistsBell, Ian M. / Bednar, Rodney A. / Corcoran, Halea A. et al. | 2009
- 4743
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Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastaseShreder, Kevin R. / Cajica, Julia / Du, Lingling et al. | 2009
- 4747
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Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates – subtype selective, high affinity α7 nicotinic acetylcholine receptor agonistsO’Donnell, Christopher J. / Peng, Langu / O’Neill, Brian T. et al. | 2009
- 4747
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Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates - subtype selective, high affinity a7 nicotinic acetylcholine receptor agonistsO'Donnell, C. J. / Peng, L. / O'Neill, B. T. et al. | 2009
- 4752
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Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acidMeyers, Ross O. / Lambert, Joshua D. / Hajicek, Nicole et al. | 2009
- 4756
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Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensisSingh, Sheo B. / Ondeyka, John G. / Herath, Kithsiri B. et al. | 2009
- 4760
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Potent aza-peptide derived inhibitors of HCV NS3 proteaseVenkatraman, Srikanth / Wu, Wanli / Shih, Neng-Yang et al. | 2009
- 4764
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Synthesis of radiolabeled cytarabine conjugatesLagisetty, Pallavi / Vilekar, Prachi / Awasthi, Vibhudutta et al. | 2009
- 4768
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Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemiaSchmidt, Darby / Smenton, Abigail / Raghavan, Subharekha et al. | 2009
- 4773
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Novel derivatives of ISO-1 as potent inhibitors of MIF biological functionBalachandran, Sarala / Rodge, Atish / Gadekar, Pradip K. et al. | 2009
- 4777
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Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonistsThompson, Scott K. / Washburn, David G. / Frazee, James S. et al. | 2009
- 4781
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Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonistsCho, Kaimei / Ando, Makoto / Kobayashi, Kensuke et al. | 2009
- 4786
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Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potentialPaira, Priyankar / Hazra, Abhijit / Kumar, Shrabanti et al. | 2009
- 4790
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Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitorsOdell, Luke R. / Nilsson, Mikael T. / Gising, Johan et al. | 2009
- 4794
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7-Azaindole-3-acetic acid derivatives: Potent and selective CRTh2 receptor antagonistsSandham, David A. / Adcock, Claire / Bala, Kamlesh et al. | 2009
- 4799
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Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part one: Lead identificationHolmes, Ian P. / Micheli, Fabrizio / Gaines, Simon et al. | 2009
- 4802
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Carbonic anhydrase inhibitors. Inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with anionsInnocenti, Alessio / Leewattanapasuk, Worraanong / Mühlschlegel, Fritz A. et al. | 2009
- 4802
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Carbonic anhydrase inhibitors. Inhibition of the b-class enzyme from the pathogenic yeast Candida glabrata with anionsInnocenti, A. / Leewattanapasuk, W. / Muhlschlegel, F. A. et al. | 2009
- 4806
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Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitorVandurm, Pierre / Cauvin, Christine / Guiguen, Allan et al. | 2009
- 4806
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Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoic acid as HIV-1 integrase inhibitorVandurm, P. / Cauvin, C. / Guiguen, A. et al. | 2009
- 4810
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Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclaseSpyridonidou, Katerina / Fousteris, Manolis / Antonia, Marazioti et al. | 2009
- 4814
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Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cellsDrag-Zalesinska, Malgorzata / Kulbacka, Julita / Saczko, Jolanta et al. | 2009
- 4818
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From lead to preclinical candidate: Optimization of β-homophenylalanine based inhibitors of dipeptidyl peptidase IVNordhoff, Sonja / López-Canet, Meritxell / Hoffmann-Enger, Barbara et al. | 2009
- 4818
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From lead to preclinical candidate: Optimization of b-homophenylalanine based inhibitors of dipeptidyl peptidase IVNordhoff, S. / Lopez-Canet, M. / Hoffmann-Enger, B. et al. | 2009
- 4824
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Synthesis and application of photoaffinity probe containing an intact isoprenoid chainLi, Lingdong / Tang, Wei / Zhao, Zongbao Kent et al. | 2009
- 4827
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Sulfonamides with the N-alkyl-N′-dialkylguanidine moiety as 5-HT7 receptor ligandsZajdel, Paweł / Subra, Gilles / Verdie, Pascal et al. | 2009
- 4827
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Sulfonamides with the N-alkyl-Nprime-dialkylguanidine moiety as 5-HT7 receptor ligandsZajdel, P. / Subra, G. / Verdie, P. et al. | 2009
- 4832
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Novel inhibitors of the avb3 integrin-lead identification strategyElliot, D. / Henshaw, E. / MacFaul, P. A. et al. | 2009
- 4832
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Novel inhibitors of the αvβ3 integrin—lead identification strategyElliot, David / Henshaw, Eleanor / MacFaul, Philip A. et al. | 2009
- 4836
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Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of an octacyclic analogue of eilatinBouffier, Laurent / Dinica, Rodica / Debray, Julien et al. | 2009
- 4839
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Identification of new Hsp90 inhibitors by structure-based virtual screeningHong, Tae-Joon / Park, Hwangseo / Kim, Yun-Jung et al. | 2009
- 4843
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Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporterSchou, Magnus / Steiger, Carsten / Varrone, Andrea et al. | 2009
- 4846
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Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonistsBiggadike, Keith / Caivano, Matilde / Clackers, Margaret et al. | 2009
- 4851
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In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivativesAhlskog, Julia K.J. / Dumelin, Christoph E. / Trüssel, Sabrina et al. | 2009
- 4857
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Respiratory syncytial virus fusion inhibitors. Part 7: Structure–activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivoSin, Ny / Venables, Brian L. / Combrink, Keith D. et al. | 2009
- 4863
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The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease reninYamaguchi, Yasuchika / Menear, Keith / Cohen, Nissim-Claude et al. | 2009
- 4868
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Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor β type 1 receptor (ALK5)Li, Xingzhou / Wang, Lili / Long, Long et al. | 2009
- 4868
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Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor b type 1 receptor (ALK5)Li, X. / Wang, L. / Long, L. et al. | 2009
- 4873
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Synthesis and evaluation of novel F-18 labeled fluoroarylvaline derivatives: Potential PET imaging agents for tumor detectionQiao, Yali / He, Yong / Zhang, Shuting et al. | 2009
- 4878
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Benzothiophene inhibitors of MK2. Part 1: Structure–activity relationships, assessments of selectivity and cellular potencyAnderson, David R. / Meyers, Marvin J. / Kurumbail, Ravi G. et al. | 2009
- 4882
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Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potencyAnderson, David R. / Meyers, Marvin J. / Kurumbail, Ravi G. et al. | 2009
- 4885
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Corrigendum to “The discovery of a structurally novel class of inhibitors of the type 1glycine transporter” [Bioorg. Med. Chem. Lett. 19 (2009) 2974]Lowe, John A. III / Hou, Xinjun / Schmidt, Christopher et al. | 2009
- 4886
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Corrigendum to “Bis-neonicotinoid insecticides: Observed and predicted binding interactions with the nicotinic receptor” [Bioorg. Med. Chem. Lett. 19 (2009) 3449]Ohno, Ikuya / Tomizawa, Motohiro / Durkin, Kathleen A. et al. | 2009
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Instructions to contributors| 2009
- IFC
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Editorial board| 2009