4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo (Unknown)
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In:
Journal of Medicinal Chemistry
;
48
, 18
;
5644-5647
;
2005
- Article (Journal) / Electronic Resource
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Title:4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo
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Additional title:J. Med. Chem.
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Contributors:Kallander, Lara S. ( author ) / Lu, Qing ( author ) / Chen, Wenfang ( author ) / Tomaszek, Thaddeus ( author ) / Yang, Guang ( author ) / Tew, David ( author ) / Meek, Thomas D. ( author ) / Hofmann, Glenn A. ( author ) / Schulz-Pritchard, Christina K. ( author ) / Smith, Ward W. ( author )
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Published in:Journal of Medicinal Chemistry ; 48, 18 ; 5644-5647
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Publisher:
- New search for: American Chemical Society
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Publication date:2005-09-08
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ISSN:
-
Coden:
-
DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 48, Issue 18
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 5613
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Joys of Molecules. 2. Endeavors in Chemical Biology and Medicinal Chemistry †Nicolaou, K. C. et al. | 2005
- 5639
-
Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor ActivityWittman, Mark / Carboni, Joan / Attar, Ricardo / Balasubramanian, Balu / Balimane, Praveen / Brassil, Patrick / Beaulieu, Francis / Chang, Chiehying / Clarke, Wendy / Dell, Janet et al. | 2005
- 5644
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4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in VivoKallander, Lara S. / Lu, Qing / Chen, Wenfang / Tomaszek, Thaddeus / Yang, Guang / Tew, David / Meek, Thomas D. / Hofmann, Glenn A. / Schulz-Pritchard, Christina K. / Smith, Ward W. et al. | 2005
- 5648
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A Systematic Analysis of the Effect of Small-Molecule Binding on Protein Flexibility of the Ligand-Binding SitesYang, Chao-Yie / Wang, Renxiao / Wang, Shaomeng et al. | 2005
- 5651
-
Enhancement of Aqueous Solubility and Stability Employing a Trans Acetate Axis in Trans Planar Amine Platinum Compounds while Maintaining the Biological ProfileMa, Erin S. F. / Bates, W. Douglas / Edmunds, Armistead / Kelland, Lloyd R. / Fojo, Tito / Farrell, Nicholas et al. | 2005
- 5655
-
The First de Novo-Designed Antagonists of the Human NK2 ReceptorAli, Mohammed A. / Bhogal, Nirmala / Findlay, John B. C. / Fishwick, Colin W. G. et al. | 2005
- 5659
-
Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro−Fidarestat ComplexPetrova, Tatiana / Steuber, Holger / Hazemann, Isabelle / Cousido-Siah, Alexandra / Mitschler, Andre / Chung, Roland / Oka, Mitsuru / Klebe, Gerhard / El-Kabbani, Ossama / Joachimiak, Andrzej et al. | 2005
- 5666
-
Impact of Induced Fit on Ligand Binding to the Androgen Receptor: A Multidimensional QSAR Study To Predict Endocrine-Disrupting Effects of Environmental ChemicalsLill, Markus A. / Winiger, Fabienne / Vedani, Angelo / Ernst, Beat et al. | 2005
- 5675
-
6,19-Sulfur-Bridged Progesterone Analogues with Antiimmunosuppressive Activity1Veleiro, A.S. et al. | 2005
- 5675
-
6,19-Sulfur-Bridged Progesterone Analogues with Antiimmunosuppressive ActivityVeleiro, Adriana S. / Pecci, Adali / Monteserín, María C. / Baggio, Ricardo / Garland, María T. / Lantos, Carlos P. / Burton, Gerardo et al. | 2005
- 5684
-
6-Acylamino-2-aminoquinolines as Potent Melanin-Concentrating Hormone 1 Receptor Antagonists. Identification, Structure−Activity Relationship, and Investigation of Binding ModeUlven, Trond / Frimurer, Thomas M. / Receveur, Jean-Marie / Little, Paul Brian / Rist, Øystein / Nørregaard, Pia K. / Högberg, Thomas et al. | 2005
- 5698
-
Autocorrelation of Molecular Electrostatic Potential Surface Properties Combined with Partial Least Squares Analysis as New Strategy for the Prediction of the Activity of Human A3 Adenosine Receptor AntagonistsMoro, Stefano / Bacilieri, Magdalena / Cacciari, Barbara / Spalluto, Giampiero et al. | 2005
- 5705
-
Synthesis and Biological Activity of Flurbiprofen Analogues as Selective Inhibitors of b-Amyloid1-42 SecretionPeretto, I. et al. | 2005
- 5705
-
Synthesis and Biological Activity of Flurbiprofen Analogues as Selective Inhibitors of β-Amyloid1 - 42 SecretionPeretto, Ilaria / Radaelli, Stefano / Parini, Carlo / Zandi, Michele / Raveglia, Luca F. / Dondio, Giulio / Fontanella, Laura / Misiano, Paola / Bigogno, Chiara / Rizzi, Andrea et al. | 2005
- 5705
-
Synthesis and Biological Activity of Flurbiprofen Analogues as Selective Inhibitors of beta-Amyloid~1~-~4~2 SecretionPeretto, I. / Radaelli, S. / Parini, C. / Zandi, M. / Raveglia, L. F. / Dondio, G. / Fontanella, L. / Misiano, P. / Bigogno, C. / Rizzi, A. et al. | 2005
- 5721
-
Carbonic Anhydrase Inhibitors: Stacking with Phe131 Determines Active Site Binding Region of Inhibitors As Exemplified by the X-ray Crystal Structure of a Membrane-Impermeant Antitumor Sulfonamide Complexed with Isozyme IIMenchise, Valeria / De Simone, Giuseppina / Alterio, Vincenzo / Di Fiore, Anna / Pedone, Carlo / Scozzafava, Andrea / Supuran, Claudiu T. et al. | 2005
- 5728
-
Theoretical and Experimental Design of Atypical Kinase Inhibitors: Application to p38 MAP KinaseMcClure, Kim F. / Abramov, Yuriy A. / Laird, Ellen R. / Barberia, John T. / Cai, Weiling / Carty, Thomas J. / Cortina, Santo R. / Danley, Dennis E. / Dipesa, Alan J. / Donahue, Kathleen M. et al. | 2005
- 5738
-
Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 Carbonyl Functionality Reveals the Essential Role of the sn-1 Carbonyl at the Lipid Interface in the Binding of DAG-Lactones to Protein Kinase CKang, Ji-Hye / Peach, Megan L. / Pu, Yongmei / Lewin, Nancy E. / Nicklaus, Marc C. / Blumberg, Peter M. / Marquez, Victor E. et al. | 2005
- 5749
-
E-Ring Modified Steroids as Novel Potent Inhibitors of 17beta-Hydroxysteroid Dehydrogenase Type 1Fischer, D. S. / Allan, G. M. / Bubert, C. / Vicker, N. / Smith, A. / Tutill, H. J. / Purohit, A. / Wood, L. / Packham, G. / Mahon, M. F. et al. | 2005
- 5749
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E-Ring Modified Steroids as Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1Fischer, Delphine S. / Allan, Gillian M. / Bubert, Christian / Vicker, Nigel / Smith, Andrew / Tutill, Helena J. / Purohit, Atul / Wood, Lynn / Packham, Graham / Mahon, Mary F. et al. | 2005
- 5749
-
E-Ring Modified Steroids as Novel Potent Inhibitors of 17b-Hydroxysteroid Dehydrogenase Type 1Fischer, D.S. et al. | 2005
- 5771
-
Pharmacophore-Guided Drug Discovery Investigations Leading to Bioactive 5-Aminotetrahydropyrazolopyridines. Implications for the Binding Mode of Heterocyclic Dopamine D3 Receptor Agonists §Elsner, Jan / Boeckler, Frank / Heinemann, Frank W. / Hübner, Harald / Gmeiner, Peter et al. | 2005
- 5780
-
Design and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 AntagonistsGross, Raymond S. / Guo, Zhiqiang / Dyck, Brian / Coon, Tim / Huang, Charles Q. / Lowe, Richard F. / Marinkovic, Dragan / Moorjani, Manisha / Nelson, Jodene / Zamani-Kord, Said et al. | 2005
- 5794
-
4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as Non-Nucleoside Inhibitors of Human Cytomegalovirus and Related Herpesvirus PolymerasesSchnute, Mark E. / Cudahy, Michele M. / Brideau, Roger J. / Homa, Fred L. / Hopkins, Todd A. / Knechtel, Mary L. / Oien, Nancee L. / Pitts, Thomas W. / Poorman, Roger A. / Wathen, Michael W. et al. | 2005
- 5805
-
Modifications to the Tetracaine Scaffold Produce Cyclic Nucleotide-Gated Channel Blockers with Widely Varying EfficaciesStrassmaier, Timothy / Uma, Ramalinga / Ghatpande, Ambarish S. / Bandyopadhyay, Tapasree / Schaffer, Michelle / Witte, John / McDougal, Patrick G. / Brown, R. Lane / Karpen, Jeffrey W. et al. | 2005
- 5813
-
Synthesis and Structure−Activity Relationship of a Novel Series of Aminoalkylindoles with Potential for Imaging the Neuronal Cannabinoid Receptor by Positron Emission TomographyWillis, Peter G. / Pavlova, Olga A. / Chefer, Svetlana I. / Vaupel, D. Bruce / Mukhin, Alexey G. / Horti, Andrew G. et al. | 2005
- 5823
-
Novel Potent Antagonists of Transient Receptor Potential Channel, Vanilloid Subfamily Member 1: Structure−Activity Relationship of 1,3-Diarylalkyl Thioureas Possessing New Vanilloid EquivalentsSuh, Young-Ger / Lee, Yong-Sil / Min, Kyung-Hoon / Park, Ok-Hui / Kim, Jin-Kwan / Seung, Ho-Sun / Seo, Seung-Yong / Lee, Bo-Young / Nam, Yeon-Hee / Lee, Kwang-Ok et al. | 2005
- 5837
-
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 1)Tremont, Samuel J. / Lee, Len F. / Huang, Horng-Chih / Keller, Bradley T. / Banerjee, Shyamal C. / Both, Scott R. / Carpenter, Andrew J. / Wang, Ching-Cheng / Garland, Danny J. / Huang, Wei et al. | 2005
- 5853
-
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 2)Huang, Horng-Chih / Tremont, Samuel J. / Lee, Len F. / Keller, Bradley T. / Carpenter, Andrew J. / Wang, Ching-Cheng / Banerjee, Shyamal C. / Both, Scott R. / Fletcher, Theresa / Garland, Danny J. et al. | 2005
- 5869
-
Cytostatic 6-Arylpurine Nucleosides. 6. † SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine RibonucleosidesHocek, Michal / Nauš, Petr / Pohl, Radek / Votruba, Ivan / Furman, Phillip A. / Tharnish, Phillip M. / Otto, Michael J. et al. | 2005
- 5874
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Synthesis and Biological Evaluation of Dimeric RGD Peptide−Paclitaxel Conjugate as a Model for Integrin-Targeted Drug Delivery.Chen, Xiayuan / Plasencia, Carmen / Hou, Yingping / Neamati, Nouri et al. | 2005