A Small-Molecule Inhibitor of Nipah Virus Envelope Protein-Mediated Membrane Fusion (English)
- New search for: Niedermeier, S.
- New search for: Singethan, K.
- New search for: Rohrer, S.G.
- New search for: Matz, M.
- New search for: Kossner, M.
- New search for: Diederich, S.
- New search for: Maisner, A.
- New search for: Schmitz, J.
- New search for: Hiltensperger, G.
- New search for: Baumann, K.
- New search for: Niedermeier, S.
- New search for: Singethan, K.
- New search for: Rohrer, S.G.
- New search for: Matz, M.
- New search for: Kossner, M.
- New search for: Diederich, S.
- New search for: Maisner, A.
- New search for: Schmitz, J.
- New search for: Hiltensperger, G.
- New search for: Baumann, K.
In:
JOURNAL OF MEDICINAL CHEMISTRY
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52
, 14
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4257-4265
;
2009
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ISSN:
- Article (Journal) / Print
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Title:A Small-Molecule Inhibitor of Nipah Virus Envelope Protein-Mediated Membrane Fusion
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Contributors:Niedermeier, S. ( author ) / Singethan, K. ( author ) / Rohrer, S.G. ( author ) / Matz, M. ( author ) / Kossner, M. ( author ) / Diederich, S. ( author ) / Maisner, A. ( author ) / Schmitz, J. ( author ) / Hiltensperger, G. ( author ) / Baumann, K. ( author )
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Published in:JOURNAL OF MEDICINAL CHEMISTRY ; 52, 14 ; 4257-4265
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Publisher:
- New search for: ACS AMERICAN CHEMICAL SOCIETY
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Publication date:2009-01-01
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Size:9 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 615
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 52, Issue 14
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4073
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The pK BHX Database: Toward a Better Understanding of Hydrogen-Bond Basicity for Medicinal ChemistsLaurence, Christian / Brameld, Ken A. / Graton, Jérôme / Le Questel, Jean-Yves / Renault, Eric et al. | 2009
- 4087
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Virtual Screening Approach for the Identification of New Rac1 InhibitorsFerri, Nicola / Corsini, Alberto / Bottino, Paolo / Clerici, Francesca / Contini, Alessandro et al. | 2009
- 4091
-
Identification of an Orally Active Opioid Receptor-like 1 (ORL1) Receptor Antagonist 4-{3-[(2R)-2,3-Dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1′-cyclopropan]-3-ylmethyl]piperidine as Clinical CandidateSatoh, Atsushi / Sagara, Takeshi / Sakoh, Hiroki / Hashimoto, Masaya / Nakashima, Hiroshi / Kato, Tetsuya / Goto, Yasuhiro / Mizutani, Sayaka / Azuma-Kanoh, Tomoko / Tani, Takeshi et al. | 2009
- 4095
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Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s TherapyZheng, Hailin / Youdim, Moussa B. H. / Fridkin, Mati et al. | 2009
- 4099
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Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA PolymeraseVandyck, Koen / Cummings, Maxwell D. / Nyanguile, Origène / Boutton, Carlo W. / Vendeville, Sandrine / McGowan, David / Devogelaere, Benoit / Amssoms, Katie / Last, Stefaan / Rombauts, Klara et al. | 2009
- 4103
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Discovery of Molecular Switches That Modulate Modes of Metabotropic Glutamate Receptor Subtype 5 (mGlu5) Pharmacology in Vitro and in Vivo within a Series of Functionalized, Regioisomeric 2- and 5-(Phenylethynyl)pyrimidinesSharma, Sameer / Kedrowski, Jeffrey / Rook, Jerri M. / Smith, Randy L. / Jones, Carrie K. / Rodriguez, Alice L. / Conn, P. Jeffrey / Lindsley, Craig W. et al. | 2009
- 4107
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Trisulfonated Porphyrazines: New Photosensitizers for the Treatment of Retinal and Subretinal Edemavan Lier, Johan E. / Tian, Hongjian / Ali, Hasrat / Cauchon, Nicole / Hasséssian, Haroutioun M. et al. | 2009
- 4111
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Synthesis and Biological Evaluation of a Novel 3-Sulfonyl-8-azabicyclo[3.2.1]octane Class of Long Chain Fatty Acid Elongase 6 (ELOVL6) InhibitorsNagase, Tsuyoshi / Takahashi, Toshiyuki / Sasaki, Takahide / Nagumo, Akira / Shimamura, Ken / Miyamoto, Yasuhisa / Kitazawa, Hidefumi / Kanesaka, Maki / Yoshimoto, Ryo / Aragane, Katsumi et al. | 2009
- 4115
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Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)Engers, Darren W. / Niswender, Colleen M. / Weaver, C. David / Jadhav, Satyawan / Menon, Usha N. / Zamorano, Rocio / Conn, P. Jeffrey / Lindsley, Craig W. / Hopkins, Corey R. et al. | 2009
- 4119
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The Immobilization of Gossypol Derivative on N-Polyvinylpyrrolidone Increases its Water Solubility and Modifies Membrane-Active PropertiesIonov, Maksim / Gordiyenko, Nataliya / Olchowik, Ewa / Baram, Nina / Zijaev, Khairulla / Salakhutdinov, Bakhtiyar / Bryszewska, Maria / Zamaraeva, Maria et al. | 2009
- 4126
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Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either alpha 4 beta 2 or alpha 7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype SelectivityBunnelle, W.H. / Tietje, K.R. / Frost, J.M. / Peters, D. / Ji, J. / Li, T. / Scanio, M.J.C. / Shi, L. / Anderson, D.J. / Dyhring, T. et al. | 2009
- 4126
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Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either α4β2 or α7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype SelectivityBunnelle, William H. / Tietje, Karin R. / Frost, Jennifer M. / Peters, Dan / Ji, Jianguo / Li, Tao / Scanio, Marc J. C. / Shi, Lei / Anderson, David J. / Dyhring, Tino et al. | 2009
- 4142
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The First Bioreversible Prodrug of Metformin with Improved Lipophilicity and Enhanced Intestinal AbsorptionHuttunen, Kristiina M. / Mannila, Anne / Laine, Krista / Kemppainen, Eeva / Leppänen, Jukka / Vepsäläinen, Jouko / Järvinen, Tomi / Rautio, Jarkko et al. | 2009
- 4149
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Na+ Currents in Cardioprotection: Better to Be LateLe Grand, Bruno / Pignier, Christophe / Létienne, Robert / Colpaert, Francis / Cuisiat, Florence / Rolland, Françoise / Mas, Agnes / Borras, Maud / Vacher, Bernard et al. | 2009
- 4161
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In Vitro Intrinsic Clearance-Based Optimization of N 3-Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF1) Receptor AntagonistsHartz, Richard A. / Ahuja, Vijay T. / Rafalski, Maria / Schmitz, William D. / Brenner, Allison B. / Denhart, Derek J. / Ditta, Jonathan L. / Deskus, Jeffrey A. / Yue, Eddy W. / Arvanitis, Argyrios G. et al. | 2009
- 4173
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Synthesis, Structure−Activity Relationships, and In Vivo Evaluation of N 3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor AntagonistsHartz, Richard A. / Ahuja, Vijay T. / Arvanitis, Argyrios G. / Rafalski, Maria / Yue, Eddy W. / Denhart, Derek J. / Schmitz, William D. / Ditta, Jonathan L. / Deskus, Jeffrey A. / Brenner, Allison B. et al. | 2009
- 4192
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Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship (SAR) Discussion of Dipeptidyl Boronate Proteasome Inhibitors, Part I: Comprehensive Understanding of the SAR of alpha -Amino Acid BoronatesZhu, Y. / Zhao, X. / Zhu, X. / Wu, G. / Li, Y. / Ma, Y. / Yuan, Y. / Yang, J. / Hu, Y. / Ai, L. et al. | 2009
- 4192
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Design, Synthesis, Biological Evaluation, and Structure−Activity Relationship (SAR) Discussion of Dipeptidyl Boronate Proteasome Inhibitors, Part I: Comprehensive Understanding of the SAR of α-Amino Acid BoronatesZhu, Yongqiang / Zhao, Xin / Zhu, Xinrong / Wu, Gang / Li, Yuejie / Ma, Yuheng / Yuan, Yunxia / Yang, Jie / Hu, Yang / Ai, Li et al. | 2009
- 4200
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Novel Lead Structures for p38 MAP Kinase via FieldScreen Virtual ScreeningCheeseright, Timothy J. / Holm, Melanie / Lehmann, Frank / Luik, Sabine / Göttert, Marcia / Melville, James L. / Laufer, Stefan et al. | 2009
- 4210
-
Discovery of Geranylgeranyltransferase-I Inhibitors with Novel Scaffolds by the Means of Quantitative Structure−Activity Relationship Modeling, Virtual Screening, and Experimental ValidationPeterson, Yuri K. / Wang, Xiang S. / Casey, Patrick J. / Tropsha, Alexander et al. | 2009
- 4221
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Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer ActivityChiang, Yi-Kun / Kuo, Ching-Chuan / Wu, Yu-Shan / Chen, Chung-Tong / Coumar, Mohane Selvaraj / Wu, Jian-Sung / Hsieh, Hsing-Pang / Chang, Chi-Yen / Jseng, Huan-Yi / Wu, Ming-Hsine et al. | 2009
- 4234
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Structural Assessment and Biological Evaluation of Two N3S Bombesin DerivativesGourni, Eleni / Bouziotis, Penelope / Benaki, Dimitra / Loudos, George / Xanthopoulos, Stavros / Paravatou-Petsotas, Maria / Mavri-Vavagianni, Maria / Pelecanou, Maria / Archimandritis, Spyros C. / Varvarigou, Alexandra D. et al. | 2009
- 4247
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Inhibition of Influenza Virus Infections by Sialylgalactose-Binding Peptides Selected from a Phage LibraryMatsubara, Teruhiko / Sumi, Machiko / Kubota, Hiroyuki / Taki, Takao / Okahata, Yoshio / Sato, Toshinori et al. | 2009
- 4257
-
A Small-Molecule Inhibitor of Nipah Virus Envelope Protein-Mediated Membrane FusionNiedermeier, Sabine / Singethan, Katrin / Rohrer, Sebastian G. / Matz, Magnus / Kossner, Markus / Diederich, Sandra / Maisner, Andrea / Schmitz, Jens / Hiltensperger, Georg / Baumann, Knut et al. | 2009
- 4266
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Side Chain Flexibilities in the Human Ether-a-go-go Related Gene Potassium Channel (hERG) Together with Matched-Pair Binding Studies Suggest a New Binding Mode for Channel BlockersZachariae, Ulrich / Giordanetto, Fabrizio / Leach, Andrew G. et al. | 2009
- 4277
-
Structure−Activity Relationships and Cancer-Cell Selective Toxicity of Novel Inhibitors of Glioma-Associated Oncogene Homologue 1 (Gli1) Mediated TranscriptionMahindroo, Neeraj / Connelly, Michele C. / Punchihewa, Chandanamali / Kimura, Hiromichi / Smeltzer, Matthew P. / Wu, Song / Fujii, Naoaki et al. | 2009
- 4288
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Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor AgentsHuang, Kenneth H. / Veal, James M. / Fadden, R. Patrick / Rice, John W. / Eaves, Jeron / Strachan, Jon-Paul / Barabasz, Amy F. / Foley, Briana E. / Barta, Thomas E. / Ma, Wei et al. | 2009
- 4306
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Conjugation of 2-(1′-Hexyloxyethyl)-2-devinylpyropheophorbide-a (HPPH) to Carbohydrates Changes its Subcellular Distribution and Enhances Photodynamic Activity in VivoZheng, Xiang / Morgan, Janet / Pandey, Suresh K. / Chen, Yihui / Tracy, Erin / Baumann, Heinz / Missert, Joseph R. / Batt, Carrie / Jackson, Jennifer / Bellnier, David A. et al. | 2009
- 4319
-
Is Glutathione the Major Cellular Target of Cisplatin? A Study of the Interactions of Cisplatin with Cancer Cell ExtractsKasherman, Yonit / Sturup, Stefan / Gibson, Dan et al. | 2009
- 4329
-
Chemical and Biological Investigation of Cyclopropyl Containing Diaryl-pyrazole-3-carboxamides as Novel and Potent Cannabinoid Type 1 Receptor AntagonistsSzabó, György / Varga, Balázs / Páyer-Lengyel, Dóra / Szemző, Attila / Erdélyi, Péter / Vukics, Krisztina / Szikra, Judit / Hegyi, Éva / Vastag, Mónika / Kiss, Béla et al. | 2009
- 4338
-
The Role of Amphiphilicity and Negative Charge in Glycoprotein 41 Interactions in the Hydrophobic PocketGochin, Miriam / Cai, Lifeng et al. | 2009
- 4345
-
Synthesis, Binding, and Modeling Studies of New Cytisine Derivatives, as Ligands for Neuronal Nicotinic Acetylcholine Receptor SubtypesTasso, Bruno / Canu Boido, Caterina / Terranova, Emanuela / Gotti, Cecilia / Riganti, Loredana / Clementi, Francesco / Artali, Roberto / Bombieri, Gabriella / Meneghetti, Fiorella / Sparatore, Fabio et al. | 2009
- 4358
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Potential Neuroprotective Drugs in Cerebral Ischemia: New Saturated and Polyunsaturated Lipids Coupled to Hydrophilic Moieties: Synthesis and Biological ActivityBiraboneye, Alain César / Madonna, Sébastien / Laras, Younes / Krantic, Slavica / Maher, Pamela / Kraus, Jean-Louis et al. | 2009
- 4370
-
Novel Small Molecule Bradykinin B2 Receptor AntagonistsGibson, Christoph / Schnatbaum, Karsten / Pfeifer, Jochen R. / Locardi, Elsa / Paschke, Matthias / Reimer, Ulf / Richter, Uwe / Scharn, Dirk / Faussner, Alexander / Tradler, Thomas et al. | 2009
- 4380
-
Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity RelationshipsErmoli, Antonella / Bargiotti, Alberto / Brasca, Maria Gabriella / Ciavolella, Antonella / Colombo, Nicoletta / Fachin, Gabriele / Isacchi, Antonella / Menichincheri, Maria / Molinari, Antonio / Montagnoli, Alessia et al. | 2009
- 4391
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Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial TherapeuticsKeough, Dianne T. / Hocková, Dana / Holý, Antonín / Naesens, Lieve M. J. / Skinner-Adams, Tina S. / Jersey, John de / Guddat, Luke W. et al. | 2009
- 4400
-
Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)Tremblay, Martin R. / Lescarbeau, André / Grogan, Michael J. / Tan, Eddy / Lin, Grace / Austad, Brian C. / Yu, Lin-Chen / Behnke, Mark L. / Nair, Somarajan J. / Hagel, Margit et al. | 2009
- 4419
-
Identification of Peptide Substrate and Small Molecule Inhibitors of Testis-Specific Serine/Threonine Kinase1 (TSSK1) By the Developed AssaysZhang, Leilei / Yan, Yu / Liu, Zijie / Abliz, Zeper / Liu, Gang et al. | 2009
- 4419
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Identification of Peptide Substrate and Small Molecule Inhibitors of Testis-Specific Serine/Threonine Kinasel (TSSK1) By the Developed AssaysZhang, L. / Yan, Y. / Liu, Z. / Abliz, Z. / Liu, G. et al. | 2009
- 4429
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Definition of the G Protein-Coupled Receptor Transmembrane Bundle Binding Pocket and Calculation of Receptor Similarities for Drug DesignGloriam, David E. / Foord, Steven M. / Blaney, Frank E. / Garland, Stephen L. et al. | 2009
- 4443
-
Discovery of a Peroxisome Proliferator Activated Receptor γ (PPARγ) Modulator with Balanced PPARα Activity for the Treatment of Type 2 Diabetes and DyslipidemiaLiu, Weiguo / Liu, Kun / Wood, Harold B. / McCann, Margaret E. / Doebber, Thomas W. / Chang, Ching H. / Akiyama, Taro E. / Einstein, Monica / Berger, Joel P. / Meinke, Peter T. et al. | 2009
- 4443
-
Discovery of a Peroxisome Proliferator Activated Receptor gamma (PPAR gamma ) Modulator with Balanced PPAR alpha Activity for the Treatment of Type 2 Diabetes and DyslipidemiaLiu, W. / Liu, K. / Wood, H.B. / McCann, M.E. / Doebber, T.W. / Chang, C.H. / Akiyama, T.E. / Einstein, M. / Berger, J.P. / Meinke, P.T. et al. | 2009
- 4454
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One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment His Discovered by Virtual ScreeningMpamhanga, C.P. / Spinks, D. / Tulloch, L.B. / Shanks, E.J. / Robinson, D.A. / Collie, I.T. / Fairlamb, A.H. / Wyatt, P.G. / Frearson, J.A. / Hunter, W.N. et al. | 2009
- 4454
-
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual ScreeningMpamhanga, Chidochangu P. / Spinks, Daniel / Tulloch, Lindsay B. / Shanks, Emma J. / Robinson, David A. / Collie, Iain T. / Fairlamb, Alan H. / Wyatt, Paul G. / Frearson, Julie A. / Hunter, William N. et al. | 2009
- 4466
-
Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)Roth, Gerald J. / Heckel, Armin / Colbatzky, Florian / Handschuh, Sandra / Kley, Jörg / Lehmann-Lintz, Thorsten / Lotz, Ralf / Tontsch-Grunt, Ulrike / Walter, Rainer / Hilberg, Frank et al. | 2009
- 4481
-
Heterobiaryl Human Immunodeficiency Virus Entry InhibitorsLu, Rong-Jian / Tucker, John A. / Pickens, Jason / Ma, You-An / Zinevitch, Tatiana / Kirichenko, Olga / Konoplev, Vitalii / Kuznetsova, Svetlana / Sviridov, Sergey / Brahmachary, Enugurthi et al. | 2009
- 4488
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In Silico Prediction of Volume of Distribution in Human Using Linear and Nonlinear Models on a 669 Compound Data SetBerellini, Giuliano / Springer, Clayton / Waters, Nigel J. / Lombardo, Franco et al. | 2009
- 4496
-
Discovery of 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an Active Metabolite. A Novel, Potent and Selective Cannabinoid-1 Receptor Inverse Agonist with High Antiobesity Efficacy in DIO MiceWu, Chien-Huang / Hung, Ming-Shiu / Song, Jen-Shin / Yeh, Teng-Kuang / Chou, Ming-Chen / Chu, Cheng-Ming / Jan, Jiing-Jyh / Hsieh, Min-Tsang / Tseng, Shi-Liang / Chang, Chun-Ping et al. | 2009
- 4511
-
Apogossypol Derivatives as Pan-Active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family ProteinsWei, Jun / Kitada, Shinichi / Rega, Michele F. / Stebbins, John L. / Zhai, Dayong / Cellitti, Jason / Yuan, Hongbin / Emdadi, Aras / Dahl, Russell / Zhang, Ziming et al. | 2009
- 4524
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Synthesis and Preclinical Evaluation of Novel PET Probes for P-Glycoprotein Function and Expressionvan Waarde, Aren / Ramakrishnan, Nisha K. / Rybczynska, Anna A. / Elsinga, Philip H. / Berardi, Francesco / de Jong, Johan R. / Kwizera, Chantal / Perrone, Roberto / Cantore, Mariangela / Sijbesma, Jurgen W. A. et al. | 2009
- 4533
-
L337H Mutant of Rat Neuronal Nitric Oxide Synthase Resembles Human Neuronal Nitric Oxide Synthase toward InhibitorsFang, Jianguo / Ji, Haitao / Lawton, Graham R. / Xue, Fengtian / Roman, Linda J. / Silverman, Richard B. et al. | 2009
- 4538
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Isocombretastatins A versus Combretastatins A: The Forgotten isoCA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin AgentMessaoudi, Samir / Tréguier, Bret / Hamze, Abdallah / Provot, Olivier / Peyrat, Jean-François / De Losada, Jordi Rodrigo / Liu, Jian-Miao / Bignon, Jérôme / Wdzieczak-Bakala, Joanna / Thoret, Sylviane et al. | 2009
- 4543
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Allosteric Modulators of the Adenosine A1 Receptor: Synthesis and Pharmacological Evaluation of 4-Substituted 2-Amino-3-benzoylthiophenesAurelio, Luigi / Valant, Celine / Flynn, Bernard L. / Sexton, Patrick M. / Christopoulos, Arthur / Scammells, Peter J. et al. | 2009
- 4548
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Book Review of The Cannabinoid ReceptorsPatrick, Kennerly S. et al. | 2009
- 4548
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Theilheimer’s Synthetic Methods of Organic Chemistry. Volume 73Vennerstrom, Jonathan L. et al. | 2009
- 4549
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Corrections to Large-Scale Application of High-Throughput Molecular Mechanics with Poisson−Boltzmann Surface Area for Routine Physics-Based Scoring of Protein−Ligand ComplexesBrown, Scott P. / Muchmore, Steven W. et al. | 2009
- 4549
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Corrections to Rational Modification of a Candidate Cancer Drug for Use against Chagas DiseaseKraus, James M. / Verlinde, Christophe L. M. J. / Karimi, Mandana / Lepesheva, Galina I. / Gelb, Michael H. / Buckner, Frederick S. et al. | 2009