Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (A51940477), a Potent p38 MAP Kinase Inhibitor (English)
- New search for: Asano, T.
- New search for: Yamazaki, H.
- New search for: Kasahara, C.
- New search for: Kubota, H.
- New search for: Kontani, T.
- New search for: Harayama, Y.
- New search for: Ohno, K.
- New search for: Mizuhara, H.
- New search for: Yokomoto, M.
- New search for: Misumi, K.
- New search for: Asano, T.
- New search for: Yamazaki, H.
- New search for: Kasahara, C.
- New search for: Kubota, H.
- New search for: Kontani, T.
- New search for: Harayama, Y.
- New search for: Ohno, K.
- New search for: Mizuhara, H.
- New search for: Yokomoto, M.
- New search for: Misumi, K.
In:
JOURNAL OF MEDICINAL CHEMISTRY
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55
, 17
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7772-7785
;
2012
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ISSN:
- Article (Journal) / Print
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Title:Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (A51940477), a Potent p38 MAP Kinase Inhibitor
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Contributors:Asano, T. ( author ) / Yamazaki, H. ( author ) / Kasahara, C. ( author ) / Kubota, H. ( author ) / Kontani, T. ( author ) / Harayama, Y. ( author ) / Ohno, K. ( author ) / Mizuhara, H. ( author ) / Yokomoto, M. ( author ) / Misumi, K. ( author )
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Published in:JOURNAL OF MEDICINAL CHEMISTRY ; 55, 17 ; 7772-7785
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Publisher:
- New search for: ACS AMERICAN CHEMICAL SOCIETY
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Publication date:2012-01-01
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Size:14 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 615
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 55, Issue 17
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 7299
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Current Landscape of Phosphodiesterase 10A (PDE10A) InhibitionChappie, Thomas A. / Helal, Christopher J. / Hou, Xinjun et al. | 2012
- 7332
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Conformation-Specific Effects of Raf Kinase InhibitorsWang, Xiaolun / Kim, Joseph et al. | 2012
- 7342
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Scaling the Druggability Landscape of Human Bromodomains, a New Class of Drug TargetsZhang, Guangtao / Sanchez, Roberto / Zhou, Ming-Ming et al. | 2012
- 7346
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Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding SitesVidler, Lewis R. / Brown, Nathan / Knapp, Stefan / Hoelder, Swen et al. | 2012
- 7360
-
Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene‑6H‑dibenz[b,e]azepin-6-one SkeletonAoyama, Atsushi / Endo-Umeda, Kaori / Kishida, Kenji / Ohgane, Kenji / Noguchi-Yachide, Tomomi / Aoyama, Hiroshi / Ishikawa, Minoru / Miyachi, Hiroyuki / Makishima, Makoto / Hashimoto, Yuichi et al. | 2012
- 7378
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Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1Hazeldine, Stuart / Pachaiyappan, Boobalan / Steinbergs, Nora / Nowotarski, Shannon / Hanson, Allison S. / Casero, Robert A. / Woster, Patrick M. et al. | 2012
- 7392
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Development of o‑Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase InhibitorsLawrence, Harshani R. / Martin, Mathew P. / Luo, Yunting / Pireddu, Roberta / Yang, Hua / Gevariya, Harsukh / Ozcan, Sevil / Zhu, Jin-Yi / Kendig, Robert / Rodriguez, Mercedes et al. | 2012
- 7417
-
Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment LibraryBrožič, Petra / Turk, Samo / Adeniji, Adegoke O. / Konc, Janez / Janežič, Dušanka / Penning, Trevor M. / Lanišnik Rižner, Tea / Gobec, Stanislav et al. | 2012
- 7425
-
Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate DehydrogenaseMarwaha, Alka / White, John / El_Mazouni, Farah / Creason, Sharon A / Kokkonda, Sreekanth / Buckner, Frederick S. / Charman, Susan A. / Phillips, Margaret A. / Rathod, Pradipsinh K. et al. | 2012
- 7437
-
An Aromatic Region To Induce a Switch between Agonism and Inverse Agonism at the Ghrelin ReceptorEls, Sylvia / Schild, Enrico / Petersen, Pia Steen / Kilian, Tom-Marten / Mokrosinski, Jacek / Frimurer, Thomas M. / Chollet, Constance / Schwartz, Thue W. / Holst, Birgitte / Beck-Sickinger, Annette G. et al. | 2012
- 7450
-
Design, Synthesis, and Evaluation of pH-Dependent Hydrolyzable Emetine Analogues as Treatment for Prostate CancerAkinboye, Emmanuel S. / Rosen, Marc D. / Denmeade, Samuel R. / Kwabi-Addo, Bernard / Bakare, Oladapo et al. | 2012
- 7450
-
Design, Synthesis, and Evaluation of pH-Dependent Hydrolyzable Emeting Analogues as Treatment for Prostate CancerAkinboye, E.S. / Rosen, M.D. / Denmeade, S.R. / Kwabi-Addo, B. / Bakare, O. et al. | 2012
- 7460
-
Stabilization and Structural Alteration of the G‑Quadruplex DNA Made from the Human Telomeric Repeat Mediated by Tröger’s Base Based Novel Benzimidazole DerivativesPaul, Ananya / Maji, Basudeb / Misra, Santosh K. / Jain, Akash K. / Muniyappa, K. / Bhattacharya, Santanu et al. | 2012
- 7460
-
Stabilization and Structural Alteration of the G-Quadruplex DNA Made from the Human Telomeric Repeat Mediated by Troger's Base Based Novel Benzimidazole DerivativesPaul, A. / Maji, B. / Misra, S.K. / Jain, A.K. / Muniyappa, K. / Bhattacharya, S. et al. | 2012
- 7472
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Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical CandidatePress, Neil J. / Taylor, Roger J. / Fullerton, Joseph D. / Tranter, Pamela / McCarthy, Clive / Keller, Thomas H. / Arnold, Nicola / Beer, David / Brown, Lyndon / Cheung, Robert et al. | 2012
- 7480
-
Discovery of (2S)‑1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]‑9H‑purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 InhibitorKim, Se-Ho / Bajji, Ashok / Tangallapally, Rajendra / Markovitz, Benjamin / Trovato, Richard / Shenderovich, Mark / Baichwal, Vijay / Bartel, Paul / Cimbora, Daniel / McKinnon, Rena et al. | 2012
- 7502
-
Development of Novel Bisphosphonate Prodrugs of Doxorubicin for Targeting Bone Metastases That Are Cleaved pH Dependently or by Cathepsin B: Synthesis, Cleavage Properties, and Binding Properties to Hydroxyapatite As Well As Bone MatrixHochdörffer, Katrin / Abu Ajaj, Khalid / Schäfer-Obodozie, Cynthia / Kratz, Felix et al. | 2012
- 7516
-
Rational Design of a Low Molecular Weight, Stable, Potent, and Long-Lasting GRP103 Aza- beta ^3-pseudopeptide AgonistNeveu, C. / Lefranc, B. / Tasseau, O. / Do-Rego, J.-C. / Bourmaud, A. / Chan, P. / Bauchat, P. / Le Marec, O. / Chuquet, J. / Guilhaudis, L. et al. | 2012
- 7516
-
Rational Design of a Low Molecular Weight, Stable, Potent, and Long-Lasting GPR103 Aza‑β3‑pseudopeptide AgonistNeveu, Cindy / Lefranc, Benjamin / Tasseau, Olivier / Do-Rego, Jean-Claude / Bourmaud, Adèle / Chan, Philippe / Bauchat, Patrick / Marec, Olivier Le / Chuquet, Julien / Guilhaudis, Laure et al. | 2012
- 7525
-
Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 InhibitorsKümmerle, Arthur E. / Schmitt, Martine / Cardozo, Suzana V. S. / Lugnier, Claire / Villa, Pascal / Lopes, Alexandra B. / Romeiro, Nelilma C. / Justiniano, Hélène / Martins, Marco A. / Fraga, Carlos A. M. et al. | 2012
- 7546
-
Discovery of a Novel Noniminosugar Acid α Glucosidase Chaperone SeriesXiao, Jingbo / Westbroek, Wendy / Motabar, Omid / Lea, Wendy A. / Hu, Xin / Velayati, Arash / Zheng, Wei / Southall, Noel / Gustafson, Ann Marie / Goldin, Ehud et al. | 2012
- 7546
-
Discovery of a Novel Noniminosugar Acid alpha Glucosidase Chaperone SeriesXiao, J. / Westbroek, W. / Motabar, O. / Lea, W.A. / Hu, X. / Velayati, A. / Zheng, W. / Southall, N. / Gustafson, A.M. / Goldin, E. et al. | 2012
- 7560
-
Noncyclam Tetraamines Inhibit CXC Chemokine Receptor Type 4 and Target Glioma-Initiating CellsRos-Blanco, Laia / Anido, Judit / Bosser, Ramon / Esté, José / Clotet, Bonaventura / Kosoy, Ana / Ruíz-Ávila, Luis / Teixidó, Jordi / Seoane, Joan / Borrell, José I. et al. | 2012
- 7571
-
Tuning the Activity of Platinum(IV) Anticancer Complexes through Asymmetric AcylationChin, Chee Fei / Tian, Quan / Setyawati, Magdiel Inggrid / Fang, Wanru / Tan, Emelyn Sue Qing / Leong, David Tai / Ang, Wee Han et al. | 2012
- 7583
-
Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds to Treat Sickle Cell Disease Symptoms. Part II: Furoxan DerivativesDos Santos, Jean Leandro / Lanaro, Carolina / Chelucci, Rafael Consolin / Gambero, Sheley / Bosquesi, Priscila Longhin / Reis, Juliana Santana / Lima, Lídia Moreira / Cerecetto, Hugo / González, Mercedes / Costa, Fernando Ferreira et al. | 2012
- 7593
-
New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological EvaluationsDong, Guoqiang / Wang, Shengzheng / Miao, Zhenyuan / Yao, Jianzhong / Zhang, Yongqiang / Guo, Zizhao / Zhang, Wannian / Sheng, Chunquan et al. | 2012
- 7614
-
A New Class of Selective and Potent 7‑Dehydrocholesterol Reductase InhibitorsHorling, Aline / Müller, Christoph / Barthel, Richard / Bracher, Franz / Imming, Peter et al. | 2012
- 7623
-
Identification of a Promising Drug Candidate for the Treatment of Type 2 Diabetes Based on a P2Y1 Receptor AgonistYelovitch, Shir / Barr, Haim M. / Camden, Jean / Weisman, Gary A. / Shai, Ela / Varon, David / Fischer, Bilha et al. | 2012
- 7636
-
Novel beta -Amino Acid Derivatives as Inhibitors of Cathepsin ARuf, S. / Buning, C. / Schreuder, H. / Horstick, G. / Linz, W. / Olpp, T. / Pemerstorfer, J. / Hiss, K. / Kroll, K. / Kannt, A. et al. | 2012
- 7636
-
Novel β‑Amino Acid Derivatives as Inhibitors of Cathepsin ARuf, Sven / Buning, Christian / Schreuder, Herman / Horstick, Georg / Linz, Wolfgang / Olpp, Thomas / Pernerstorfer, Josef / Hiss, Katrin / Kroll, Katja / Kannt, Aimo et al. | 2012
- 7650
-
Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)Beaulieu, Pierre L. / Bös, Michael / Cordingley, Michael G. / Chabot, Catherine / Fazal, Gulrez / Garneau, Michel / Gillard, James R. / Jolicoeur, Eric / LaPlante, Steven / McKercher, Ginette et al. | 2012
- 7667
-
Discovery and in Vivo Evaluation of Dual PI3K beta / delta Inhibitorsde Turiso, F.G.-L. / Shin, Y. / Brown, M. / Cardozo, M. / Chen, Y. / Fong, D. / Hao, X. / He, X. / Henne, K. / Hu, Y.-L. et al. | 2012
- 7667
-
Discovery and in Vivo Evaluation of Dual PI3Kβ/δ InhibitorsGonzalez-Lopez de Turiso, Felix / Shin, Youngsook / Brown, Matthew / Cardozo, Mario / Chen, Yi / Fong, David / Hao, Xiaolin / He, Xiao / Henne, Kirk / Hu, Yi-Ling et al. | 2012
- 7686
-
Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase DeltaMurray, Jeremy M. / Sweeney, Zachary K. / Chan, Bryan K. / Balazs, Mercedesz / Bradley, Erin / Castanedo, Georgette / Chabot, Christine / Chantry, David / Flagella, Michael / Goldstein, David M. et al. | 2012
- 7696
-
Design and Characterization of a Selenium-Containing Inhibitor of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa), a Zinc-Containing MetalloproteaseYoshimoto, Nobuko / Sasaki, Tomoyuki / Sugimoto, Katsuyoshi / Ishii, Hidemi / Yamamoto, Keiko et al. | 2012
- 7706
-
Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual ScreeningAndersson, C. David / Karlberg, Tobias / Ekblad, Torun / Lindgren, Anders E. G. / Thorsell, Ann-Gerd / Spjut, Sara / Uciechowska, Urszula / Niemiec, Moritz S. / Wittung-Stafshede, Pernilla / Weigelt, Johan et al. | 2012
- 7719
-
Synthesis and Biological Evaluation of 2‑Amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5‑Modification on Allosteric Enhancer Activity at the A1 Adenosine ReceptorRomagnoli, Romeo / Baraldi, Pier Giovanni / Carrion, Maria Dora / Cara, Carlota Lopez / Cruz-Lopez, Olga / Salvador, Maria Kimatrai / Preti, Delia / Tabrizi, Mojgan Aghazadeh / Moorman, Allan R. / Vincenzi, Fabrizio et al. | 2012
- 7736
-
Structure–Activity Studies of RFamide-Related Peptide‑1 Identify a Functional Receptor Antagonist and Novel Cardiac Myocyte Signaling Pathway Involved in Contractile PerformanceNichols, Ruthann / Bass, Chloe / Demers, Leslie / Larsen, Brian / Li, Elton / Blewett, Nathan / Converso-Baran, Kimber / Russell, Mark W. / Westfall, Margaret V. et al. | 2012
- 7746
-
3‑(3,4-Dihydroisoquinolin-2(1H)‑ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-β-Hydroxysteroid Dehydrogenase AKR1C3Jamieson, Stephen M. F. / Brooke, Darby G. / Heinrich, Daniel / Atwell, Graham J. / Silva, Shevan / Hamilton, Emma J. / Turnbull, Andrew P. / Rigoreau, Laurent J. M. / Trivier, Elisabeth / Soudy, Christelle et al. | 2012
- 7746
-
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17- beta -Hydroxysteroid Dehydrogenase AKR1C3Jamieson, S.M.F. / Brooke, D.G. / Heinrich, D. / Atwell, G.J. / Silva, S. / Hamilton, E.J. / Tumbull, A.P. / Rigoreau, L.J.M. / Trivier, E. / Soudy, C. et al. | 2012
- 7759
-
Selective and Potent Urea Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate DehydrogenaseGorla, Suresh Kumar / Kavitha, Mandapati / Zhang, Minjia / Liu, Xiaoping / Sharling, Lisa / Gollapalli, Deviprasad R. / Striepen, Boris / Hedstrom, Lizbeth / Cuny, Gregory D. et al. | 2012
- 7772
-
Identification, Synthesis, and Biological Evaluation of 6‑[(6R)‑2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5‑a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)‑one (AS1940477), a Potent p38 MAP Kinase InhibitorAsano, Toru / Yamazaki, Hitoshi / Kasahara, Chiyoshi / Kubota, Hirokazu / Kontani, Toru / Harayama, Yu / Ohno, Kazuki / Mizuhara, Hidekazu / Yokomoto, Masaharu / Misumi, Keiji et al. | 2012
- 7772
-
Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (A51940477), a Potent p38 MAP Kinase InhibitorAsano, T. / Yamazaki, H. / Kasahara, C. / Kubota, H. / Kontani, T. / Harayama, Y. / Ohno, K. / Mizuhara, H. / Yokomoto, M. / Misumi, K. et al. | 2012
- 7786
-
EC144 Is a Potent Inhibitor of the Heat Shock Protein 90Shi, Jiandong / Van de Water, Ryan / Hong, Kevin / Lamer, Ryan B. / Weichert, Kenneth W. / Sandoval, Cristina M. / Kasibhatla, Srinivas R. / Boehm, Marcus F. / Chao, Jianhua / Lundgren, Karen et al. | 2012
- 7796
-
Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511Norman, Mark H. / Andrews, Kristin L. / Bo, Yunxin Y. / Booker, Shon K. / Caenepeel, Sean / Cee, Victor J. / D’Angelo, Noel D. / Freeman, Daniel J. / Herberich, Bradley J. / Hong, Fang-Tsao et al. | 2012
- 7817
-
Synthesis, Aqueous Reactivity, and Biological Evaluation of Carboxylic Acid Ester-Functionalized Platinum–Acridine Hybrid Anticancer AgentsGraham, Leigh A. / Suryadi, Jimmy / West, Tiffany K. / Kucera, Gregory L. / Bierbach, Ulrich et al. | 2012
- 7828
-
Discovery of Tofogliflozin, a Novel C‑Arylglucoside with an O‑Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 DiabetesOhtake, Yoshihito / Sato, Tsutomu / Kobayashi, Takamitsu / Nishimoto, Masahiro / Taka, Naoki / Takano, Koji / Yamamoto, Keisuke / Ohmori, Masayuki / Yamaguchi, Marina / Takami, Kyoko et al. | 2012
- 7841
-
Crystal Structure of Human Aurora B in Complex with INCENP and VX-680Elkins, Jonathan M. / Santaguida, Stefano / Musacchio, Andrea / Knapp, Stefan et al. | 2012
- 7849
-
The Discovery of N‑[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]‑N′‑propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor AntagonistBolli, Martin H. / Boss, Christoph / Binkert, Christoph / Buchmann, Stephan / Bur, Daniel / Hess, Patrick / Iglarz, Marc / Meyer, Solange / Rein, Josiane / Rey, Markus et al. | 2012
- 7862
-
Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38 alpha InhibitorsMartz, K.E. / Dorn, A. / Baur, B. / Schattel, V. / Goettert, M.I. / Mayer-Wrangowski, S.C. / Rauh, D. / Laufer, S.A. et al. | 2012
- 7862
-
Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38α InhibitorsMartz, Kathrin E. / Dorn, Angelika / Baur, Benjamin / Schattel, Verena / Goettert, Márcia I. / Mayer-Wrangowski, Svenja C. / Rauh, Daniel / Laufer, Stefan A. et al. | 2012
- 7875
-
Carbamoylphosphonates Control Tumor Cell Proliferation and Dissemination by Simultaneously Inhibiting Carbonic Anhydrase IX and Matrix Metalloproteinase-2. Toward Nontoxic Chemotherapy Targeting Tumor Microenvironment(1)Reich, Reuven et al. | 2012
- 7875
-
Carbamoylphosphonates Control Tumor Cell Proliferation and Dissemination by Simultaneously Inhibiting Carbonic Anhydrase IX and Matrix Metalloproteinase-2. Toward Nontoxic Chemotherapy Targeting Tumor MicroenvironmentReich, Reuven / Hoffman, Amnon / Veerendhar, Ainelly / Maresca, Alfonso / Innocenti, Alessio / Supuran, Claudiu T. / Breuer, Eli et al. | 2012
- 7883
-
Synthesis and Biological Investigations of Nitric Oxide Releasing Nateglinide and Meglitinide Type II Antidiabetic Prodrugs: In-Vivo Antihyperglycemic Activities and Blood Pressure Lowering StudiesKaur, Jatinder / Bhardwaj, Atul / Huang, Zhangjian / Narang, Deepak / Chen, Ting-Yueh / Plane, Frances / Knaus, Edward E. et al. | 2012
- 7892
-
Malaria-Infected Mice Live Until at Least Day 30 after a New Artemisinin-Derived Thioacetal Thiocarbonate Combined with Mefloquine Are Administered Together in a Single, Low, Oral DoseJacobine, Alexander M. / Mazzone, Jennifer R. / Slack, Rachel D. / Tripathi, Abhai K. / Sullivan, David J. / Posner, Gary H. et al. | 2012
- 7900
-
Synthesis and Evaluation of Silanediols as Highly Selective Uncompetitive Inhibitors of Human Neutrophil ElastaseMadsen, Julie L. H. / Andersen, Thomas L. / Santamaria, Salvatore / Nagase, Hideaki / Enghild, Jan J. / Skrydstrup, Troels et al. | 2012
- 7909
-
Toward Rational Fragment-Based Lead Design without 3D StructuresHenen, Morkos A. / Coudevylle, Nicolas / Geist, Leonhard / Konrat, Robert et al. | 2012
- 7920
-
Discovery of Highly Selective and Orally Active Lysophosphatidic Acid Receptor‑1 Antagonists with Potent Activity on Human Lung FibroblastsQian, Yimin / Hamilton, Matthew / Sidduri, Achyutharao / Gabriel, Stephen / Ren, Yonglin / Peng, Ruoqi / Kondru, Rama / Narayanan, Arjun / Truitt, Terry / Hamid, Rachid et al. | 2012
- 7940
-
Identification of Antitubercular Benzothiazinone Compounds by Ligand-Based DesignKaroli, Tomislav / Becker, Bernd / Zuegg, Johannes / Möllmann, Ute / Ramu, Soumya / Huang, Johnny X. / Cooper, Matthew A. et al. | 2012