4-(3'alpha15'beta-Dihydroxy-5'beta- estran-17'beta-yl)furan-2-methyl Alcohol: An Anti-Digoxin Agent with a Novel Mechanism of Action (English)
- New search for: Deutsch, J.
- New search for: Jang, H. G.
- New search for: Mansur, N.
- New search for: Ilovich, O.
- New search for: Shpolansky, U.
- New search for: Galili, D.
- New search for: Feldman, T.
- New search for: Rosen, H.
- New search for: Lichtstein, D.
- New search for: Deutsch, J.
- New search for: Jang, H. G.
- New search for: Mansur, N.
- New search for: Ilovich, O.
- New search for: Shpolansky, U.
- New search for: Galili, D.
- New search for: Feldman, T.
- New search for: Rosen, H.
- New search for: Lichtstein, D.
In:
JOURNAL OF MEDICINAL CHEMISTRY
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49
, 2
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600-606
;
2006
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ISSN:
- Article (Journal) / Print
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Title:4-(3'alpha15'beta-Dihydroxy-5'beta- estran-17'beta-yl)furan-2-methyl Alcohol: An Anti-Digoxin Agent with a Novel Mechanism of Action
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Contributors:Deutsch, J. ( author ) / Jang, H. G. ( author ) / Mansur, N. ( author ) / Ilovich, O. ( author ) / Shpolansky, U. ( author ) / Galili, D. ( author ) / Feldman, T. ( author ) / Rosen, H. ( author ) / Lichtstein, D. ( author )
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Published in:JOURNAL OF MEDICINAL CHEMISTRY ; 49, 2 ; 600-606
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Publisher:
- New search for: ACS AMERICAN CHEMICAL SOCIETY
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Publication date:2006-01-01
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Size:7 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 615
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 49, Issue 2
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 441
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Potent and Selective Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors. 1. 4-(4-Bromo-2-fluorophenylamino)-1- methylpyridin-2(1H)-onesWallace, Eli M. / Lyssikatos, Joseph / Blake, James F. / Seo, Jeongbeob / Yang, Hong Woon / Yeh, Tammie C. / Perrier, Michele / Jarski, Heidi / Marsh, Vivienne / Poch, Gregory et al. | 2006
- 445
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HIV Integrase Inhibitors with Nucleobase Scaffolds: Discovery of a Highly Potent Anti-HIV AgentNair, Vasu / Chi, Guochen / Ptak, Roger / Neamati, Nouri et al. | 2006
- 448
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A Minimalist Design Approach to Antimicrobial Agents Based on a Thionin TemplateVila-Perelló, Miquel / Tognon, Sabrina / Sánchez-Vallet, Andrea / García-Olmedo, Francisco / Molina, Antonio / Andreu, David et al. | 2006
- 452
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Novel Potential Anticancer Naphthyl Phosphoramidates of BVdU: Separation of Diastereoisomers and Assignment of the Absolute Configuration of the Phosphorus CenterCongiatu, Costantino / Brancale, Andrea / Mason, Malcolm D. / Jiang, Wen G. / McGuigan, Christopher et al. | 2006
- 456
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Selective Inhibition of Matrix Metalloproteinase Isozymes and in Vivo Protection against Emphysema by Substituted γ-Keto Carboxylic AcidsMa, Dawei / Jiang, Yongwen / Chen, Fangping / Gong, Li-kun / Ding, Ke / Xu, Yong / Wang, Renxiao / Ge, Aihua / Ren, Jin / Li, Jingya et al. | 2006
- 456
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Selective Inhibition of Matrix Metalloproteinase Isozymes and in Vivo Protection against Emphysema by Substituted gamma-Keto Carboxylic AcidsMa, D. / Jiang, Y. / Chen, F. / Li-kun / Gong / Ding, K. / Xu, Y. / Wang, R. / Ge, A. / Ren, J. et al. | 2006
- 459
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Novel Tacrine−Melatonin Hybrids as Dual-Acting Drugs for Alzheimer Disease, with Improved Acetylcholinesterase Inhibitory and Antioxidant PropertiesRodríguez-Franco, María Isabel / Fernández-Bachiller, María Isabel / Pérez, Concepción / Hernández-Ledesma, Blanca / Bartolomé, Begoña et al. | 2006
- 463
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Targeting FtsZ for Antituberculosis Drug Discovery: Noncytotoxic Taxanes as Novel Antituberculosis AgentsHuang, Qing / Kirikae, Fumiko / Kirikae, Teruo / Pepe, Antonella / Amin, Amol / Respicio, Laurel / Slayden, Richard A. / Tonge, Peter J. / Ojima, Iwao et al. | 2006
- 467
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Rapid Synthesis of Triazole-Modified Resveratrol Analogues via Click ChemistryPagliai, Francesca / Pirali, Tracey / Del Grosso, Erika / Di Brisco, Riccardo / Tron, Gian Cesare / Sorba, Giovanni / Genazzani, Armando A. et al. | 2006
- 471
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Identification and Biological Characterization of 6-Aryl-7-isopropylquinazolinones as Novel TRPV1 Antagonists that Are Effective in Models of Chronic PainCulshaw, Andrew J. / Bevan, Stuart / Christiansen, Martin / Copp, Prafula / Davis, Andrew / Davis, Clare / Dyson, Alex / Dziadulewicz, Edward K. / Edwards, Lee / Eggelte, Hendrikus et al. | 2006
- 475
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Insight into the Structural Requirements of Urokinase-Type Plasminogen Activator Inhibitors Based on 3D QSAR CoMFA/CoMSIA ModelsBhongade, Bhoomendra A. / Gadad, Andanappa K. et al. | 2006
- 490
-
Knowledge-Based Design of Target-Focused Libraries Using Protein−Ligand Interaction ConstraintsDeng, Zhan / Chuaqui, Claudio / Singh, Juswinder et al. | 2006
- 501
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Computational Study of Antagonist-a1A Adrenoceptor ComplexesObservations of Conformational Variations on the Formation of Ligand-Receptor ComplexesKinsella, G.K. et al. | 2006
- 501
-
Computational Study of Antagonist/alpha~1~A Adrenoceptor Complexes-Observations of Conformational Variations on the Formation of Ligand/Receptor ComplexesKinsella, G. K. / Rozas, I. / Watson, G. W. et al. | 2006
- 501
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Computational Study of Antagonist/α1A Adrenoceptor ComplexesObservations of Conformational Variations on the Formation of Ligand/Receptor ComplexesKinsella, Gemma K. / Rozas, Isabel / Watson, Graeme W. et al. | 2006
- 511
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Metal-Mediated Inhibition of Escherichia c oli Methionine Aminopeptidase: Structure−Activity Relationships and Development of a Novel Scoring Function for Metal−Ligand InteractionsSchiffmann, Rolf / Neugebauer, Alexander / Klein, Christian D. et al. | 2006
- 523
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Classification of Chemical Compounds by Protein−Compound Docking for Use in Designing a Focused LibraryFukunishi, Yoshifumi / Mikami, Yoshiaki / Takedomi, Kei / Yamanouchi, Masaya / Shima, Hideaki / Nakamura, Haruki et al. | 2006
- 534
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Novel Procedure for Modeling Ligand/Receptor Induced Fit EffectsSherman, Woody / Day, Tyler / Jacobson, Matthew P. / Friesner, Richard A. / Farid, Ramy et al. | 2006
- 554
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3D-QSAR Studies on Cannabinoid CB1 Receptor Agonists: G-Protein Activation as Biological DataSalo, Outi M. H. / Savinainen, Juha R. / Parkkari, Teija / Nevalainen, Tapio / Lahtela-Kakkonen, Maija / Gynther, Jukka / Laitinen, Jarmo T. / Järvinen, Tomi / Poso, Antti et al. | 2006
- 567
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Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 ProteaseChen, Kevin X. / Njoroge, F. George / Pichardo, John / Prongay, Andrew / Butkiewicz, Nancy / Yao, Nanhua / Madison, Vincent / Girijavallabhan, Viyyoor et al. | 2006
- 575
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Synthesis, Chiral Resolution, and Enantiopharmacology of a Potent 2,3-Benzodiazepine Derivative as Noncompetitive AMPA Receptor AntagonistZappalà, Maria / Postorino, Giovanna / Micale, Nicola / Caccamese, Salvatore / Parrinello, Nunziatina / Grazioso, Giovanni / Roda, Gabriella / Menniti, Frank S. / De Sarro, Giovambattista / Grasso, Silvana et al. | 2006
- 582
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Trisubstituted Acridines as G-quadruplex Telomere Targeting Agents. Effects of Extensions of the 3,6- and 9-Side Chains on Quadruplex Binding, Telomerase Activity, and Cell ProliferationMoore, Michael J. B. / Schultes, Christoph M. / Cuesta, Javier / Cuenca, Francisco / Gunaratnam, Mekala / Tanious, Farial A. / Wilson, W. David / Neidle, Stephen et al. | 2006
- 600
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4-(3‘α15‘β-Dihydroxy-5‘β-estran-17‘β-yl)furan-2-methyl Alcohol: An Anti-Digoxin Agent with a Novel Mechanism of ActionDeutsch, Joseph / Jang, Huang G. / Mansur, Nura / Ilovich, Ohad / Shpolansky, Uri / Galili, Dana / Feldman, Tomer / Rosen, Haim / Lichtstein, David et al. | 2006
- 600
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4-(3'a15'b-Dihydroxy-5'b-estran-17'&bgr- ;-yl)furan-2-methyl Alcohol: An Anti-Digoxin Agent with a Novel Mechanism of ActionDeutsch, J. et al. | 2006
- 600
-
4-(3'alpha15'beta-Dihydroxy-5'beta- estran-17'beta-yl)furan-2-methyl Alcohol: An Anti-Digoxin Agent with a Novel Mechanism of ActionDeutsch, J. / Jang, H. G. / Mansur, N. / Ilovich, O. / Shpolansky, U. / Galili, D. / Feldman, T. / Rosen, H. / Lichtstein, D. et al. | 2006
- 607
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Library Design, Synthesis, and Screening: Pyridine Dicarbonitriles as Potential Prion Disease TherapeuticsReddy, Tummala R. K. / Mutter, Roger / Heal, William / Guo, Kai / Gillet, Valerie J. / Pratt, Steven / Chen, Beining et al. | 2006
- 616
-
Identification of the Key Residue of Calcitonin Gene Related Peptide (CGRP) 27−37 to Obtain Antagonists with Picomolar Affinity at the CGRP ReceptorLang, Manja / De Pol, Silvia / Baldauf, Carsten / Hofmann, Hans-Jörg / Reiser, Oliver / Beck-Sickinger, Annette G. et al. | 2006
- 625
-
3D-QSAR Studies of Arylpyrazole Antagonists of Cannabinoid Receptor Subtypes CB1 and CB2. A Combined NMR and CoMFA ApproachChen, Jian-Zhong / Han, Xiu-Wen / Liu, Qian / Makriyannis, Alexandros / Wang, Junmei / Xie, Xiang-Qun et al. | 2006
- 637
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Overlapping, Nonidentical Binding Sites of Different Classes of Nonpeptide Antagonists for the Human Gonadotropin-Releasing Hormone ReceptorBetz, Stephen F. / Reinhart, Greg J. / Lio, Francisco M. / Chen / Struthers, R. Scott et al. | 2006
- 648
-
Protein−Protein Interactions: Modeling the Hepatitis C Virus Ion Channel p7Patargias, George / Zitzmann, Nicole / Dwek, Raymond / Fischer, Wolfgang B. et al. | 2006
- 656
-
Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel SynthesisPetros, Andrew M. / Dinges, Jurgen / Augeri, David J. / Baumeister, Steven A. / Betebenner, David A. / Bures, Mark G. / Elmore, Steven W. / Hajduk, Philip J. / Joseph, Mary K. / Landis, Shelley K. et al. | 2006
- 664
-
The First Potent Inhibitors for Human Glutaminyl Cyclase: Synthesis and Structure−Activity RelationshipBuchholz, Mirko / Heiser, Ulrich / Schilling, Stephan / Niestroj, André J. / Zunkel, Katrin / Demuth, Hans-Ulrich et al. | 2006
- 678
-
Discovery of Two Novel, Small-Molecule Inhibitors of DNA MethylationSiedlecki, Pawel / Boy, Regine Garcia / Musch, Tanja / Brueckner, Bodo / Suhai, Sandor / Lyko, Frank / Zielenkiewicz, Piotr et al. | 2006
- 684
-
Structure−Activity Study of Brassinin Derivatives as Indoleamine 2,3-Dioxygenase InhibitorsGaspari, Paul / Banerjee, Tinku / Malachowski, William P. / Muller, Alexander J. / Prendergast, George C. / DuHadaway, James / Bennett, Shauna / Donovan, Ashley M. et al. | 2006
- 693
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Miliusanes, A Class of Cytotoxic Agents from Miliusa sinensisZhang, Hong-Jie / Ma, Cuiying / Hung, Nguyen Van / Cuong, Nguyen Manh / Tan, Ghee Teng / Santarsiero, Bernard D. / Mesecar, Andrew D. / Soejarto, D. Doel / Pezzuto, John M. / Fong, Harry H. S. et al. | 2006
- 709
-
Synthesis and Biological Activity of Isoxazolidinyl Polycyclic Aromatic Hydrocarbons: Potential DNA IntercalatorsRescifina, Antonio / Chiacchio, Maria A. / Corsaro, Antonino / De Clercq, Erik / Iannazzo, Daniela / Mastino, Antonio / Piperno, Anna / Romeo, Giovanni / Romeo, Roberto / Valveri, Vincenza et al. | 2006
- 716
-
(+)-(2R,5S)-4-[4-Cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an Orally Potent and Peripherally Selective Nonsteroidal Androgen Receptor AntagonistKinoyama, Isao / Taniguchi, Nobuaki / Toyoshima, Akira / Nozawa, Eisuke / Kamikubo, Takashi / Imamura, Masakazu / Matsuhisa, Akira / Samizu, Kiyohiro / Kawanimani, Eiji / Niimi, Tatsuya et al. | 2006
- 716
-
(+)-(2R,5S)-4-[4-Cyano-3-(trifluoromethyl)phenyl]-2,5-d- imethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an Orally Potent and Peripherally Selective Nonsteroidal Androgen Receptor Antagonist1Kinoyama, I. et al. | 2006
- 727
-
Structure−Activity Relationship Studies of Novel Benzophenones Leading to the Discovery of a Potent, Next Generation HIV Nonnucleoside Reverse Transcriptase InhibitorRomines, Karen R. / Freeman, George A. / Schaller, Lee T. / Cowan, Jill R. / Gonzales, Steve S. / Tidwell, Jeffrey H. / Andrews, Clarence W. / Stammers, David K. / Hazen, Richard J. / Ferris, Robert G. et al. | 2006
- 740
-
Wortmannin-C20 Conjugates Generate WortmanninYuan, Hushan / Luo, Ji / Weissleder, Ralph / Cantley, Lewis / Josephson, Lee et al. | 2006
- 748
-
Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic AcidsSalem, Ola I. A. / Frotscher, Martin / Scherer, Christiane / Neugebauer, Alexander / Biemel, Klaus / Streiber, Martina / Maas, Ruth / Hartmann, Rolf W. et al. | 2006
- 748
-
Novel 5alpha-Reductase Inhibitors: Synthesis, Structure-Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic AcidsSalem, O. I. A. / Frotscher, M. / Scherer, C. / Neugebauer, A. / Biemel, K. / Streiber, M. / Maas, R. / Hartmann, R. W. et al. | 2006
- 748
-
Novel 5a-Reductase Inhibitors: Synthesis, Structure-Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic AcidsSalem, O.I.A. et al. | 2006
- 760
-
Dopamine-Serotonin Receptor Ligands. 10:1 SAR Studies on Azecine-type Dopamine Receptor Ligands by Functional Screening at Human Cloned D1, D2L, and D5 Receptors with a Microplate Reader Based Calcium Assay Lead to a Novel Potent D1-D5 Selective AntagonistHoefgen, B. et al. | 2006
- 760
-
Dopamine/Serotonin Receptor Ligands. 10: SAR Studies on Azecine-type Dopamine Receptor Ligands by Functional Screening at Human Cloned D1, D2L, and D5 Receptors with a Microplate Reader Based Calcium Assay Lead to a Novel Potent D1/D5 Selective AntagonistHoefgen, Barbara / Decker, Michael / Mohr, Patrick / Schramm, Astrid M. / Rostom, Sherif A. F. / El-Subbagh, Hussein / Schweikert, Peter M. / Rudolf, Dirk R. / Kassack, Matthias U. / Lehmann, Jochen et al. | 2006
- 770
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Prodrug Forms of N-[(4-Deoxy-4-amino-10-methyl)-pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a Potent Inhibitor of Folylpoly-gamma-glutamate Synthetase: Synthesis and Hydrolytic StabilityFeng, Y. / Coward, J. K. et al. | 2006
- 770
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Prodrug Forms of N-[(4-Deoxy-4-amino-10-methyl)pteroyl]glutamate-γ-[ψP(O)(OH)]-glutarate, a Potent Inhibitor of Folylpoly-γ-glutamate Synthetase: Synthesis and Hydrolytic StabilityFeng, Yan / Coward, James K. et al. | 2006
- 789
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Synthesis and Biological Evaluation of Novel Phenylcarbazoles as Potential Anticancer AgentsRoutier, Sylvain / Mérour, Jean-Yves / Dias, Nathalie / Lansiaux, Amélie / Bailly, Christian / Lozach, Olivier / Meijer, Laurent et al. | 2006
- 800
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Aromatic Sulfide Inhibitors of Histone Deacetylase Based on Arylsulfiny1-2,4-hexadienoic Acid HydroxyamidesMarson, C. M. / Savy, P. / Rioja, A. S. / Mahadevan, T. / Mikol, C. / Veerupillai, A. / Nsubuga, E. / Chahwan, A. / Joel, S. P. et al. | 2006
- 800
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Aromatic Sulfide Inhibitors of Histone Deacetylase Based on Arylsulfinyl-2,4-hexadienoic Acid HydroxyamidesMarson, Charles M. / Savy, Pascal / Rioja, Alphonso S. / Mahadevan, Thevaki / Mikol, Catherine / Veerupillai, Arthi / Nsubuga, Eva / Chahwan, Angela / Joel, Simon P. et al. | 2006
- 806
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Synthesis and in Vitro Antileukemic Activity of Some New 1,3-(Oxytetraethylenoxy)cyclotriphosphazene Derivatives §Siwy, Mariola / Sȩk, Danuta / Kaczmarczyk, Bożena / Jaroszewicz, Iwona / Nasulewicz, Anna / Pelczyñska, Marzena / Nevozhay, Dmitry / Opolski, Adam et al. | 2006
- 811
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Correlation of Antifungal Activity with Fungal Phospholipase Inhibition Using a Series of Bisquaternary Ammonium SaltsNg, Clarissa K. L. / Obando, Daniel / Widmer, Fred / Wright, Lesley C. / Sorrell, Tania C. / Jolliffe, Katrina A. et al. | 2006
- 817
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Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90Biamonte, Marco A. / Shi, Jiandong / Hong, Kevin / Hurst, David C. / Zhang, Lin / Fan, Junhua / Busch, David J. / Karjian, Patricia L. / Maldonado, Angelica A. / Sensintaffar, John L. et al. | 2006
- 829
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Synthesis and in Vitro Antitumor Activity of Platinum Acetonimine ComplexesBoccarelli, Angelina / Intini, Francesco P. / Sasanelli, Rossella / Sivo, Maria F. / Coluccia, Mauro / Natile, Giovanni et al. | 2006
- 838
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Frontiers in Drug Design and Discovery. Volume 1. Edited by Gary W. Caldwell, Atta-ur-Rahman, and Barry A. Springer. Bentham Science Publishers Ltd., Hilversum, The Netherlands. 2005. vi + 360 pp. 18 × 25 cm. ISBN 90-77527-03-06. $130.00.Wolff, Manfred E. et al. | 2006
- 838
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Frontiers in Drug Design and Discovery. Volume 1Wolff, M. E. et al. | 2006
- 838
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Named Organic Reactions. Second Edition By Thomas Laue and Andreas Plagens. Wiley & Sons, Ltd., Chichester, England. 2005. x + 310 pp. 15 × 23 cm. ISBN 0-470-01041. $55.00.Griffith, Robert K. et al. | 2006
- 838
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Named Organic Reactions. Second Edition. By Thomas Laue and Andreas PlagensGriffith, R. K. et al. | 2006