4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4) (Unknown)
- New search for: Tsou, Hwei-Ru
- New search for: Otteng, Mercy
- New search for: Tran, Tritin
- New search for: Floyd, M. Brawner
- New search for: Reich, Marvin
- New search for: Birnberg, Gary
- New search for: Kutterer, Kristina
- New search for: Ayral-Kaloustian, Semiramis
- New search for: Ravi, Malini
- New search for: Nilakantan, Ramaswamy
- New search for: Grillo, Mary
- New search for: McGinnis, John P.
- New search for: Rabindran, Sridhar K.
- New search for: Tsou, Hwei-Ru
- New search for: Otteng, Mercy
- New search for: Tran, Tritin
- New search for: Floyd, M. Brawner
- New search for: Reich, Marvin
- New search for: Birnberg, Gary
- New search for: Kutterer, Kristina
- New search for: Ayral-Kaloustian, Semiramis
- New search for: Ravi, Malini
- New search for: Nilakantan, Ramaswamy
- New search for: Grillo, Mary
- New search for: McGinnis, John P.
- New search for: Rabindran, Sridhar K.
In:
Journal of Medicinal Chemistry
;
51
, 12
;
3507-3525
;
2008
- Article (Journal) / Electronic Resource
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Title:4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)
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Additional title:4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones
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Contributors:Tsou, Hwei-Ru ( author ) / Otteng, Mercy ( author ) / Tran, Tritin ( author ) / Floyd, M. Brawner ( author ) / Reich, Marvin ( author ) / Birnberg, Gary ( author ) / Kutterer, Kristina ( author ) / Ayral-Kaloustian, Semiramis ( author ) / Ravi, Malini ( author ) / Nilakantan, Ramaswamy ( author )
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Published in:Journal of Medicinal Chemistry ; 51, 12 ; 3507-3525
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Publisher:
- New search for: American Chemical Society
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Publication date:2008-06-26
-
ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 51, Issue 12
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 3331
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Non-Peptide Gonadotropin-Releasing Hormone Receptor AntagonistsBetz, Stephen F. / Zhu, Yun-Fei / Chen, Chen / Struthers, R. Scott et al. | 2008
- 3349
-
X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding DomainBiggadike, Keith / Bledsoe, Randy K. / Hassell, Anne M. / Kirk, Barrie E. / McLay, Iain M. / Shewchuk, Lisa M. / Stewart, Eugene L. et al. | 2008
- 3353
-
Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal SubunitIppolito, Joseph A. / Kanyo, Zoltan F. / Wang, Deping / Franceschi, Francois J. / Moore, Peter B. / Steitz, Thomas A. / Duffy, Erin M. et al. | 2008
- 3357
-
Synthesis and Biological Evaluation of d-Amino Acid Oxidase InhibitorsFerraris, Dana / Duvall, Bridget / Ko, Yao-Sen / Thomas, Ajit G. / Rojas, Camilo / Majer, Pavel / Hashimoto, Kenji / Tsukamoto, Takashi et al. | 2008
- 3360
-
Chemically Induced Dimerization of Human Nonpancreatic Secretory Phospholipase A2 by Bis-indole DerivativesZhou, Lu / Fang, Chao / Wei, Ping / Liu, Shiyong / Liu, Ying / Lai, Luhua et al. | 2008
- 3367
-
Discovery of Novel Small-Molecule Inhibitors of Human Epidermal Growth Factor Receptor-2: Combined Ligand and Target-Based ApproachGundla, Rambabu / Kazemi, Roza / Sanam, Ramadevi / Muttineni, Ravikumar / Sarma, Jagarlapudi A. R. P. / Dayam, Raveendra / Neamati, Nouri et al. | 2008
- 3378
-
Homology Modeling and Site-Directed Mutagenesis To Identify Selective Inhibitors of Endothelin-Converting Enzyme-2Gagnidze, Khatuna / Sachchidanand / Rozenfeld, Raphael / Mezei, Mihaly / Zhou, Ming-Ming / Devi, Lakshmi A. et al. | 2008
- 3388
-
Indole Cytosolic Phospholipase A~2 alpha Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, EfipladibMcKew, J.C. / Lee, K.L. / Shen, M.W.H. / Thakker, P. / Foley, M.A. / Behnke, M.L. / Hu, B. / Sum, F.-W. / Tam, S. / Hu, Y. et al. | 2008
- 3388
-
Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, EfipladibMcKew, John C. / Lee, Katherine L. / Shen, Marina W. H. / Thakker, Paresh / Foley, Megan A. / Behnke, Mark L. / Hu, Baihua / Sum, Fuk-Wah / Tam, Steve / Hu, Yonghan et al. | 2008
- 3414
-
New C5-Alkylated Indolobenzazepinones Acting as Inhibitors of Tubulin Polymerization: Cytotoxic and Antitumor ActivitiesKeller, Laurent / Beaumont, Stéphane / Liu, Jian-Miao / Thoret, Sylviane / Bignon, Jérôme S. / Wdzieczak-Bakala, Joanna / Dauban, Philippe / Dodd, Robert H. et al. | 2008
- 3422
-
Discovery of Imidazo[1,5-c]imidazol-3-ones: Weakly Basic, Orally Active Factor Xa InhibitorsImaeda, Yasuhiro / Kuroita, Takanobu / Sakamoto, Hiroki / Kawamoto, Tetsuji / Tobisu, Mamoru / Konishi, Noriko / Hiroe, Katsuhiko / Kawamura, Masaki / Tanaka, Toshimasa / Kubo, Keiji et al. | 2008
- 3437
-
A Series of Potent and Selective, Triazolylphenyl-Based Histone Deacetylases Inhibitors with Activity against Pancreatic Cancer Cells and Plasmodium falciparumChen, Yufeng / Lopez-Sanchez, Miriam / Savoy, Doris N. / Billadeau, Daniel D. / Dow, Geoffrey S. / Kozikowski, Alan P. et al. | 2008
- 3449
-
Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment LibraryNordström, Helena / Gossas, Thomas / Hämäläinen, Markku / Källblad, Per / Nyström, Susanne / Wallberg, Hans / Danielson, U. Helena et al. | 2008
- 3460
-
Development of Paramagnetic Probes for Molecular Recognition Studies in Protein KinasesVazquez, Jesus / De, Surya K. / Chen, Li-Hsing / Riel-Mehan, Megan / Emdadi, Aras / Cellitti, Jason / Stebbins, John L. / Rega, Michele F. / Pellecchia, Maurizio et al. | 2008
- 3466
-
4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pK a on Activity vs Chloroquine Resistant MalariaNatarajan, Jayakumar K. / Alumasa, John N. / Yearick, Kimberly / Ekoue-Kovi, Kekeli A. / Casabianca, Leah B. / de Dios, Angel C. / Wolf, Christian / Roepe, Paul D. et al. | 2008
- 3480
-
CYP53A15 of Cochliobolus lunatus, a Target for Natural Antifungal CompoundsPodobnik, Barbara / Stojan, Jure / Lah, Ljerka / Kras̆evec, Nada / Selis̆kar, Matej / Riz̆ner, Tea Lanis̆nik / Rozman, Damjana / Komel, Radovan et al. | 2008
- 3487
-
Synthesis and Quantitative Structure−Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl AlkylcarbamatesMor, Marco / Lodola, Alessio / Rivara, Silvia / Vacondio, Federica / Duranti, Andrea / Tontini, Andrea / Sanchini, Silvano / Piersanti, Giovanni / Clapper, Jason R. / King, Alvin R. et al. | 2008
- 3499
-
Protein−Ligand Docking Accounting for Receptor Side Chain and Global Flexibility in Normal Modes: Evaluation on Kinase Inhibitor Cross DockingMay, Andreas / Zacharias, Martin et al. | 2008
- 3507
-
4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)Tsou, Hwei-Ru / Otteng, Mercy / Tran, Tritin / Floyd, M. Brawner / Reich, Marvin / Birnberg, Gary / Kutterer, Kristina / Ayral-Kaloustian, Semiramis / Ravi, Malini / Nilakantan, Ramaswamy et al. | 2008
- 3526
-
Conformationally Constrained Analogues of N-(Piperidinyl)-5-(4-Chlorophenyl)-1-(2,4- Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxamide (SR141716): Design, Synthesis, Computational Analysis, And Biological EvaluationsZhang, Yanan / Burgess, Jason P. / Brackeen, Marcus / Gilliam, Anne / Mascarella, S. Wayne / Page, Kevin / Seltzman, Herbert H. / Thomas, Brian F. et al. | 2008
- 3540
-
Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic StudiesWen, Xiaoan / Sun, Hongbin / Liu, Jun / Cheng, Keguang / Zhang, Pu / Zhang, Liying / Hao, Jia / Zhang, Luyong / Ni, Peizhou / Zographos, Spyros E. et al. | 2008
- 3555
-
Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human α-AmylaseLo Piparo, Elena / Scheib, Holger / Frei, Nathalie / Williamson, Gary / Grigorov, Martin / Chou, Chieh Jason et al. | 2008
- 3555
-
Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human alpha -AmylasePiparo, E.L. / Scheib, H. / Frei, N. / Williamson, G. / Grigorov, M. / Chou, C.J. et al. | 2008
- 3562
-
Synthesis and Evaluation of Estrogen Agonism of Diaryl 4,5-Dihydroisoxazoles, 3-Hydroxyketones, 3-Methoxyketones, and 1,3-Diketones: A Compound Set Forming a 4D Molecular LibraryPulkkinen, Juha T. / Honkakoski, Paavo / Peräkylä, Mikael / Berczi, Istvan / Laatikainen, Reino et al. | 2008
- 3572
-
Conjugation of Poly-l-lysine to Bacterial Cytosine Deaminase Improves the Efficacy of Enzyme/Prodrug Cancer TherapyLi, Cong / Wildes, Flonne / Winnard, Paul / Artemov, Dmitri / Penet, Marie-France / Bhujwalla, Zaver M. et al. | 2008
- 3583
-
Clavatadine A, A Natural Product with Selective Recognition and Irreversible Inhibition of Factor XIaBuchanan, Malcolm S. / Carroll, Anthony R. / Wessling, Deborah / Jobling, Michael / Avery, Vicky M. / Davis, Rohan A. / Feng, Yunjiang / Xue, Yafeng / Öster, Linda / Fex, Tomas et al. | 2008
- 3588
-
Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid AggregationCamps, Pelayo / Formosa, Xavier / Galdeano, Carles / Gómez, Tània / Muñoz-Torrero, Diego / Scarpellini, Michele / Viayna, Elisabet / Badia, Albert / Clos, M. Victòria / Camins, Antoni et al. | 2008
- 3588
-
Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced beta -Amyloid AggregationCamps, P. / Formosa, X. / Galdeano, C. / Gomez, T. / Munoz-Torrero, D. / Scarpellini, M. / Viayna, E. / Badia, A. / Clos, M.V. / Camins, A. et al. | 2008
- 3599
-
1-[(Imidazolidin-2-yl)imino]indazole. Highly alpha ~2/I~1 Selective Agonist: Synthesis, X-ray Structure, and Biological ActivitySaczewski, F. / Kornicka, A. / Rybczynska, A. / Hudson, A.L. / Miao, S.S. / Gdaniec, M. / Boblewski, K. / Lehmann, A. et al. | 2008
- 3599
-
1-[(Imidazolidin-2-yl)imino]indazole. Highly α2/I1 Selective Agonist: Synthesis, X-ray Structure, and Biological ActivitySa̧czewski, Franciszek / Kornicka, Anita / Rybczyńska, Apolonia / Hudson, Alan L. / Miao, Shu Sean / Gdaniec, Maria / Boblewski, Konrad / Lehmann, Artur et al. | 2008
- 3609
-
Designing Selective, High Affinity Ligands of 5-HT1D Receptor by Covalent Dimerization of 5-HT1F Ligands Derived From 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamideChoi, Seok-Ki / Green, David / Ho, Anne / Klein, Uwe / Marquess, Daniel / Taylor, Robert / Turner, S. Derek et al. | 2008
- 3617
-
Synthesis, Cytotoxicity, DNA Interaction, and Topoisomerase II Inhibition Properties of Novel Indeno[2,1-c]quinolin-7-one and Indeno[1,2-c]isoquinolin-5,11-dione DerivativesRyckebusch, Adina / Garcin, Deborah / Lansiaux, Amélie / Goossens, Jean-François / Baldeyrou, Brigitte / Houssin, Raymond / Bailly, Christian / Hénichart, Jean-Pierre et al. | 2008
- 3630
-
16-Cyclopentadienyl Tricarbonyl 99mTc 16-Oxo-hexadecanoic Acid: Synthesis and Evaluation of Fatty Acid Metabolism in Mouse MyocardiumLee, Byung Chul / Kim, Dong Hyun / Lee, Iljung / Choe, Yearn Seong / Chi, Dae Yoon / Lee, Kyung-Han / Choi, Yong / Kim, Byung-Tae et al. | 2008
- 3635
-
DNA Interactions of Monofunctional Organometallic Osmium(II) Antitumor Complexes in Cell-Free MediaKostrhunova, Hana / Florian, Jakub / Novakova, Olga / Peacock, Anna F. A. / Sadler, Peter J. / Brabec, Viktor et al. | 2008
- 3644
-
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl RingsBiava, Mariangela / Porretta, Giulio Cesare / Poce, Giovanna / De Logu, Alessandro / Saddi, Manuela / Meleddu, Rita / Manetti, Fabrizio / De Rossi, Edda / Botta, Maurizio et al. | 2008
- 3649
-
Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria Parasite Plasmodium falciparumPhillips, Margaret A. / Gujjar, Ramesh / Malmquist, Nicholas A. / White, John / El Mazouni, Farah / Baldwin, Jeffrey / Rathod, Pradipsinh K. et al. | 2008
- 3654
-
Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium DerivativesGe, Jian-Feng / Arai, Chika / Kaiser, Marcel / Wittlin, Sergio / Brun, Reto / Ihara, Masataka et al. | 2008
- 3659
-
Bitter Nemesis. The Intimate History of StrychnineCannon, J.G. et al. | 2008
- 3659
-
Bioactive Natural Products. Detection, Isolation, and Structural Determination. Second EditionKrueger, R.J. et al. | 2008
- 3659
-
Book Review of Bitter Nemesis. The Intimate History of StrychnineCannon, Joseph G. et al. | 2008
- 3659
-
Book Review of Bioactive Natural Products. Detection, Isolation, and Structural Determination. Second EditionKrueger, Robert J. et al. | 2008
- 3660
-
Books of InterestCannon, Joseph G. et al. | 2008
- 3660
-
Carbonic Anhydrase-II Inhibition. What Are the True Enzyme–Inhibitory Properties of the Sulfamide Cognate of Topiramate?Maryanoff, Bruce E. / McComsey, David F. / Lee, Jung / Smith-Swintosky, Virginia L. / Wang, Yuanping / Minor, Lisa K. / Todd, Matthew J. et al. | 2008