An overview of the safety pharmacology society strategic plan (Unknown)
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In:
Journal of pharmacological and toxicological methods
;
93
;
35-45
;
2018
-
ISSN:
- Article (Journal) / Print
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Title:An overview of the safety pharmacology society strategic plan
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Contributors:Pugsley, M.K. ( author ) / Authier, S. ( author ) / Koerner, J.E. ( author ) / Redfern, W.S. ( author ) / Markgraf, C.G. ( author ) / Brabham, T. ( author ) / Correll, K. ( author ) / Soloviev, M.V. ( author ) / Botchway, A. ( author ) / Engwall, M. ( author )
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Published in:Journal of pharmacological and toxicological methods ; 93 ; 35-45
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Publisher:
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Publication date:2018-01-01
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Size:11 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:Unknown
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Classification:
DDC: 615.9 -
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© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 93
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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Safety pharmacology methods and regulatory considerations evolve togetherPugsley, Michael K. / Harter, Marci L. / de Korte, Tessa / Connaughton, Chantelle / Authier, Simon / Curtis, Michael J. et al. | 2018
- 26
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Safety pharmacology in and for Africa: Establishment of the pre-clinical drug development platformGuth, Brian D. / Grobler, Anne et al. | 2018
- 29
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The use of human tissue in safety assessmentJackson, Samuel J. / Prior, Helen / Holmes, Anthony et al. | 2018
- 35
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An overview of the safety pharmacology society strategic planPugsley, M.K. / Authier, S. / Koerner, J.E. / Redfern, W.S. / Markgraf, C.G. / Brabham, T. / Correll, K. / Soloviev, M.V. / Botchway, A. / Engwall, M. et al. | 2018
- 46
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Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytesBot, Corina T. / Juhasz, Krisztina / Haeusermann, Fabian / Polonchuk, Liudmila / Traebert, Martin / Stoelzle-Feix, Sonja et al. | 2018
- 69
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Regulatory respiratory data refinement with reduced animal usageSladen, Louise / Matheson, Rommel / Norton, Kevin / Milne, Aileen et al. | 2018
- 75
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Challenges in implementing and obtaining acceptance for J-Tpeak assessment as the clinical component of CiPADarpo, Borje / Couderc, Jean-Philippe et al. | 2018
- 90
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A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmissionMarkert, Michael / Trautmann, Thomas / Krause, Florian / Cioaga, Marius / Mouriot, Sebastien / Wetzel, Miriam / Guth, Brian D. et al. | 2018
- 108
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Using swimming bouts for a refined data analysis of drug-induced convulsant activity in the zebrafish larvaeBeusch, Christian / Aegler, Monika / Steiner, Guido / Dinklo, Theo et al. | 2018
- 108
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Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project to develop safer drugsDelaunois, Annie / Bouzom, François / Rospo, Chiara C. / André, Véronique M. / Wood, Martyn / Laredj, Faiza / Accardi, Michael / Authier, Simon / Valentin, Jean-Pierre et al. | 2018
- 109
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Inter-company reproducibility of Irwin/FOB CNS safety assessment following reference drugs chlorpromazine and amphetamineHimmel, Herbert M. / Heers, Cara / van Amsterdam, Christoph / Habermann, Christopher / Schauerte, Heike / Rosch, Anke / van der Linde, Henk / Teuns, Greet / Eriksson Faelker, Therese M. / Hempel, Katja et al. | 2018
- 109
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Drug discrimination studies in rats: Impact of the route of administrationFroger-Colleaux, Christelle E. / Paillard, Stéphanie G. / Davoust, Karelle G. / Castagné, Vincent et al. | 2018
- 110
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Applying home cage monitoring systems in rodent preclinical CNS safety studiesHarris, Kate / Redfern, Will S. / Tse, Karen / Armstrong, Douglas / Holmes, Anthony et al. | 2018
- 110
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Data strength assessment of the social-housed modified Irwin test when performed concurrently with a CNS tetrad evaluationShaffer, Jennifer / Adkins, Nick / Graham, Alec / Roche, Brian et al. | 2018
- 111
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A refined method to detect rat pica behaviour for assessing nausea riskTse, Karen K.-Y. / Pedersen, John C. / Redfern, Will S. et al. | 2018
- 111
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Impaired spatial memory retrieval with inhibition of ERK-CREB signal pathway in the chlorpyrifos treated ratsYan, Changhui / Chen, Shuang et al. | 2018
- 111
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Considerations on the neurobehavioral assessment (modified Irwin test) in non-human primatesSmieja, Daniela / Niehoff, Marc / Korte, Sven et al. | 2018
- 112
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The abuse potential of the synthetic cathinone alpha-pyrrolidinopentiothiophenone (α-PVT) in rodentsYoon, Seong Shoon / Lee, Youngeun / Seo, Joung-Wook et al. | 2018
- 112
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Adult human primary cardiomyocyte model for the simultaneous prediction of drug-induced inotropic and pro-arrhythmia riskNguyen, Nathalie / Nguyen, William / Miron, Yannick / Ratchada, Phachareeya / Page, Guy / Miller, Paul / Ghetti, Andre / Abi-Gerges, Najah et al. | 2018
- 112
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Measuring multiple ion current components in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clampMann, Stefan / Heide, Juliane / Radu, Beatrice Mihaela / Amuzescu, Bogdan / Knott, Thomas et al. | 2018
- 113
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Non-rodent isolated mature ventricular cardiomyocytes for multi-ion channel inhibition during proarrhythmia screeningHuang, Hai / Accardi, Michael / Pugsley, Michael K. / Authier, Simon et al. | 2018
- 113
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In silico cardiomyocyte action potential modeling using GLP manual patch clamp inhibition profiles from CiPA ion channelsAuthier, Simon / Huang, Hai / Jacquemet, Vincent / Accardi, Michael / Ascah, Alexis / Pugsley, Michael K. et al. | 2018
- 114
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High-throughput pharmacology of cardiac L-type Ca2+ channels in overexpressing cell lines and iPSC-cardiomyocytesStoelzle-Feix, Sonja / Rapedius, Markus / Goetze, Tom / Haarmann, Claudia / Brinkwirth, Nina / George, Michael / Brueggemann, Andrea / Fertig, Niels et al. | 2018
- 114
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A new analysis capability to improve assessment of cardiac liability in high-throughput electrophysiologyBridgland-Taylor, Matt / Teixeira, Ana / Talbot, Verity / McWilliams, Lisa / Ginkel, Martin / Steigele, Stephan et al. | 2018
- 114
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A human cardiomyocyte cell-line expressing hERG: An improved system for testing drug-associated hERG blocking and cardiotoxicityBhat, Rakesh / Houghton, Michael et al. | 2018
- 115
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Purkinje fiber action potentials in cynomolgus monkeysHimmel, Herbert M. / Rexa, Annika / Hink, Waldemar / Herbold, Susanne / Becker, Alexandra / Wrobel, Eva et al. | 2018
- 115
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Temperature effect on hERG channel pharmacology measured by using the Qube automated patch clamp systemLindqvist, Anders / Mattson, Göran et al. | 2018
- 115
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Cardiac electrophysiological effects of loperamide mimick clinical misuse and abuse outcomeBallet, Veronique / Carriot, Thierry / Chantoiseau, Celine / Guillon, Jean-michel et al. | 2018
- 116
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Unraveling the role of cardiac IKs-related repolarization reserve in human induced pluripotent stem cell-derived cardiomyocytesLu, Hua Rong / Kopljar, Ivan / Geysken, Danny / Teisman, Ard / Gallacher, David J. et al. | 2018
- 116
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ΔKPQ Nav1.5 channels for late current cardiac pharmacology assessmentFuller, Matt / Santos, Sonia C. / Mathes, Chris / Chapman, Mark L. / Gerlach, Aaron et al. | 2018
- 116
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Characterization of electrically and optically paced hiPSC-derived cardiomyocytes in vitro using multiwell microelectrode array technologyMillard, Daniel C. / Hayes, Heather B. / de Korte, Tessa / Wilbers, René / Nicolini, Anthony M. / Arrowood, Colin A. / Clements, Mike et al. | 2018
- 117
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Novel imaging-based assay system detecting delayed inhibitory effect on hERG channel using human iPS-derived cardiomyocytesNagakura, Tadashi / Matsubara, Takayoshi / Ohashi, Hiromi / Sawada, Kohei / Yoshinaga, Takashi et al. | 2018
- 117
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Improvements to multiwell microelectrode array technology for characterization of neural and cardiac electrophysiology in vitroMillard, Daniel C. / Hayes, Heather B. / Chvatal, Stacie A. / Nicolini, Anthony M. / Arrowood, Colin A. / Clements, Mike / Ross, James D. et al. | 2018
- 118
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Effect of multiple drugs interacting with the hERG channel—In vitro studyLisowski, Bartosz / Kulig, Magdalena / Wiśniowska, Barbara / Polak, Sebastian et al. | 2018
- 118
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Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) to model arrhythmogenic diseasesPourrier, Marc / Dou, Ying / Luerman, Greg / Fedida, David et al. | 2018
- 119
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Measurements of voltage, intracellular Ca2+ and contraction from spontaneous iPSC-derived cardiomyocytes using CellOPTIQ® platform reveals complex effects from drugs that parallel in vivo cardiac effectsHortigon-Vinagre, Maria P. / Zamora, Victor / Burton, Francis L. / Butler, Paul / Smith, Godfrey L. et al. | 2018
- 119
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Assessing the impact and translation from the effects of three tyrosine kinase inhibitors from a single cardiac cell to the whole heartRoche, Brian / Ross, John / Waines, Michelle / Kramer, James / Bruening-Wright, Andrew / Obejero-Paz, Carlos A. et al. | 2018
- 119
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Measurements of action potentials, intracellular Ca2+ and contraction in stimulated isolated adult cardiomyocytes using CellOPTIQ® platform for lead development screeningMcGlynn, Karen P. / LaChaud, Quentin / Burton, Francis L. / Smith, Godfrey L. et al. | 2018
- 120
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Is iCEB a universal proarrhythmic biomarker covering TdP to non-TdP arrhythmias? A comparison against existing biomarkersUrmaliya, Vijay / van der Linde, Henk / Lu, Hua Rong / Van Ammel, Karel / Teisman, Ard / Gallacher, David J. et al. | 2018
- 120
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Assessing potential mechanisms underlying non-hERG mediated QT prolongationVillar, Conchi C. et al. | 2018
- 120
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Validating cardiac ion channels assays on the IonFlux HT system for the CiPA paradigmWei, Haiyang / Renganathan, Muthukrishnan / Cook, Andrew et al. | 2018
- 121
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JTp and Tpe as Biomarkers of proarrhythmic risk in nonclinical models: Historical data evaluation by the HESI consortiumGendron-Parra, Nicolas / Abernathy, Matthew M. / Boulay, Emmanuel / Chui, Ray / Friedrichs, Gregory S. / Greiter-Wilke, Andrea / Guillon, Jean-michel / Leishman, Derek J. / Nichols, Jill / Pierson, Jennifer et al. | 2018
- 121
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Usefulness of combining multi-ion-channel assays with the Langendorff assay in an assessment of proarrhythmic risksYamaguchi, Mao / Nakano, Koji / Tomizawa, Satomi / Ura, Rie / Izumi, Taku / Ohshiro, Hironori / Matsukawa, Hiroshi / Kanno, Akihiro et al. | 2018
- 122
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Impact of cage-front veranda on non-human primate cardiovascular telemetryBarnes, Robert J. / Cordes, Jason S. / Rubino, Susan R. / Nichols, Jill et al. | 2018
- 122
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Cardiac safety pharmacology in the St. Kitts African green monkeyBanerjee, Aryamitra / Liddie, Shervin / Moddrelle, David / Lindeblad, Matthew / Chen, Yongmei / Lyubimov, Alexander / Lawrence, Matthew et al. | 2018
- 123
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Incidence of ventricular arrhythmia in Göttingen minipigs instrumented with intra-ventricular pressure transducersHoldsworth, David / O'Donohue, Kyle / Gesaman, Janelle / Herrmann, Eric / Dalton, Jill / Baird, Theodore et al. | 2018
- 123
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In Vivo evaluation of the easyTEL+ fully-implantable digital telemetry system: Responsiveness and characterization in beagle dogsdel Rio, Carlos / Ueyama, Yukie / Geist, Beth / Roof, Steve / Ferris, Erin / Youngblood, Brad / Shellhammer, Laurie / Bower, Michael / Burton, Josh / Lan, Henry et al. | 2018
- 124
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Biowire™ II matured human engineered 3D cardiac tissue for drug discovery and cardiotoxicity applicationsFeric, Nicole / Aschar-Sobbi, Roozbeh / Zhao, Yimu / Zhang, Boyang / Ronaldson, Kacey / Pallotta, Isabella / Vunjak-Novakovic, Gordana / Radisic, Milica et al. | 2018
- 124
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In vitro to in vivo translation of effects of phosphodiesterase inhibitors on cardiac contractilityLiu, Xiaoqin / Shaughnessy, Thomas / Polakowski, Jim / Foley, C. Michael M. et al. | 2018
- 125
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Characterization of low-incidence cardiac arrhythmias in chaired cynomolgus monkeys and the utility of Bayesian statistics to determine a relationship to test articleHarris, Peter D. / Li, Dingzhou / Petrella, Corey / Nichols, Jill / Potter, David / Bhatt, Siddhartha et al. | 2018
- 125
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Systemic and left-ventricular hemodynamics in neonatal rats: Response to sodium nitroprusside and phenylephrineGeist, Beth / del Rio, Carlos / Ueyama, Yukie / Roof, Steve / Derakhchan, Kathy / Muir, William / Hamlin, Robert L. et al. | 2018
- 125
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Comparison of signal quality in canine jacketed vs. implanted telemetryGriffiths, Shamila / Ashcroft-Hawley, Kelly / Lawson, Robert et al. | 2018
- 126
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Identification pharmacological effects of test articles from analysis of the central and peripheral arterial pressure curveHawk, Michael A. / Vinci, Tom M. / Fetzek, Carolyn G. / Ramsuchit, Elizabeth A. / Hamlin, Robert L. / Rajasuriyar, Aaron S. et al. | 2018
- 127
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An investigation into the prevalence of sarcomatosis following rat telemetry implant surgery: How long should rats remain on study following device implantation?Lincoln, Rachael J. / Williams, Ann M. / White, Helen L. / Ward, Simon A. / Robinson, Ali / Cartwright, Karen A. / Hildenbrand, Deon D. / Rossman, Eric I. et al. | 2018
- 127
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Development of an in vitro platform using the human primary cardiomyocyte work loop assay to screen for drug-induced effects on cardiac contractilityGharanei, Mayel / Bonner, Matthew / Linekar, Adam / Wallis, Rob / Chuizbaian, Oana / Maddock, Helen et al. | 2018
- 128
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A clinical and laboratory assessment of Zucker diabetic fatty (ZDF) rats on low or high fat dietPugsley, Michael K. / Katavolos, Paula / Walker, Dana B. / Brooks, Marjory B. / Koerner, John K. / Parish, Stanley T. / Schultze, Albert E. et al. | 2018
- 128
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Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend, J-Tpeak and T-wave amplitudeSkinner, Matt / White, Pete / Peers, Ian / Ceuppens, Pete et al. | 2018
- 128
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Cardiovascular effects of verapamil in the Göttingen minipigRoberts, Sonia / Jenni, Roland / Waiz, David / Greiter-Wilke, Andrea et al. | 2018
- 129
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Double-decker rodent telemetry—A 'stretch' objectiveSkinner, Matt et al. | 2018
- 129
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Cardiotoxicity evaluation of chronic BMS-986094 exposure in human iPSC-derived cardiomyocytes using a microelectrode array (MEA) assayStrock, Christopher J. / Bradley, Jenifer / Qin, Shuzhen et al. | 2018
- 130
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Effect of training on agility at high altitude in Border Collie dogs in some heart rate variability componentsVargas-Pinto, Piero / Galindo, Vladimir / Pedraza-Toscano, Adriana / Vargas-Pinto, Pedro et al. | 2018
- 131
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Comparison of cardiovascular parameters of male and female cynomolgus monkeysWu, Rui / Zhou, Shaonan / An, Shanshan / Jin, Yi / McPherson, Sue et al. | 2018
- 131
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Feasibility studies to investigate the use of jacketed telemetry in the Göttingen minipig for the assessment of ECG and respirationWaiz, David / Roberts, Sonia / Greiter-Wilke, Andrea / Jenni, Roland et al. | 2018
- 131
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Arrhythmia prevalence in healthy beagle dogsVormberge, Thomas / Hoffmann, Michael et al. | 2018
- 132
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HYPNOS: A new software for EEG-mediated Assessment of drug-induced changes in sleep macrostructures in the ratCayre, Emilie / Denibaud, Anne-Sophie / Rion, Bertrand / Loiodice, Simon / Viardot, Geoffrey / L'Hostis, Philippe / La Rochelle, Christophe Drieu et al. | 2018
- 132
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Seizure liability assessments using the hippocampal brain slice: Comparison of nonclinical speciesAccardi, Michael / Huang, Hai / Authier, Simon et al. | 2018
- 133
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Multiparametric assessment of networked electrical activity using induced pluripotent stem cell-derived glutamatergic neuronsKim, Kwi Hye / Carlson, Coby / Kannemeier, Christian / Feaster, T.K. / Swanson, Brad / Schlesinger, David / Anson, Blake D. / Mangan, Kile P. et al. | 2018
- 133
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Gastrointestinal motility assessment comparing two species (rat vs. mouse)Coffee, Matt / Sloan, Nicole / Roche, Brian et al. | 2018
- 134
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Optimization of GiPCR cell-based assays—Use of a selective cyclase activator and miRNA approachJolas, Thierry / Brock, Carsten / Sabatier, Fabienne / Fouchaq, Benoit et al. | 2018
- 134
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Multiple pathway activation in a human M4 muscarinic receptor cell-based assayBrock, Carsten / Jolas, Thierry / Rein, Chantal / Martin, Maryse / Fouchaq, Benoit et al. | 2018
- 135
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Inhibition of long-term kindled seizures induced alterations in expression of CD cell surface markers by AC-31BNisar, Uzair / Simjee, Shabana U. et al. | 2018
- 135
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What should be noted when you use neurospheres in the pharmacological experiments—The neurosphere culture period affects the yield of neurons after differentiationTakahashi, Kanako / Ohara, Hisashi / Kasahara, Nozomi / Takase, Masahiro / Chujo, Kaori / Kanda, Yasunari / Sekino, Yuko / Tanabe, Mitsuo / Sato, Kaoru et al. | 2018
- 136
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Evaluating the pharmacology and neurotoxic predictability of neuroactive compounds using human induced pluripotent stem cell-derived glutamatergic neurons co-cultured with astrocytes using a microelectrode array platformBradley, Jenifer / Metea, Monica / Strock, Christopher J. et al. | 2018
- 136
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In vivo and in vitro immunochemical assay for CNS synaptic dysfunction by X-irradiationShirao, Tomoaki / Puspitasari, Anggraeini / Koganezawa, Noriko / Kawamura, Hidemasa / Takahashi, Akihisa / Sekino, Yuko / Nakano, Takashi / Held, Kathryn D. et al. | 2018
- 137
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Using hiPSC-derived neuronal cultures to assess the safety of pre-screened potential therapeutic compounds against Zika VirusSlavin, Ileana / Dea, Steven / Montefusco, Sandro / Siqueira-Neto, Jair L. / Petcavich, Robert / Zanella, Fabian / Carromeu, Cassiano et al. | 2018
- 137
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Statistical analysis to identify biomarkers for safetyClark, Matthew et al. | 2018
- 137
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Applications and direct comparisons of EEG collection methodologies in nonclinical studiesKearney, Ken / Voss, Kate / Shaffer, Jennifer / Brandon Borders, R. / Snyder, Lisa / Roche, Brian et al. | 2018
- 138
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The ambiguous effects of pristine C60 fullerenes on liver under modeled colon pathologiesKuznietsova, Halyna M. / Lynchak, Oksana V. / Dziubenko, Natalia V. / Chereschuk, Iryna O. / Prylutskyy, Yuriy I. / Rybalchenko, Volodymyr K. et al. | 2018
- 138
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Diversity of primary hepatocytes models allow for choosing the best tools for hepatotoxicity assessmentsFroget, Guillaume / Ekué, Lucie / Simon, Florian / Kitchener, Pierre et al. | 2018
- 139
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Defining the optimal mix of cardiac ion channels for development of safe non-antiarrhythmic small moleculesAbernathy, Matthew M. / Leishman, Derek J. et al. | 2018
- 139
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Quercetin co-administration ameliorates metronidazole induced neurotoxicityChaturvedi, Swati / Uddin, Wahaj et al. | 2018
- 140
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Coupled impedance and field potential data analysis of in vitro cardiomyocyte assaysBatista, Levy / Doerr, Leo / Beckler, Matthias / Fertig, Niels / Bastogne, Thierry et al. | 2018
- 140
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Genomic comparison of drug metabolizing enzymes in African green monkeys versus other speciesBanerjee, Aryamitra / Attwood, Jordan / Lawrence, Matthew et al. | 2018
- 140
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A data-driven modeling method to analyze cardiomyocyte impedance dataBatista, Levy / Bastogne, Thierry / Atienzar, Franck / Delaunois, Annie / Valentin, Jean-Pierre et al. | 2018
- 141
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Development of an in silico action potential model of the rabbit Purkinje cell for assessment of cardiac safety liabilitiesCano, Jordi / Romero, Lucía / Gomis-Tena, Julio / Amberg, Alexander / Anger, Lennart / Ballet, Veronique / Guillon, Jean-Michel / Pastor, Manuel / Sanz, Ferran / Saiz, Javier et al. | 2018
- 141
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Statistical design of in silico experiments for the robustness analysis of electrophysiologic response simulatorsDuponnois, Romain / Docquier, Théo / Aiguier, Thomas / Bastogne, Thierry et al. | 2018
- 142
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Towards prediction of acute and chronic drug effects using multi-parameter profiling of hiPSC-derived cardiomyocytesde Korte, Tessa / Wilbers, René / Stevenhagen, Fleur / Langenberg, Karin / Nacken, Peter / Vlaming, Maria L. / Braam, Stefan R. et al. | 2018
- 142
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In silico QT assay for preclinical assessment of drug-induced proarrhythmicityRomero, Lucía / Cano, Jordi / Gomis-Tena, Julio / Trenor, Beatriz / Sanz, Ferran / Pastor, Manuel / Saiz, Javier et al. | 2018
- 142
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Integrating dynamic clamping with automated patch clamping devices: Adding virtual IK1 channels to iPSC-CMGoversen, Birgit / Becker, Nadine / Stoelzle-Feix, Sonja / Obergrussberger, Alison / van Veen, Toon / Fertig, Niels / de Boer, Teun P. et al. | 2018
- 143
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A new paradigm for the assessment of chronic anthracycline mitochondrial cardiotoxicityde Oliveira, Bernardo L. / Niederer, Steven A. et al. | 2018
- 143
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Targettri: A toxicity-based triaging system for novel drug targetsVenhorst, Jennifer / van Someren, Eugene P. / van de Brug, Fred J. / Kalkman, Gino J. / Folkertsma, Simon et al. | 2018
- 144
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Unblinded: Responses to CiPA 28 compounds in COR.4U cardiomyocytesKettenhofen, Ralf / Luerman, Greg / Bohlen, Heribert et al. | 2018
- 144
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Successful integrative approach of the pro-arrhythmic risk assessment of the multichannel ion channel inhibitor vanoxerine, via combination of in silico human cardiomyocyte models and in vivo guinea-pig electromechanical window assayMorissette, Pierre / Gerenser, Pamela / Travis, Jeffrey / Fanelli, Patrick / Balasubramanian, Bharathi / Passini, Elisa / Bueno-Orovio, Alfonso / Rodriguez, Blanca / Regan, Christopher / Sannajust, Frederick et al. | 2018
- 144
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Tailoring in silico model to electrophysiology of individual iPSC-derived cardiomyocyte lines: One-size fits all?Lei, Chon Lok / Wang, Ken / Gissinger, Evgenia / Flint, Nicholas / Mamta, Chabria / Badi, Laura / Hoflack, Jean-Christophe / Schuler, Franz / Lave, Thierry / Singer, Thomas et al. | 2018
- 145
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In silico electro-mechanical window shortening and repolarisation abnormalities predict clinical risk of torsade de pointes for 40 reference compoundsPassini, Elisa / Bueno-Orovio, Alfonso / Morissette, Pierre / Sannajust, Frederick / Rodriguez, Blanca et al. | 2018
- 146
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Pluricyte® cardiomyocytes as a predictive tool for preclinical safety assessment: A comparison with isolated guinea-pig ventricular cardiomyocytesGuilbot, Stephanie / Printemps, Richard / Hautefeuille, Ludovic / de Korte, Tessa / Le Grand, Marie et al. | 2018
- 146
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Current comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi: HEART initiative) –The second stage: Ca transient platformTakasuna, Kiyoshi / Honda, Yayoi / Watanabe, Hitoshi / Kato, Natsumi / Hisada, Sunao et al. | 2018
- 146
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Measurements of action potentials from iPSC-derived cardiomyocytes using CellOPTIQ® platform predicts both single ion channel effects and in vitro whole heart electrophysiological responsesMcGlynn, Karen P. / Taylor, Amy E. / Burton, Francis L. / Chapman, Hugh / Kuosmanen, Tarja / Smith, Godfrey L. et al. | 2018
- 147
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Comparison and assessment of CaV1.2 kinetics described by different in silico cellular cardiac electrophysiology modelsWang, Ken / Cooper, Jonathan / Mirams, Gary / Gavaghan, David / Davies, Mark / Schuler, Franz / Lave, Thierry / Singer, Thomas / Polonchuk, Liudmila et al. | 2018
- 148
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Automatic ionic profiling on iPSC-CM from MEA signals using mathematical modeling and machine learningTixier, Eliott / Raphel, Fabien / Lombardi, Damiano / Zitoun, Philippe / Gerbeau, Jean-Frédéric et al. | 2018
- 148
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Use of hERG binding in lead optimization provides greater predictivity for QTc prolongation in vivo compared to manual patch hERG assayAbernathy, Matthew M. / Leishman, Derek J. et al. | 2018
- 148
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Testing excipients for possible adverse reactionsArmstrong, Duncan / Dumotier, Berengere / Fekete, Alex / Shankey, Vincent / Bieberich, Andrew / Fatig, Raymond / Pottel, Josh / Shoichet, Brian / Berg, Ellen / Urban, Laszlo et al. | 2018
- 149
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Hypothermia associated with a putative ophthalmic therapeutic in preclinical speciesDerakhchan, Kathy / Savinainen, Anneli / Newman, Jennifer / Josiah, Serene / Carey, Galen et al. | 2018
- 149
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Towards the use of bioassays as predictors for safety pharmacologyClark, Matthew / Shkrob, Maria / Yuryev, Anton et al. | 2018
- 150
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Proposed QT-interval correction method for the influence of changes in core body temperature based on circadian variations in conscious non-restrained cynomolgus monkeysEl Amrani, Abdel-Ilah / El Amrani-Callens, Francine / Loriot, Stéphane / Singh, Pramila / Forster, Roy et al. | 2018
- 150
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Multiparametric assessment of cardiotoxicity of chemotherapeutic drugs in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytesMulder, Petra / Famili, Farbod / de Korte, Tessa / Hechard, Celine / Braam, Stefan R. / Vlaming, Maria L. et al. | 2018
- 150
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Blinded analysis of CiPA compounds with human engineered heart tissueHansen, Arne / Eder, Alexandra / Mannhardt, Ingra / Eschenhagen, Thomas et al. | 2018
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Binding and functional analysis—Complementary approaches in safety pharmacologyJolas, Thierry / Migeon, Jacques / Wei, Haiyang David / Ko, Amber et al. | 2018
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Application of PBPK modelling of enterocyte exposure aids in vitro to in vivo translational risk assessment of μ-opioid-induced clinical constipationRibeiro, Lyn Rosenbrier / Sharma, Pradeep / Kavanagh, Stefan / Noeske, Tobias et al. | 2018
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Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluationRossman, Eric I. / Cools, Frank / Cordes, Jason S. / Dhuyvetter, Deborah / Doyle, Jennifer / Friedrichs, Gregory S. / Guth, Brian / Parish, Stanley T. / Pugsley, Michael K. / Dustan Sarazan, R. et al. | 2018
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Could a systematic threshold analysis approach optimize the NOEL/OEL setting within a safety pharmacology study?van der Linde, Henk / Van Ammel, Karel / Teisman, Ard / Gallacher, David J. et al. | 2018
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Rotational thromboelastometry for ex vivo assessment of drug effects on platelet functionSt-Jean, Camille / Boulay, Emmanuel / Gendron-Parra, Nicolas / Troncy, Eric / Authier, Simon et al. | 2018
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Action potential recordings and analysis in human ventricular trabeculae for assessment of pro-arrhythmic riskQu, Yusheng / Page, Guy / Abi-Gerges, Najah / Miller, Paul / Ghetti, Andre / Vargas, Hugo M. et al. | 2018
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Generation of expanded primary cells for cell-based toxicity and metabolism screeningsJohannssen, Timo / Runge, Nils / Nörenberg, Astrid et al. | 2018
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Diverse approaches to understand functional pharmacology—Examples of the 5-HT1B and 5-HT2A receptorsJolas, Thierry / Ko, Amber / Migeon, Jacques / Liu, Elsa et al. | 2018
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A comprehensive evaluation of four antineoplastic agents in the Langendorff isolated heart assayRoss, John / Waines, Michelle / Peachee, Vanessa / Walling, Brent / Roche, Brian et al. | 2018
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Neurotransmitter screening via dynamic calcium flux and MEA-based seizure liability assessment in human IPS neuronsHess, Dietmar / Kettenhofen, Ralf / Fleming, Chris / Luerman, Greg / Bohlen, Heribert et al. | 2018
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Dawn of a new era with simultaneous multi-system (ECG, BP, LVP, EEG and respiratory) monitoringAscah, Alexis / Maghezzi, Said / Authier, Simon et al. | 2018
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Cardiovascular safety studies on dopamine D3 receptor antagonists and cocaineAppel, Nathan M. / Acri, Jane B. et al. | 2018
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Development of native and stem cell-derived electrophysiological assays for neurotoxicology screening and translational drug discoveryRush, Anthony M. / Webdale, Louise / Rogers, Marc et al. | 2018
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Investigation of individual analysis of QT interval in beagle dogsMatsubara, Fuminori / Okada, Kazuhide / Miyazaki, Souji / Hashiguchi, Noriko / Nakano, Koji / Tsuboi, Masaru / Kanno, Akihiro / Kazusa, Katsuyuki / Tadano, Kiyoshi / Tasaka, Tomoya et al. | 2018
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Improvement of ECG monitoring quality using solid tip lead transmitters in the guinea-pigLe Quément, Catherine / Loiseau, Mathilde / Garreau, Myriam / Bruezière, Servane / Deal, Anthony / Maurin, Anne / La Rochelle, Christophe Drieu et al. | 2018
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A comparison of baseline cardiovascular parameters and the sensitivity to detect changes in systemic blood pressure and heart rate in beagle dogs using DSI M11 disposable telemetry devicesSadekova, Nataliya / Abernathy, Matthew M. / Leishman, Derek / Norton, Kevin et al. | 2018
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Why are non-rodents not socially housed during cardiovascular telemetry recordings on safety pharmacology studies?Prior, Helen / Gellatly, Nikki / Jackson, Sam et al. | 2018
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Effects of diurnal variation, group variability, model sensitivity, and acclimation on the evaluation of rat respiratory function using plethysmographyBaublits, Joel T. / Speece, Ty / Atterson, Phil / Love, Sandra / Botchway, Alfred et al. | 2018
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Identification of NOEL and NOAEL in functional safety (pharmacology) studies: A survey of a contract research organization master scheduleBaird, Ted / Kilgus, Quinn / Hutchins, Charity / Holdsworth, David / Tapp, Rachel / May, Jonelle / Harter, Marci / Gauvin, David / Dalton, Jill et al. | 2018
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Studying inotropic compound effects in relatively mature human iPSC-derived cardiomyocytes using 2D and 3D modelsde korte, Tessa / Mannhardt, Ingra / Hansen, Arne / Saleem, Umber / Eschenhagen, Thomas / Denning, Chris / Braam, Stefan R. / Vlaming, Maria L. et al. | 2018
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A comparison of methods for delineation of wave boundaries in 12 lead ECGGuyot, Pauline / Voiriot, Pascal / Batista, Levy / Bastogne, Thierry / Papelier, Stéphane et al. | 2018
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The gene expression profiles and drug responses of human pluripotent stem cell-derived myocardial micro-tissues on aligned fibrous scaffoldsAiba, Kazuhiro / Hori, Kosuke / Tooi, Norie / Yamamoto, Yuka / Yabuuchi, Mie / Uda, Junki / Craig, Margaret A. / Kato, Kensuke / Nakatsuji, Norio et al. | 2018
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Evaluation of human iPS cell-derived cardiomyocytes in high-throughput toxicity screening applicationsAméen, Caroline / Dahlenborg, Kerstin / Åkesson, Karolina / Flood, Maria / Aspegren, Anders / Juhasz, Krisztina / Stoelzle-Feix, Sonja et al. | 2018
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A novel, label-free system to interrogate the function and 3D phenotype of iPSC cardiomyocyte co-culture spheroids for discovery applicationsBurnham, Matthew / Harvey, Rachel / Thomas, Ulrich / Fertig, Niels / Haddrick, Malcolm et al. | 2018
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Application of human-induced pluripotent stem cell-derived cardiomyocytes in high-throughput screening assays for drug safety and efficacy testingNacken, Peter / D'Angelo, Jean Marc / Stevenhagen, Fleur / de Korte, Tessa / Wilbers, René / Famili, Farbod / Braam, Stefan R. / Vlaming, Maria L. et al. | 2018
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Cytotoxicity monitoring for safety assessments: iPS cardiomyocytes and cancer cellsStoelzle-Feix, Sonja / Bot, Corina T. / Dragicevic, Elena / Juhasz, Krisztina / Doerr, Leo / Beckler, Matthias / George, Michael / Haedo, Rodolfo / Fertig, Niels et al. | 2018
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Development of a 3D-spheroid culture system to assess drug induced liver injury using induced pluripotent stem cell-derived hepatocytesHancock, Michael / Feaster, T.K. / Carlson, Coby / Aoyama, Natsuyo / Schlesinger, David / Mann, David / Anson, Blake D. et al. | 2018
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Assessing functional and structural cardiotoxicity in cultured human iPSC-cardiomyocytes in a single plate formatGuo, Liang / Furniss, Michael / Hamre, John / Batista, Levy / Bastogne, Thierry / Yan, Zhuge / Wu, Joseph C. / Eldridge, Sandy / Davis, Myrtle et al. | 2018
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Leveraging genetic diversity in vitro: Evolution or revolution in cardiac safety assessment?Fine, Eli J. / Sullivan, Denise D. / Nguyen, Anh H. / Chal, Jerome / Hamilton, Jonathon B. / Coyne, Kevin P. / Coyne, Shawn T. / Mobley, Sheldon L. / Poe-Yamagata, Emma M. / Dobric, Maja et al. | 2018
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Impact of serum in the pharmacological response of human iPSC-derived cardiomyocytesGoineau, Sonia / Legrand, Christophe / Hunault, Marion / Froget, Guillaume / Castagné, Vincent et al. | 2018
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Validation of cardiotoxicity testing using cardiomyocytes differentiated from human embryonic stem cells in multi-electrode-arrayKim, Ki-Suk / Lee, Hyang-Ae et al. | 2018
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Development of human iPS cell-based platform for developmental neurotoxicity testingYamada, Shigeru / Yamazaki, Daiju / Kanda, Yasunari et al. | 2018
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Objective interpretation of calcium transient screening data on hiPS-derived cardiomyocytes using a novel hazard prediction systemKopljar, Ivan / Lu, Hua Rong / Van Ammel, Karel / Otava, Martin / Tekle, Fetene / Teisman, Ard / Gallacher, David J. et al. | 2018
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Trial for data analysis of drug responses in primary rodent neurons and human-induced pluripotent stem cell-derived neurons using MEA and deep learningMiyamoto, Norimasa / Ojima, Atsuko / Kitamura, Tetsuo / Osada, Tomoharu / Kadowaki, Tadashi / Yoshinaga, Takashi et al. | 2018
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Opening the molecular toolbox: Co-transfection of KCNJ2 and channelrhodopsin 2 mRNAs for precise control of IPS cardiomyocyte pacing and functionalityKettenhofen, Ralf / Wolters, Benjamin / Luerman, Greg / Bohlen, Heribert et al. | 2018
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Multiwell optogenetics for enhanced cell-based assaysMillard, Daniel C. / Clements, Mike / Clements, Isaac C. / Hayes, Heather B. / Nicolini, Anthony M. / Ross, James D. et al. | 2018
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Sex-related differences in drug-induced QT prolongation and Torsades de pointes: A new model system with human iPSC-CMsPang, Li / Juo, Jianhua / Lyn-Cook, Beverly / Stockbridge, Norman et al. | 2018
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Development and application of cardiac microtissues to cardiovascular safetyArcher, Caroline / Basak, Jayati / Sargeant, Rebecca / Pilling, James / Wang, Yinhai / Barnes, Jen / Pointon, Amy et al. | 2018
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Comprehensive profiling of axiogenesis ventricular vCor.4U iPSC-derived cardiomyocytes—From electrophysiology to phenotypic assaysEl Haou, Said / Williams, Sarah / Webdale, Louise / Rogers, Marc / Sutton, Kathy et al. | 2018
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Cardiac spheroid co-cultures as a novel in vitro model to study human heart microenvironmentPolonchuk, Liudmila / Chabria, Mamta / Badi, Laura / Hoflack, Jean-Christophe / Davies, Michael J. / Figtree, Gemma / Gentile, Carmine et al. | 2018
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Differentiation and validation of human iPSC-derived atrial cardiomyocytesSutton, Kathy / El Haou, Said / Williams, Sarah / Devalla, Harsha / Stoelzle-Feix, Sonja / Juhasz, Krisztina / Doerr, Leo / Beckler, Matthias / Haarmann, Claudia / George, Michael et al. | 2018
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Electrophysiological characterisation of cellular dynamics international ventricular iCell2 iPSC-derived cardiomyocytesWilliams, Sarah / El Haou, Said / Webdale, Louise / Rogers, Marc / Sutton, Kathy et al. | 2018
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Proarrhythmic risk evaluation of vanoxerine in normal and hypertrophic cardiomyopathy human stem cell-derived cardiomyocytesShi, Hong / Huang, Minxue / Levesque, Paul et al. | 2018
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Electrophysiological responses of cultured human iPSC-derived neuronal networks to convulsants or anti-convulsant drugsOdawara, Aoi / Matsuda, Naoki / Ishibashi, Yuto / Yokoi, Remi / Suzuki, Ikuro et al. | 2018
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The influence of fibroblast co-culture and 3D structures on cardiac action potentials of human stem cell-derived cardiomyocytesHortigon-Vinagre, Maria P. / Zamora, Victor / Gintant, Gary / Green, Jonathon / Burton, Francis L. / Smith, Godfrey L. et al. | 2018
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Modeling heart failure for therapeutic screens in engineered human myocardiumTiburcy, Malte / Meyer, Tim / Long, Chengzu / Olson, Eric N. / Zimmermann, Wolfram H. et al. | 2018
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Drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytesYamazaki, Daiju / Kitaguchi, Takashi / Ishimura, Masakazu / Taniguchi, Tomohiko / Yamanishi, Atsuhiro / Saji, Daisuke / Takahashi, Etsushi / Oguchi, Masao / Moriyama, Yuta / Maeda, Sanae et al. | 2018
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Studying sensitisation and cross-sensitisation potential of ß-lactam antibiotics using a modified biphasic local lymph node assay in miceAhuja, Varun / Stahlmann, Ralf et al. | 2018
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Modifying standard assay for assessing allosteric activityMigeon, Jacques / Ko, Amber / Lin, Heng-Hsu / Liu, Elsa / Feng, Jin-Jye et al. | 2018
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Evolution in diversity of a drugs primary target class poses a challenge to standard secondary pharmacology profiling: A look to future requirements and opportunitiesRibeiro, Lyn Rosenbrier / Larner, Carrie / Persson, Mikael / Scott, Clay et al. | 2018
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Effects of sympathetic tone in the QT interval and heart rate variability indices of beagle dogsYoungblood, Brad / Ferris, Erin / Geist, Beth / Ueyama, Yukie / Muir, William W. / del Rio, Carlos / Hamlin, Robert L. et al. | 2018
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Molecular modeling a tool for postulating the mechanism of drug interaction: Glimepiride alters the pharmacokinetics of sildenafil citrate in diabetic nephropathy animalsTripathi, Alok S. et al. | 2018
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NOAELs or not in safety pharmacology—An industry surveyAndersen, Ninette / Authier, Simon / Bass, Alan / Baird, Ted / Bhatt, Siddhartha / Curtis, Michael / Dragsted, Nils / Engwall, Michael / Jones, David / Lassen, Anders et al. | 2018
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Editorial Board| 2018