Bioorganic and Medicinal Chemistry Letters
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
Table of contents
- 1
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Graphical contents list| 2009
- 26
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Exploring SAR features in diverse library of 4-cyanomethyl-pyrazole-3-carboxamides suitable for further elaborations as CB1 antagonistsCooper, Martin / Receveur, Jean-Marie / Bjurling, Emelie et al. | 2009
- 31
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Reaction of reductively activated mitomycin C with aqueous bicarbonate: Isolation and characterization of an oxazolidinone derivative of cis-1-hydroxy-2,7-diaminomitosenePaz, Manuel M. et al. | 2009
- 35
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Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P1) receptor agonistsZécri, Frédéric J. / Albert, Rainer / Landrum, Gregory et al. | 2009
- 38
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3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA)Jeong, Jin Ah / Cho, Haelim / Jung, Soo Yeon et al. | 2009
- 42
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2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure–activity relationship, and docking studyBasnet, Arjun / Thapa, Pritam / Karki, Radha et al. | 2009
- 48
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Solvent-free, microwave assisted synthesis of polyhalo heterocyclic ketene aminals as novel anti-cancer agentsYan, Sheng-Jiao / Huang, Chao / Zeng, Xiang-Hui et al. | 2009
- 52
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Total synthesis and biological evaluation of methylgerambulloneMoon, Jong Taik / Ha, Sung Hoon / Lee, So Hyung et al. | 2009
- 56
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Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomersYao, Jingjing / Zhang, Qingye / Min, Jun et al. | 2009
- 60
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Synthesis and evaluation of 3prime-azido-2prime,3prime-dideoxypurine nucleosides as inhibitors of human immunodeficiency virusZhang, H. w. / Coats, S. J. / Bondada, L. et al. | 2010
- 60
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Synthesis and evaluation of 3′-azido-2′,3′-dideoxypurine nucleosides as inhibitors of human immunodeficiency virusZhang, Hong-wang / Coats, Steven J. / Bondada, Lavanya et al. | 2009
- 65
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SAR of N-phenyl piperidine based oral integrin α5β1 antagonistsZischinsky, Gunther / Osterkamp, Frank / Vossmeyer, Doerte et al. | 2009
- 65
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SAR of N-phenyl piperidine based oral integrin a5b1 antagonistsZischinsky, G. / Osterkamp, F. / Vossmeyer, D. et al. | 2010
- 69
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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assayLee, Pil H. / Conradi, Robert / Shanmugasundaram, Veerabahu et al. | 2009
- 74
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Microwave-assisted synthesis and structure–activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivativesNascimento-Júnior, Nailton M. / Mendes, Thaiana C.F. / Leal, Daniella M. et al. | 2009
- 78
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Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indolesIvachtchenko, Alexandre V. / Frolov, Eugen B. / Mitkin, Oleg D. et al. | 2009
- 83
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Synthesis and anticancer activities of ageladine A and structural analogsMa, Yuelong / Nam, Sangkil / Jove, Richard et al. | 2009
- 87
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Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DF508-CFTRMills, A. D. / Yoo, C. / Butler, J. D. et al. | 2010
- 87
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Design and synthesis of a hybrid potentiator–corrector agonist of the cystic fibrosis mutant protein ΔF508-CFTRMills, Aaron D. / Yoo, Choong / Butler, Jeffrey D. et al. | 2009
- 92
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Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitorOwen, Dafydd R. / Bull, David J. / Bunnage, Mark E. et al. | 2009
- 97
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Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methyleneAppendino, Giovanni / Ech-Chahad, Abdellah / Minassi, Alberto et al. | 2009
- 100
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In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalconesAponte, José C. / Castillo, Denis / Estevez, Yannick et al. | 2009
- 104
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Structure-activity relationships of N-substituted ligands for the a7 nicotinic acetylcholine receptorMortell, K. H. / Schrimpf, M. R. / Bunnelle, W. H. et al. | 2010
- 104
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Structure–activity relationships of N-substituted ligands for the α7 nicotinic acetylcholine receptorMortell, Kathleen H. / Schrimpf, Michael R. / Bunnelle, William H. et al. | 2009
- 108
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Pyrrole derivatives as potent inhibitors of lymphocyte-specific kinase: Structure, synthesis, and SARTakayama, Tetsuo / Umemiya, Hiroki / Amada, Hideaki et al. | 2009
- 112
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Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SARTakayama, Tetsuo / Umemiya, Hiroki / Amada, Hideaki et al. | 2009
- 117
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Gastroprotective flavonoid constituents from Oroxylum indicum Vent.Hari Babu, T. / Manjulatha, K. / Suresh Kumar, G. et al. | 2009
- 121
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Drug design and synthesis of a novel κ opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacologyNagase, Hiroshi / Watanabe, Akio / Nemoto, Toru et al. | 2009
- 121
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Drug design and synthesis of a novel k opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacologyNagase, H. / Watanabe, A. / Nemoto, T. et al. | 2010
- 125
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A selective ‘Off–On’ fluorescent sensor for Zn2+ based on hydrazone–pyrene derivative and its application for imaging of intracellular Zn2+Zhou, Ying / Kim, Ha Na / Yoon, Juyoung et al. | 2009
- 129
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Facile and efficient approach for the synthesis of N2-dimethylaminomethylene-2′-O-methylguanosineMukobata, Tsuyoshi / Ochi, Yosuke / Ito, Yuji et al. | 2009
- 129
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Facile and efficient approach for the synthesis of N2-dimethylaminomethylene-2prime-O-methylguanosineMukobata, T. / Ochi, Y. / Ito, Y. et al. | 2010
- 132
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Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studiesSahoo, Anasuya / Yabanoglu, Samiye / Sinha, Barij N. et al. | 2009
- 137
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Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitorsLunniss, C. / Eldred, C. / Aston, N. et al. | 2009
- 141
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Inhibition of CTP synthase from Escherichia coli by xanthines and uric acidsRoy, Alexander C. / Lunn, Faylene A. / Bearne, Stephen L. et al. | 2009
- 145
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Oxo-bridged isomers of aza-trishomocubane sigma (σ) receptor ligands: Synthesis, in vitro binding, and molecular modelingBanister, Samuel D. / Moussa, Iman A. / Jordan, Meredith J.T. et al. | 2009
- 149
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Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasisHwang, Jong Yeon / Smithson, David / Connelly, Michele et al. | 2009
- 153
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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitorsWang, Tiansheng / Ledeboer, Mark W. / Duffy, John P. et al. | 2009
- 157
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The discovery of tetrahydro-b-carbolines as inhibitors of the kinesin Eg5Barsanti, P. A. / Wang, W. / Ni, Z. J. et al. | 2010
- 157
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The discovery of tetrahydro-β-carbolines as inhibitors of the kinesin Eg5Barsanti, Paul A. / Wang, Weibo / Ni, Zhi-Jie et al. | 2009
- 161
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Investigation of the sequence and length dependence for cell-penetrating prenylated peptidesWollack, James W. / Zeliadt, Nicholette A. / Ochocki, Joshua D. et al. | 2009
- 164
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Solid-phase synthesis and antibiotic activities of cyclodecapeptides on the scaffold of naturally occurring LaterocidinXu, Chunlan / Qin, Chuanguang / Zhang, Ruijie et al. | 2009
- 168
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Novel P2–P4 macrocyclic inhibitors of HCV NS3/4A protease by P3 succinamide fragment depeptidization strategyPompei, Marco / Francesco, Maria Emilia Di / Pesci, Silvia et al. | 2009
- 175
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Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptorTresadern, Gary / Cid, Jose María / Macdonald, Gregor J. et al. | 2009
- 180
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Novel lead for potent inhibitors of breast cancer resistance protein (BCRP)Pick, Anne / Müller, Henrik / Wiese, Michael et al. | 2009
- 184
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Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activitySpanka, Carsten / Glatthar, Ralf / Desrayaud, Sandrine et al. | 2009
- 189
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Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41Wang, Yong / Lu, Hong / Zhu, Qiang et al. | 2009
- 193
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Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-dionesSantos, Maria M.M. / Faria, Natália / Iley, Jim et al. | 2009
- 196
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Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimizationGoulet, Sylvie / Poupart, Marc-André / Gillard, James et al. | 2009
- 201
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Discovery of dipiperidines as new antitubercular agentsBogatcheva, Elena / Hanrahan, Colleen / Chen, Ping et al. | 2009
- 206
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Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A’s zinc endopeptidaseČapková, Kateřina / Hixon, Mark S. / Pellett, Sabine et al. | 2009
- 209
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4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonistsBernotas, Ronald C. / Singhaus, Robert R. / Kaufman, David H. et al. | 2009
- 213
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5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitorStock, Nicholas / Baccei, Christopher / Bain, Gretchen et al. | 2009
- 218
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Antiplasmodial activity of piperazine sulfonamidesMartyn, Derek C. / Cortese, Joseph F. / Tyndall, Erin et al. | 2009
- 222
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Synthesis and structure–activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT1A receptor and the serotonin transporterShen, Zhongqi / Siva Ramamoorthy, P. / Hatzenbuhler, Nicole T. et al. | 2009
- 228
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Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidinesMartyn, Derek C. / Nijjar, Amarjit / Celatka, Cassandra A. et al. | 2009
- 232
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Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclasesEmmrich, Thomas / El-Tayeb, Ali / Taha, Hesham et al. | 2009
- 236
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Novel potent apoA-I peptide mimetics that stimulate cholesterol efflux and pre-β particle formation in vitroIngenito, Raffaele / Burton, Charlotte / Langella, Annunziata et al. | 2009
- 236
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Novel potent apoA-I peptide mimetics that stimulate cholesterol efflux and pre-b particle formation in vitroIngenito, R. / Burton, C. / Langella, A. et al. | 2010
- 240
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Synthesis and antitumor activity of novel 2prime,3prime-dideoxy-2prime,3prime-diethanethionucleosides bearing 1,2,3-triazole residuesYu, J. L. / Wu, Q. P. / Zhang, Q. S. et al. | 2010
- 240
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Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residuesYu, Jin-Lan / Wu, Qin-Pei / Zhang, Qing-Shan et al. | 2009
- 244
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Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agentsMishra, Jitendra Kumar / Samanta, Krishnananda / Jain, Manish et al. | 2009
- 248
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Synthesis and in vivo evaluation of 3,4-disubstituted gababutinsBlakemore, David C. / Bryans, Justin S. / Carnell, Pauline et al. | 2009
- 252
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Antimalarial activity of azadipeptide nitrilesLöser, Reik / Gut, Jiri / Rosenthal, Philip J. et al. | 2009
- 256
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Substituted tetrahydro-b-carbolines as potential agents for the treatment of human papillomavirus infectionMiller, J. F. / Turner, E. M. / Sherrill, R. G. et al. | 2010
- 256
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Substituted tetrahydro-β-carbolines as potential agents for the treatment of human papillomavirus infectionMiller, John F. / Turner, Elizabeth M. / Sherrill, Ronald G. et al. | 2009
- 260
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DNA methylation by dimethyl sulfoxide and methionine sulfoxide triggered by hydroxyl radical and implications for epigenetic modificationsKawai, Kazuaki / Li, Yun-Shan / Song, Ming-Fen et al. | 2009
- 266
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Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesityLiu, Kevin K.-C. / Cornelius, Peter / Patterson, Terrell A. et al. | 2009
- 272
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Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancerHarada, Koichiro / Kubo, Hideki / Tomigahara, Yoshitaka et al. | 2009
- 272
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Coumarins as novel 17b-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancerHarada, K. / Kubo, H. / Tomigahara, Y. et al. | 2010
- 276
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Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptorDeFalco, Jeff / Steiger, Daniel / Gustafson, Amy et al. | 2009
- 280
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A single step purification for autolytic zinc proteinasesWilfong, Erin M. / Locklear, Ursala / Toone, Eric J. et al. | 2009
- 283
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Anti-tumor activity of a new series of benzoxazepine derivatives in breast cancerSamanta, Krishnananda / Chakravarti, Bandana / Mishra, Jitendra Kumar et al. | 2009
- 288
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Two novel neo-clerodane diterpenoids from Scutellaria barbataLee, Hanna / Kim, YuJin / Choi, Inho et al. | 2009
- 291
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Synthesis of substituted aryloxy alkyl and aryloxy aryl alkyl imidazoles as antileishmanial agentsBhandari, Kalpana / Srinivas, Nagarapu / Marrapu, Vijay K. et al. | 2009
- 294
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Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitorsAngibaud, Patrick / Emelen, Kristof Van / Decrane, Laurence et al. | 2009
- 299
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2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assemblyZhu, Xuejun / Zhao, Guoming / Zhou, Xiaoping et al. | 2009
- 302
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Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitationHishikawa, Kazuhiro / Nakagawa, Hidehiko / Furuta, Toshiaki et al. | 2009
- 306
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Thyroid receptor agonists for the treatment of androgenetic alopeciaLi, Jie Jack / Mitchell, Lorna H. / Dow, Robert L. et al. | 2009
- 309
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Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cellsTung, Nguyen Huu / Song, Gyu Yong / Kim, Jeong-Ah et al. | 2009
- 315
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Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99mde Barros, André Luís Branco / Cardoso, Valbert Nascimento / Mota, Luciene das Graças et al. | 2009
- 318
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Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonistsLiu, Fa / Stephen, Andrew G. / Waheed, Abdul A. et al. | 2009
- 322
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Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline–triazine conjugatesManohar, Sunny / Khan, Shabana I. / Rawat, Diwan S. et al. | 2009
- 326
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Pyrazolone based TGFβR1 kinase inhibitorsGuckian, Kevin / Carter, Mary Beth / Lin, Edward Yin-Shiang et al. | 2009
- 326
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Pyrazolone based TGFbR1 kinase inhibitorsGuckian, K. / Carter, M. B. / Lin, E. Y. et al. | 2010
- 330
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2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding modeArgiriadi, Maria A. / Ericsson, Anna M. / Harris, Christopher M. et al. | 2009
- 334
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2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimizationHarris, Christopher M. / Ericsson, Anna M. / Argiriadi, Maria A. et al. | 2009
- 338
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On the mechanism of microsomal prostaglandin E synthase type-2—A theoretical study of endoperoxide reaction with MeS−Li, Yi / Angelastro, Michael / Shimshock, Stephen et al. | 2009
- 341
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Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty ratsUto, Yoshikazu / Ogata, Tsuneaki / Kiyotsuka, Yohei et al. | 2009
- 346
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2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moietySmith, Cameron J. / Ali, Amjad / Chen, Liya et al. | 2009
- 350
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A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazoles as antitubercular agentsKarthikeyan, Subramanian Vedhanarayanan / Bala, Balasubramanian Devi / Raja, Velanganni Paul Alex et al. | 2009
- 354
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CD4 mimics targeting the mechanism of HIV entryYamada, Yuko / Ochiai, Chihiro / Yoshimura, Kazuhisa et al. | 2009
- 359
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Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimumGoswami, Abhishek / Saikia, Partha P. / Barua, Nabin C. et al. | 2009
- 362
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Synthesis and in vivo evaluation of 3-substituted gababutinsBlakemore, David C. / Bryans, Justin S. / Carnell, Pauline et al. | 2009
- 366
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Hit to lead studies on (hetero)arylpyrimidines—Agonists of the canonical Wnt-β-catenin cellular messaging systemGilbert, Adam M. / Bursavich, Matthew G. / Alon, Nippa et al. | 2009
- 366
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Hit to lead studies on (hetero)arylpyrimidines-Agonists of the canonical Wnt-b-catenin cellular messaging systemGilbert, A. M. / Bursavich, M. G. / Alon, N. et al. | 2010
- 371
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Improving the developability profile of pyrrolidine progesterone receptor partial agonistsKallander, Lara S. / Washburn, David G. / Hoang, Tram H. et al. | 2009
- 375
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Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3KVerheijen, Jeroen C. / Yu, Ker / Toral-Barza, Lourdes et al. | 2009
- 380
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Discovery of orally available integrin α5β1 antagonistsZischinsky, Gunther / Osterkamp, Frank / Vossmeyer, Doerte et al. | 2009
- 380
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Discovery of orally available integrin a5b1 antagonistsZischinsky, G. / Osterkamp, F. / Vossmeyer, D. et al. | 2010
- 383
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Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533)Choi, Hojin / Lee, Jaekwang / Kim, Young Hoon et al. | 2009
- 387
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Novel sulfamoyl benzamides as selective CB2 agonists with improved in vitro metabolic stabilitySellitto, Ian / Bourdonnec, Bertrand Le / Worm, Karin et al. | 2009
- 392
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Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure–activity relationship studiesWang, Haofan / Byun, Youngjoo / Barinka, Cyril et al. | 2009
- 398
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Small molecule inhibitors of HIV RT Ribonuclease HGrandi, Martin Di / Olson, Matthew / Prashad, Amar S. et al. | 2009
- 403
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p16INK4a Peptide mimetics identified via virtual screeningKlein, Mark A. / Mayo, Kevin H. / Kratzke, Robert A. et al. | 2009
- 406
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In vitro antitubercular and antimicrobial activities of 1-substituted quinoxaline-2,3(1H,4H)-dionesRamalingam, P. / Ganapaty, S. / Rao, Ch. Babu et al. | 2009
- 409
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Neolignans from Piper kadsura and their anti-neuroinflammatory activityKim, Ki Hyun / Choi, Jung Wook / Ha, Sang Keun et al. | 2009
- 413
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Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanomaKim, Hee Jin / Jung, Myung-Ho / Kim, Hwan et al. | 2009
- 418
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Highly selective and potent m opioid ligands by unexpected substituent on morphine skeletonLi, W. / Tao, Y. M. / Tang, Y. et al. | 2010
- 418
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Highly selective and potent μ opioid ligands by unexpected substituent on morphine skeletonLi, Wei / Tao, Yi-Min / Tang, Yun et al. | 2009
- 422
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Corrigendum to “Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers” [Bioorg. Med. Chem. Lett. 19 18 (2008) 3440]Graulich, Amaury / Lamy, Cédric / Alleva, Livia et al. | 2009
- 423
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Corrigendum to “A flexizyme that selectively charges amino acids activated by a water-friendly leaving group” [Bioorg. Med. Chem. Lett. 19 (2009) 3892]Niwa, Nobuyoshi / Yamagishi, Yusuke / Murakami, Hiroshi et al. | 2009
- 424
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Corrigendum to "New PPARg ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies" [Bioorg. Med. Chem. Lett. 18 (2008) 4959]Sundriyal, S. / Viswanad, B. / Ramarao, P. et al. | 2010
- 424
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Corrigendum to “New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies” [Bioorg. Med. Chem. Lett. 18 (2008) 4959]Sundriyal, Sandeep / Viswanad, Bhoomi / Ramarao, Poduri et al. | 2009
- IFC
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Editorial board| 2009