4-(N-Phenyl-N′-substituted benzenesulfonyl)-6-(4-hydroxyphenyl)quinolines as inhibitors of mammalian target of rapamycin (English)
- New search for: Venkateswarlu, V.
- New search for: Pathania, A. S.
- New search for: Aravinda Kumar, K. A.
- New search for: Mahajan, P.
- New search for: Nargotra, A.
- New search for: Vishwakarma, R. A.
- New search for: Malik, F. A.
- New search for: Sawant, S. D.
- New search for: Venkateswarlu, V.
- New search for: Pathania, A. S.
- New search for: Aravinda Kumar, K. A.
- New search for: Mahajan, P.
- New search for: Nargotra, A.
- New search for: Vishwakarma, R. A.
- New search for: Malik, F. A.
- New search for: Sawant, S. D.
In:
BIOORGANIC AND MEDICINAL CHEMISTRY
;
23
, 15
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4237-4247
;
2015
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ISSN:
- Article (Journal) / Print
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Title:4-(N-Phenyl-N′-substituted benzenesulfonyl)-6-(4-hydroxyphenyl)quinolines as inhibitors of mammalian target of rapamycin
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Contributors:Venkateswarlu, V. ( author ) / Pathania, A. S. ( author ) / Aravinda Kumar, K. A. ( author ) / Mahajan, P. ( author ) / Nargotra, A. ( author ) / Vishwakarma, R. A. ( author ) / Malik, F. A. ( author ) / Sawant, S. D. ( author )
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Published in:BIOORGANIC AND MEDICINAL CHEMISTRY ; 23, 15 ; 4237-4247
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2015-01-01
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Size:11 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 615.19
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615.19 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 23, Issue 15
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4093
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Graphical contents list| 2015
- 4119
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Intriguing possibilities and beneficial aspects of transporter-conscious drug designTashima, Toshihiko et al. | 2015
- 4132
-
Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcriptionDemizu, Yosuke / Misawa, Takashi / Nagakubo, Takaya / Kanda, Yasunari / Okuhira, Keiichiro / Sekino, Yuko / Naito, Mikihiko / Kurihara, Masaaki et al. | 2015
- 4139
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Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimicsNkizinkiko, Yves / Suneel Kumar, B.V.S. / Jeankumar, Variam Ullas / Haikarainen, Teemu / Koivunen, Jarkko / Madhuri, Chanduri / Yogeeswari, Perumal / Venkannagari, Harikanth / Obaji, Ezeogo / Pihlajaniemi, Taina et al. | 2015
- 4150
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Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolensArai, Midori A. / Uchida, Kyoko / Sadhu, Samir K. / Ahmed, Firoj / Koyano, Takashi / Kowithayakorn, Thaworn / Ishibashi, Masami et al. | 2015
- 4155
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Synthesis of new oxadiazole derivatives as α-glucosidase inhibitorsTaha, Muhammad / Ismail, Nor Hadiani / Imran, Syahrul / Rokei, Muhammad Qamarruddin Bin / Saad, Syed Muhammad / Khan, Khalid Mohammed et al. | 2015
- 4163
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In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amineTaleli, Lebusetsa / de Kock, Carmen / Smith, Peter J. / Pelly, Stephen C. / Blackie, Margaret A.L. / van Otterlo, Willem A.L. et al. | 2015
- 4172
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Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agentsWani, Mohmmad Younus / Ahmad, Aijaz / Shiekh, Rayees Ahmad / Al-Ghamdi, Khalaf J. / Sobral, Abilio J.F.N. et al. | 2015
- 4181
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Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moietiesCeruso, Mariangela / Carta, Fabrizio / Osman, Sameh M. / Alothman, Zeid / Monti, Simona Maria / Supuran, Claudiu T. et al. | 2015
- 4188
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Ring-substituted 8-hydroxyquinoline-2-carboxanilides as potential antimycobacterial agentsKos, Jiri / Zadrazilova, Iveta / Nevin, Eoghan / Soral, Michal / Gonec, Tomas / Kollar, Peter / Oravec, Michal / Coffey, Aidan / O’Mahony, Jim / Liptaj, Tibor et al. | 2015
- 4197
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N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols—their physicochemical and anticonvulsant propertiesWaszkielewicz, Anna M. / Cegła, Marek / Żesławska, Ewa / Nitek, Wojciech / Słoczyńska, Karolina / Marona, Henryk et al. | 2015
- 4218
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4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding sitePogorelčnik, Barbara / Janežič, Matej / Sosič, Izidor / Gobec, Stanislav / Solmajer, Tom / Perdih, Andrej et al. | 2015
- 4230
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Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenesLee, Hsueh-Yun / Chang, Chih-Yi / Lai, Mei-Jung / Chuang, Hsun-Yueh / Kuo, Ching-Chuan / Chang, Chi-Yen / Chang, Jang-Yang / Liou, Jing-Ping et al. | 2015
- 4237
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4-(N-Phenyl-N′-substituted benzenesulfonyl)-6-(4-hydroxyphenyl)quinolines as inhibitors of mammalian target of rapamycinVenkateswarlu, Vunnam / Pathania, Anup Singh / Aravinda Kumar, K.A. / Mahajan, Priya / Nargotra, Amit / Vishwakarma, Ram A. / Malik, Fayaz A. / Sawant, Sanghapal D. et al. | 2015
- 4248
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Hybrid chemistry. Part 4: Discovery of etravirine–VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitorsWan, Zheng-Yong / Tao, Yuan / Wang, Ya-Feng / Mao, Tian-Qi / Yin, Hong / Chen, Fen-Er / Piao, Hu-Ri / De Clercq, Erik / Daelemans, Dirk / Pannecouque, Christophe et al. | 2015
- 4256
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Studies on the preferred uracil–adenine base pair at the cleavage site of 10–23 DNAzyme by functional group modifications on adenineZhu, Junfei / Li, Zhiwen / Yang, Zhenjun / He, Junlin et al. | 2015
- 4264
-
Benzoic acid derivatives with improved antifungal activity: Design, synthesis, structure–activity relationship (SAR) and CYP53 docking studiesBerne, Sabina / Kovačič, Lidija / Sova, Matej / Kraševec, Nada / Gobec, Stanislav / Križaj, Igor / Komel, Radovan et al. | 2015
- 4277
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Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanaminesTorres-Gómez, Héctor / Lehmkuhl, Kirstin / Frehland, Bastian / Daniliuc, Constantin / Schepmann, Dirk / Ehrhardt, Christina / Wünsch, Bernhard et al. | 2015
- 4286
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Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptorStehouwer, Jeffrey S. / Birnbaum, Matthew S. / Voll, Ronald J. / Owens, Michael J. / Plott, Susan J. / Bourke, Chase H. / Wassef, Michael A. / Kilts, Clinton D. / Goodman, Mark M. et al. | 2015
- 4303
-
Anti-growth effect of a novel trans-dichloridobis[2-(2-hydroxyethyl)pyridine]platinum (II) complex via induction of apoptosis on breast cancer cell linesOral, Arzu Yilmaztepe / Cevatemre, Buse / Sarimahmut, Mehmet / Icsel, Ceyda / Yilmaz, Veysel Turan / Ulukaya, Engin et al. | 2015
- 4311
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Development of novel DIF-1 derivatives that selectively suppress innate immune responsesNguyen, Van Hai / Kikuchi, Haruhisa / Kubohara, Yuzuru / Takahashi, Katsunori / Katou, Yasuhiro / Oshima, Yoshiteru et al. | 2015
- 4316
-
Synthesis of new fluorinated analogs of GABA, Pregabalin bioisosteres, and their effects on [3H]GABA uptake by rat brain nerve terminalsBorisova, T. / Pozdnyakova, N. / Shaitanova, E. / Gerus, I. / Dudarenko, M. / Mironets, R. / Haufe, G. / Kukhar, V. et al. | 2015
- 4324
-
One-pot synthesis of human metabolites of SAR548304 by fungal peroxygenasesKiebist, Jan / Holla, Wolfgang / Heidrich, Johannes / Poraj-Kobielska, Marzena / Sandvoss, Martin / Simonis, Reiner / Gröbe, Glenn / Atzrodt, Jens / Hofrichter, Martin / Scheibner, Katrin et al. | 2015
- 4333
-
Discovery of novel N-(5-(tert-butyl)isoxazol-3-yl)-N′-phenylurea analogs as potent FLT3 inhibitors and evaluation of their activity against acute myeloid leukemia in vitro and in vivoXu, Ying / Wang, Ning-Yu / Song, Xue-Jiao / Lei, Qian / Ye, Ting-Hong / You, Xin-Yu / Zuo, Wei-Qiong / Xia, Yong / Zhang, Li-Dan / Yu, Luo-Ting et al. | 2015
- 4344
-
Pyrrolo[2,3-b]pyridine derivatives as potent Bruton’s tyrosine kinase inhibitorsZhao, Xinge / Huang, Wei / Wang, Yazhou / Xin, Minhang / Jin, Qiu / Cai, Jianfeng / Tang, Feng / Zhao, Yong / Xiang, Hua et al. | 2015
- 4354
-
Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidinesTemburnikar, Kartik W. / Ross, Christina R. / Wilson, Gerald M. / Balzarini, Jan / Cawrse, Brian M. / Seley-Radtke, Katherine L. et al. | 2015
- 4364
-
Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitorsWang, Lei / Hou, Xuben / Fu, Huansheng / Pan, Xiaole / Xu, Wenfang / Tang, Weiping / Fang, Hao et al. | 2015
- 4375
-
The twin drug approach for novel nicotinic acetylcholine receptor ligandsTomassoli, Isabelle / Gündisch, Daniela et al. | 2015
- 4390
-
Synthesis and evaluation of the anti-nociceptive and anti-inflammatory activity of 4-aminoquinoline derivativesde Meneses Santos, Raquel / Barros, Pooline Rocha / Bortoluzzi, Janaína Heberle / Meneghetti, Mario Roberto / da Silva, Yolanda Karla Cupertino / da Silva, Amanda Evelyn / da Silva Santos, Mariana / Alexandre-Moreira, Magna Suzana et al. | 2015
- 4397
-
γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effectAlves, Silmara L.G. / Paixão, Natasha / Ferreira, Letícia G.R. / Santos, Felipe R.S. / Neves, Luiza D.R. / Oliveira, Gisele C. / Cortes, Vanessa F. / Salomé, Kahlil S. / Barison, Andersson / Santos, Fabio V. et al. | 2015
- 4405
-
Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktisDe Luca, Viviana / Vullo, Daniela / Del Prete, Sonia / Carginale, Vincenzo / Scozzafava, Andrea / Osman, Sameh M. / AlOthman, Zeid / Supuran, Claudiu T. / Capasso, Clemente et al. | 2015
- 4410
-
Design and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives bearing an imidazolone moiety as c-Met kinase inhibitorsLiao, Weike / Hu, Gang / Guo, Zhuang / Sun, Deyu / Zhang, Lixia / Bu, Yanxin / Li, Yingxiu / Liu, Yajing / Gong, Ping et al. | 2015
- 4423
-
Anti-HIV screening for cell-penetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteinsMizuguchi, Takaaki / Ohashi, Nami / Nomura, Wataru / Komoriya, Mao / Hashimoto, Chie / Yamamoto, Naoki / Murakami, Tsutomu / Tamamura, Hirokazu et al. | 2015
- 4428
-
Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activitiesWang, Wenbin / He, Yi / Xu, Pei / You, Qidong / Xiao, Hong / Xiang, Hua et al. | 2015
- 4434
-
Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesisMasaki, So / Kii, Isao / Sumida, Yuto / Kato-Sumida, Tomoe / Ogawa, Yasushi / Ito, Nobutoshi / Nakamura, Mitsuhiro / Sonamoto, Rie / Kataoka, Naoyuki / Hosoya, Takamitsu et al. | 2015
- 4442
-
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agentsKnez, Damijan / Brus, Boris / Coquelle, Nicolas / Sosič, Izidor / Šink, Roman / Brazzolotto, Xavier / Mravljak, Janez / Colletier, Jacques-Philippe / Gobec, Stanislav et al. | 2015
- 4453
-
BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase 10A (PDE10A) inhibitorsVlasceanu, Alexandru / Jessing, Mikkel / Kilburn, John Paul et al. | 2015
- 4462
-
Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substratesFonseca, Emanuella M.B. / Trivella, Daniela B.B. / Scorsato, Valéria / Dias, Mariana P. / Bazzo, Natália L. / Mandapati, Kishore R. / de Oliveira, Fábio L. / Ferreira-Halder, Carmen V. / Pilli, Ronaldo A. / Miranda, Paulo C.M.L. et al. | 2015
- 4472
-
Synthesis of C-5, C-2′ and C-4′-neomycin-conjugated triplex forming oligonucleotides and their affinity to DNA-duplexesTähtinen, Ville / Granqvist, Lotta / Virta, Pasi et al. | 2015
- 4481
-
Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activityDuan, Wenwen / Hou, Jinning / Chu, Xiaojing / Li, Xiaoqian / Zhang, Jian / Li, Jin / Xu, Wenfang / Zhang, Yingjie et al. | 2015
- 4489
-
Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptorsBerger, Michael L. / Maciejewska, Dorota / Vanden Eynde, Jean Jacques / Mottamal, Madhusoodanan / Żabiński, Jerzy / Kaźmierczak, Paweł / Rezler, Mateusz / Jarak, Ivana / Piantanida, Ivo / Karminski-Zamola, Grace et al. | 2015
- 4501
-
Selenorhodamine photosensitizers with the Texas-red core for photodynamic therapy of cancer cellsKryman, Mark W. / Davies, Kellie S. / Linder, Michelle K. / Ohulchanskyy, Tymish Y. / Detty, Michael R. et al. | 2015
- 4508
-
Synthesis and evaluation of N-analogs of 1,2-diarylethane as Helicobacter pylori urease inhibitorsXiao, Zhu-Ping / Shi, Wei-Kang / Wang, Peng-Fei / Wei, Wei / Zeng, Xiao-Tong / Zhang, Ji-Rong / Zhu, Na / Peng, Miao / Peng, Bin / Lin, Xiao-Yi et al. | 2015
- 4514
-
Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expressionDuan, Hongliang / Li, Yu / Lim, Hui-Ying / Wang, Weidong et al. | 2015
- 4522
-
Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dionesLee, Chia-Chung / Liu, Fei-Lan / Chen, Chun-Liang / Chen, Tsung-Chih / Liu, Feng-Cheng / Ahmed Ali, Ahmed Atef / Chang, Deh-Ming / Huang, Hsu-Shan et al. | 2015
- 4533
-
Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitorsLokwani, Deepak / Azad, Rajaram / Sarkate, Aniket / Reddanna, Pallu / Shinde, Devanand et al. | 2015
- 4544
-
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilitiesSato, Kenjiro / Takahagi, Hiroki / Kubo, Osamu / Hidaka, Kousuke / Yoshikawa, Takeshi / Kamaura, Masahiro / Nakakariya, Masanori / Amano, Nobuyuki / Adachi, Ryutaro / Maki, Toshiyuki et al. | 2015
- 4561
-
Potential antibacterial activity of triazine dendrimer: Synthesis and controllable drug release propertiesVembu, Sandhirakasu / Pazhamalai, Srinivasan / Gopalakrishnan, Mannathusamy et al. | 2015
- 4567
-
In vitro evaluation and in silico screening of synthetic acetylcholinesterase inhibitors bearing functionalized piperidine pharmacophoresBrahmachari, Goutam / Choo, CheeYan / Ambure, Pravin / Roy, Kunal et al. | 2015
- 4576
-
In silico investigation of FOXM1 binding and novel inhibitors in epithelial ovarian cancerChen, Yi / Ruben, Eliza A. / Rajadas, Jayakumar / Teng, Nelson N.H. et al. | 2015
- 4583
-
Strong positive cooperativity in binding to the A3T3 repeat by Hoechst 33258 derivatives attaching the quinoline units at the end of a branched linkerKoda, Hironori / Brazier, John Alan / Onishi, Ippei / Sasaki, Shigeki et al. | 2015
- 4591
-
Discovery of a novel class anti-proliferative agents and potential inhibitors of EGFR tyrosine kinases based on 4-anilinotetrahydropyrido[4,3-d]pyrimidine scaffold: Design, synthesis and biological evaluationsZhang, Yong / Zhang, Kai / Zhao, Meng / Zhang, Lixia / Qin, Mingze / Guo, Shuchun / Zhao, Yanfang / Gong, Ping et al. | 2015
- 4608
-
Synthesis of 2-aryl-1,2,4-oxadiazolo-benzimidazoles: Tubulin polymerization inhibitors and apoptosis inducing agentsKamal, Ahmed / Reddy, T. Srinivasa / Vishnuvardhan, M.V.P.S. / Nimbarte, Vijaykumar D. / Subba Rao, A.V. / Srinivasulu, Vunnam / Shankaraiah, Nagula et al. | 2015
- 4624
-
Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic painOgiyama, Takashi / Yonezawa, Koichi / Inoue, Makoto / Watanabe, Toshihiro / Sugano, Yukihito / Gotoh, Takayasu / Kiso, Tetsuo / Koakutsu, Akiko / Kakimoto, Shuichiro / Shishikura, Jun-ichi et al. | 2015
- 4638
-
Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liabilityOgiyama, Takashi / Yonezawa, Koichi / Inoue, Makoto / Katayama, Naoko / Watanabe, Toshihiro / Yoshimura, Seiji / Gotoh, Takayasu / Kiso, Tetsuo / Koakutsu, Akiko / Kakimoto, Shuichiro et al. | 2015
- 4649
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5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XIICvijetić, Ilija N. / Tanç, Muhammet / Juranić, Ivan O. / Verbić, Tatjana Ž. / Supuran, Claudiu T. / Drakulić, Branko J. et al. | 2015
- 4660
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How to find the optimal partner—studies of snurportin 1 interactions with U snRNA 5′ TMG-cap analogues containing modified 2-amino group of 7-methylguanosinePiecyk, Karolina / Niedzwiecka, Anna / Ferenc-Mrozek, Aleksandra / Lukaszewicz, Maciej / Darzynkiewicz, Edward / Jankowska-Anyszka, Marzena et al. | 2015
- 4669
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Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODHAbdullah, Iskandar / Chee, Chin Fei / Lee, Yean-Kee / Thunuguntla, Siva Sanjeeva Rao / Satish Reddy, K. / Nellore, Kavitha / Antony, Thomas / Verma, Jitender / Mun, Kong Wai / Othman, Shatrah et al. | 2015
- 4681
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Modified quaternary ammonium salts as potential antimalarial agentsBasilico, Nicoletta / Migotto, Mara / Ilboudo, Denise Patoinewende / Taramelli, Donatella / Stradi, Riccardo / Pini, Elena et al. | 2015
- 4688
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NO-donor thiacarbocyanines as multifunctional agents for Alzheimer’s diseaseChegaev, Konstantin / Federico, Antonella / Marini, Elisabetta / Rolando, Barbara / Fruttero, Roberta / Morbin, Michela / Rossi, Giacomina / Fugnanesi, Valeria / Bastone, Antonio / Salmona, Mario et al. | 2015
- 4699
-
Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporterTu, Zhude / Zhang, Xiang / Jin, Hongjun / Yue, Xuyi / Padakanti, Prashanth K. / Yu, Lihai / Liu, Hui / Flores, Hubert P. / Kaneshige, Kota / Parsons, Stanley M. et al. | 2015
- 4710
-
Discovery of small molecules with vasodilating characteristics and adjustable hydrolytic behaviorBrunhofer-Bolzer, Gerda / Gabriel, Mario / Studenik, Christian R. / Erker, Thomas et al. | 2015
- 4719
-
Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytesRao, Yong / Liu, Hong / Gao, Lin / Yu, Hong / Tan, Jia-Heng / Ou, Tian-Miao / Huang, Shi-Liang / Gu, Lian-Quan / Ye, Ji-Ming / Huang, Zhi-Shu et al. | 2015
- 4728
-
Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitorsJin, Kang / Li, Shanshan / Li, Xiaoguang / Zhang, Jian / Xu, Wenfang / Li, Xuechen et al. | 2015
- 4737
-
Synthesis and antileukemic activities of C1–C10-modified parthenolide analoguesKempema, Aaron M. / Widen, John C. / Hexum, Joseph K. / Andrews, Timothy E. / Wang, Dan / Rathe, Susan K. / Meece, Frederick A. / Noble, Klara E. / Sachs, Zohar / Largaespada, David A. et al. | 2015
- 4746
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Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumariumKarmakar, Utpal K. / Ishikawa, Naoki / Toume, Kazufumi / Arai, Midori A. / Sadhu, Samir K. / Ahmed, Firoj / Ishibashi, Masami et al. | 2015
- 4755
-
Synthesis, β-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium bergheiRomero, Angel H. / Acosta, María E. / Gamboa, Neira / Charris, Jaime E. / Salazar, José / López, Simón E. et al. | 2015
- 4763
-
Synthesis and anti-Trypanosoma cruzi activity of new 3‐phenylthio-nor-β-lapachone derivativesCardoso, Mariana F. do Carmo / Salomão, Kelly / Bombaça, Ana Cristina / da Rocha, David R. / da Silva, Fernando de C. / Cavaleiro, José A.S. / de Castro, Solange L. / Ferreira, Vitor F. et al. | 2015
- 4769
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Thermodynamics and kinetic studies in the binding interaction of cyclic naphthalene diimide derivatives with double stranded DNAsIslam, Md. Monirul / Fujii, Satoshi / Sato, Shinobu / Okauchi, Tatsuo / Takenaka, Shigeori et al. | 2015
- 4777
-
Synthesis and evaluation of hedgehog signaling inhibitor with novel core systemOhashi, Tomohiro / Tanaka, Yuta / Shiokawa, Zenyu / Banno, Hiroshi / Tanaka, Toshio / Shibata, Sachio / Satoh, Yoshihiko / Yamakawa, Hiroko / Yamamoto, Yukiko / Hattori, Harumi et al. | 2015
- 4792
-
Orally active ghrelin receptor inverse agonists and their actions on a rat obesity modelTakahashi, Bitoku / Funami, Hideaki / Iwaki, Takehiko / Maruoka, Hiroshi / Shibata, Makoto / Koyama, Makoto / Nagahira, Asako / Kamiide, Yoshiyuki / Kanki, Satomi / Igawa, Yoshiyuki et al. | 2015
- 4804
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Enzymatic synthesis of bile acid derivatives and biological evaluation against Trypanosoma cruziGarcía Liñares, Guadalupe / Antonela Zígolo, M. / Simonetti, Leandro / Longhi, Silvia A. / Baldessari, Alicia et al. | 2015
- 4815
-
New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compoundsZhang, Yu / Liu, Bin / Wu, Xingyu / Li, Ridong / Ning, Xianling / Liu, Yu / Liu, Zhenming / Ge, Zemei / Li, Runtao / Yin, Yuxin et al. | 2015
- 4824
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Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2Stroth, Nikolas / Niso, Mauro / Colabufo, Nicola A. / Perrone, Roberto / Svenningsson, Per / Lacivita, Enza / Leopoldo, Marcello et al. | 2015
- 4831
-
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosaPinard, Melissa A. / Lotlikar, Shalaka R. / Boone, Christopher D. / Vullo, Daniela / Supuran, Claudiu T. / Patrauchan, Marianna A. / McKenna, Robert et al. | 2015
- 4839
-
Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocolNoha, Stefan M. / Fischer, Katrin / Koeberle, Andreas / Garscha, Ulrike / Werz, Oliver / Schuster, Daniela et al. | 2015
- 4846
-
Discovery of 3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one derivatives as novel JAK inhibitorsYamagishi, Hiroaki / Shirakami, Shohei / Nakajima, Yutaka / Tanaka, Akira / Takahashi, Fumie / Hamaguchi, Hisao / Hatanaka, Keiko / Moritomo, Ayako / Inami, Masamichi / Higashi, Yasuyuki et al. | 2015
- 4860
-
Synthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-gastric ulcer agentWang, Xu-Dong / Wei, Wei / Wang, Peng-Fei / Yi, Li-Cheng / Shi, Wei-Kang / Xie, Yong-Xiang / Wu, Lang-Zhou / Tang, Nian / Zhu, Liang-Song / Peng, Jia et al. | 2015
- 4866
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Lipocarbazole, an efficient lipid peroxidation inhibitor anchored in the membraneFabre, Gabin / Hänchen, Anne / Calliste, Claude-Alain / Berka, Karel / Banala, Srinivas / Otyepka, Michal / Süssmuth, Roderich D. / Trouillas, Patrick et al. | 2015
- 4871
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Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3Nakajima, Yutaka / Inoue, Takayuki / Nakai, Kazuo / Mukoyoshi, Koichiro / Hamaguchi, Hisao / Hatanaka, Keiko / Sasaki, Hiroshi / Tanaka, Akira / Takahashi, Fumie / Kunikawa, Shigeki et al. | 2015
- 4884
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Synthesis and bioevaluation of heterocyclic derivatives of Cleistanthin-AZhao, Yu / Zhang, Rui / Lu, Yapeng / Ma, Jinlong / Zhu, Li et al. | 2015
- 4891
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Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel designDu, Yongli / Ling, Hao / zhang, Meng / Shen, Jingkang / Li, Qunyi et al. | 2015
- 4899
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Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE)Valiveti, Aditya Kapil / Bhalerao, Uma M. / Acharya, Jyotiranjan / Karade, Hitendra N. / Acharya, Badri Narayan / Raviraju, G. / Halve, Anand K. / Kaushik, Mahabir Parshad et al. | 2015
- 4911
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Plasmid DNA delivery using fluorescein-labeled arginine-rich peptidesOba, Makoto / Demizu, Yosuke / Yamashita, Hiroko / Kurihara, Masaaki / Tanaka, Masakazu et al. | 2015
- 4919
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6-Phenoxy-2-phenylbenzoxazoles, novel inhibitors of receptor for advanced glycation end products (RAGE)Choi, Kwanghyun / Lim, Kwang Su / Shin, Juhee / Kim, Seo Hee / Suh, Young-Ger / Hong, Hyun-Seok / Kim, Hee / Ha, Hee-Jin / Kim, Young-Ho / Lee, Jiyoun et al. | 2015
- 4936
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Identification of peptidic substrates for the human kinase Myt1 using peptide microarraysRohe, Alexander / Platzer, Charlott / Masch, Antonia / Greiner, Sandra / Henze, Claudia / Ihling, Christian / Erdmann, Frank / Schutkowski, Mike / Sippl, Wolfgang / Schmidt, Matthias et al. | 2015
- 4943
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Double Sonogashira reactions on dihalogenated aminopyridines for the assembly of an array of 7-azaindoles bearing triazole and quinoxaline substituents at C-5: Inhibitory bioactivity against Giardia duodenalis trophozoitesLeboho, Tlabo C. / Giri, Somnath / Popova, Inessa / Cock, Ian / Michael, Joseph P. / de Koning, Charles B. et al. | 2015
- 4952
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Discovery and structural analyses of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogsNakao, Akira / Suzuki, Hiroko / Ueno, Hiroaki / Iwasaki, Hiroshi / Setsuta, Tomofumi / Kashima, Akiko / Sunada, Shinji et al. | 2015
- 4970
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Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effectsLee, Young Hun / Kim, Hyoung Ja / Yoo, Ho / Jung, Seo Yun / Kwon, Bong Jin / Kim, Nam-Jung / Jin, Changbae / Lee, Yong Sup et al. | 2015
- 4980
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PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cellsKim, Youseung / Maciag, Anna E. / Cao, Zhao / Deschamps, Jeffrey R. / Saavedra, Joseph E. / Keefer, Larry K. / Holland, Ryan J. et al. | 2015
- 4989
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Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XIIIbrahim, Diaa A. / Lasheen, Deena S. / Zaky, Maysoun Y. / Ibrahim, Amany W. / Vullo, Daniela / Ceruso, Mariangela / Supuran, Claudiu T. / Abou El Ella, Dalal A. et al. | 2015
- 5000
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Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitorFujimori, Ikuo / Yukawa, Tomoya / Kamei, Taku / Nakada, Yoshihisa / Sakauchi, Nobuki / Yamada, Masami / Ohba, Yusuke / Takiguchi, Maiko / Kuno, Masako / Kamo, Izumi et al. | 2015
- 5015
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Discovery of substituted 1,4-dihydroquinolines as novel class of ABCB1 modulatorsHemmer, Marc / Krawczyk, Sören / Simon, Ina / Lage, Hermann / Hilgeroth, Andreas et al. | 2015
- 5022
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Synthesis and biological activity of novel deoxycholic acid derivativesPopadyuk, Irina I. / Markov, Andrey V. / Salomatina, Oksana V. / Logashenko, Evgeniya B. / Shernyukov, Andrey V. / Zenkova, Marina A. / Salakhutdinov, Nariman F. et al. | 2015
- 5035
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Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybridsKaldre, Dainis / Wang, Tian-Tian / Fischer, Joshua / White, John H. / Gleason, James L. et al. | 2015
- 5050
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N-mustard analogs of S-adenosyl-l-methionine as biochemical probes of protein arginine methylationHymbaugh Bergman, Sarah J. / Comstock, Lindsay R. et al. | 2015
- 5056
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Synthesis and bioactivity of a Goralatide analog with antileukemic activityLi, Zhiliang / Lebedyeva, Iryna O. / Golubovskaya, Vita M. / Cance, William G. / Alamry, Khalid A. / Faidallah, Hassan M. / Dennis Hall, C. / Katritzky, Alan R. et al. | 2015
- 5061
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Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor LargazoleClausen, Dane J. / Smith, William B. / Haines, Brandon E. / Wiest, Olaf / Bradner, James E. / Williams, Robert M. et al. | 2015
- 5075
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Corrigendum to “Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR” [Bioorg. Med. Chem. 23, 2015, 2767–2780]Basu, Debjit / Richters, André / Rauh, Daniel et al. | 2015
- 5076
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Corrigendum to “Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2” [Bioorg. Med. Chem. 22 (2014) 4735–4744]Shi, Lei / Wu, Ting-Ting / Wang, Zhi / Xue, Jia-Yu / Xu, Yun-Gen et al. | 2015
- 5077
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Corrigendum to “Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease” [Bioorg. Med. Chem. 23 (2015) 1102–1111]Dixon, Monica / Woodrick, Jordan / Gupta, Suhani / Karmahapatra, Soumendra Krishna / Devito, Stephen / Vasudevan, Sona / Dakshanamurthy, Sivanesan / Adhikari, Sanjay / Yenugonda, Venkata M. / Roy, Rabindra et al. | 2015
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Instructions to contributors| 2015
- IFC
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Editorial board| 2015