Optimizing cultivation strategies in different scales of hollow fiber bioreactors (English)
- New search for: Rodriguez, G.
- New search for: Arias, M. A.
- New search for: Suarez, J.
- New search for: Chea, M.
- New search for: Bouzo, L.
- New search for: Cuervo, R.
- New search for: Alvarez
- New search for: Chico, E.
- New search for: Rodriguez, G.
- New search for: Arias, M. A.
- New search for: Suarez, J.
- New search for: Chea, M.
- New search for: Bouzo, L.
- New search for: Cuervo, R.
- New search for: Alvarez
- New search for: Chico, E.
- New search for: Godia Casablancas, F.
- New search for: Fussenegger, M.
In:
European Society of Animal Cell Technology.; Animal cell technology meets genomics
;
747-750
;
2005
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ISBN:
- Conference paper / Print
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Title:Optimizing cultivation strategies in different scales of hollow fiber bioreactors
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Contributors:Rodriguez, G. ( author ) / Arias, M. A. ( author ) / Suarez, J. ( author ) / Chea, M. ( author ) / Bouzo, L. ( author ) / Cuervo, R. ( author ) / Alvarez ( author ) / Chico, E. ( author ) / Godia Casablancas, F. / Fussenegger, M.
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Conference:General Meeting; 18th, European Society of Animal Cell Technology.; Animal cell technology meets genomics ; 2003 ; Granada, Spain
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Published in:PROCEEDINGS OF THE 18TH ESACT MEETING ; 747-750
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Publisher:
- New search for: Springer,
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Place of publication:Dordrecht , Norwell, MA:
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Publication date:2005-01-01
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Size:4 pages
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Remarks:Includes bibliographical references and indexes
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ISBN:
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Type of media:Conference paper
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Type of material:Print
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Language:English
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Keywords:
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Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents conference proceedings
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 3
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Effect of osmotic pressure on GS-NSO expression systemWu, M. / Dimopolous, G. / Mantalaris, A. / Varley, J. et al. | 2005
- 15
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Molecular approaches to influence epigenetic effectors of transient and stable transgene expression in mammalian cellsHacker, D. / Cotten, M. / Wurm, F. et al. | 2005
- 23
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Genomic exploration on Chinese hamster ovary cellsde Leon Gatti, M. / Wlaschin, K. / Rink, A. / Sanny, A. / Tan, K. S. / Nissom, P. M. / Ong, P. F. / Wong, K. / Philip, R. J. / Cham, B. et al. | 2005
- 31
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Roles for glycosylation in receptor-ligand interactions in the immune systemRudd, P. M. / Merry, A. H. / Dwek, R. A. et al. | 2005
- 43
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Investigations on mannose-6-phosphate receptor mediated protein uptakeDuerrschmid, M. / Jursik, C. / Borth, N. / Grabherr, R. / Doblhoff-Dier, O. et al. | 2005
- 51
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Analysis of multiple apoptosis parameters using a microfluidic chip-based systemValer, M. / Preckel, T. / Luedke, G. / Buhlmann, C. et al. | 2005
- 59
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Inhibiting apoptosis in cell culture using multiple inhibitorsFigueroa, B. / Ailor, E. / Reff, M. / Hardwick, J. M. / Betenbaugh, M. J. et al. | 2005
- 67
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Pausing of mammalian cells by cold exposure, limits and opportunitiesHunt, L. / Hacker, D. / El Abridi, H. / Grosjean, F. / DeJesus, M. / Jordan, M. / Wurm, F. et al. | 2005
- 71
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The functional competence of animal cells: analysis of the secretory pathwayRacher, A. J. / Birch, J. R. / James, D. C. / Alete, D. E. / Smales, C. M. et al. | 2005
- 75
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Proteome analysis of recombinant CHO cells under hyperosmotic stressLee, M. S. / Kim, K. W. / Kim, Y. H. / Lee, G. M. et al. | 2005
- 79
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Expression profiling analysis of sodium butyrate-induced Chinese hamster ovary cells in defined mediumMelville, M. W. / Sinacore, M. / Hann, L. E. et al. | 2005
- 83
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Intracellular nucleotide pools for optimizing product-oriented transient transfection of HEK293 cells in suspensionBassani Molinas, M. M. / Beer, C. / Hesse, F. / Wirth, M. / Durocher, Y. / Kamen, A. / Wagner, R. et al. | 2005
- 87
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Impact of yeast pyruvate carboxylase on the productivity of animal host cell linesBollati Fogolin, M. / Irani, N. / Beccaria, A. J. / Schulz, C. / Van den Heuvel, J. / Elias, C. B. / Carpentier, E. / Durocher, Y. / Bisson, L. / Etcheverrigaray, M. et al. | 2005
- 91
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Environmental effects of lactate on High-Five™ insect cell metabolismDrugmand, J.-C. / Schneider, Y.-J. / Agathos, S. N. et al. | 2005
- 95
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Correlation of intracellular nucleotide pools to amino acid concentrations in culture media by the application of multivariate methodsHesse, F. / Nelving, A. / Wagner, R. et al. | 2005
- 99
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Engineering Trichoplusia ni (High Five™) insect cells to express a cytosolic pyruvate carboxlase enzyme improves the viability of the cells in batch, fed-batch and perfusion culturesLocas, M.-C. / Elias, C. B. / Lanthier, S. / Bisson, L. / Perrier, M. / Kamen, A. et al. | 2005
- 103
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Insect cell culture medium selection and optimisation based on monitoring and economical considerationsLecina, M. / Soley, A. / Passamani, P. / Casablancas, A. / De Gracia, J. / Vela, C. / Espuna, E. / Cairo, J. J. / Godia, F. et al. | 2005
- 107
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Antiapoptotic activity of synthetic and natural peptidesFranek, F. et al. | 2005
- 111
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Effect of antiapoptotic genes expression on cell growth and monoclonal antibody productivity in a hybridoma cell lineJuanola, S. / Vives, J. / Andersen, J. / Prats, E. / Cornudella, L. / Cairo, J. / Godia, F. et al. | 2005
- 115
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Amplified dicistronic expression units mediate apoptosis protection in CHO-DG44 cells adapted for growth in serum-free media, impact on mitochondria copy numberMeents, H. / Enenkel, B. / Fussenegger, M. et al. | 2005
- 121
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Effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic ss HIT-T15 cellShirahata, S. / Li, Y. / Teruya, K. / Katakura, Y. / Kabayama, S. / Otsubo, K. / Morisawa, S. / Ishii, Y. / Gadek, Z. et al. | 2005
- 125
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Characterization of apoptosis in a CHO cell line cultivated in batch and continuous culture: Effect of medium, specific perfusion rate and chemical inhibitorsThrift, J. / Yamasaki, G. / Heidemann, R. / Abbas, N. / Konstantinov, K. et al. | 2005
- 129
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Hydrogen peroxide-induced cellular senescence is regulated via two different pathwaysYoshizaki, K. / Katakura, Y. / Fujiki, T. / Tsunematu, T. / Teruya, K. / Shirahata, S. et al. | 2005
- 133
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Identification of autocrine factors influencing proliferation in serum free cultures of Trichoplusia ni cellsEriksson, U. / Haggstrom, L. et al. | 2005
- 137
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The effects of insulin and Long™R^3IGF-I on Chinese hamster ovary cells: cell survival, receptor activation and second messenger pathwaysYandell, C. A. / Butler, I. P. / Sheehan, A. J. / Wade, B. J. / Simula, A. P. / Goddard, C. et al. | 2005
- 143
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Conditioned medium factors in protein-free cultures of NS0 cellsSpens, E. / Haggstrom, L. et al. | 2005
- 147
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Production of human anti-peptide antibody for clinical use by in vitro immunizationTamura, T. / Katakura, Y. / Yamashita, M. / Aiba, Y. / Matsumoto, S. / Teruya, K. / Shirahata, S. et al. | 2005
- 151
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Optimization of in vitro immunization protocol to produce antigen specific human monoclonal antibody by demonstrating the role of IL-10Xu, Q. H. / Katakura, Y. / Yamashita, M. / Teruya, K. / Shirahata, S. et al. | 2005
- 155
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Extracellular histone H4 from SF9 cells is antimicrobialCalles, K. / Lindskog, E. / Nossed, A. / Svensson, I. / Haggstrom, L. et al. | 2005
- 159
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Analyzing calcium phosphate transfection of adherent CHO cells using microscopic live imagingGrosjean, F. / Jordan, M. / Wurm, F. M. et al. | 2005
- 163
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Effects of multiplicity of infection (MOI) and cell cycle on Baculovirus infection kineticsHaas, R. / Reid, S. / Nielsen, L. K. et al. | 2005
- 167
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Non-freezing preservation and subsequent recovery of hepatocytes under pO~2- and pH-controlled conditions for continuous supply of cells for bioartificial liver supportIding, K. / Buntemeyer, H. / Lehmann, J. et al. | 2005
- 171
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Selection of MDCK subclones with various genotypic and phenotypic markers: sensitivity to influenza virus infectionKessler, N. / Roche, G. / Vernet, A. / Abismil, C. et al. | 2005
- 175
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Extracellular metalloproteases and their inhibitors expressed by the IFN-gamma producing CHO-320 cell lineMols, J. / Verhoeye, F. / Peeters-Joris, C. / Agathos, S. N. / Schneider, Y.-J. et al. | 2005
- 179
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Novel small-molecule AKT1 inhibitors discovered by Redistribution™-based high-throughput screeningPraestegaard, M. / Nielsen, S. J. / Lundholt, B. K. / Mikkelsen, I. / Loechel, S. / Heide, M. / Linde, V. et al. | 2005
- 183
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Influence of mistletoe extracts and its components on in-vitro physiology of cancer cellsSidler, F. / Wermelinger, T. / Rist, L. / Hensel, A. / Viviani, A. et al. | 2005
- 187
-
Rapid in-process monitoring of antibody integrity, purity and titre-2100 Bioanalyser (Lab on a chip) studyNesredin, A. / Mussa, N. A. / Cheung, K. Y. / Alam, I. M. / Flatman, S. et al. | 2005
- 193
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Toxicological evaluation of haine river waste-water samples to appropriately sensitised cultured Fathead Minnow cells compared with the microtox® methodDierickx, P. J. / Van der Wielen, C. et al. | 2005
- 199
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3D-cultivation and characterisation of osteogenic cells for the production of highly viable bone tissue implantsBarthold, M. / Majore, I. / Fargali, S. / Stahl, F. / Schulz, R. / Lose, S. / Mayer, H. / Jager, V. et al. | 2005
- 207
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Carbon source has a considerable influence on extracellular matrix formation, demonstrated on specific collagen expression of primary human tenocytesMobest, D. / Jaeger, M. / Hoben, G. / Hamann, D. / Wollner, S. / Stark, G. B. et al. | 2005
- 213
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Design and characterization of cardiomyocyte-derived micro tissuesKelm, M. J. / Ehler, E. / Perriard, J. C. / Fussenegger, M. et al. | 2005
- 221
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Process development for standardized generation of monocyte-derived dendritic cells: applicability in breast cancer immunotherapyBohnenkamp, H. R. / Noll, T. et al. | 2005
- 229
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Stemline™ hematopoietic stem cell expansion medium, a serum-free medium for expansion of CD34^+ hematopoietic stem cells and progenitorsLeugers, S. / Allison, D. / Pronold, B. J. / Rennebeck, G. / Van Zant, G. / Tario, J. / Swartzwelder, F. / Donahue, L. et al. | 2005
- 233
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Mesenchymal stem cells: a very first step towards large scale cell culture strategies transplantationBensellam, M. / Bassens, C. / Toallati, M. / Lowagie, S. / Werenne, J. et al. | 2005
- 237
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Expansion of murine embryonic stem cells on microcarriers-functional characteristics and scale-up potentialBurg, M. / Quel, G. / Rudiger, M. / Zweigerdt, R. et al. | 2005
- 241
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In vitro cultivation of rabbit mesenchymal stromal cells on 3D bioresorbable calcium phosphate scaffolds for the generation of bone tissue implantsFargali, S. / Barthold, M. / Rohde, M. / Majore, I. / Jager, V. et al. | 2005
- 245
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Establishment and characterization of human medullary thyroid carcinoma cell lines for immunotherapyStradler, G. / Voglauer, R. / Wieser, M. / Katinger, H. / Pfragner, R. et al. | 2005
- 249
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Suppression of cell growth by platinum nanocolloids as scavengers against reactive oxygen speciesHamasaki, T. / Kashiwagi, T. / Aramaki, S. / Imada, T. / Komatsu, T. / Li, Y. / Teruya, K. / Katakura, Y. / Kabayama, S. / Otsubo, K. et al. | 2005
- 253
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Comparison of fluidized bed and fed batch reactor cultures for production of anti-HIV-antibodyHinterleitner, P. / Unterluggauer, F. / Landauer, K. / Muller, D. / Kunert, R. / Bluml, G. / Doblhoff-Dier, O. / Katinger, H. et al. | 2005
- 257
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Suppression of oxidative stress-induced apoptosis of neuronal cells by electrolyzed-reduced waterKashiwagi, T. / Hamasaki, T. / Kabayama, S. / Takaki, M. / Teruya, K. / Katakura, Y. / Otubo, K. / Morisawa, S. / Shirahata, S. et al. | 2005
- 261
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Spheroid formation by encapsulation of cancer cells to mimic small size tumorsMarc, A. / Markvicheva, E. / Jourdain, C. / Bezdetnaya, L. / Merlin, J.-L. / Guillemin, F. / Zubov, V. / Goergen, J.-L. et al. | 2005
- 265
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Bioreactor for continuous biomechanical characterization of cellular systems and tissue-engineered biohybrid tissuesMobest, D. / Jaeger, M. / Guttmann, J. / Schneider, M. / Stark, G. B. et al. | 2005
- 269
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Membrane-separated cocultivation of cord blood hematopoietic stem cells with stromal cell linesFischbach, T. / Noll, T. et al. | 2005
- 273
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Anti-apoptotic genes protect an insulinoma cell line from cell death induced by hyperglycemiaOgawa, A. / Terada, S. / Miki, M. / Kumagai, T. / Kimura, T. / Yamaguchi, A. et al. | 2005
- 277
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Preparation and characterization of an idiotype-dendritic cell vaccine for immunotherapy of multiple myelomaOpalka, B. / Schutt, P. / Brandhorst, D. / Buttkereit, U. / Tewes, M. / Moritz, T. / Seeber, S. / Nowrousain, M. R. et al. | 2005
- 281
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Pretreatment with polycations enhances Adenoviral infection levels in serum-free PER.C6™ cells as well as HEK 293 cellsPadilla, J. / Burke, V. / Johnson, J. / Hartshorn, J. / McNorton, S. / Etchberger, K. et al. | 2005
- 285
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Optimizing the production of cardiomyocytes from mouse embryonic stem cells in a 2L stirred tank reactorSchroeder, M. / Niebruegge, S. / Werner, A. / Zweigerdt, R. / Burg et al. | 2005
- 289
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Establishment and characterization of CD4^+ Killer-T-Cells (KTCs)Voglauer, R. / Jursik, C. / Prchal, M. / Jungfer, H. / Grillari, J. / Katinger, H. et al. | 2005
- 295
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Successful development of a robust adenovirus production process primarily relies on a better understanding of packaging cell line physiology and vector replication kineticsKamen, A. / Henry, O. / Jacob, D. / Bernier, A. et al. | 2005
- 303
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Retroviral vector stability: inactivation kinetics and membrane propertiesCruz, P. / Carmo, M. / Coroadinha, A. S. / Bengala, A. / Goncalves, D. / Texeira, M. / Merten, O.-W. / Geny-Fiamma, C. / Carrondo, M. J. T. et al. | 2005
- 309
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Comparison of host cell lines and production methods for a new generation of oncolytic adenoviral vectorsForestell, S. / Celeri, C. / Dang, C. / Gong, T. / Olsen, M. / Sifi, I. / Yuk, I. / Geyer, S. et al. | 2005
- 317
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Process development for a veterinary vaccine against heartwaterMarcelino, I. / Sousa, M. / Verissimo, C. / Peixoto, C. / Carrondo, M. J. T. / Alves, P. M. et al. | 2005
- 321
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A new method for the quantitative determination of enveloped viral particlesBeer, C. / Wirth, M. et al. | 2005
- 325
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Development of a 293T cell line for the production of virus like particles in bioreactorsCosta, M. J. L. / Malho, R. / Goncalves, J. / Ferreira, G. N. M. / Aires-Barros, M. R. et al. | 2005
- 329
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Effect of MOI and medium composition on adenovirus infection kineticsFerreira, T. / Alves, P. M. / Goncalves, D. / Carrondo, M. J. T. et al. | 2005
- 333
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ION-exchange chromatography based strategies for purification of viral vectorsVasi, J. / Morenweiser, R. / Eriksson, K. / Lemmens, R. / Herzer, S. et al. | 2005
- 339
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Scaling up of endothelial cells culture for the production of a rickettsiae vaccine: evaluation of the importance of the interference effectsHendrick, V. / Kagye, N. / Kamba, Y. / Simon, S. / Thinsy, A.-L. / Marigue, T. / Werenne, J. et al. | 2005
- 345
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Inducible gene expression for antibiotic drug discovery and diagnosticsWeber, W. / Link, N. / Spielmann, M. / Weber, C. C. / Keller, B. / Fussenegger, M. et al. | 2005
- 351
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Nucleic acid capture assay: a novel high-throughput method for direct mRNA quantitationVan de Goor, J. / Tsai, S. P. / Wong, A. / Mehta, S. / Zheng, L. / Elliott, L. O. / Stephan, J. P. et al. | 2005
- 359
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High throughput transient transfections of HEK293EBNA cells: development of an integrated expression purification process at 100 ml scaleHeine, H. / Rey, L. / Arod, C. Y. / Gaudry, J.-P. / Antonsson, B. / Feger, G. / Battle, T. et al. | 2005
- 365
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Transient gene expression in suspension HEK293 cells: application to large-scale protein productionBaldi, L. / Jacquet, R. / Picasso, S. / Tromba, P. / Derow, E. / Girard, P. / Hacker, D. / Wurm, F. M. et al. | 2005
- 369
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Monoclonal antibody production: determination of appropriate system and medium for production enhancement and decrease of overall production timeFritchman, K. / Tilsaghani, C. / Sumnall, T. et al. | 2005
- 373
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The secrets of transfection in serum-free suspension cultureGeisse, S. / Di Maiuta, N. / Ten Buren, B. / Henke, M. et al. | 2005
- 377
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From genes to proteins: full open reading frame (ORF) clones and their application in functional researchGoedde, A. / Baars, S. / Czerny, K. / Schultz, E. / Gernold, N. / Scheuermann, T. / Schatten, R. / Henze, S. / Schick, M. / Ebert, L. et al. | 2005
- 381
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A versatile disposable culture system for high throughput screening of process parameters and production cell linesJordan, M. / DeJesus, M. / Eigenmann, C. / Gleich, T. / Wurm, F. M. et al. | 2005
- 385
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Long time storage of pre-inoculated multi-well plates for cell-based assay kits used for drug identification and characterisationLoa, A. / Gelli, C. / Laffert, B. et al. | 2005
- 389
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Comparative secretion levels of recombinant proteins between insect cell-baculovirus and mammalian HEK293EBNA cellsLosberger, C. / Battle, T. et al. | 2005
- 393
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Microfluidic technology applied to protein sizing and quantitationValer, M. / Neumann, T. / Barthmaier, P. / Kuschel, M. / Buhlman, C. et al. | 2005
- 397
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CryoStock - a software for cell culture managementZerlin, M. / Greiffenberg, L. / Wurm, Y. / Winkler, I. / Kreusel, D. / Tomoe, S. / Ballabas, L. / Martin, J. et al. | 2005
- 403
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Targeting the human Immunoglobulin loci for high level heterologous gene expressionWinkler, K. / Wermelinger, T. / Paul, C. / Koch, S. / Brecht, R. / Zietze, S. / Nuck, R. / Thiel, G. / Marx, U. / Sandig, V. et al. | 2005
- 411
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MAR elements as tools to increase protein production by CHO cellsGirod, P.-A. / Zahn-Zabal, M. M. / Mermod, N. et al. | 2005
- 417
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Cell line engineering for production of therapeutic antibody glycoforms with increased biological activityUmana, P. / Bruenker, P. / Ferrara, C. / Moser, S. / Suter, T. / Gerdes, C. A. / Puentener, U. / Jean-Mairet / Buholzer, P. / Spaeni, M. et al. | 2005
- 423
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Development of a metabolically optimized fermentation process based on glucose-limited CHO perfusion culture| 2005
- 431
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Applications of quasi real-time metabolic flux analysis in mammalian cell culture process developmentGoudar, C. / Biener, R. / Michaels, J. / Zhang, C. / Piret, J. / Konstantinov, K. et al. | 2005
- 439
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Data-based modelling of cell culturesCunha-Bakeev, C. / Glassey, J. / Montague, G. / Al-Rubeai, M. / Hardwicke, P. et al. | 2005
- 447
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Cell culture and downstream processing integration using ProteinChip® technology. Application to protein analysis and purification in biopharmaceutical manufacturingBengio, S. / Santambien, P. / Cleverley, S. et al. | 2005
- 453
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The prospects for insect cells for use as a cell substrate for the production of biotherapeuticsGalbraith, D. N. et al. | 2005
- 459
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High-performance cell culture platform technology for Mab productionChang, D. Y. H. / Garza, P. / Huang, Y. M. / Talabardon, M. / Rahmati, S. / Fallon, E. / Noe, W. et al. | 2005
- 465
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Development and integration of a new animal-component-free process for the production of UK-279,276Pluschkell, S. / Blocker, L. / Geldart, R. / Hawrylik, S. / Mensah, P. / Okediadi, C. / Pias, S. / Subashi, A. / Zhu, M. et al. | 2005
- 471
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Towards an affinity-based capture system for the isolation of high expression cells using a co-expressed surface proteinDerouazi, M. / Pick, H. M. / Deluz, C. / Picasso, S. / Wurm, F. M. et al. | 2005
- 475
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Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant CHO cellsChung, J. Y. / Lim, S. W. / Hong, Y. J. / Koh, Y. W. / Hwang, S. O. / Lee, G. M. et al. | 2005
- 479
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Recombinant glycoprotein expression. Development of a homologous CHO expression systemNoone, C. / Smith, T. / Cairns, M. et al. | 2005
- 483
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Generation of recombinant antibody manufacturing cell lines using cell-cell fusionZeng, W. / Puchacz, E. / Heineken, K. / Raymond, I. / Chang, C. / Ryll, T. / Chamow, S. et al. | 2005
- 489
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Cloning and expression of biopharmaceuticals in CHO.K1 and BHK-21 cellsCastilho, L. R. / Asensi, G. F. / Cavalcanti, J. C. / Sousa, P. M. / Del Aguila, E. M. / Silva, J. T. / Paschoalin, V. M. F. et al. | 2005
- 493
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Camel single-domain antibodies as modular building blocks to make bivalent constructs for use in immunotheraphy of cancerCortez-Retamozo, V. / Backmann, N. / Senter, P. D. / Wernery, U. / De Baetselier, P. / Muyldermans, S. / Revets, H. et al. | 2005
- 497
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Establishment of efficient cloning method for variable region genes of antigen specific human monoclonal antibodyMatsumoto, S. / Katakura, Y. / Yamashita, M. / Aiba, Y. / Noguchi, E. / Teruya, K. / Shirahata, S. et al. | 2005
- 501
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From gene to monoclonal antibody: efficient screening by cell sortingBorth, N. / Bohm, E. / Grillari, J. / Loscher, M. / Gross, S. / Voglauer, R. / Ferko, B. / Kunert, R. / Katinger, H. et al. | 2005
- 505
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Development of an integrated strategy for recombinant cell line selectionCastillo, A. J. / Victores, S. / Faife, E. / Rabasa, Y. / De La Luz, K. R. et al. | 2005
- 509
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Gene transfer to animal cells in culture by microinjection: A novel tool to create recombinant cell lines?Derouazi, M. / Girard, P. / Jordan, M. / Denoya, C. / Wurm, F. M. et al. | 2005
- 513
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Evaluation of the stability of NS0 cell lines expressing recombinant human IgGForrest-Owen, W. / Daramola, L. / Hatton, D. / Field, R. et al. | 2005
- 517
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High throughput screening and selection of single cells in suspension using fluorescence parametersGiese, C. / Demmler, C. / Gradl, G. / Marx, U. et al. | 2005
- 521
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Control of key parameters in the development of mammalian production clonesKunert, R. / Wolbank, S. / Chang, M. / Preis, S. / Steinfellner, W. / Borth, N. / Katinger, H. et al. | 2005
- 525
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Establishment of screening systems for recombinant cell lines: early prediction of the suitability as a production cloneLattenmayer, C. / Kunert, R. / Katinger, H. et al. | 2005
- 529
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Characterisation of CHO subclones showing profound changes in performance when propagated in different cultivation systemsTrummer, E. / Muller, D. / Steinfellner, W. / Kunert, R. / Steindl, F. / Hesse, F. / Katinger, H. et al. | 2005
- 533
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High level production of recombinant IgG in the human cell line PER.C6™Yallop, C. / Raamsman, M. / Zuijderwijk, M. / van Noordenburg, Y. / Vooys, A. / Keehnen, R. / van Montfort, B. / Jansen, M. / Lagerwerf, F. / Dijkstra, R. et al. | 2005
- 537
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Creating a new medium to help meet the variable nutritional requirements of Chinese hamster ovary (CHO) cell clonesDeeds, Z. W. / Albee, A. / Delong, B. / Gifford, J. / Ross, J. S. / Kao, K. / Caple, M. V. et al. | 2005
- 541
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Development of an efficient medium optimization kit for factorial matrix design - a statistical approach to increase cell growth and productivity of recombinant CHO cellsDelong, B. / Albee, A. / Deeds, Z. / Gifford, J. / Ross, J. / Kao, K. / Caple, M. et al. | 2005
- 549
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An efficient approach to cell culture medium optimization - a statistical method to medium mixingGifford, J. / Albee, A. / Deeds, Z. W. / Delong, B. / Kao, K. / Ross, J. S. / Caple, M. V. et al. | 2005
- 555
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Virus inactivation in foetal calf serum by a combined treatment of gamma-irradiation and UV-C irradiationHermann, H. / Burian, R. / Waldmann, R. et al. | 2005
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Advances in media optimization: two automated approaches that increase expression while reducing development timeHoldread, S. / Hunt, C. / Haaland, P. / Chaney, B. / Porter, W. / Heidaran, M. / Wannlund, J. et al. | 2005
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The importance of cholesterol for insect cell growth and baculovirus productionLua, L. H. L. / Reid, S. et al. | 2005
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Use of rapeseed proteins and peptides as supplements in insect cell culturesMarc, A. / Deparis, V. / Durrieu, C. / Marc, I. / Goergen, J. L. / Chevalot, I. et al. | 2005
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Nutritional performance of wheat gluten -derived protein hydrolysates in hybridoma cell culturesMartens, D. E. / Wegkamp, H. B. A. / Simpson, N. H. / Huttinga, H. H. / Kunst, T. / Siemensma, A. D. et al. | 2005
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SyntheChol™ synthetic cholesterol for cholesterol dependent cell culture. Development of non-animal derived chemically defined NS0 mediumTalley, D. / Cutak, B. / Rathbone, E. / Al-Kolla, T. / Allison, D. / Blasberg, J. / Koa, K. / Caple, M. et al. | 2005
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NS0 derivatives: MAb production in large-scale SFM formatsManwaring, J. / Barnett, B. / Pence, B. / Whitford, W. et al. | 2005
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Silk protein sericin accelerates proliferation of various mammalian cellsTerada, S. / Yanagihara, K. / Kaito, K. / Miki, M. / Sasaki, M. / Tsujimoto, K. / Yamada, H. et al. | 2005
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Image analysis based realtime-control of glucose concentrationBrueckerhoff, T. / Frerichs, J. / Joeris, K. / Konstantinov, K. / Scheper, T. et al. | 2005
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On line analysis of microcarrier cultivationsBurzlaff, A. / Kasper, C. / Scheper, T. et al. | 2005
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Error analysis during estimation of metabolic fluxes through metabolite balancingGoudar, C. / Biener, R. / Michaels, J. / Piret, J. / Konstantinov, K. et al. | 2005
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Generalized logistic equation modeling of mammalian cell batch culturesGoudar, C. / Heidemann, R. / Joeris, K. / Michaels, J. / Piret, J. / Konstantinov, K. et al. | 2005
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In-situ microscopy based monitoring of mammalian cell culture processesJoeris, K. / Frerichs, J.-D. / Scheper, T. / Konstantinov, K. et al. | 2005
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A novel disposable microtube for rapid assessment of biomass in cell culturesJordan, M. et al. | 2005
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Intracellular monitoring of baculovirus infection of Sf9 insect cells and r-protein production using anti-alpha-1,3/4 fucosyltransferase antibodies and flow cytometryMarc, A. / Deparis, V. / Jestin, A. / Goergen, J. L. et al. | 2005
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Effect of glucose and glutamine concentration on metabolism of animal cells in chemostat cultureMatsuoka, H. / Takeda, T. et al. | 2005
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Evaluation of a novel capacitance probe for on-line monitoring of viable cell densities in batch and fed-batch animal cell culture processesSchmid, G. / Zacher, D. et al. | 2005
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Sodium butyrate enhancement of protein expression in HeLa cells: follow-up of a chimeric reporter gene behaviour for process developmentBassens, C. / Rigaux, P. / Hendrick, V. / Cherlet, M. / Sato, K. / Kotarsky, K. / Werenne, J. et al. | 2005
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Scalable, serum-free, high efficiency transfection of CHO Cells using an economical DNA transfer vehicleGirard, P. / Derouazi, M. / Van Tilborgh, F. / Wurm, F. M. et al. | 2005
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Process optimization for an NS0-derived hybridoma cell line in a chemically defined, protein-free mediumJohnson, J. M. / Hartshorn, J. / McNorton, S. / Padilla-Zamudio, J. / Etchberger, K. et al. | 2005
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Impact of change in fermentation process pH and dissolved carbon dioxide concentration on secreted antibody structure and cell physiology of a GS-NS0 cell line expressing a human antibodyRidley, A. / Dempsey, J. / Gee, C. / Turner, R. / Osborne, M. / Ruddock, S. / Ritchie, C. / Field, R. et al. | 2005
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Experimental factorial design for the study of some variables in roller bottles cell cultureRodriguez, E. N. / Perez, M. / Ordaz, Y. / Casanova, P. R. / Martinez, L. / Herrera, N. et al. | 2005
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Evaluation of RollerCell system for high scale production of biopharmaceuticalsRodriguez, E. N. / Perez, M. / Ordaz, Y. / Casanova, P. R. / Martinez, L. / Herrera, N. et al. | 2005
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Strategies for the process development of monoclonal antibodies for therapeutic useDe Mattei, C. / De Bernardi, N. / Gaspari, F. / Castiglioni, S. / Orlandi, A. / Muru, E. / Cavenaghi, C. / Nolli, M. et al. | 2005
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Optimisation of Pei-mediated transient expression in Chinese hamster ovary cellsTait, A. / Hoare, M. / Birch, J. / Gailbraith, D. J. / Hines, M. / Brown, J. C. / James, D. C. et al. | 2005
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Development of fed-batch process producing monoclonal antibodies using in-house mediaHuang, Y. M. / Huynh, T. / Ly, L. / Noe, W. / Chang, D. Y. H. et al. | 2005
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Production of an anti beta2 integrin monoclonal antibody by a hybridoma cell line grown in a 2 liter bioreactorKallel, H. / Bellila, A. / Fathallah, D. M. et al. | 2005
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Economic evaluation of disposables vs stainless steel within a modular pilot plant facility - a comparative analysisMonge, M. / Sinclair, A. et al. | 2005
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cGMP manufacturing of a fusion protein in mammalian cells using a large scale acoustic perfusion systemCrowley, J. / Schlukebir, C. / Dijkstal, M. / Hoeksma, S. / Olthof, E. / Hussmann, S. / Esser, S. / Herrmann, A. / Coco Martin, J. M. / Hof, R. et al. | 2005
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Influence of culture parameters on viability in perfusion processDalm, M. C. F. / Cuijten, S. M. R. / Van Grunsven, W. M. J. / Oudshoorn, A. / Tramper, J. / Martens, D. E. et al. | 2005
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Use of hydrocyclone as an efficient tool for cell retention in perfusion culturesElsayed, E. A. / Piehl, G.-W. / Nothnagel, J. / Medronho, R. A. / Deckwer, W.-D. / Wagner, R. et al. | 2005
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Effect of different variables on the long-term spinfilter clogging during pilot-scale animal cell perfusion runsFigueredo, A. / Navarrete, J. / Viton, P. / Martinez, E. / Castro, A. / Chico, E. et al. | 2005
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Integrating acoustic perfusion in mammalian cell culture: temperature controlKeijzer, T. / Trampler, F. / Oudshoorn, A. / Bergv/d, H. et al. | 2005
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Flexible fed-batch process control of animal cellsFrahm, B. / Portner, R. et al. | 2005
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Development of a fed-batch strategy for the production of NS0-derived humanised MAb in protein free mediumOjito Magaz, E. / Arias, M. A. / Chico Veliz, E. et al. | 2005
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Transfection to manufacturing: reducing timelines for high yielding GS-CHO processesRendall, M. / Maxwell, A. / Tatham, D. / Khan, P. / Gay, R. D. / Kallmeier, R. C. / Wayte, J. R. T. / Racher, A. J. et al. | 2005
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Optimization of a fed-batch process producing humanized antibodiesSauer, P. et al. | 2005
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Optimized feeding strategy for NS0 cellsWalowitz, J. / Tescione, L. / Paul, W. / Jayme, D. / Gorfien, S. et al. | 2005
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Comparison of complementary interactions between synthetic ligands and t-PA by HPMDCTappe, A. / Kretzmer, G. / Kasper, C. / Scheper, T. / Vlakh, E. G. / Tennikova, T. B. / Platonova, G. A. et al. | 2005
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Effect of nutrient supplementation on the biological quality of t-PA produced by CHO cells on serum-free mediumAltamirano, C. / Illanes, A. / Canessa, R. / Becerra, S. / Berrios, J. et al. | 2005
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Modulation of the glycosylation repertoire of a recombinant human EPO expressing model cell line under different culture conditionsDuvar, S. / Berlin, J. / Ziehr, H. / Conradt, H. S. et al. | 2005
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Physicochemical estimation of rhEPO potency produced in suspension cultureEtcheverrigaray, M. / Amadeo, G. I. / Didier, C. / Pereira Bacci, D. A. / Cavatorta, F. A. / Kratje, R. B. et al. | 2005
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Post-translational modification of recombinant human GM-CSF expressed by stable-transfected CHO cells under different culture conditionsForno, A. G. / Etcheverrigaray, M. / Nimtz, M. / Kratje, R. B. et al. | 2005
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Softmix, a new scaleable mixing system for the cultivation of sensitive cells on microcarrier under protein-free conditionsNaschberger, S. / Rutten, K. / Muller, D. / Katinger, H. et al. | 2005
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Establishment of fermentation process for hrepo using stirred tank fermenters in perfusion mode using a commercial protein-free culture mediumBouzo, L. / Ojito, E. / Arias, M. A. / Suarez, J. / Chico, E. / Alvarez, A. / Chea, M. / Alvarez, I. / Diaz, C. / Valiente, O. et al. | 2005
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Continuous GMP production in hollow fibre bioreactors-a viable alternative for the production of low volume biopharmaceuticalsBrecht, R. / Bushnaq-Josting, H. / Zietze, S. / Nuck, R. / Kloth, C. / Schwadtke, A. / Obermayer, N. / Marx, U. / Koch, S. et al. | 2005
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Optimizing cultivation strategies in different scales of hollow fiber bioreactorsRodriguez, G. / Arias, M. A. / Suarez, J. / Chea, M. / Bouzo, L. / Cuervo, R. / Alvarez / Chico, E. et al. | 2005
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Increasing antibody production from hollow fiber systemsGramer, M. J. et al. | 2005
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Production of poliovirus, rubella virus, measles virus and recombinant adenovirus in protein-free mediaCard, C. / Smith, T. / Hunsaker, B. / Barnett, B. et al. | 2005
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Serum-free production of poliovirus: a comparative study using microcarriers, roller bottles and stationary cell cultureCard, C. / Smith, T. / Hunsaker, B. / Barnett, B. et al. | 2005
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Glutamine-free media for vaccine production processesGenzel, Y. / Alt, R. / Reichl, U. et al. | 2005
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Serum free cultivation of primary chicken embryo fibroblasts in microcarrier systems for vaccine productionHundt, B. / Schanzler, A. / Reichl, U. et al. | 2005
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Design of an animal protein free medium to sustain Vero cells growth in a stirred tank bioreactorKallel, H. / Rourou, S. / Van Der ark, A. / Thalen, M. / Van Der Velden De Groot, T. et al. | 2005
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Use of on-line our measurements to monitor and improve insect cell cultures for recombinant protein productionLecina, M. / Casablancas, A. / Soley, A. / Vela, C. / Espuna, E. / de Gracia, J. / Cairo, J. J. / Godia, F. et al. | 2005
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Production of live influenza vaccine in MDCK cell lineMazurkova, N. / Nechaeva, E. / Ryabicheva, T. / Varaksin, N. / Sen kina, T. / Sviridenko, T. / Kolokoltsova, S. / Markushin, S. / Gendon, V. et al. | 2005
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Elaboration of the microencapsulated forms of the viral vaccinesNechaeva, E. / Varaksin, N. / Ryabicheva, T. / Getmanova, T. / Mazurkova, N. / Senkina, T. / Kolokoltsova, T. et al. | 2005
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HTS-based development of high-producing CHO cell linesSautter, K. / Fieder, J. / Otto, R. / Enenkel, B. et al. | 2005